ライフサイエンスコーパス: heterophilic

1 unoglobulin-inhibiting reagent, also blocked heterophilic activity.

2 The neuroligin-neurexin complex mediates heterophilic adhesion and can trigger assembly of glutam

3 ting cell adhesion and proliferation, and in heterophilic adhesion as a receptor for E-selectin and N

4 ed to investigate the molecular mechanism of heterophilic adhesion between the murine T-cell adhesion

5 Here, we report the crystal structure of the heterophilic adhesion complex between the amino-terminal

6 Pax3 transfectants having high PSA-NCAM show heterophilic adhesion involving polysialic acid to hepar

7 Furthermore, heterophilic adhesion is not substantially weaker than h

8 V and midline glial-expressed Wrapper act as heterophilic adhesion molecules that mediate multiple ce

9 an act in vitro either as a receptor in NCAM heterophilic adhesion or as a promoter of binding betwee

10 ession profiles are complemented by specific heterophilic adhesion patterns of SynCAM family members,

11 that encompass a superfamily of hydrolases, heterophilic adhesion proteins, and chaperone domains re

12 The neuroligin-neurexin complex is a heterophilic adhesion system that promotes assembly and

13 Mel-CAM mediates cell-cell adhesion through heterophilic adhesion to an as yet unidentified ligand p

14 hilic adhesion) or with non-PECAM-1 ligands (heterophilic adhesion).

15 ellular interactions via both homophilic and heterophilic adhesive mechanisms.

16 4 (also known as SHPS-1, BIT, and SIRP) is a heterophilic adhesive membrane protein involved in recep

17 For heterophilic aggregation to occur, a conserved 5-amino a

18 unoglobulin G (IgG) molecule reactive to the heterophilic alpha-Gal epitope [Galalpha-1-3Galbeta1-(3)

19 lobulin G molecule (IgG) that recognizes the heterophilic alpha-gal epitope.

20 e domains of L1 have been implicated in both heterophilic and homophilic binding, the function of the

21 to L1 through a mechanism that is primarily heterophilic and integrin dependent.

22 lso in other conditions in which RF or other heterophilic antibodies may be present.

23 Serum rheumatoid factor (RF) and other heterophilic antibodies potentially interfere with antib

24 Signal amplification by heterophilic antibodies was blocked effectively by Heter

25 Assay kinetics indicated that heterophilic antibodies were responsible for the false-p

26 bited significant confounding by RF or other heterophilic antibodies.

27 ch assays to improve reliability by reducing heterophilic antibody interference, thereby improving bi

28 oth SALMs 4 and 5 formed homophilic, but not heterophilic associations, whereas no trans associations

29 These data establish that heterophilic axonal-L1 interactions mediate adhesion bet

30 orption or were exposed to agents that block heterophilic binding activity.

31 that small differences in the homophilic and heterophilic binding affinities of different type I fami

32 cadherin and, unexpectedly, the N/E-cadherin heterophilic binding affinity is intermediate in strengt

33 ee interactions, others affect homophilic or heterophilic binding alone.

34 Blocking Abs targeting the heterophilic binding domain of PECAM-1 significantly inh

35 f the immune system, P84 and IAP represent a heterophilic binding pair that is likely to be involved

36 Recently, NB1 has been shown to be a heterophilic binding partner for the endothelial cell ju

37 etina indicated that cPTPRO has at least one heterophilic binding partner in the retina.

38 84 and integrin associated protein (IAP) are heterophilic binding partners that are expressed in the

39 d immune response through its homophilic and heterophilic binding patterns.

40 known to participate in both homophilic and heterophilic binding, the latter including mechanisms th

41 s suggested that PSA can also be involved in heterophilic binding.

42 n superfamily capable of both homophilic and heterophilic binding.

43 Two other blocking agents, heterophilic blocking reagent and immunoglobulin-inhibit

44 The mechanical and kinetic properties of the heterophilic bonds are similar to the homophilic interac

45 f chimeric isoforms that bind to each other (heterophilic) but not to themselves (homophilic).

46 ths and dissociation rates of homophilic and heterophilic cadherin (CAD) bonds.

47 differences between different homophilic and heterophilic cadherin dimerizaton affinities can result

48 ne whether the mechanism of aggregation is a heterophilic calcium-dependent process or a homophilic c

49 The heterophilic CD2-CD58 adhesion interface contains interd

50 e show that Ft and Ds mediate preferentially heterophilic cell adhesion in vitro, and that each stabi

51 beta-neurexins and neuroligins) function as heterophilic cell adhesion molecules in a Ca2+-dependent

52 1 to evaluate their potential to function as heterophilic cell adhesion molecules.

53 cting with beta-neurexins (beta-NXs) to form heterophilic cell adhesions.

54 Thus, mammalian teneurins act as heterophilic cell-adhesion molecules that may be involve

55 s, in addition to binding to latrophilins as heterophilic cell-adhesion molecules.

56 uently lost in carcinomas; it functions as a heterophilic cell-cell adhesion molecule in breast epith

57 fically, isoforms containing exon 14 mediate heterophilic cell-cell aggregation while those variants

58 AMs) that are responsible for homophilic and heterophilic cell-cell interactions.

59 in Drosophila S2 cells, the lectin mediates heterophilic cellular aggregation.

60 Specifically, heterophilic coiled-coil interactions linked Sstn and St

61 ormation in vivo closely correlates with the heterophilic complex affinity, which appears to be tuned

62 icrovillar tips and interact to form a trans-heterophilic complex.

63 , yet preferentially assemble into specific, heterophilic complexes as shown for the synaptic SynCAM

64 The NTB-A homophilic and CD2-CD58 heterophilic dimers show overall structural similarities

65 actions by same-charge repulsion and promote heterophilic Dsg:Dsc interactions through opposite-charg

66 For each cell, we contrast heterophilic E:N-cadherin binding with the respective ho

67 lack any known PECAM-1 counter receptor, but heterophilic engagement of PECAM-1 can involve glycosami

68 Ft and Ds bind in a preferentially heterophilic fashion, and Ds is expressed in distinct pa

69 in genotypes are also negatively correlated (heterophilic) in friends.

70 ost responded to EHEC infection by promoting heterophilic infiltration of the colonic epithelium and

71 f disseminated anthrax included suppurative (heterophilic) inflammation, edema, fibrin, necrosis, and

72 trate that preferential adhesion mediated by heterophilic interacting cell-adhesion molecules can cre

73 te that the differential localization of two heterophilic interacting nectins mediates the selective

74 on molecules, whereas our findings suggest a heterophilic interaction mechanism.

75 CD166 displays strong heterophilic interaction with CD6 and weaker homophilic

76 le C (JAM-C) was recently shown to undergo a heterophilic interaction with the leukocyte beta2 integr

77 face glycoproteins, which form homophilic or heterophilic interactions across the intercellular space

78 ecules (SynCAMs) 1 and 2 engage in homo- and heterophilic interactions and bridge the synaptic cleft

79 owth and neuronal survival in homophilic and heterophilic interactions and enhances neurite outgrowth

80 eneficial functions of L1 via homophilic and heterophilic interactions are functionally optimized and

81 and specific homophilic, and in some cases, heterophilic interactions between cells.

82 Initially, heterophilic interactions between glial and axonal cell

83 experiments for interactions of TRAILR2 and heterophilic interactions between the two death receptor

84 eristic repeats that regulate homophilic and heterophilic interactions during adhesion and cell sorti

85 rthermore, Ncad isoforms mediate promiscuous heterophilic interactions in an in vitro cell-aggregatio

86 a to human CEACAM1, and other homophilic and heterophilic interactions of CEA family members.

87 epithelial cells, probably via homophilic or heterophilic interactions of the PKD domains.

88 s as a result of the numerous homophilic and heterophilic interactions that CEACAM1 can have with its

89 rvous system are triggered by homophilic and heterophilic interactions that stimulate signal transduc

90 Neurexin and neuroligin, which undergo heterophilic interactions with each other at the synapse

91 1 N-terminal domain are not only involved in heterophilic interactions with Opa proteins and H influe

92 AMs are brought about through homophilic and heterophilic interactions with other cell surface recept

93 where it bridges cells through homophilic or heterophilic interactions with other nectins.

94 ng affinities associated with homophilic and heterophilic interactions within the nectin family.

95 omains of L1 are required for homophilic and heterophilic interactions.

96 hat its effects on outgrowth are mediated by heterophilic interactions.

97 specific and are mediated by homophilic and heterophilic interactions.

98 te cell-cell adhesion through homophilic and heterophilic interactions.

99 omophilic adhesion, homophilic repulsion and heterophilic interactions.

100 specificity in homophilic binding as well as heterophilic interactions.

101 ertoli and germ cells through homophilic and heterophilic interactions.

102 Homophilic or heterophilic L1 binding and concomitant signaling have b

103 the activation of the myosin phosphatase via heterophilic leucine zipper interactions between its tar

104 sults suggest a model in which Nrg acts as a heterophilic ligand and activator of Ed, which in turn a

105 omain of human L1 (L1-Ig6) can function as a heterophilic ligand for multiple members of the integrin

106 Thus, CEACAM1 serves as a heterophilic ligand for TIM-3 that is required for its a

107 r activation, but can also be activated by a heterophilic ligand, Gas6, a member of the family of vit

108 noglycans have been implicated as one of the heterophilic ligands for PECAM-1.

109 exploitation of homophilic and possibly also heterophilic mechanisms of neural stem cells overexpress

110 ative cell line, consistent with an ALCAM-L1 heterophilic molecular interaction.

111 First, it can mediate cell adhesion via a heterophilic molecular interaction.

112 homophilic PECAM-PECAM-1 engagement, but not heterophilic neutrophil PECAM-1 interactions, and is int

113 hus determine whether PECAM-1 functions as a heterophilic or homophilic adhesion molecule by processe

114 hat the Necl proteins preferentially mediate heterophilic rather than homophilic interactions.

115 2B4 is the only heterophilic receptor of the SLAM family, whose other me

116 eural IgCAMs function as both homophilic and heterophilic receptors for a variety of cell-surface and

117 lecule (SLAM) family includes homophilic and heterophilic receptors that modulate both adaptive and i

118 lecule (SLAM) family includes homophilic and heterophilic receptors that regulate both innate and ada

119 receptors thought to provide homophilic and heterophilic recognition specificity for neuronal wiring

120 This analysis revealed the basis for heterophilic recognition within the SLAM family.

121 as homophilic cell adhesion molecules and as heterophilic repulsive ligands of Unc5/Netrin receptors.

122 r these effects, suggesting the existence of heterophilic signaling.

123 tion experiments, we demonstrate family-wise heterophilic specificity: All Dsgs form adhesive dimers

124 homophilic and an immune system gene set is heterophilic, suggesting that these systems may play a r

125 n unusual orthogonal docking geometry in the heterophilic SYG-1/SYG-2 complex.

126 support stable cell adhesion, different from heterophilic teneurin-latrophilin binding.

127 ine phosphorylation and led to a switch from heterophilic to homophilic aggregation.

128 sults in a change in ligand specificity from heterophilic to homophilic binding.

129 ace change the mechanism of aggregation from heterophilic to homophilic, and 4) PECAM-1-dependent hom

130 ilic adhesion molecule and also engages in a heterophilic trans-interaction with Drosophila Neuroglia

131 efine SynCAM proteins as components of novel heterophilic transsynaptic adhesion complexes that set u

132 vide a mechanistic basis to explain stronger heterophilic versus weaker homophilic interactions among