ライフサイエンスコーパス: heterosynaptic

1 nal motoneurons were frequency-dependent and heterosynaptic.

2 icity induced by PAS and cTBS interacts in a heterosynaptic and bidirectional manner.

3 icity presents unique features as it is both heterosynaptic and homosynaptic in nature and requires C

4 types of LTD in vivo, including associative, heterosynaptic and homosynaptic LTD.

5 This form of plasticity is heterosynaptic and is expressed as an increase (long-ter

6 The two mechanisms, homosynaptic and heterosynaptic, are the distinguishing characteristics o

7 The effects of priming also were heterosynaptic, because the induction of synaptic plasti

8 term potentiation (LTP), coactivation of the heterosynaptic CF input, which evokes large dendritic ca

9 These heterosynaptic changes are weight-dependent and balanced

10 Induction of these heterosynaptic changes depended on the rise of intracell

11 The direction of heterosynaptic changes is weight-dependent, with balance

12 ell-studied neurons, such as Purkinje cells, heterosynaptic competition between inputs from different

13 ual cortex have been interpreted in terms of heterosynaptic competition between inputs.

14 We show that heterosynaptic competition within single neurons, when c

15 hat one set of inputs can exert long-lasting heterosynaptic control over another, allowing the coupli

16 In these cases of heterosynaptic cooperativity, thalamocortical efficacy d

17 Afferent Glu spillover provides heterosynaptic cross talk with GABAergic inhibition in N

18 ut theoreticians have also seen the need for heterosynaptic decreases in synaptic efficacy, both in n

19 cording has been used to study the effect of heterosynaptic depolarization on pure N-methyl-D-asparta

20 adaptation in vivo, there was no evidence of heterosynaptic depression between independent inputs in

21 tivation during cortical seizures in vivo or heterosynaptic depression in situ is independent of Nt5e

22 e touch (T) mechanosensory neurons induces a heterosynaptic depression of nociceptive (N) synapses th

23 lar GABA, which in turn caused a short-lived heterosynaptic depression of the parallel fiber to Purki

24 We speculate that this heterosynaptic depression provides the mossy fiber synap

25 terosynaptic facilitation' at -60 mV and of 'heterosynaptic depression' at +40 mV of EPSPN was simila

26 ation from 'heterosynaptic facilitation' to 'heterosynaptic depression' of EPSPN.

27 t for cerebellar transmission in vivo, since heterosynaptic depression, produced by activating GABAer

28 y of eliciting LTD accompanied by persistent heterosynaptic depression.

29 ed from interneurons contribute to 'diffuse' heterosynaptic depression.

30 otentiation and mediated activity-dependent, heterosynaptic depression.

31 Heterosynaptic ecLTD was unaffected by antagonists for N

32 Activity-dependent heterosynaptic effects acting within network cellular as

33 second input served as a control to monitor heterosynaptic effects.

34 This heterosynaptic, endocannabinoid-dependent long-term depr

35 This heterosynaptic, endocannabinoid-dependent modulation of

36 eceptor antagonists, suggesting an indirect, heterosynaptic enhancement of GABA release caused by a V

37 vity that differentially modulates long-term heterosynaptic facilitation at the converging inputs.

38 By contrast, the heterosynaptic facilitation mediated by the modulatory t

39 at CRF-R2 may regulate glutamate release via heterosynaptic facilitation of GABA synapses.

40 ation involve multiple mechanisms, including heterosynaptic facilitation of sensory neuron-motor neur

41 hich activates Cdc42 and Rac1, but not RhoA; heterosynaptic facilitation of sLTP, which is conveyed b

42 nin-induced facilitation; this suggests that heterosynaptic facilitation primarily involves an increa

43 The heterosynaptic facilitation produced by a single pulse o

44 The time course of 'heterosynaptic facilitation' at -60 mV and of 'heterosyn

45 eterosynaptic paired-pulse stimulation from 'heterosynaptic facilitation' to 'heterosynaptic depressi

46 ation of the individually produced homo- and heterosynaptic facilitation.

47 her, the sensory neurons exhibit significant heterosynaptic facilitation.

48 mina I NK1R(+) neurons may contribute to the heterosynaptic facilitatory mechanisms underlying mechan

49 ain access to specific spinal circuitry, via heterosynaptic facilitatory mechanisms, to mediate mecha

50 This heterosynaptic form of plasticity is involved in changes

51 This I-LTD is heterosynaptic in nature, requiring glutamate release to

52 We tested the hypothesis that heterosynaptic influences from excitatory motor axon inp

53 weakening during later development and that heterosynaptic influences from sensory synapses during e

54 utoreceptor inhibition by glutamate or GABA, heterosynaptic inhibition by GABA, tonic adenosine inhib

55 The blockade of heterosynaptic inhibition by the membrane-permeant Ca2+

56 ming stimulation of mPFC projections induced heterosynaptic inhibition in auditory cortical inputs to

57 evidence, we propose that the time course of heterosynaptic inhibition is determined primarily by the

58 Heterosynaptic inhibition of mossy fiber responses was o

59 Heterosynaptic inhibition of synaptic currents and calci

60 l and electrophysiological data suggest that heterosynaptic inhibition was enhanced by higher frequen

61 umed that the role of the strongly activated heterosynaptic input during the induction of associative

62 lasticity induced by PAS can be modulated by heterosynaptic inputs of cTBS150.

63 y associated with LTP, with LTD appearing at heterosynaptic inputs.

64 This unique type of heterosynaptic interaction is a hallmark feature of syna

65 emporal order of activation are critical for heterosynaptic interactions among convergent synaptic in

66 ergic cotransmission can provide a basis for heterosynaptic interactions between the B and C pathways

67 We found that both homosynaptic and heterosynaptic interactions increase the likelihood of d

68 elayed by homosynaptic interactions, whereas heterosynaptic interactions may help detect coincident s

69 ltage-clamp conditions (tested at +40 mV) no heterosynaptic interactions were seen.

70 two different presynaptic neurons interact (heterosynaptic interactions), and (3) what is the time c

71 red-pulse stimulation) did not result in any heterosynaptic interactions.

72 what is the time course of homosynaptic and heterosynaptic interactions?

73 Release from OSNs was strongly suppressed by heterosynaptic, intraglomerular inhibition.

74 l at mossy-fiber synapses in KA2-/- neurons, heterosynaptic kainate receptor-mediated facilitation re

75 The induction of heterosynaptic L-LTP is associative and critically depen

76 ico-hippocampal activity provides a powerful heterosynaptic learning rule for long-term gating of inf

77 at in the CA1 region of the hippocampus this heterosynaptic long-term depression has the property tha

78 However, much less is known about heterosynaptic long-term plasticity induced by mGluRs at

79 tic acetyl choline receptors account for the heterosynaptic loss in vitro.

80 Protein kinase C (PKC) mediates a heterosynaptic loss of efficacy, and we now show that pr

81 Heterosynaptic LTD can occur at synapses that are inacti

82 When the test stimulations were resumed, heterosynaptic LTD could not be observed.

83 Moreover, this dopamine-mediated heterosynaptic LTD is abolished after withdrawal from co

84 5 min) of the glutamatergic synapses induced heterosynaptic LTD of GABAergic transmission, and the LT

85 to the pathway which was silent during LFS (heterosynaptic LTD) in experiments conducted above spiki

86 term depression (LTD), and slowly developing heterosynaptic LTD, of Schaffer collateral-pyramidal cel

87 conversion of LTD to LTP and elimination of heterosynaptic LTD, whereas blocking ryanodine receptors

88 ate transmission in the VTA via a concerted, heterosynaptic manner that may become altered by stress-

89 f different forms of plasticity--Hebbian and heterosynaptic--may prevent runaway synaptic dynamics an

90 This may provide an additional heterosynaptic mechanism for controlling excitation and

91 This heterosynaptic mechanism is likely to boost the efficacy

92 er, we found that mossy fiber NMDARs mediate heterosynaptic metaplasticity between mossy fiber and as

93 The heterosynaptic modulation interacted with short-term hom

94 neurobiological correlate of sensitization, heterosynaptic modulation of sensory neuron excitability

95 ons can be enhanced in one of two ways: by a heterosynaptic (modulatory input-dependent) mechanism th

96 Importantly, GABAergic STDP is heterosynaptic (NMDA receptor dependent): triggered by c

97 examined the reciprocal impact of short-term heterosynaptic or homosynaptic plasticity at sensorimoto

98 Mg(2+)-free medium converted the response to heterosynaptic paired-pulse stimulation from 'heterosyna

99 However, under current-clamp conditions, heterosynaptic paired-pulse stimulation resulted in hete

100 stimulation of a second set of fibres (i.e. heterosynaptic paired-pulse stimulation) did not result

101 at potentials of between -30 and +40 mV then heterosynaptic paired-pulse stimulation, in normal Mg(2+

102 ynaptic paired-pulse stimulation resulted in heterosynaptic 'paired-pulse facilitation' of the NMDA r

103 Here we describe L-LTP elicited by such heterosynaptic pairing at the Schaffer collateral synaps

104 forms of learning are likely to require the heterosynaptic pairing of stimuli.

105 We propose that when a heterosynaptic pathway has been recently used, continuou

106 tic pathway, the 0.017 Hz test pulses to the heterosynaptic pathway were interrupted for 25 min.

107 rization, is sufficient to induce LTP in the heterosynaptic pathway, whereas an enzymatic glutamate s

108 synaptic strength could also be detected in heterosynaptic pathways, indicating a global response.

109 omosynaptic depression (HSD)], or short-term heterosynaptic plasticity [serotonin-induced facilitatio

110 one increases sleep pressure), modulation of heterosynaptic plasticity by adenosine represents an end

111 ations, we show that experimentally observed heterosynaptic plasticity can indeed serve the theoretic

112 nstrated that co-occurring, weight-dependent heterosynaptic plasticity can robustly prevent runaway d

113 We find that heterosynaptic plasticity effectively prevented runaway

114 Short-term heterosynaptic plasticity induced by 5-HT (facilitation)

115 We conclude that heterosynaptic plasticity is an inherent property of pla

116 ong and repeated, the magnitude of LTP after heterosynaptic plasticity is greatly increased, specific

117 Importantly, this form of heterosynaptic plasticity is induced at unpaired synapse

118 and lack mechanisms for synaptic competition.Heterosynaptic plasticity may solve these problems by co

119 This subthreshold form of heterosynaptic plasticity occurs in the absence of somat

120 s, this experimentally characterized form of heterosynaptic plasticity prevents runaway dynamics of s

121 ying synaptic signalling in this new form of heterosynaptic plasticity remain unclear.

122 This new form of heterosynaptic plasticity represents the cellular basis

123 ns, such changes of the weight dependence of heterosynaptic plasticity shifted their operating point

124 s, in intercalated neurons at least, inverse heterosynaptic plasticity tends to compensate for homosy

125 . (2015) present a cortically driven form of heterosynaptic plasticity that could promote oscillatory

126 weight dependence determines the ability of heterosynaptic plasticity to prevent runaway dynamics of

127 el implementing both homosynaptic (STDP) and heterosynaptic plasticity with properties matching the e

128 earning is correlated with differences in SN heterosynaptic plasticity within a background of evoluti

129 Changing the weight dependence of heterosynaptic plasticity within an experimentally obser

130 ltiple terminals and allows the emulation of heterosynaptic plasticity, an important learning rule in

131 rt-term homosynaptic plasticity to long-term heterosynaptic plasticity, and we implicate dopamine in

132 c regulation of synaptic efficacy, including heterosynaptic plasticity, gain control, output balancin

133 and to generate a temporally precise form of heterosynaptic plasticity.

134 accompanied by changes in unpaired synapses: heterosynaptic plasticity.

135 es hippocampus-amygdala interactions to gate heterosynaptic plasticity.

136 detection that gives rise to a novel form of heterosynaptic plasticity.

137 hat adenosine regulates weight dependence of heterosynaptic plasticity: adenosine strengthened weight

138 adenosine modulates the weight dependence of heterosynaptic plasticity: blockade of adenosine A1 rece

139 adenosine strengthened weight dependence of heterosynaptic plasticity; blockade of adenosine A1 rece

140 methyl ester (L-NAME), completely prevented heterosynaptic potentiation and associated reduction in

141 Thus, CA1 neurons expressing heterosynaptic potentiation induced by external sensory

142 results are consistent with the notion that heterosynaptic potentiation is of pre-synaptic origin an

143 on of apical tuft synapses alone resulted in heterosynaptic potentiation of proximal synapses.

144 Our studies reveal a mechanistically unique heterosynaptic PP1 gate that is constitutively driven by

145 aminobutyric acid (GABA) act as autaptic and heterosynaptic presynaptic inhibitory transmitters throu

146 sensitization, became labile with short-term heterosynaptic reactivation and reversed when the reacti

147 e of PKC activity or a homosynaptic, but not heterosynaptic, reactivation when paired with rapamycin.

148 This novel form of LTP is heterosynaptic, requiring postsynaptic NMDA (N-methyl-d-

149 at the first central synapses, suggesting a heterosynaptic role for the Group II mGluRs in shaping b

150 The molecular mechanism for heterosynaptic sharing involves metabotropic glutamate r

151 Heterosynaptic sharing is blocked by postsynaptic disrup

152 This heterosynaptic sharing of plasticity represents a dynami

153 ial thereby altering homosynaptic as well as heterosynaptic short-term ionic plasticity at GABAergic

154 The induction of LTD at homo- and heterosynaptic sites requires functional ryanodine recep

155 Such heterosynaptic spread of synaptic facilitation could acc

156 e homosynaptic pathway was involved, with no heterosynaptic stimulation, as in conventional experimen

157 comes labile following selective activations-heterosynaptic stimuli that evoke opposite forms of plas

158 to 0.033 Hz) during a 25 min interruption of heterosynaptic stimulus did not preserve homosynaptic LT

159 contribution of KOR signaling in PFC-driven heterosynaptic suppression of HP inputs onto MSNs using

160 resulted in complete blockade of PFC-induced heterosynaptic suppression of less salient HP inputs.

161 triggers the release of endocannabinoids and heterosynaptic suppression of PF inputs.

162 BLA train stimulation also produced heterosynaptic suppression of responses from the amygdal

163 Heterosynaptic suppression was unidirectional as HP trai

164 eads to what we call spatial competition, or heterosynaptic synaptic modification.

165 ere the first well-defined mechanism for the heterosynaptic transmitter-mediated regulation of transm