ライフサイエンスコーパス: heterologous

1 vitro stimulation with homologous (NF54) or heterologous (7G8) PfSPZ were highly correlated.

2 n for a majority of immunized mice against a heterologous A/California/07/2009 H1N1 virus.

3 Seroconversion to heterologous A/H3N2, for example, was 84.0% for homologo

4 ation that can be largely substituted by the heterologous activation domain VP16.

5 Furthermore, we implemented heterologous Ad/protein immunization regimens that inclu

6 In contrast to pre-AIT sera, the presence of heterologous and autologous post-AIT sera significantly

7 Using a set of functional readouts in heterologous and endogenous expression systems, we ident

8 T-cell responses to heterologous and homologous insert regimens targeted a s

9 as well as agrin-induced AChR clustering in heterologous and muscle cells.

10 ive against influenza viruses in homologous, heterologous, and heterosubtypic murine challenge models

11 urs during the first administration of these heterologous antibodies.

12 ic IgGs could react to homologous as well as heterologous antigens and parasites, suggesting that con

13 studies on RASV development differ on where heterologous antigens are expressed and localized within

14 Sheaths displaying heterologous antigens generated better immune responses

15 ) autotransporter system for accumulation of heterologous antigens in cell culture supernatant.

16 rains is a promising strategy for presenting heterologous antigens to the mammalian immune system to

17 ease-causing meningococci expressing vaccine-heterologous antigens.

18 ice were subjected to secondary challenge by heterologous B. burgdorferi at different time points pos

19 This method was used to diversify a heterologous beta-carotene biosynthetic pathway that pro

20 ils with functional outcomes 18 months after heterologous bilateral hand and forearm transplantation

21 Without heterologous binding partners, BECN1 forms an antiparall

22 omogenate binding assays with homologous and heterologous blockades using tauopathy brain samples.

23 nificant protection following homologous and heterologous blood-stage challenge.

24 9 titanium meshes and particulate autologous-heterologous bone.

25 protein (r30/antigen 85B [Ag85B]) (rLm30) as heterologous booster vaccines in animals primed with BCG

26 hallenge not only by WEHI-164 cells but also heterologous C51 or CT26 colorectal tumor cells in a CD8

27 is a 'molecular sled,' because it can slide heterologous cargos along DNA, for example, a streptavid

28 ccharides to a carrier protein that recruits heterologous CD4 T cells to help B cell maturation.

29 o-MDSC are unable to suppress autologous and heterologous CD8 T-cell proliferations, display decrease

30 es, yet most cellular expression systems use heterologous cDNA-based vectors which express proteins w

31 ion protein contribute to protection against heterologous CDV strains.IMPORTANCE Rabies virus and can

32 We show that a heterologous cell fusion assay in vitro and allelic comp

33 Using a heterologous cell system, we show that human leptin secr

34 lectively manipulate this channel complex in heterologous cells and adult rat cardiomyocytes.

35 e, mSIRK, increases DA efflux through DAT in heterologous cells and primary dopaminergic neurons in c

36 Der p1 also induced the release of IL-6 from heterologous cells expressing MRGPRX1.

37 a cell-nonautonomous UPR-based regulation of heterologous cells may be phylogenetically conserved.

38 utes RyR2 into clusters when co-expressed in heterologous cells whereas minispryn lacks this activity

39 (i) BigLEN-mediated activation of GPR171 in heterologous cells, (ii) BigLEN-mediated hyperpolarizati

40 s anchoring partner the EphrinB2 receptor in heterologous cells, cultured neurons and in mouse brain.

41 In transfected heterologous cells, the L1302F mutation caused a large h

42 protein kinase A (PKA) both in vitro and in heterologous cells.

43 and to inhibit the induction of autophagy in heterologous cells.

44 s to GABAB receptor-induced Kir3 currents in heterologous cells.

45 ts of CYPs on the ligand responses of ORs in heterologous cells.

46 nel in the plasma membrane when expressed in heterologous cells; and 4) there are other proteins, suc

47 it does significantly impair recovery from a heterologous challenge virus, highlighting an important

48 unit vaccine candidate and then subjected to heterologous challenge with the virulent Kenya-128B-15 R

49 us challenge and complete protection against heterologous challenge.

50 tly reintegrate into DNA breaks induced on a heterologous chromosome.

51 irectly coassemble with Cav2.2 channels upon heterologous coexpression.

52 owever, diversity was more limited following heterologous coinfection.

53 Results of heterologous coinfections with pH1N1 and H3N2 viruses we

54 h a preference to the cis-acting elements in heterologous combinations to reduce AtCCA1 expression, w

55 1155 and a heterologous competitive hapten, where the 2'-OH group w

56 conditions we employed, while the reciprocal heterologous complementation demonstrates that U. botryt

57 Heterologous complementation using C. heterostrophus MAT

58 Homologous and heterologous cross-linked polymers of whey protein isola

59 higher viremia when exposed to a subsequent, heterologous dengue or Zika infection than those patient

60 virus could potentially enhance infection by heterologous Dengue serotypes.

61 ns for the outcome of sequential exposure to heterologous DENVs.

62 In addition, niacin induced heterologous desensitization and internalization of FPR1

63 etagamma/PKC-dependent ERK1/2 activation and heterologous desensitization of chemoattractant receptor

64 , conflicting reports on the ability of Rap1-heterologous DNA-binding domain fusion proteins to serve

65 The antibodies were raised using a heterologous DNA-viral vector prime-boost regimen, resul

66 changes in processing rates for each of six heterologous downstream modules compared with those of t

67 hat when ATP hydrolysis is present, flanking heterologous dsDNA regions increase the reversibility of

68 Vaccines can have nontargeted heterologous effects that manifest as increased protecti

69 timal point to redirect glycolytic flux into heterologous engineered pathways in Escherichia coli, re

70 is quantitative control over the loading of heterologous enzymes to the interior of the organelles.

71 ons, and the localization and interaction of heterologous expressed CRF-BP and CRF2alphaR in yeast, h

72 tric probe to assay functional modulators of heterologous expressed GABAA receptor (GABAAR) isoforms

73 The QUAC1/ALMT12 anion channel heterologous expressed in oocytes was gated open by extr

74 this study we determined that the in planta heterologous expressed OeGLU, an oleuropein-specific bet

75 Here, we report the heterologous expression and partial purification of His-

76 equently, this study reports the first super heterologous expression and secretion of apidaecin in ye

77 component of an MA channel partly based on a heterologous expression approach.

78 OST isoforms and their chimeric forms in the heterologous expression host S. cerevisiae where we were

79 These genes were characterized by heterologous expression in a modular metabolic engineeri

80 es sp. L-9-10 as well as its verification by heterologous expression in a nonproducing host are descr

81 pleuromutilin biosynthesis, through rational heterologous expression in Aspergillus oryzae coupled wi

82 es from different medicinal plant species by heterologous expression in engineered yeasts and report

83 Through heterologous expression in Escherichia coli, we also dem

84 sembly requirements of Te-Rubisco hinder its heterologous expression in leaf chloroplasts.

85 Transport Protein 43 (IFT43) was studied by heterologous expression in mIMCD3 and MDCK cells.

86 mbination of in vitro biochemical assays and heterologous expression in planta to demonstrate that Tc

87 n interaction properties were examined using heterologous expression in the TJ-free cell line HEK 293

88 Using heterologous expression in Xenopus oocytes and the engin

89 Using heterologous expression in Xenopus oocytes, we demonstra

90 zed the highly expressed isoform Delta0-ELO1 Heterologous expression in yeast (Saccharomyces cerevisi

91 ed role for SLC25A3 in copper transport, its heterologous expression in yeast complemented copper-spe

92 Heterologous expression of AfarsM1 in an Escherichia col

93 In this study, we showed that heterologous expression of an oxygenase gene (oxyBAC) pr

94 f all APP family members and could show that heterologous expression of APLP1 or APLP2 in non-neurona

95 ituting the last step of the pathway through heterologous expression of BioB and provision of its sub

96 is constitutively expressed in Bacillus sp. Heterologous expression of BlarsM conferred As(III) resi

97 Heterologous expression of Brachypodium SoPIN1 and PIN1b

98 mechanically activated (MA) currents is via heterologous expression of candidate channels in naive c

99 thiobacillus neapolitanus are sufficient for heterologous expression of carboxysomes in Escherichia c

100 in mice, can be utilized as a vector for the heterologous expression of EHV-1 glycoprotein D (gD) and

101 defects of Deltamogsk1 are recovered via the heterologous expression of Fusarium graminearum GSK3 hom

102 es that exhibited the highest propensity for heterologous expression of gene clusters, led to the ide

103 Heterologous expression of GPD2, a putative chloroplasti

104 particularly at the azole binding site, and heterologous expression of LmCYP51B and LbCYP51B, with f

105 Heterologous expression of mnx suppressed the Mn-sensiti

106 However, heterologous expression of P2X7R-Gln460Arg together with

107 Heterologous expression of PvACR3 markedly increased As

108 nce addition of recombinant SdrD protein and heterologous expression of SdrD in Lactococcus lactis pr

109 PCS1) and phosphate effluxer (PHO1), and the heterologous expression of the As-hyperaccumulator Pteri

110 However, heterologous expression of the Drosophila kainate recept

111 Heterologous expression of the mutant channel revealed s

112 Heterologous expression of the psbA4 gene, which we rena

113 Heterologous expression of TmELO genes in yeast revealed

114 Heterologous expression of TRPV1 also increases excitato

115 nsferase activity is demonstrated in vivo by heterologous expression of V. cholerae pathway enzymes i

116 Heterologous expression studies revealed the central rol

117 calize to numerous subcellular organelles in heterologous expression studies, but there are limited d

118 ical and genetic dissection in situ and in a heterologous expression system indicate that this acid e

119 logical characterization of duck Piezo2 in a heterologous expression system shows that duck Piezo2 is

120 However, in a heterologous expression system, it acts as a nucleotide

121 In a heterologous expression system, TbAAT10-1 is selective f

122 In a heterologous expression system, TDAG8 potentiated the ac

123 f the Drosophila KCNQ potassium channel in a heterologous expression system.

124 In 2 heterologous expression systems (HEK-293T cells and Xeno

125 In heterologous expression systems and cultured sensory neu

126 Experiments with heterologous expression systems show that some of the id

127 d fluorescence-based transport assays in two heterologous expression systems to establish a broad sub

128 rties of 11 ASD-associated SCN2A variants in heterologous expression systems using whole-cell voltage

129 t voltage-gated calcium (Ca(2+)) channels in heterologous expression systems were used to determine t

130 In heterologous expression systems, both the TMD and CR of

131 difficulties in the expression of hClC-Kb in heterologous expression systems, the functional conseque

132 e subcellular localization of human ClC-4 in heterologous expression systems.

133 two receptor subtypes have been described in heterologous expression systems.

134 inetics based solely on protein derived from heterologous expression systems.

135 Here we used CYP51 protein modelling and heterologous expression to determine whether there are i

136 We used reverse genetics and heterologous expression to identify the enzyme for Chl f

137 Using heterologous expression, in both Drosophila olfactory se

138 Here we report the heterologous expression, purification, and functional re

139 venting difficulties associated with in vivo heterologous expression.

140 We then generated a heterologous F-ATP synthase model system, which demonstr

141 serogroup B test strains expressing vaccine-heterologous factor H binding protein variants: PMB80 (A

142 coccal B test strains that expressed vaccine-heterologous factor H-binding proteins representative of

143 erated swapping of GP with counterparts from heterologous filoviruses, allowing high-throughput scree

144 Additionally, heterologous functional analyses in Arabidopsis resulted

145 This is the first demonstration of heterologous functional expression of mammalian OPN4 in

146 In vivo myomaker-mediated heterologous fusion and nuclear reprogramming.

147 Whether myomaker-mediated heterologous fusion is functional in vivo and whether th

148 ining bioinformatics, synthetic biology, and heterologous gene cluster expression can rapidly expand

149 Heterologous gene expression in E. coli confirmed its fu

150 These results indicate that heterologous gene expression in N. caninum is a useful t

151 t enable functionalization and patterning of heterologous gene expression within the cellulose matrix

152 and cellular levels, mixing and assembly of heterologous gene segments within coinfected cells, and

153 Introduction of just a few heterologous genes can endow cyanobacteria with the abil

154 onse elicited by one genotype can neutralize heterologous genotypes is unclear.

155 replicated to near-wild-type titers, and the heterologous glycoproteins were efficiently expressed an

156 Covalent fusion of this peptide tag to heterologous guest molecules led to their internalizatio

157 anisms or from Escherichia coli expressing a heterologous GV gene cluster and purified using buoyancy

158 uorescent immunospot assay (FluoroSpot) with heterologous H1N1 and H3N2 IAVs and CD8+ peptides from t

159 to recipient mice in a homologous, but not a heterologous, H1N1 viral challenge model.

160 g antibodies that neutralized homologous and heterologous H5 viruses with different degrees of cross-

161 ferrets were challenged with homologous and heterologous H5 viruses, challenge virus replication was

162 petent HIV-1 reporter virus that expresses a heterologous HA-tag on the surface of infected cells and

163 oportional hazards model, reinfection with a heterologous HCV genotype (adjusted Hazard Ratio [aHR]:

164 1, 95% CI: 0.27-0.94) when reinfected with a heterologous HCV genotype.

165 ed for transcriptional regulation in various heterologous host cells, offers unprecedented ease in de

166 a protocol for isolating GVs from native and heterologous host organisms, functionalizing these nanos

167 e C-methylation, we employed the rarely used heterologous host Rhizobium leguminosarum to invoke the

168 ogy approach to reconstitute, in a nonnative heterologous host, a minimal machinery capable of buildi

169 e components of these defense compounds in a heterologous host.

170 of these lineages appear to be shared among heterologous hosts providing evidence of interspecies tr

171 basidiomycete natural products in ascomycete heterologous hosts, and open up new possibilities of fur

172 ing sustainable production of salidroside in heterologous hosts.

173 raction appears evolutionarily conserved, as heterologous (human, mouse and Arabidopsis) Oxs1 and Pap

174 re susceptible to secondary challenge with a heterologous IAV, despite improving their antibody respo

175 ing a profound private specificity effect in heterologous immunity between these two viruses.

176 This study extends our understanding of heterologous immunity in the context of persistent viral

177 Heterologous immunity is recognized as a significant bar

178 For the first time, our results illustrate heterologous immunity of virus-infected animals toward a

179 sed as a persistent infection model to study heterologous immunity with LCMV.

180 This is termed "heterologous immunity" and has not been assessed previou

181 uence disease outcome through the process of heterologous immunity.

182 cell (ASC) response following homologous and heterologous inactivated FMDV vaccination regimes.

183 itate the rapid elimination of homologous or heterologous infections.

184 provided 100% survival against 7 of 9 lethal heterologous influenza challenges.

185 conferred protection against homologous and heterologous influenza virus challenges.

186 nd protected 100% of mice from 8 of 9 lethal heterologous influenza virus challenges.

187 Heterologous inhibition of the F1-ATPase of P. denitrifi

188 fidence interval [CI], .6-1.6; P = .91), but heterologous insert regimens induced significantly more

189 contacts and has an effect on the "seam" of heterologous interactions, enforcing a conformation more

190 A heterologous Lactococcus lactis expression system was us

191 but failed to protect against five different heterologous lethal influenza challenges.

192 w that this broadening is functional using a heterologous lethal virus challenge in ferrets.

193 Through heterologous localization assays with rickettsial ZitP a

194 crystals is to introduce nucleation-inducing heterologous materials into the crystallization solution

195 In summary, our study introduces a heterologous mouse model that allows further investigati

196 nal activity, net lengthening of the PATs of heterologous mRNAs with concomitant stabilization, inclu

197 tivity through regulation of cell firing and heterologous neurotransmitter release.

198 e transition from narrow autologous to broad heterologous neutralization over time.

199 to determine the HIV-1 sequence required for heterologous, non-viral RNAs to be packaged into viral p

200 pMS is targeted to the cytoplasm employing a heterologous nuclear export signal, it is expressed at v

201 quences were tested for the ability to drive heterologous nuclear transgene expression.

202 ds and Diphylleia, and it uniquely possesses heterologous, nucleus-, and mitochondrion-encoded cytoch

203 Our study demonstrates that heterologous O-antigen expression is a promising strateg

204 LT18 (pCZ1) induced specific IgG against the heterologous O-antigen, which mediated significant killi

205 ) and SLT12 (pCZ1) efficiently expressed the heterologous O-antigen.

206 arabinose, SLT16 (pCZ1) mainly expressed the heterologous O-antigen.

207 ccines through the recombinant expression of heterologous O-antigens from Salmonella Choleraesuis in

208 T16 (pCZ1) expressed both the homologous and heterologous O-antigens, whereas in the absence of arabi

209 Here we report on the heterologous overexpression and purification of PfVIT, a

210 The heterologous overexpression of integral membrane protein

211 Heterologous overexpression of OsbHLH068 in Arabidopsis

212 in vitro, and at least in the fission yeast, heterologous Oxs1 and Pap1-homologues can substitute for

213 th which segments carrying homologous versus heterologous packaging signals were incorporated into re

214 lysed in co-culture assays with all possible heterologous pairwise combinations.

215 yeast counterpart, human ANTs associate with heterologous partner proteins, including the respiratory

216 tions based on known BECN1 interactions with heterologous partners.

217 ine induction of protective immunity against heterologous pathogens.

218 a combination of precursor feeding studies, heterologous pathway expression and gene deletion experi

219 sults also suggest that the encapsulation of heterologous pathways in bacterial microcompartments mig

220 st durable protection against homologous and heterologous Pf parasites can be achieved with PfSPZ Vac

221 mic subjects, six underwent repeat CHMI with heterologous Pf7G8 parasites 33 wk after final immunizat

222 Because heterologous phosphorylation is a common phenomenon amon

223 Neospora caninum, and used this system as a heterologous platform for the expression of foreign gene

224 uld be produced by transglutaminase-mediated heterologous polymerization of protein mixtures.

225 other protein component more effectively in heterologous polymers than in homologous polymers.

226 the IgE reactivity of protein components in heterologous polymers was significantly lower than that

227 conditions revealed that both homologous and heterologous polymers were less digestible than untreate

228 binding trimeric Env, of which 6 neutralized heterologous primary isolates of various HIV-1 subtypes

229 s in successive immunization campaigns or as heterologous prime-boost agents.

230 Heterologous prime-boost immunization with plasmid DNA a

231 Heterologous prime-boost may provide a more effective va

232 Only heterologous prime-boost vaccination induced modest cros

233 Completing the serial immunization steps for heterologous prime-boost-boost can be lengthy, leaving t

234 Heterologous prime-boost-boost immunization has been sho

235 Heterologous production of betalains is thus anticipated

236 We show that heterologous production of salidroside can be achieved i

237 ility of these CYPs by engineering yeast for heterologous production of six oxygenated diterpenoids,

238 ain biosynthetic pathway, we demonstrate the heterologous production of these pigments in a variety o

239 monstrate that both polymerases can copy the heterologous promoter sequence.

240 provided limited cross-reactive immunity and heterologous protection against H3N2 CIV.

241 te that attenuated MACV vaccines can provide heterologous protection against NW arenaviruses.

242 8 (pCZ1) immunization resulted in 83% or 50% heterologous protection against Salmonella Choleraesuis

243 T cells from W7-791-immunized mice conferred heterologous protection, indicating a role for T cell-me

244 avior and may enable improved integration of heterologous protein and metabolite pathways.

245 ast strains that show significantly enhanced heterologous protein expression and higher titers of ter

246 ombinant protein extracted and purified from heterologous protein expression systems.

247 and reveal additional complexity involved in heterologous protein expression.

248 velopment of drug targets and improvement of heterologous protein production with many biotechnologic

249 egated protein templates the misfolding of a heterologous protein, is one mechanism proposed to stimu

250 ork enabled us to increase the production of heterologous proteins and metabolites.

251 es allow general control over the loading of heterologous proteins localized by two different N-termi

252 of QSSM precursors, (iii) the production of heterologous QSSMs negatively impacts the production of

253 hat homologous reassortment was random while heterologous reassortment was characterized by specific

254 become potent secondary effectors following heterologous rechallenge.

255 We used phylogenetic analysis and heterologous reconstitution of bilin biosynthesis to inv

256 cation of these biosynthetic enzymes and the heterologous reconstitution of the indole-sulfur phytoal

257 d the pathway with target gene inactivation, heterologous reconstitution, and biochemical characteriz

258 clear dose-response pattern was evident for heterologous recurrences of P. vivax infection.

259 perated effectively in cis to protect linked heterologous regulatory elements from methylation, there

260 ) and for TRP of A. mellifera (AmTRP-R) in a heterologous reporter assay system to determine the acti

261 Due to intrinsic limitations of heterologous reporter assays, we sought to develop a gen

262 ed in a corresponding intronic position in a heterologous reporter.

263 No differences in heterologous response were seen in the adjuvanted versus

264 We show that a heterologous RNA that lacks complementary piRNAs is proc

265 ogous) symbiont Symbiodinium minutum and the heterologous S. trenchii Analysis of the host gene and m

266 roduced with staphylococcal enterotoxin B, a heterologous SAg that also targets Vbeta8(+) T cells, an

267 rry receptors that enable 'cross-feeding' on heterologous siderophores made by neighboring organisms,

268 remarkable for its ability to use dozens of heterologous siderophores.

269 eated low-dose, intravaginal challenges with heterologous SIVsmE660 in animals that carried TRIM5alph

270 Heterologous SlRd2 overexpression in yeast conferred res

271 cle trafficking is driven by the assembly of heterologous SNARE proteins orchestrated by the binding

272 another bacterial genus immunized using the heterologous SpCas9 system favoured for genome editing.

273 Using an Escherichia coli heterologous sterol expression system, we demonstrate th

274 nst a low-dose intravaginal challenge with a heterologous strain of SIV in animals with TRIM5a restri

275 In PLGA-KAg vaccinated and heterologous SwIV H1N1 challenged pigs, clinical flu sym

276 immune processes occurred in response to the heterologous symbiont type.

277 metabolite expression profiles revealed that heterologous symbionts induced an expression pattern int

278 nd forming a multi-channel complex both in a heterologous system and in rat hippocampal and sympathet

279 we utilized an advanced Aspergillus nidulans heterologous system for the expression of the PKS PfmaE

280 Z from diverse photosynthetic organisms in a heterologous system to compare their intrinsic assembly

281 ponse have intrinsic repressor activity in a heterologous system, which does not depend on the domain

282 g with CsPYL1 were cloned and expressed in a heterologous system.

283 IIH have precluded their reconstitution from heterologous systems, and purification relies on scarce

284 producing medicinally important compounds in heterologous systems, such as yeast.

285 economy of protein expression in natural and heterologous systems.

286 ease desiccation tolerance when expressed in heterologous systems.

287 verage titer of about 115 against a panel of heterologous Tier 2 isolates.

288 ificantly improved neutralizing responses to heterologous tier 2 viruses in nearly all study particip

289 m protection against CHMI using Pf parasites heterologous to the vaccine strain.

290 ant of CRISPR-Cas9 proteins (dCas9) fused to heterologous transactivation domains can act as a potent

291 elongation rate, and that optimization of a heterologous transcript for faster elongation rate is ac

292 It also enhances translation in a heterologous translation system and thus represents the

293 Strikingly, transient, heterologous Tret1 overexpression reconstituted autophag

294 When a heterologous vaccination regime was used with the sequen

295 Checkpoint blockade strongly synergized with heterologous vaccination to enhance overall survival in

296 Although heterologous vascular composite allotransplantation has

297 Participants in the heterologous versus homologous insert groups had T-cell

298 mmune responses with limited potency against heterologous viral strains and genotypes.

299 ared the NAb activity against autologous and heterologous viruses between 10 participants with intras

300 Vaccinated dams challenged with a heterologous ZIKV strain at embryo day 6 (E6) and evalua