ライフサイエンスコーパス: heteromultimeric

1 inity of binding of the MPO molecules to the heteromultimeric alphabeta IL-3 receptor expressed on TF

2 re, we report detection of distinct CLV2-CRN heteromultimeric and CLV1-BAM multimeric complexes in tr

3 sed of a homomultimer of K(V)1.3, unlike the heteromultimeric arrangement of the receptor in rat brai

4 the proton-gated Na(+) current formed by the heteromultimeric ASIC1a/2a channel was up-regulated by w

5 he TRP-TRPL-dependent current is mediated by heteromultimeric association between the two subunits.

6 difference between the putative GIRK2/GIRK3 heteromultimeric channel and GIRK1/GIRKx channels at the

7 We propose that heteromultimeric channel complexes composed of Kv2.1 and

8 suggest that DRASIC subunits participate in heteromultimeric channel complexes in sensory neurons.

9 teins (KChIPs) are auxiliary subunits of the heteromultimeric channel complexes that underlie neurona

10 RACM homologs, suggesting that they can form heteromultimeric channel complexes.

11 believed that the NMDA receptor (NMDAR) is a heteromultimeric channel comprising the ubiquitous NR1 s

12 ant in CNS neurons, where homomultimeric and heteromultimeric channel configurations co-exist.

13 and TRPC5 contribute a constitutively active heteromultimeric channel of adipocytes that negatively r

14 ortantly, S1P also activates the TRPC5-TRPC1 heteromultimeric channel.

15 voltage-evoked currents flowing through the heteromultimeric channel.

16 ly to the agonist-induced sensitivity of the heteromultimeric channel.

17 onical TRP 5) homomultimeric and TRPC5-TRPC1 heteromultimeric channels by extracellular reduced thior

18 onstructs of the rod CNG channel to generate heteromultimeric channels composed of wild-type and muta

19 ant GIRK2 weaver homomultimeric channels and heteromultimeric channels comprised of GIRK2 weaver and

20 hose reported for Kv2.1 and Kv5.1 and/or Kv6 heteromultimeric channels demonstrated a marked similari

21 In heteromultimeric channels formed by coexpressing subunit

22 At saturating concentrations of agonist, heteromultimeric channels were intermediate between wild

23 se-response relations for homomultimeric and heteromultimeric channels were well fit by a Monod, Wyma

24 These two beta subunits can form heteromultimeric channels with any of the alpha2, alpha3

25 ubpopulation of the expressed hTrp3 may form heteromultimeric channels with endogenous proteins that

26 ls, suggesting that mKir4.2 forms functional heteromultimeric channels with Kir5.1, as has been shown

27 eep cortical layers where they probably form heteromultimeric channels with Kv3.1 subunits.

28 uch of the current was produced by ASIC1a/2a heteromultimeric channels, and individual subunits made

29 to the ENaCs and the degenerins, which form heteromultimeric channels, BNaC1 and BNaC2 may be subuni

30 otection seems to correlate to antagonism to heteromultimeric channels, involving the Kv1.2 alpha-sub

31 a key determinant of which subtypes can form heteromultimeric channels, suggesting that T1 functions

32 milies functionally interact, most likely as heteromultimeric channels.

33 ing both ASIC1a homomultimeric and ASIC1a/2a heteromultimeric channels.

34 on the biophysical properties of KCNQ2/KCNQ3 heteromultimeric channels.

35 n junctional areas suggests the formation of heteromultimeric channels.

36 elayed rectifier K+ (IKs) channels formed by heteromultimeric coassembly of KvLQT1 and minimal K+ cha

37 tassium current, or IKs, is believed to be a heteromultimeric combination of KCNQ1 and KCNE1, but it

38 I(KACh) is a heteromultimeric complex formed by Kir3.1 and Kir3.4 sub

39 Y and blocking the formation of an essential heteromultimeric complex involving MraY and other murein

40 nucleic acid-conducting channel (NACh) is a heteromultimeric complex of at least two proteins; a 45-

41 operate either in series or as subunits of a heteromultimeric complex.

42 provide evidence to support the formation of heteromultimeric complexes among different SK channel su

43 e data provide evidence for the formation of heteromultimeric complexes among different SK channel su

44 We find that Kv1.1, Kv1.2, and Kvbeta2 form heteromultimeric complexes at juxtaparanodal zones in my

45 , which are critical to these processes, are heteromultimeric complexes composed of alpha1, alpha2/de

46 he formation of recognition element-specific heteromultimeric complexes containing additional tissue-

47 K(ATP) channels are large heteromultimeric complexes containing four subunits from

48 NMDARs are heteromultimeric complexes formed through association of

49 ATP-sensitive potassium (KATP) channels are heteromultimeric complexes of an inwardly rectifying Kir

50 Functional NMDA receptors are heteromultimeric complexes of the NR1 subunit in combina

51 Kv1.1N206Tag is mediated by the formation of heteromultimeric complexes with the native channels and

52 5 and Kv1.4 revealed that Kv1.1N206Tag forms heteromultimeric complexes with the native Kv1.4 and Kv1

53 ity of the TRPC to form functional homo- and heteromultimeric complexes, these data provide evidence

54 -sensitive Ca(2+) channels (VSCCs) are often heteromultimeric complexes.

55 ix orthologous MCM proteins that function as heteromultimeric complexes.

56 tants co-assembled and formed both homo- and heteromultimeric complexes.

57 logical conditions, CD40L molecules exist as heteromultimeric complexes.

58 (3) Despite the heteromultimeric composition of L-type channels (compose

59 Heteromultimeric cyclic nucleotide-gated (CNG) channels

60 tivation and subsequent desensitization of a heteromultimeric cyclic-nucleotide-gated (CNG) channel p

61 This provides indirect evidence that the heteromultimeric debranching enzyme ISA1-ISA2 is not inv

62 f [NiFe]-hydrogenases, and the bidirectional heteromultimeric enzymes may serve as valuable models to

63 at SRC-1 family members may exist in vivo in heteromultimeric forms with each other.

64 assemble with different SUR isoforms to form heteromultimeric functional K(ATP) channels, it is not k

65 Heteromultimeric G protein-activated inward rectifier K+

66 We investigated the stoichiometry of the heteromultimeric G protein-coupled inward-recitfier K+ c

67 unctional expression of wild-type and mutant heteromultimeric G protein-coupled inward-rectifier K+ (

68 ued and therefore might coassemble to form a heteromultimeric GABA receptor.

69 ion of a large protein complex, the 3.6-MDa, heteromultimeric, hexagonal bilayer hemoglobin (Hb) and

70 inds to both GIRK1 and GIRK4 subunits of the heteromultimeric IKACh.

71 Heteromultimeric interactions of K+ channel subunits acr

72 for information transfer between subunits in heteromultimeric ion channels that is likely to underlie

73 The alpha3 subunit can form heteromultimeric ion channels with other alpha subunits

74 ) has low affinity for K(v)1.2 channels, but heteromultimeric K(v)1.1-K(v)1.2 channels form a recepto

75 red side effects due to its interaction with heteromultimeric K(v)1.1-K(v)1.2 channels, such as those

76 In addition, neither the heteromultimeric KCNQ1-KCNE1 channels nor native I(Ks) c

77 omomultimeric KCNQ1 channels and unsaturated heteromultimeric (KCNQ1)4(KCNE1)n (n < 4) channels.

78 These data indicate that unsaturated heteromultimeric (KCNQ1)4(KCNE1)n channels are present a

79 hinese hamster ovary cells stably expressing heteromultimeric KCNQ2/Q3 channels (EC(50) = 0.4 microM)

80 s might account for the lack of detection of heteromultimeric Kv2 channels in situ despite the coexpr

81 acilitate biochemical studies of these rare, heteromultimeric membrane proteins.

82 We studied the G protein inhibition of heteromultimeric neuronal Ca2+ channels by constructing

83 GIRK1/GIRK4 chimeras reveal that an intact, heteromultimeric P region is necessary and sufficient fo

84 homomultimeric P2X2, homomultimeric P2X3, or heteromultimeric P2X2/3 receptors.

85 The pntA gene encoding the alpha subunit of heteromultimeric PntAB in Synechocystis sp. PCC 6803 was

86 potassium current (I(Ks)) is generated by a heteromultimeric potassium channel complex consisting of

87 proteins that marshal Src-family kinases to heteromultimeric potassium channel signaling complexes,

88 vis oocytes coexpressing the rat MOR and the heteromultimeric potassium channel, K(IR)3.1/3.2, pretre

89 Dynactin is a heteromultimeric protein complex, enriched in neurons, t

90 tion of local hydrogen/deuterium exchange in heteromultimeric protein complexes poses a challenge for

91 les characterization of specific proteins in heteromultimeric protein complexes without interference

92 his topogenic signal is capable of directing heteromultimeric protein import in plant cells.

93 GABAA receptors (GABARs) are heteromultimeric proteins composed of five subunits.

94 I(Ks) channels are heteromultimeric proteins consisting of four identical a

95 e-dependent L-type calcium (Ca) channels are heteromultimeric proteins that are regulated through pho

96 rs of the vacuolar-type ATPase (V-ATPase), a heteromultimeric proton pump.

97 lypeptides may interact to generate homo- or heteromultimeric regulatory complexes.

98 pread family of PII proteins (NifI) that are heteromultimeric, respond to 2OG and ATP, and bind and r

99 mily protein tyrosine kinases (PTKs) bind to heteromultimeric Shaker-family voltage-gated potassium (

100 nization and bone resorption by activating a heteromultimeric signaling complex that includes gelsoli

101 Mycoplasma pneumoniae, yielding 443 and 116 heteromultimeric soluble protein complexes, respectively

102 These results support the presence of a heteromultimeric structure of Synechocystis bacterioferr

103 the effective overlapping truncations form a heteromultimeric structure, antibody to FLAG coprecipita

104 tive potassium channels (K+ATP channels) are heteromultimeric structures formed by a member of the su

105 n, indicating that they both contribute to a heteromultimeric transduction channel in vivo.

106 units, respectively, of the V1 domain of the heteromultimeric V-ATPase complex.

107 The presence of CD40L heteromultimeric variants implies an additional regulati