ライフサイエンスコーパス: heterotetramer

1 57, or alphaSer116 (NHases are alpha 2beta 2 heterotetramers).

2 or alphaSer(112) (NHases are alpha(2)beta(2)-heterotetramers).

3 utyryl-CoA and n-butyryl-CoA and exists as a heterotetramer.

4 e two MEM83 epitopes across the LFA-1/ICAM-1 heterotetramer.

5 pstream segments of MYPT1 via formation of a heterotetramer.

6 ubsequently diverged into an alpha(2)beta(2) heterotetramer.

7 stal structure of the full-length human GINS heterotetramer.

8 build a model of the yeast m1A58 tRNA Mtase heterotetramer.

9 ly with nanomolar affinity to form a 1:1:1:1 heterotetramer.

10 te faces of the neuroligin-1 dimer to form a heterotetramer.

11 ners can bridge each other at the top of the heterotetramer.

12 stituted by AP3beta3B in the neuron-specific heterotetramer.

13 d physically blocking formation of the H3/H4 heterotetramer.

14 and purified from Escherichia coli as a J2K2 heterotetramer.

15 the polypeptides of the MADH alpha(2)beta(2) heterotetramer.

16 nA dimer, and the two proteins form a stable heterotetramer.

17 heterodimer and a RAD51B/RAD51C/RAD51D/XRCC2 heterotetramer.

18 eractions control catalysis in a recombining heterotetramer.

19 conversion of the latter to the native BCKD heterotetramer.

20 s specifically associate to form an A(2)B(2) heterotetramer.

21 se-8 was not further processed to its active heterotetramer.

22 xpressed as a catalytically inactive, labile heterotetramer.

23 teolytic cleavage and the active enzyme is a heterotetramer.

24 r alpha-like subunits form either a homo- or heterotetramer.

25 inhibit the activity of the mature caspase-3 heterotetramer.

26 (beta) subunits associated as an alpha2beta2 heterotetramer.

27 e-3 present as its free approximately 60-kDa heterotetramer.

28 the two homodimers coassemble in forming the heterotetramer.

29 a heteromeric complex that is most likely a heterotetramer.

30 erformed by discrete subunits of the adaptor heterotetramer.

31 composed of 34- and 24-kD polypeptides as a heterotetramer.

32 a Sec23-Sec24 heterodimer and a Sec13-Sec31 heterotetramer.

33 pported quaternary structure of the spectrin heterotetramer.

34 orresponds to a specific subunit forming the heterotetramer.

35 peptide binds to a hydrophobic pocket in the heterotetramer.

36 tor complex AP2 is thought to be an obligate heterotetramer.

37 ntified L2-specific receptor, the annexin A2 heterotetramer.

38 OAPs but can coassemble with M23 in OAPs as heterotetramers.

39 that the hybrids have predominant amounts of heterotetramers.

40 alculated mass consistent with a pair of RAG heterotetramers.

41 TRPC3 and TRPC6 form heterotetramers.

42 human EGFR type 2 can associate as homo- and heterotetramers.

43 suggesting that the channels are composed of heterotetramers.

44 ontributes to the extraordinary stability of heterotetramers.

45 appears to reversibly self-associate to form heterotetramers.

46 Ps), PIP1 and PIP2 monomers interact to form heterotetramers.

47 erwise trapped mutant heterodimers to active heterotetramers.

48 ic species, followed by conversion to active heterotetramers.

49 and C-terminal interaction in both homo- and heterotetramers.

50 lular Ca(2+) channels that exist as homo- or heterotetramers.

51 caspases to form active approximately 60-kDa heterotetramers.

52 the 32 and 34 kDa polypeptides reside within heterotetramers.

53 idate the coassembly of the peptides to form heterotetramers.

54 gatively cooperative formation of asymmetric heterotetramers.

55 2 but, in vivo, kainate receptors are likely heterotetramers.

56 bfamilies, such as Eag and Erg, fail to form heterotetramers.

57 Kv channel subfamily may co-assemble to form heterotetramers.

58 e Sig1R bound directly to GluN1/GluN2A NMDAR heterotetramers.

59 endence and kinetics, carried by K(v)7.2/7.3 heterotetramers, 4% activated at the resting membrane po

60 Before the broken RNAs were ligated by the heterotetramer, a methyl group was added to the 2'-OH gr

61 sh that ChsE1-ChsE2 forms an alpha(2)beta(2) heterotetramer, a new architecture for an ACAD.

62 ha(2) and alpha(4) endonucleases but forms a heterotetramer: a dimer of two heterodimers of the catal

63 Annexin A2 (A2) heterotetramer (A2.p11)(2) is a key profibrinolytic comp

64 ace plasmon resonance analysis showed that a heterotetramer (A2t) of p11 and annexin A2, but not p11

65 recently identified receptor, the annexin A2 heterotetramer (A2t).

66 that forms a heterotetramer (annexin II-p11 heterotetramer; A2t) with p11 (S100A10).

67 The protein complex annexin A2 heterotetramer (AIIt) is an important plasminogen recept

68 of two subunits, alpha and beta, that form a heterotetramer (alpha(2)beta(2)) in solution.

69 ultimately dictates the high fidelity of the heterotetramer (alpha*beta*)2 assembly, is the binding o

70 ed that BslI forms heterodimers (alphabeta), heterotetramers (alpha(2)beta(2)), and possibly oligomer

71 complex of Bacillus stearothermophilus is a heterotetramer (alpha2beta2) of E1alpha and E1beta polyp

72 xes reveal two distinct architectures: a 2:2 heterotetramer and a continuous ligand/receptor assembly

73 t interact physically with the (CenH3-H4)(2) heterotetramer and are required for the deposition of Ce

74 t they are probably shielded in the spectrin heterotetramer and become exposed only after CaM binds a

75 ied that the ORF6 protein was an alpha2beta2 heterotetramer and direct evidence for this came from ma

76 or, which in yeast consists of the Get1/Get2 heterotetramer and in mammals of the WRB protein (trypto

77 HJURP binding disrupts the Mis18alpha-beta heterotetramer and removes Mis18alpha from centromeres.

78 e in coordinating catalysis within the XerCD heterotetramer and suggest that the interactions between

79 2 interact to form a (IFT81)(2)(IFT74/72)(2) heterotetramer and that IFT27 and IFT25 form a heterodim

80 that p110 and p107 are subunits of a 430-kD heterotetramer and that they both originate from the sam

81 l rigidity to both the subnucleosomal CENP-A heterotetramer and the corresponding assembled nucleosom

82 hemical properties of both the reconstituted heterotetramer and the heterodimer of the p125 and p50 s

83 The structures show that MRP1/MRP2 is a heterotetramer and, despite little sequence homology, ea

84 ombine to make a presumptive alpha(2)beta(2) heterotetramer and, in particular, the location of the s

85 site prevented the formation of a CITFA2-LC8 heterotetramer and, in vivo, was lethal, affecting assem

86 of E1p and E3 demonstrated 40 copies of E1p heterotetramers and 20 copies of E3 dimers associated wi

87 ed for cell surface targeting of GIRK1/GIRK4 heterotetramers and a 25-amino acid region required for

88 transthyretin and human/murine transthyretin heterotetramers and compared their structures and biophy

89 Both AP-1 complexes are heterotetramers and differ only in their 50-kD mu1A or m

90 otrimers, M(x)S-Au-Pt-Fe(3)O(4) (M = Pb, Cu) heterotetramers and higher-order oligomers based on the

91 eins are catalytically inactive, do not form heterotetramers, and do not bind pyridoxal phosphate.

92 a phospholipid-binding protein that forms a heterotetramer (annexin II-p11 heterotetramer; A2t) with

93 These studies demonstrate that AQP4 heterotetramers are formed from two overlapping polypept

94 sent in the prototypical linear antiparallel heterotetramer as well as recently reported inter-strand

95 : H1, H2A/H2B heterodimers followed by H3/H4 heterotetramers, as predicted from their spatial organiz

96 ctures for the GluR6/KA2 ATD heterodimer and heterotetramer assemblies.

97 ovides a structural outlook of the FXIIIA2B2 heterotetramer assembly, its association and dissociatio

98 with AnxA2 in association with S100A10 as a heterotetramer at the cell surface in a Ca(2+)-dependent

99 activate TERT, probably by facilitating GABP heterotetramer binding.

100 s are homodimers and prokaryotic enzymes are heterotetramers, both prokaryotic and eukaryotic type II

101 t4/5 complex is dominated by a single Get4/5 heterotetramer bound to one monomer of a Get3 dimer, unc

102 cross-linking agent, indicating formation of heterotetramer BslI complex (alpha(2)beta(2)).

103 erminal region of RAG2 stabilizes the RAG1/2 heterotetramer but destabilizes the RAG-DNA precleavage

104 rate that Asf1 blocks formation of the H3-H4 heterotetramer by a mechanism that likely involves occlu

105 o demonstrate the occurrence of diverse AP-1 heterotetramers by combinatorial assembly of various gam

106 Our results show that PIP2-PIP1 heterotetramers can assemble with 3:1, 1:3, or 2:2 stoic

107 tetramer channel, in astrocytes as homo- and heterotetramer channels together with KIR5.1.

108 lso report the structure of a (Cse4 : H4)(2) heterotetramer; comparison with the structure of the Scm

109 on the same face of the DNA helix stabilizes heterotetramer complex binding.

110 ABPbeta formed a stable heterodimer, with no heterotetramer complex detected.

111 ests that FDM1 may exist as a homodimer in a heterotetramer complex in vivo.

112 but readily binds as the GABPalpha(2)beta(2) heterotetramer complex on DNA containing two PEA3/EBSs.

113 transcriptionally active GABPalpha(2)beta(2) heterotetramer complex requires the presence of specific

114 inity when they are part of the PXR/RXRalpha heterotetramer complex than they do when each ligand-bin

115 show quite clearly that the heterodimer and heterotetramer complexes do not behave in solution as di

116 functional NMDA receptor is thought to be a heterotetramer composed mainly of two NR1 and two NR2 su

117 The receptor is a heterotetramer composed of a family of related subunits.

118 key enzyme in chromosomal replication, is a heterotetramer composed of the p125, p50, p68 and p12 su

119 We report here that a stable heterotetramer composed of two bacterial proteins, Pnkp

120 Sec13p/31p is a heterotetramer composed of two copies of Sec13p and two

121 They signal by assembling a receptor heterotetramer composed of two TbetaRI:TbetaRII heterodi

122 otropic glutamate receptors that function as heterotetramers composed mainly of GluN1 and GluN2 subun

123 The functional NMDA receptors, heterotetramers composed mainly of two NR1 and two NR2 s

124 In heterotetramers composed of both subunit types, it appea

125 s the transactivation potential of homo- and heterotetramers composed of different p63 isoforms and t

126 Heterotetramers composed of murine and human subunits ar

127 NMDA receptors are obligate heterotetramers composed of two GluN1 and typically two

128 d cyclic nucleotide-gated (CNG) channels are heterotetramers comprised of both CNGA1 and CNGB1 subuni

129 (15)N-Edited NOESY shows the 2:2 heterotetramer comprises two different homodimers, rathe

130 uce a functional Kv channel by investigating heterotetramers comprising combinations of full-length K

131 Intriguingly, these complexes appear as heterotetramers, comprising two HD-ZIPIII and two ZPR mo

132 Coagulation factor XIII (FXIII) is a heterotetramer consisting of 2 catalytic A subunits (FXI

133 ed to apparent homogeneity and found to be a heterotetramer consisting of two alpha (32 kDa) and two

134 soluble pm142-pm143 complex appears to be a heterotetramer consisting of two molecules of pm142 asso

135 her plant ADP-glucose pyrophosphorylase is a heterotetramer consisting of two subunit types, which ha

136 They are believed to be heterotetramers consisting of GIRK1 (Kir3.1) and either

137 These channels are heterotetramers consisting of two homologous subunits, G

138 her plant AGPs are complex in nature and are heterotetramers consisting of two similar but distinct s

139 Annexin II is a heterotetramer, consisting of two 11-kDa (p11) and two 3

140 The annexin A2 (A2) heterotetramer, consisting of two copies of A2 and two c

141 I.HGPRT-II and suggests that the predominant heterotetramer consists of one HGPRT-I subunit and three

142 technologies, we have demonstrated that the heterotetramer constituents bind to C-1-P.

143 Although the annexin a2-p11 heterotetramer constituents do not bind the lipid C-1-P

144 ceramide 1-phosphate and the annexin a2-p11 heterotetramer constituents.

145 model that considers A2AR-D2R heteromers as heterotetramers, constituted by A2AR and D2R homodimers,

146 The heterotetramer contained Ni (0.9 +/- 0.1 atom/mol), Fe (

147 The MoFe protein folds as a heterotetramer containing two copies each of the homolog

148 The nitrogenase MoFe protein is a heterotetramer containing two unique high-nuclearity met

149 lation, RNAs repaired by bacterial Pnkp/Hen1 heterotetramer could not be cleaved again by the ribotox

150 se 3alpha (IDH3alpha), a subunit of the IDH3 heterotetramer, decreased alpha-ketoglutarate levels and

151 Sh2hs33, identified a greater propensity for heterotetramer dissociation in WT AGP.

152 The pyruvate decarboxylase component, a heterotetramer E1(alpha(2)beta(2)), is responsible for t

153 r 3-fold axis of symmetry that relates three heterotetramers, each of which is composed of two tightl

154 ngly, the kinetochore recruits two Mad1-Mad2 heterotetramers for every Bub3-Bub1 molecule.

155 re co-expressed in E. coli, HGPRT-I.HGPRT-II heterotetramers form.

156 Mis18alpha-beta heterotetramer formation is required for Mis18BP1 bindin

157 in Xenopus laevis oocytes demonstrated that heterotetramer formation reflects the relative expressio

158 Co-expression in Escherichia coli results in heterotetramer formation with a 3000-fold increase in en

159 efinitive biochemical evidence of endogenous heterotetramer formation.

160 homotetramers as the rate-limiting step for heterotetramer formation.

161 and DNcSHMT tetramers, and the formation of heterotetramers from cSHMT and DNcSHMT homodimers does n

162 ons of the two active sites in the human E1b heterotetramer harboring the reaction intermediate are i

163 The predominant heterotetramer has enzymatic activity similar to HGPRT-I

164 properties of an epsilon -globin-containing heterotetramer (Hb Gower-2) both in vitro as well as in

165 d by structural modeling predictions for ASL heterotetramer/homotetramer formation.

166 rt the crystal structure of a subnucleosomal heterotetramer, human (CENP-A-H4)(2), that reveals three

167 ptor complex that is either a heterodimer or heterotetramer (i.e. a dimer of dimers).

168 f the promoter regions was bound by a single heterotetramer, i.e. the flgAMN and flgBCD operons are c

169 GIRK4 proteins in atria combine to form the heterotetramer IKACh, whereas the remaining GIRK4 forms

170 This TA system forms an alpha(2)beta(2) heterotetramer in the crystal and in solution.

171 ric intermediate to a native alpha(2)beta(2) heterotetramer in the E1 assembly pathway.

172 and protein disulfide isomerase coexist as a heterotetramer in the ER, we discuss the effects of Hyp

173 s 46 +/- 15 nm, indicating that the spectrin heterotetramer in the native membrane skeleton is a frac

174 o bacterial enzymes in that it consists of a heterotetramer in which the alpha-subunits contain the a

175 eranyl diphosphate synthase from Mentha is a heterotetramer in which the large subunit shares functio

176 g reveal that the peptides form a mixture of heterotetramers in 3:1, 2:2, and 1:3 stoichiometries, in

177 efficiently expressed in Escherichia coli as heterotetramers in a temperature-dependent manner.

178 ha- and beta-globin subunits into hemoglobin heterotetramers in both primitive and definitive erythro

179 aA3-crystallins associate predominantly into heterotetramers in equilibrium with heterodimers.

180 ys of communication between heterodimers and heterotetramers in the hetero-octamer.

181 s suggest that an observed asymmetry between heterotetramers in the holoenzyme contributes to interac

182 eta-crystallins associate predominantly into heterotetramers in vitro.

183 Like histone H3, CENP-A can form CENP-A-H4 heterotetramers in vitro.

184 n of a H3-H4 chaperone binding to (H3-H4)(2) heterotetramers in vivo.

185 strate that Rtt106 interacts with (H3-H4)(2) heterotetramers in vivo.

186 r dimerize through SAV1 WW domains to form a heterotetramer, in which MST2 undergoes trans-autophosph

187 showed the presence of heterodimers, but not heterotetramers, in the hen spinal cord extract.

188 Characterization of the cSHMT/DNcSHMT heterotetramers indicates that DNcSHMT and cSHMT monomer

189 The role of beta(116His) (G-18) in heterotetramer-induced stabilization of the bond with ox

190 The role of heterotetramer interaction sites in assembly and autoxid

191 DNMT3A.DNMT3A homotetramer and DNMT3A.DNMT3L heterotetramer interfaces.

192 complete dissociation of the alpha(2)beta(2) heterotetramers into inactive alphabeta heterodimers.

193 The 230-kilodalton RAG1-RAG2 heterotetramer is 'Y-shaped', with the amino-terminal do

194 This heterotetramer is capable of a low-level receptor transp

195 nary organization of the alphabetagammagamma heterotetramer is poorly understood and contradictory pa

196 ural model for a XRCC1 x DNA ligase IIIalpha heterotetramer is proposed as a core base excision repai

197 -alpha-helical bundle are such that only the heterotetramer is stable in solution; corresponding homo

198 only weakly stimulated by PCNA, whereas the heterotetramer is strongly stimulated to a level with a

199 altered interactions within the recombining heterotetramer lead to changes in the relative concentra

200 r alternatively, formation of the SLIP1-SLBP heterotetramer may facilitate removal of SLBP from the h

201 Plant AGPases are heterotetramers, most of which are activated by 3-phosph

202 AP2, a heterotetramer of alpha, beta, mu and sigma subunits, li

203 f the oxygen carrier, haemoglobin A (HbA), a heterotetramer of alpha- and beta-haemoglobin subunits.

204 t during the assembly of the alpha(2)beta(2) heterotetramer of human mitochondrial branched-chain alp

205 tinating enzyme converted the p110:p107 PEPC heterotetramer of immature proteoid roots into a p107 ho

206 Centralspindlin, a constitutive 2:2 heterotetramer of MKLP1 (a kinesin-6) and the non-motor

207 ion factor IIF (TFIIF) is an alpha(2)beta(2) heterotetramer of RNA polymerase II-associating 74 (RAP7

208 Human TFIIF appears to be an alpha2beta2 heterotetramer of RNA polymerase II-associating protein

209 Conventional kinesin, kinesin-I, is a heterotetramer of two kinesin heavy chain (KHC) subunits

210 ESCRT-I is a heterotetramer of Vps23, Vps28, Vps37, and Mvb12.

211 ent and that this current could be formed by heterotetramers of active and silent subunits.

212 w that ESCRT-0 forms mostly heterodimers and heterotetramers of Hrs and STAM when analyzed in the pre

213 his conductance is most probably a result of heterotetramers of Kir2 gene products, with this regulat

214 Muscarinic potassium channels are heterotetramers of Kir3.1 and other Kir3 channel subunit

215 Kv7 (KCNQ) channels, formed as homo- or heterotetramers of Kv7.4 and Kv7.5 alpha-subunits, are i

216 r channel aquaporin-4 (AQP4) is expressed as heterotetramers of M1 and M23 isoforms in which the pres

217 operties and a long evolutionary separation, heterotetramers of potato small subunit and maize large

218 e may be two conformers of E1alpha in the E1 heterotetramer, one being more susceptible to proteolysi

219 umed to be the deposition of a histone H3-H4 heterotetramer onto DNA.

220 results indicate that Rtt106 deposits H3-H4 heterotetramers onto DNA and provide the first descripti

221 vidence that the two active sites in the E1b heterotetramer operate independently during the ThDP-dep

222 inhibit the formation of active FlhD(2)C(2) heterotetramers or inhibit FlhD(2)C(2) binding to DNA.

223 from proteolytic degradation as an inactive heterotetramer, or alternatively, formation of the SLIP1

224 Concomitant with formation of the active heterotetramer, p20 is autoprocessed to p17.

225 t the four-subunit complex is a dimer of the heterotetramer (Pol3, Cdc1, Cdc27, and Cdm1), similar to

226 ility of each tetramer and show that the 2:2 heterotetramer predominates.

227 This designed heterotetramer preferentially recombined a particular pa

228 e irreversible step in assembly results from heterotetramer rather than heterodimer dissociation and

229 ion of Kir2.6 as a subunit in a Kir2 channel heterotetramer reduces the abundance of Kir2 channels on

230 Because NMDA-Rs are obligatory heterotetramers requiring the GluN1 subunit, it is criti

231 trometric analysis of cross-linked homo- and heterotetramers reveals species of distinct molecular ma

232 be deduced from the earliest origins of the heterotetramer/scaffold coat to its multiple manifestati

233 -Sss1, the Sec63-Sec71-Sec72 trimer, and the heterotetramer Sec62-Sec63-Sec71-Sec72, respectively.

234 The peptides within the heterotetramer segregate in forming the homodimer subuni

235 Structural analysis of the CsrA/FliW heterotetramer shows that FliW interacts with a C-termin

236 eceptor recruitment to the ligand, induced a heterotetramer signaling complex, and propagated Smad2 a

237 An activated SCF complex, a heterotetramer (Skp1, Cul-1, beta-TrCP [F-box protein],

238 of about 1 day at room temperature, and the heterotetramer slowly dissociated to the monomeric state

239 Assembly of T150D K5 is arrested at the heterotetramer stage coinciding with increased heat shoc

240 y specifying a unique spatial arrangement of heterotetramer subunits.

241 D subunits form the carboxyltransferase (CT) heterotetramer that catalyzes the second partial reactio

242 ex forms a 2:2 high-affinity (K(D) < 0.9 nM) heterotetramer that is also incapable of binding histone

243 inase Pak2 is cleaved by caspase 3 to form a heterotetramer that is constitutively activated followin

244 Adaptor protein complex 3 (AP-3) is a heterotetramer that is involved in signal-mediated prote

245 The adaptor protein 1 (AP1) complex is a heterotetramer that participates in cargo sorting into c

246 omplex 1 (AP-1) is an evolutionary conserved heterotetramer that promotes vesicular trafficking betwe

247 These proteins form a stable heterotetramer that remains bound to the mRNA throughout

248 These two proteins form a heterotetramer that then combines with six C1q subunits.

249 complexes (APs) are evolutionarily conserved heterotetramers that couple cargo selection to the forma

250 ed altered-specificity Cre monomers can form heterotetramers that recombine nonidentical asymmetric s

251 ugh the caspase-3 subunits reassemble to the heterotetramer, the activity return is low after the pro

252 at the tracking assembly comprises a UvrA2B2 heterotetramer, the configurations of the damage engagem

253 erohexamer of Mcm2/3/4/5/6/7, the Mcm2/4/6/7 heterotetramer, the dimer of the Mcm4/6/7 heterotrimer,

254 In a full-length heterotetramer, the LBDs could potentially be arranged e

255 xpression of Kir3.1/Kir3.2 and Kir3.1/Kir3.4 heterotetramers, the GIRK channels found in the brain an

256 heir self-assembly into a higher order H3/H4 heterotetramer, their deposition into nucleosomes by hum

257 As heterotetramers, they comprise the GIRK1 and the GIRK2,

258 demonstrate Mis18alpha and Mis18beta form a heterotetramer through their C-terminal coiled-coil doma

259 tiator caspases cannot reassociate to active heterotetramer, thus resulting in irreversible inhibitio

260 nd may enable cross-linking of multiple AP-4 heterotetramers, thus contributing to the assembly of th

261 FlhD and FlhC act together in a FlhD(2)C(2 )heterotetramer to induce flagellar gene transcription, w

262 The alpha2 and Mcm1 proteins bind DNA as a heterotetramer to repress transcription of cell-type-spe

263 ting, we describe the binding of the FlhD2C2 heterotetramer to the promoter regions of four class II

264 SLBP at Thr171 promotes dissociation of the heterotetramer to the SLIP1-SLBP heterodimer.

265 on of trans-suppressor subunits (T119M) into heterotetramers to destabilize the dissociative transiti

266 ividual subtypes within defined concatenated heterotetramers to the shaping of Ca(2+) signals.

267 They are heterotetramers, typically composed of two GluN1 and two

268 tures establish that PXR and RXRalpha form a heterotetramer unprecedented in the nuclear receptor fam

269 vering an intriguing asymmetry in the Get4/5 heterotetramer upon Get3 binding.

270 Heterotetramer voltage-gated K(+) (KV) channels KV2.1/KV

271 y expressed and purified, and the FlhD(2)C(2)heterotetramer was reconstituted in vitro.

272 We show that R2 monomers within a heterotetramer were both necessary and sufficient to dic

273 KvLm heterotetramers were produced by cell-free expression, p

274 l in isolation, but which can form an active heterotetramer when combined.

275 , and B) that self-assemble into the desired heterotetramer when mixed in a 1:1:2 molar ratio.

276 half of GIRK4 is purified as the GIRK1-GIRK4 heterotetramer, whereas the remaining GIRK4 forms a high

277 of 1:3 and have solved the structure of the heterotetramer which we believe represents a novel strat

278 Acidic residues in the core of the E1b heterotetramer, which align with the proton-wire residue

279 ax counterpart, dimerizes to form a bivalent heterotetramer, which explains how Myc can upregulate ex

280 e dissect the ordered assembly of the RAG1/2 heterotetramer with 12RSS and 23RSS DNAs.

281 1 domain and the ligase IIIalpha domain is a heterotetramer with 2:2 stoichiometry.

282 otably, two TIGIT/PVR dimers assemble into a heterotetramer with a core TIGIT/TIGIT cis-homodimer, ea

283 The structure reveals a heterotetramer with a distinctive, elongated quaternary

284 enous FXIII-B subunits to form an FXIII-A2B2 heterotetramer with a half-life of 8.5 days, similar to

285 er and more ordered pore are seen in the 1:1 heterotetramer with an antiparallel helix arrangement.

286 ered large subunit gives rise to a maize AGP heterotetramer with decreased sensitivity to its negativ

287 DNA polymerase alpha-primase (pol-prim) is a heterotetramer with DNA polymerase and primase activitie

288 ins of Mdm12 and Mmm1 associate into a tight heterotetramer with equimolecular stoichiometry.

289 ional rigidity to the initial subnucleosomal heterotetramer with histone H4 as does CENP-A.

290 atic activity and resulted in a fully active heterotetramer with kinetic constants similar to those o

291 -Myc and c-Src, and AnxA2 forms a functional heterotetramer with S100A10 to promote tumor motility.

292 lyceraldehyde-3-phosphate dehydrogenase as a heterotetramer with the Escherichia coli glyceraldehyde-

293 Our results show the formation of a heterotetramer with three nuclear receptors binding to t

294 olution, the peptides form a stable, helical heterotetramer with tight packing in the most solvent-pr

295 y, the exon 2-deleted ASL variant may form a heterotetramer with wild type or mutant ASL, causing mar

296 ins in bacteria resulted in the formation of heterotetramers with a cSHMT/DNcSHMT subunit ratio of 1.

297 suggest that sQseD regulates ler by forming heterotetramers with another LTTR.

298 Activated p53 molecules formed nuclear heterotetramers with Delta40p53 and altered downstream p

299 rogenase (ACAD) enzymes that are alpha2beta2 heterotetramers with two active sites.

300 at both transporters exist as both homo- and heterotetramers, with a predominance of homotetramers.