ライフサイエンスコーパス: heteromeric

1 on ends and mediates breakage and joining is heteromeric.

2 s form coincident with ring assembly and are heteromeric.

3 s in eukaryotes) present physiologically are heteromeric.

4 Here we characterize a heteromeric ACAD encoded by Rv3544c and Rv3543c, formerl

5 acid biosynthesis to occur in the absence of heteromeric ACCase, which is encoded in part by the plas

6 for survival in natural environments, where heteromeric acetyl-coenzyme A carboxylase encoded in par

7 e FRET imaging suggested that both homo- and heteromeric AdipoR complexes dissociate in response to a

8 Enzymes in heteromeric, allosterically regulated complexes catalyze

9 hRs) (the homomeric alpha7 receptors and the heteromeric alpha*ss* receptors) as well as the two type

10 Heteromeric alpha,beta,gamma-epithelial sodium channels

11 ms of glycinergic inhibition are mediated by heteromeric alpha/beta glycine receptors.

12 as single channel recordings, indicates that heteromeric alpha/beta subunit-containing receptors unde

13 The remaining synaptic heteromeric alpha1(Q177K)beta GlyRs had decreased curren

14 We hypothesize that heteromeric alpha1beta3 receptors can be activated by pr

15 Using structure-based design, we produced heteromeric alpha3beta4 and alpha4beta2 nAChRs that can

16 (nAChRs) and both bind with high affinity to heteromeric alpha3beta4 and alpha4beta2 nAChRs.

17 Heteromeric alpha4beta2* nAChRs typically have two ACh b

18 r (GlyR) exists either in homomeric alpha or heteromeric alphabeta forms.

19 eric alpha GlyR, subunit interfaces from the heteromeric alphabeta GlyR have not been characterized u

20 the alphaChb+a- GlyR were also found in the heteromeric alphabeta GlyR, which suggests that the alph

21 erties, of the beta+/alpha- interface in the heteromeric alphabeta GlyR.

22 hibition through a specific interaction with heteromeric alphabetaGlyRs containing phosphorylated alp

23 System xc(-) is a heteromeric amino acid cystine/glutamate antiporter that

24 Heteromeric amino acid transporters (HATs) are the uniqu

25 There is good evidence that both heteromeric AMPA and kainate receptors have a 2:2 subuni

26 desensitization of recombinant homomeric and heteromeric AMPA and kainate receptors.

27 Our data reveal organizational features of heteromeric AMPARs and provide a framework to decipher A

28 74 and related polyamine toxins at homo- and heteromeric AMPARs in the presence and absence of gamma-

29 etry in mixed populations consisting of both heteromeric and homomeric channels, additionally reveali

30 xin 1 (PcTx1) and zinc, homomeric ASIC1a and heteromeric ASIC1a/2 channels were likely responsible fo

31 single-channel currents, suggesting multiple heteromeric assemblies of TMC subunits.

32 characterization of these mutants, we found heteromeric assemblies with two equivalent Glu-binding s

33 no longer tetramerize in either homomeric or heteromeric assemblies.

34 AMPARs are tetramers formed by homo- or heteromeric assembly of GluA1-4 subunits to produce mult

35 mbly but had no obvious effect on TRPP2-PKD1 heteromeric assembly.

36 interleukin-1 receptor (TIR)-domain-mediated heteromeric association of DM1 and DM2d.

37 plexes, including the homomeric PglK and the heteromeric BtuCD as well as BtuCDF, were unambiguously

38 vation of group I mGlu receptors potentiated heteromeric but not homomeric KAR-mediated currents, wit

39 Metazoans have a higher proportion of heteromeric bZIP interactions and more network complexit

40 Thus, CNGC2 and CNGCb are expected to form heteromeric Ca(2+) channels with other related CNGCs.

41 FGF21 signals through a heteromeric cell-surface receptor composed of one of thr

42 membrane anchor domains and blocks homo- and heteromeric CerS2/6 complex formation and activity.

43 annels is debated, and their ability to form heteromeric channel assemblies is unclear.

44 homomeric TRPM6 plasma membrane channels or heteromeric channel assemblies with TRPM7.

45 a unique property of Kv1.2 that persists in heteromeric channel complexes and may influence function

46 ctivation, but this property is conferred in heteromeric channel complexes containing even a single K

47 g manuscript, we show that the PKD1L1-PKD2L1 heteromeric channel establishes the cilia as a unique ca

48 vity re-introduces Mg.ATP sensitivity to the heteromeric channel similar to that of TRPM7.

49 r5.1 also enables S-glutathionylation to the heteromeric channel.

50 these encode subunits that function only in heteromeric channels and serve to further diversify Nema

51 ence that Kv7.4 and Kv7.5 form predominantly heteromeric channels and that Kv7 activity is regulated

52 Functional heteromeric channels are however formed with Kv2.1 in he

53 c functions of different subunits present in heteromeric channels are poorly understood.

54 spite these findings, adoption of hERG 1a/1b heteromeric channels as a model for cardiac IKr has been

55 Collectively, the data identify Kv1.1/Kv1.2 heteromeric channels as key regulators of action potenti

56 and Kv7.3 homomeric channels and of Kv7.2/3 heteromeric channels by prolonging the residence time in

57 s subpopulation of muscle afferents as being heteromeric channels composed of ASIC2a and -3 subunits.

58 Also, Kv subunits usually assemble into heteromeric channels in the central nervous system, gene

59 Studies with heteromeric channels incorporating a key lysine mutation

60 Activity of the heteromeric channels is controlled by cellular availabil

61 c smooth muscle cells or through Kv7.4/Kv7.5 heteromeric channels natively expressed in rat mesenteri

62 restraining mechanisms can be disengaged in heteromeric channels to form fast and sensitive ATP sign

63 REK subfamily to assemble to form functional heteromeric channels with novel properties.

64 ects are due to the ability of ORAI2 to form heteromeric channels with ORAI1 and to attenuate CRAC ch

65 ibute to K(+) transport in planta by forming heteromeric channels with other Shaker subunits.

66 co-expressed with wild-type subunits to form heteromeric channels.

67 G1a and hERG1b, consistent with them forming heteromeric channels.

68 ization, indicating that they are carried by heteromeric channels.

69 le direct evidence that ERG1a and ERG1b form heteromeric channels.

70 ntial in lateral septal neurons, possibly as heteromeric channels.

71 that both subunits contribute to functional heteromeric channels.

72 Examples of such PPIs are heteromeric chemokine interactions that are potentially

73 establish the first purification system for heteromeric cis-PT and show that both NgBR and hCIT subu

74 Our studies establish the basis of heteromeric ClpP1P2 assembly and function, reveal tight

75 proteases function via collaboration of the heteromeric ClpP1P2 peptidase with a AAA+ partner, ClpX

76 TAX-2 and TAX-4, a gustatory neuron-specific heteromeric CNG channel complex.

77 3, with or without optional exon 5, produced heteromeric CNGA3 + CNGB3 channels exhibiting an approxi

78 e mutated the AaegGr3 gene, a subunit of the heteromeric CO2 receptor in Aedes aegypti mosquitoes.

79 iological measurements of efficacy levels at heteromeric combinations of alpha3- and alpha4-, with be

80 opus oocytes expressing recombinant homo- or heteromeric combinations of GluA1, GluA2, and GluA3 in t

81 Overall, this study of a large heteromeric complex analysed by IM-MS, coupled with inte

82 minants responsible for the formation of the heteromeric complex are still being studied.

83 Heteromeric complex formation in plasma was further show

84 a channel-forming subunit in an acid-sensing heteromeric complex formed by PKD1L3 and TRPP3, a TRP ch

85 BAK1 and demonstrates that formation of the heteromeric complex is the molecular switch for transmem

86 rugs and their crosstalk mechanism through a heteromeric complex of G protein-coupled receptors.

87 een algae, and most plants, this enzyme is a heteromeric complex requiring four different subunits fo

88 cell growth and proliferation by acting in a heteromeric complex to inhibit the mammalian target of r

89 necessary and sufficient for formation of a heteromeric complex with Ostalpha.

90 that the cell adhesion molecule Cdon forms a heteromeric complex with the Hh receptor Patched 1 (Ptc1

91 -5 (PP5) increased its association with this heteromeric complex, while apoptosis signal regulating k

92 for ISA2 and sta8 mutants lack the ISA1.ISA2 heteromeric complex.

93 c interactions, even within the context of a heteromeric complex.

94 ighly conserved in eukaroytes; they can form heteromeric complexes (known as C3POs) and participate i

95 haracterize the assembly pathways of several heteromeric complexes and show that they can be simply p

96 Heteromeric complexes are structurally distinct glycolip

97 py analysis indicates that NFP and LYK3 form heteromeric complexes at the cell periphery in M. trunca

98 e quaternary structure of alpha1A/B-AR:CXCR4 heteromeric complexes by targeting transmembrane helix 2

99 nhibition and that these Kv1 channels may be heteromeric complexes containing Kv1.2, Kv1.3, and Kv1.6

100 ophysiology, but could not determine whether heteromeric complexes have a fixed subunit stoichiometry

101 The ability of CRFRs to form heteromeric complexes in association with regulatory pro

102 ow that the two known CRFRs interact to form heteromeric complexes in HEK293 cells coexpressing both

103 tion of preassembled apo-GHSR1a:DRD1:Galphaq heteromeric complexes in hippocampal neurons.

104 CXCR4 silencing reduced alpha1A/B-AR:CXCR4 heteromeric complexes in VSMC and abolished phenylephrin

105 Although most heteromeric complexes of known structure have even stoic

106 Most AMPA receptors (AMPARs) are heteromeric complexes of subunits GluA1/GluA2 or GluA2/G

107 n and proteasomal degradation resulting from heteromeric complexes of wild-type and mutant SPOP prote

108 meodomain proteins function as components of heteromeric complexes that contain one member each of th

109 GPCRs are capable of forming heteromeric complexes that differentially alter cell sig

110 ates that AdipoR1 and AdipoR2 form homo- and heteromeric complexes under resting conditions.

111 The activity of the native heteromeric complexes was superior to that of recombinan

112 t CL-K1 exists in circulation in the form of heteromeric complexes with CL-L1 that interact with MASP

113 When co-expressed, CTRP11 forms heteromeric complexes with closely related CTRP10, CTRP1

114 t all HAS isoenzymes form homomeric and also heteromeric complexes with each other.

115 as a membrane-bound protein (mKL) that forms heteromeric complexes with FGF receptors (FGFRs) to init

116 c proteins appears to enable the assembly of heteromeric complexes with more unique components.

117 of HAS isoenzymes to form both homomeric and heteromeric complexes with potentially important functio

118 y, we showed that BAM1 is capable of forming heteromeric complexes with RPK2.

119 al correction of such defects, especially in heteromeric complexes with structurally diverse constitu

120 e CaV1.2 channels in cardiomyocytes exist as heteromeric complexes with the pore-forming CaValpha1, C

121 er member of the same subfamily, TRPC4, form heteromeric complexes with the TRPC1 subunit (TRPC1/5 an

122 complex, as well as two of the most studied heteromeric complexes, i.e., delta-OR/mu-OR and delta-OR

123 As they form heteromeric complexes, the E-Syts confer cytosolic Ca(2+

124 ors and CB(1) cannabinoid receptors can form heteromeric complexes, which affect the trafficking of O

125 hat 5-HT1A and GRPR may function as receptor heteromeric complexes.

126 F1R and CRF2betaR, along with actin in these heteromeric complexes.

127 least in part, on the formation of A2AR-CB1R heteromeric complexes.

128 on the steady-state proportion of homo- and heteromeric complexes.

129 e CaV1.2 channels in cardiomyocytes exist as heteromeric complexes.

130 Ps, revealed many previously uncharacterized heteromeric complexes.

131 ional effects, depending on the homomeric or heteromeric composition of the target, its kinetic state

132 ional studies revealed that, in homomeric or heteromeric configuration with K(V)7.2 and/or K(V)7.3 su

133 Finally, the formation of heteromeric connexons resulted in significantly increase

134 d-type, confirming the enhanced formation of heteromeric connexons.

135 ardly rectifying shape, in contrast to their heteromeric counterparts.

136 Both the homomeric CpomOrco and heteromeric CpomOrco + OR complexes can be activated by

137 study demonstrates that ORAI1 and ORAI2 form heteromeric CRAC channels, in which ORAI2 fine-tunes the

138 hat Nope and Ppk25 function as subunits of a heteromeric DEG/ENaC channel required for gustatory dete

139 The heteromeric dimer of alpha-cobratoxin and cytotoxin has

140 The switch between homo- or heteromeric DLK-1 complexes is influenced by Ca(2+) conc

141 4G, but dependent on subunits i and g of the heteromeric eIF3 complex.

142 n one isoform of the Na, K-ATPase (NKA), the heteromeric enzyme that creates the Na(+) and K(+) gradi

143 ls, fungal, and long-chain plant cis-PTs are heteromeric enzymes composed of two distantly related su

144 in Purkinje cells are presumably mediated by heteromeric erg1/erg3 or modified erg1 channels.

145 ar loop of the beta subunit further promotes heteromeric expression at the plasma membrane possibly b

146 Heteromeric expression of KCNE1 with both KCNQ1-WT and K

147 bunits GABA(B1) and GABA(B2) form functional heteromeric GABA(B(1,2)) receptors that associate with h

148 ABA(B1b), and GABA(B2) form fully functional heteromeric GABA(B(1a,2)) and GABA(B(1b,2)) receptors.

149 ns form homotypic rather than heterotypic or heteromeric gap junctions.

150 ridophores, suggest that both connexins form heteromeric gap junctions.

151 tamate-gated currents are diminished because heteromeric GLR-1/GLR-2 receptors do not reach synapses

152 s that apoplastic amino acids acting through heteromeric GLR3.2/GLR3.4 channels affect lateral root d

153 ues in the nanomolar range (252-356 nM), and heteromeric GluA1/A2 and GluA2/A3 receptors nonselective

154 toinactivation of both homomeric (GluA2) and heteromeric (GluA2:GluA1) AMPA receptors.

155 nit incorporation and substantially increase heteromeric GluCl alphabeta sensitivity to IVM.

156 Altogether, our data unveil heteromeric GluClR assemblies having three alpha and two

157 We further characterized this heteromeric GluClR mutant as a receptor having a third G

158 degree by Neto1 for both homomeric GluK2 and heteromeric GluK2/GluK5 receptors.

159 ignal approach for the study of a variety of heteromeric glutamate-gated ion channel receptors with d

160 using recombinantly expressed homomeric and heteromeric glycine receptor channels, including their s

161 ynaptic inhibition through the activation of heteromeric glycine receptors (GlyRs) composed primarily

162 )) enhances receptor activation in homo- and heteromeric glycine receptors.

163 The subunit stoichiometry of heteromeric glycine-gated channels determines fundamenta

164 ry of antiglycolipid antibodies that bind to heteromeric glycolipid complexes has generated new insig

165 TBP modulated synaptic, presumably alphabeta heteromeric, GlyRs only after priming with PGE2.

166 nificant potency enhancement was observed at heteromeric halpha3beta2 and halpha9alpha10 nAChRs.

167 Heterologous expression of these hyperactive heteromeric hemichannels increases cell membrane permeab

168 he slow inactivating current mediated by the heteromeric hP2X2/3 channel.

169 found inhibition of both homomeric hP2X3 and heteromeric hP2X2/3 receptors, an effect mediated by eff

170 , providing insights into their roles in the heteromeric HrpRS co-complex.

171 Heteromeric interactions between the catalytically impai

172 laboration with other family members through heteromeric interactions in regulation of platelet funct

173 Here we investigated the homomeric and heteromeric interactions of TbetaRIII with TbetaRI and T

174 ric interactions for GnT1IP-L in the ER, and heteromeric interactions with MGAT1 in the Golgi.

175 ic erythropoietin receptor (EpoR) and at the heteromeric interferon gamma receptor (IFNGR).

176 s in the cochlea, adaptation is regulated by heteromeric ion channels composed of Kv1.1 and Kv1.2 sub

177 We conclude that hERG1b preferentially forms heteromeric ion channels with hERG1a at the plasma membr

178 demonstrate that individual monomers within heteromeric IP3Rs contributed equally toward generating

179 Heteromeric kainate receptors (KARs) can be assembled fr

180 roxy-5-methyl-4-isoxazolepropionic acid, and heteromeric kainate receptors are all downstream targets

181 igh-resolution structure currently exists of heteromeric kainate receptors.

182 The potentiation of heteromeric KARs by mGlu1 activation was attenuated by G

183 n the responses of recombinant homomeric and heteromeric KARs to varying concentrations of glutamate.

184 uxiliary subunit Neto1 on both homomeric and heteromeric KARs.

185 ecreased KCNQ3 homomeric currents as well as heteromeric KCNQ2/3 currents.

186 The finding that the heteromeric Kir4.1-Kir5.1 channel but not the homomeric

187 , L166Q, and G83V) on homomeric (Kir4.1) and heteromeric (Kir4.1-Kir5.1) channel function.

188 onal Kv11.3 channels and the more ubiquitous heteromeric Kv11.1a/1b channels.

189 G478R) led to the formation of nonconducting heteromeric Kv2.1/Kv8.2 channels, whereas the mutations

190 Heteromeric Kv7.4/7.5 channels displayed intermediate re

191 -069673 on homomeric human Kv7.4, Kv7.5, and heteromeric Kv7.4/7.5 channels exogenously expressed in

192 nce of homomeric Kv7.4 and Kv7.5, as well as heteromeric Kv7.4/7.5 channels, and induced a negative s

193 tion of EMC-6 caused decreased expression of heteromeric levamisole-sensitive AChRs by destabilizing

194 that is associated with a decrease in their heteromeric ligand binding interaction.

195 the alpha2(+)/alpha2(-) binding site on the heteromeric low sensitivity alpha2beta2 nAChR and valida

196 An unusual set of Francisella regulators-the heteromeric macrophage growth locus protein A (MglA)-str

197 Acetylcholine receptors (AChRs) are heteromeric membrane proteins essential for neurotransmi

198 ng MORF-MORF interactome identifies specific heteromeric MORF protein interactions in plastids and in

199 ased recruitment of MDM4 by the homomeric or heteromeric mutant p53(V172F) complex that inhibits p53-

200 gnificantly increased the sensitivity of the heteromeric mutant receptor to both Glu and IVM, and imp

201 0A,N11R,E14A) indicated that the predominant heteromeric nAChR expressed by human adrenal chromaffin

202 To understand how alpha5DN impairs heteromeric nAChR functions, we coexpressed alpha4, alph

203 Although the alpha9/10 heteromeric nAChR is an important component of vestibula

204 udies show a significant age-related loss of heteromeric nAChR receptor number, which supports patch

205 neurons, the alpha5 subunit is essential for heteromeric nAChR-induced intracellular-free Ca(2+) conc

206 l mechanisms that govern agonist efficacy in heteromeric nAChRs and related ligand-gated ion channels

207 Heteromeric nAChRs are pentameric cation channels, compo

208 uctural subunit, much like a beta subunit of heteromeric nAChRs, providing only complementary compone

209 r concatenated subunits and studies of other heteromeric nAChRs.

210 istinct maximal efficacy readouts at various heteromeric nAChRs.

211 urons, probably mediated by beta2-containing heteromeric nAChRs.

212 st site and perhaps an allosteric action for heteromeric nAChRs.

213 DCC and UNC5 homologs are proposed to form a heteromeric netrin-receptor complex to mediate a chemore

214 alyzed the kinetics of the EPSCs mediated by heteromeric nicotinic receptors at the motoneuron-Rensha

215 this NLR pair thus suggests that activity of heteromeric NLR signaling complexes depends on the sum o

216 he N-methyl-d-aspartate (NMDA) receptors are heteromeric non-selective cation channels that require t

217 dependent behaviors requires the activity of heteromeric odorant receptor (OR) ion channel complexes

218 Insect odorant receptors are heteromeric odorant-gated cation channels comprising a c

219 receptors (ORs), membrane proteins that form heteromeric odour-gated ion channels comprising a variab

220 Strikingly, heteromeric oligomer formed by Cx43/Cx26 (syndromic muta

221 ed on HEK-293 cells expressing homomeric and heteromeric opioid receptors, and in the mouse tail-flic

222 al compound addition protocol, revealed that heteromeric OR (ORx/Orco) function was susceptible to st

223 (beta2 to beta4) subunits forming functional heteromeric or homomeric receptors.

224 nnels in hPECs and prostate cancer cells are heteromeric Orai1/Orai3 channels with an increased Orai1

225 irements for the activation of homomeric and heteromeric Orco channel complexes.

226 Importantly, heteromeric P2X2/3 channels present in sensory neurons e

227 ction between the alpha6beta4 nAChRs and the heteromeric P2X2/3 receptor.

228 Purinergic homomeric P2X3 and heteromeric P2X2/3 receptors are ligand-gated cation cha

229 eochromocytoma cells to form light-activated heteromeric P2X2/3 receptors.

230 sic neuronal excitability is mediated by the heteromeric P2X2/3 receptors.

231 P2X3-mediated currents, but had no effect on heteromeric P2X2/3-mediated currents.

232 The inference that p53 was unstable as a heteromeric p53(wt)/p53(V172F) complex was confirmed in

233 P35 (Nucleotide-Binding Protein 35 kDa), the heteromeric partner of CFD1 in metazoa, functions on its

234 rs can be assembled from either homomeric or heteromeric pentameric subunit combinations.

235 The in vitro characterizations indicate that heteromeric PHA polymerases composed of mixtures of diff

236 east, the main in vivo activities are due to heteromeric Pmt1-Pmt2 and homomeric Pmt4 complexes.

237 s identified a role by which GPSM1 increased heteromeric polycystin-1/polycystin-2 ion channel activi

238 critical mechanical nociception function for heteromeric PPK and Balboa channels in vivo.

239 s are the first demonstration of an obligate heteromeric PRMT, and they suggest that enzyme-prozyme o

240 cence of P. leiognathi is generated within a heteromeric protein complex composed of the bacterial lu

241 ent decades, many thousands of homomeric and heteromeric protein complex structures have been determi

242 mplex (W/SRC) is an evolutionarily conserved heteromeric protein complex.

243 a general mechanism facilitating assembly of heteromeric protein complexes involved in a range of bio

244 in 10% of a representative set of bacterial, heteromeric protein complexes.

245 ity of MS channels may represent gating of a heteromeric protein composed of different channel subuni

246 t self-chaperoning is a robust mechanism for heteromeric protein folding and assembly that could also

247 Class I RNRs are heteromeric proteins built up by alpha and beta subunits

248 Ca channels are heteromeric proteins consisting of a pore-forming alpha(

249 nto the nanomechanics of such multidomain or heteromeric proteins.

250 mbrane helix 2 of CXCR4 and depletion of the heteromeric receptor complexes by CXCR4 knockdown inhibi

251 In addition, heteromeric receptor complexes have been identified.

252 competent death receptors through formation heteromeric receptor complexes.

253 r assay" is of more general use for studying heteromeric receptor complexes.

254 bit confined motion, reflecting preassembled heteromeric receptor complexes.

255 thropoietin (EPO)-mediated signaling via the heteromeric receptor composed of the EPO receptor and th

256 It is a heteromeric receptor composed only of alpha subunits.

257 in this domain abolishes Neto2 modulation of heteromeric receptor desensitization.

258 -evoked current, indicating that most of the heteromeric receptors contained beta4 ligand-binding sit

259 momeric nAChR composed of alpha9 subunits or heteromeric receptors containing alpha9 and alpha10 subu

260 nt propensities to form homomeric or various heteromeric receptors expressed on cell surface, but the

261 As drug targets, heteromeric receptors offer an additional level of selec

262 dition of GluK5 subunits to form GluK2/GluK5 heteromeric receptors slowed the onset of desensitizatio

263 f Neto1 on the desensitization properties of heteromeric receptors was not subunit dependent.

264 and reduced channel conductance in homo- and heteromeric receptors.

265 the latter is suggestive of a population of heteromeric receptors.

266 fect on activation properties in alpha1beta3 heteromeric receptors.

267 Heteromeric rings of pRNA demonstrated that one or two c

268 ctures of ring-like complexes indicates that heteromeric rings tend to contain a weak interaction, co

269 In the case of heteromeric rings, we find that rings including at least

270 ns polymerize into filaments from rod-shaped heteromeric septin complexes.

271 nd new mechanistic insights into the role of heteromeric subunit assembly for regulation of vascular

272 libenclamide and carbamazepine stabilize the heteromeric subunit interface critical for channel bioge

273 lex was in favor of CL-K1, suggesting that a heteromeric subunit is composed of one CL-L1 and two CL-

274 spatial organization and drives formation of heteromeric TbetaRI/TbetaRII complexes and Smad activati

275 ed with GluN2 (and/or GluN3) subunits into a heteromeric tetramer.

276 Functional receptors are homo- or heteromeric tetramers with each subunit contributing a r

277 nteracting membrane anchor but establishes a heteromeric TM-TM helix interaction via its Leu1 motif t

278 TnsA and TnsB together form the heteromeric Tn7 transposase, and TnsD is a target-select

279 As a group, heteromeric transposase elements utilize diverse target

280 coded genes (tnsABCDE) including an atypical heteromeric transposase.

281 uggests that distantly related elements with heteromeric transposases exist with alternate targeting

282 a unique calcium compartment regulated by a heteromeric TRP channel, PKD1L1-PKD2L1, in mice and huma

283 We identified the first heteromeric TRP channels composed of subunits from 3 dif

284 ion of TRPC1 and the subsequent formation of heteromeric TRPC channel complexes with reduced calcium

285 intracellular Ca(2+) stores activate native heteromeric TRPC1/C5 channels in VSMCs, and that TRPC1 s

286 cipitation studies revealed that CPA induced heteromeric TRPC1/C5 channels in WT VSMCs and TRPC5 chan

287 synovial sarcoma cells which is mediated by heteromeric TRPC4/C1 channels and Na(+) loading.

288 the plant Phyllanthus engleri which acts via heteromeric TRPC4/C1 channels to cause cytotoxicity in s

289 82 cells with biophysical characteristics of heteromeric TRPC4/C1 channels.

290 mass spectrometric analysis of homomeric and heteromeric TRPM7 and TRPM6 channels identified phosphor

291 Strikingly, the activity of heteromeric TRPM7/M6 channels is independent of intracel

292 Co-expression of TRPM7 and TRPM6 produces heteromeric TRPM7/M6 channels with altered pharmacology

293 Functionally, this heteromeric TRPV4-C1-P2 channel mediates the flow-induce

294 The analysis demonstrated the formation of a heteromeric TRPV4-C1-P2 complex in primary cultured rat

295 directly with MORs to form a new functional (heteromeric) unit.

296 KCNE3 (MiRP2) forms heteromeric voltage-gated K(+) channels with the skeleta

297 overed that LRRC8 gene family members encode heteromeric VRAC composed of LRRC8A plus LRRC8B-E, which

298 ggest the existence of at least two distinct heteromeric VRACs in astroglial cells.

299 findings point to the existence of multiple heteromeric VRACs in the same cell type: LRRC8A/D-contai

300 utant, and KCNQ3 H646C produced homomeric or heteromeric (with KCNQ2) currents similar to those of wi