ライフサイエンスコーパス: heterotetrameric

1 aryl hydrocarbon receptor (AhR) exists in a heterotetrameric 9S core complex consisting of the AhR l

2 Genes encoding the alpha2beta2 heterotetrameric ACAD structures are present in multiple

3 GIRK1 and GIRK4 subunits combine to form the heterotetrameric acetylcholine-activated potassium curre

4 of overlapping hot spots of dynamin and the heterotetrameric adaptor 2 complex in Drosophila nerve t

5 lasmically exposed sorting signals to either heterotetrameric adaptor AP-1 or AP-3.

6 with distinct endocytic adaptors such as the heterotetrameric adaptor AP3 influence the trafficking o

7 The heterotetrameric adaptor complex 1 (AP-1) and the monome

8 Expression of the epithelial cell-specific heterotetrameric adaptor complex AP-1B is required for t

9 biogenesis from endosomes that requires the heterotetrameric adaptor complex AP3.

10 Heterotetrameric adaptor complexes and SNAREs play key r

11 Heterotetrameric adaptor complexes vesiculate donor memb

12 targeting and are recognized by a family of heterotetrameric adaptor complexes, which then recruit c

13 investigated the interaction of PACS-1 with heterotetrameric adaptor complexes.

14 AP-3 is a heterotetrameric adaptor involved in the biogenesis of l

15 AP-4 is a member of the heterotetrameric adaptor protein (AP) complex family inv

16 AP-4 is a member of the family of heterotetrameric adaptor protein (AP) complexes that med

17 t well-characterized member of the family of heterotetrameric adaptor protein (AP) complexes that med

18 The clathrin-associated, heterotetrameric adaptor protein (AP) complexes, AP-1, A

19 if and mediate sorting via interactions with heterotetrameric adaptor protein (AP) complexes.

20 by interaction with the clathrin-associated, heterotetrameric adaptor protein 2 (AP-2) complex.

21 Heterotetrameric adaptor protein 2 (AP2) complexes, whic

22 of genes, including several subunits of the heterotetrameric adaptor protein AP-3, which are require

23 g and vesiculation process that requires the heterotetrameric adaptor protein AP3 and a small molecul

24 The heterotetrameric adaptor protein complex AP-3 has been s

25 that hVPS41 requires both a functional AP-3 (heterotetrameric adaptor protein complex) and HOPS (homo

26 Here, we report that both the AP-3 (heterotetrameric adaptor protein complex) interaction do

27 tifs within their cytoplasmic domains by the heterotetrameric adaptor protein complex, AP-2.

28 In mammals, the heterotetrameric adaptor protein complex-2 (AP-2) is req

29 Heterotetrameric adaptor protein complexes are important

30 The heterotetrameric adaptor proteins (AP complexes) link th

31 olutionarily ancient member of the family of heterotetrameric adaptor proteins (AP complexes).

32 itment onto membranes are not dependent upon heterotetrameric adaptors or AP180 homologs in yeast.

33 In the heterotetrameric ADP-Glc PPase from potato (Solanum tube

34 The heterotetrameric, allosterically regulated enzyme, adeno

35 sferase (E2) decorated with 60 copies of the heterotetrameric (alpha(2)beta(2)) 153-kDa pyruvate deca

36 Dinitrogenase is a heterotetrameric (alpha(2)beta(2)) enzyme that catalyzes

37 acid decarboxylase/dehydrogenase (BCKD) is a heterotetrameric (alpha(2)beta(2)) thiamine diphosphate

38 nt of subunits closely resembles that of the heterotetrameric (alphabeta)(2) phenylalanyl-tRNA synthe

39 Heterotetrameric (alphabetagammadelta) sarcosine oxidase

40 coccus furiosus contains an NADPH-utilizing, heterotetrameric (alphabetagammadelta), cytoplasmic hydr

41 homotetrameric recombinant GluR2, the native heterotetrameric AMPA-R adopted various conformations, w

42 motility and ATP hydrolysis of recombinant, heterotetrameric and homodimeric conventional Drosophila

43 Sera of camelids contain both conventional heterotetrameric antibodies and unique functional heavy

44 The heterotetrameric AP and F-COPI complexes help to define

45 iae, there are 13 genes encoding homologs of heterotetrameric AP subunits and two genes encoding AP18

46 The heterotetrameric AP-1 adaptor complex is involved in the

47 high-affinity membrane-binding sites for the heterotetrameric AP-1 adaptor complex.

48 AP-4, a novel protein complex related to the heterotetrameric AP-1, AP-2, and AP-3 adaptors that medi

49 Accordingly, the heterotetrameric AP-2 adaptor complex binds not only to

50 in 1, the so-called DPW domain, binds to the heterotetrameric AP-2 adaptor complex by associating dir

51 lpha-subunit appendage that projects off the heterotetrameric AP-2 adaptor core.

52 ors is either directly or indirectly via the heterotetrameric AP-2 complex [5].

53 A heterotetrameric AP-3 adaptor complex has been implicate

54 with mutations in the beta 3A subunit of the heterotetrameric AP-3 complex.

55 The heterotetrameric AP2 adaptor (alpha, beta 2, mu 2 and si

56 to endocytosis is their ability to bind the heterotetrameric AP2 complex via their C2B domain.

57 l that clathrin function is dependent on the heterotetrameric APs and/or AP180 homologs, yeast strain

58 23 with an OAP-disrupting mutation indicated heterotetrameric AQP4 association.

59 They are heterotetrameric assemblies of Kv7.2 and Kv7.3 subunits.

60 Adaptor protein (AP) complexes are heterotetrameric assemblies of subunits named adaptins.

61 Furthermore, the contribution of any heterotetrameric assembly to the total water transport t

62 the so-called 'hinge' region of MukB forms a heterotetrameric assembly with a C-terminal DNA binding

63 ich are essential for native alpha(2)beta(2) heterotetrameric assembly.

64 ted vesicles are the clathrin triskelion and heterotetrameric associated protein (AP) complexes.

65 The structure reveals a heterotetrameric association, consisting of a disc-like

66 nd dynamics of plasma membrane OAPs, and the heterotetrameric associations of AQP4, we constructed gr

67 t proteins, the dimeric BchL protein and the heterotetrameric BchN/BchB protein.

68 The heterotetrameric (-beta4-mu4-sigma4) complex adaptor pro

69 This heterotetrameric, C(2)-symmetric bundle, A(His):B(Thr),

70 In this study we identify calpactin I, a heterotetrameric, Ca(2+)- and phospholipid-binding prote

71 Unlike heterotetrameric canonical antibodies that are composed

72 ing of the latter to the beta-subunit of the heterotetrameric channel complex.

73 suggested lessening of amino acid clashes in heterotetrameric channel complexes.

74 wild-type subunits to maintain a functional heterotetrameric channel differed among the four RyR1 mu

75 t one or more subunits of Kv1.1 rendered the heterotetrameric channel sensitive to DTX-K.

76 Hence, the inactivation rate of heterotetrameric channels comprising both N-type and non

77 DTX-K is a specific blocker of Kv1.1 and heterotetrameric channels containing Kv1.1.

78 sly expressed human Kv7.4 and Kv7.5 homo- or heterotetrameric channels in A7r5 cells.

79 P3R monomers are assembled to form homo- and heterotetrameric channels that mediate Ca(2+) release fr

80 Coexpression of WT+T421M-Kv11.1 resulted in heterotetrameric channels that remained partially traffi

81 plasma membrane expression by diverting the heterotetrameric channels to lysosomes.

82 splicing in the alpha subunit, formation of heterotetrameric channels, and combinatorial association

83 s the possibility of interaction between the heterotetrameric chromogranin and heterotetrameric IP3 r

84 analysis and mutagenesis studies reveal that heterotetrameric ChsE1-ChsE2 has only two active sites.

85 AP-2, the heterotetrameric clathrin adaptor protein, has been demo

86 Heterotetrameric clathrin adaptors directly link the cla

87 n diphosphate (ThDP)-dependent enzyme with a heterotetrameric cofactor-binding fold.

88 Lateral association seems to be mediated by heterotetrameric coiled coils between the paired C-termi

89 air interactions that directly stabilize the heterotetrameric coiled-coil state.

90 AMPA receptors (AMPA-Rs) are formed as heterotetrameric combinations of subunits known as GluR1

91 NMDARs, which are heterotetrameric, commonly are composed of two GluN1 sub

92 catalyzing intron removal from pre-tRNA is a heterotetrameric complex (splicing endonuclease [SEN] co

93 ts of this CC MBS.LZ PKG-Ialpha low-affinity heterotetrameric complex and allow reevaluation of the r

94 vate transcription, most likely by forming a heterotetrameric complex at the tcpPH promoter.

95 ystal structure and mutational analysis of a heterotetrameric complex between constitutively active R

96 two homodimers assemble into a high-affinity heterotetrameric complex by virtue of two low-affinity i

97 act in vivo and are predicted to form a core heterotetrameric complex capable of creating higher orde

98 Centralspindlin, a heterotetrameric complex consisting of kinesin-6 and Rho

99 35 are homologous P-loop NTPases that form a heterotetrameric complex essential for FeS protein matur

100 modeling of the dimer-dimer interface of the heterotetrameric complex exhibits the involvement of non

101 The heterotetrameric complex formed by these two proteins ac

102 C-1-P-directed invasion, indicating that the heterotetrameric complex is required for C-1-P-mediated

103 We also analyzed binding parameters of a heterotetrameric complex of AnxA2 with its S100A10 prote

104 SCRT-0 indicates that it exists largely as a heterotetrameric complex of its two subunits.

105 isoforms initiate signaling by assembling a heterotetrameric complex of paired type I (TbetaRI) and

106 This heterotetrameric complex reveals a cyclic arrangement of

107 A heterotetrameric complex termed AP-3 is involved in sign

108 WAVE1 exists in a heterotetrameric complex that includes orthologues of hu

109 ember of the S100 protein family and forms a heterotetrameric complex with annexin 2.

110 Analysis of the reconstituted Rad3-Rad26 heterotetrameric complex with electron microscopy enable

111 tein core domain and for AnxA2 residing in a heterotetrameric complex with its intracellular binding

112 When Kv1.1 was expressed as a heterotetrameric complex with Kv1.5, block by DTX-K domi

113 These subunits form a heterotetrameric complex with R2H2 stoichiometry.

114 Specifically, annexin A2, found in a heterotetrameric complex with S100A10, not only serves a

115 on is believed to derive from formation of a heterotetrameric complex with target proteases involving

116 The coat is largely made up of the heterotetrameric complex, adaptor protein 3, recently im

117 he hypothesis that the "normal" state in the heterotetrameric complex, in which XerC is catalytically

118 molecular and functional insights into this heterotetrameric complex, we computationally constructed

119 also interacts directly with ExsD to form a heterotetrameric complex.

120 AP-3) is a vesicle-coat protein that forms a heterotetrameric complex.

121 m SNAP-23C, syntaxin-4, and VAMP-3 to form a heterotetrameric complex.

122 ubunits alpha and beta within an alpha2beta2-heterotetrameric complex.

123 romotes formation of the GABPalpha(2)beta(2) heterotetrameric complex.

124 transcriptionally active GABPalpha(2)beta(2) heterotetrameric complex.

125 elative subunit position and number within a heterotetrameric complex.

126 g factor, is a target for the p11/annexin A2 heterotetrameric complex.

127 Cu2+ to facilitate the formation of S100A13 heterotetrameric complexes and these signal peptideless

128 ity, the composition and expression of these heterotetrameric complexes are expected to be tightly re

129 that native channels can be either homo- or heterotetrameric complexes composed of several GIRK subu

130 show that Kv1 channels assembled as homo- or heterotetrameric complexes had distinct surface expressi

131 athrin-associated adaptors AP-1 and AP-2 are heterotetrameric complexes involved in the recognition o

132 he interactions between these motifs and the heterotetrameric complexes is controversial.

133 branes in a distinctive manner by assembling heterotetrameric complexes of structurally related serin

134 Adaptor proteins (AP 1-5) are heterotetrameric complexes that facilitate specialized c

135 uitously expressed, evolutionarily conserved heterotetrameric complexes that mediate different types

136 tly expressed in the brain where it can form heterotetrameric complexes with TRPC1 and TRPC4 channel

137 hat HCN1 and HCN2 readily coassemble to form heterotetrameric complexes.

138 nus of an adjacent subunit in both homo- and heterotetrameric complexes.

139 but are instead associated with DO in tight heterotetrameric complexes.

140 , the biological properties of the different heterotetrameric configurations formed by PIP1 and PIP2

141 ion (GAIT) complex in human myeloid cells is heterotetrameric, consisting of glutamyl-prolyl-tRNA syn

142 Plant AGPs are heterotetrameric, consisting of two large and two small

143 in Alzheimer disease (AD) and consists of a heterotetrameric core complex that includes the aspartyl

144 as a heterotetramer, resembling the (H3/H4)2 heterotetrameric core of the histone octamer, suggesting

145 al complex consisting of a (Mre11)2/(Rad50)2 heterotetrameric DNA processing head and a double coiled

146 The heterotetrameric Dr1-DRAP1 transcriptional repressor com

147 dues in the E1alpha and E1beta chains of the heterotetrameric E1 (alpha(2)beta(2)) component of the P

148 ears to be conserved in the alpha-subunit of heterotetrameric E1s and multiple sequence alignments su

149 Here, we present a structural model of heterotetrameric ENaC alpha1betaalpha2gamma that is cons

150 a single subunit type, the plant AGPase is a heterotetrameric enzyme (alpha2beta2) with distinct role

151 ne oxidase from Corynebacterium sp. P-1 is a heterotetrameric enzyme (alphabetagammadelta) that conta

152 This heterotetrameric enzyme also used the analogous longer c

153 and small (SS) subunits yielded a functional heterotetrameric enzyme capable of complementing a mutat

154 ant ADP-glucose pyrophosphorylase (AGP) is a heterotetrameric enzyme composed of two large and two sm

155 e relative roles of the conserved Lys in the heterotetrameric enzyme from potato (Solanum tuberosum L

156 Protein kinase CK2 (casein kinase II) is a heterotetrameric enzyme implicated in many essential reg

157 ructure of molybdopterin synthase revealed a heterotetrameric enzyme in which the C terminus of each

158 d with SS and that the net properties of the heterotetrameric enzyme is a product of subunit synergy.

159 tide (FAD) to protein Sdh1, a subunit of the heterotetrameric enzyme succinate dehydrogenase.

160 Pyrococcus furiosus is an NADP(H)-dependent heterotetrameric enzyme that contains a nickel-iron cata

161 for NAD could be measured with the purified heterotetrameric enzyme that possessed just 16-18% activ

162 DNA polymerase delta (Pol delta4) is a heterotetrameric enzyme, whose p12 subunit is degraded i

163 ajor T. brucei PRMT, TbPRMT1, functions as a heterotetrameric enzyme-prozyme pair.

164 make up the large and small subunits of this heterotetrameric enzyme.

165 cter sp. and Pseudomonas sp. show that these heterotetrameric enzymes also contain covalently bound F

166 AP4E1 encodes the epsilon subunit of the heterotetrameric (epsilon-beta4-mu4-sigma4) AP-4 complex

167 The crystal structure of the heterotetrameric ESCRT-I complex reveals a highly asymme

168 inal domain of hVps22p in the formation of a heterotetrameric ESCRTII complex.

169 The heptamer can be dissected into a heterotetrameric F-subcomplex, which displays similariti

170 ome bacteria, archaea, and eukaryotes; and a heterotetrameric form (alpha2beta2) present in most bact

171 1K.S302N) homotetramer are compared with its heterotetrameric form assembled with S D143N.

172 of the Pol2p.Dpb2p complexes reveals a novel heterotetrameric form, consisting of two heterodimers of

173 est that molecular association of IP3Rs into heterotetrameric forms can contribute to the complexity

174 To allow for the separation of various heterotetrameric forms of the enzyme, surface residues w

175 for this diversity, we designed an A(2)B(2) heterotetrameric four-helix bundle with an active site s

176 heterooctomeric ATP-sensitive K channels and heterotetrameric G-protein-regulated inward rectifier K

177 The mature heterotetrameric GAIT complex binds the 3' UTR GAIT elem

178 The heterotetrameric GAIT complex suppresses translation of

179 tRNA synthetase (EPRS) is a component of the heterotetrameric gamma-interferon-activated inhibitor of

180 handover of TA substrates is mediated by the heterotetrameric Get4/Get5 complex (Get4/5), which tethe

181 led homotetrameric GIRK1 channels and in the heterotetrameric GIRK1/2 channel, the truncation of G1-d

182 we show the crystal structure of the intact heterotetrameric GluN1-GluN2B NMDA receptor ion channel

183 he mature insulin receptor is a cell surface heterotetrameric glycoprotein composed of two alpha- and

184 The enzyme is a heterotetrameric glycoprotein comprised of two alpha-sub

185 The heterotetrameric human pol delta complex was reconstitut

186 In alpha2beta2-heterotetrameric human pyruvate dehydrogenase, this cofa

187 es, Interferon-gamma modulates assembly of a heterotetrameric inhibitor of translation.

188 that encode monomeric forms of the normally heterotetrameric insulin receptor and monomeric platelet

189 nstituted receptor shows the alpha(2)beta(2) heterotetrameric insulin receptor to be a three-armed pi

190 Disulfide bonds observed at the heterotetrameric interfaces in the unliganded IDH hetero

191 TRP proteins assemble into heterotetrameric ion channels and are known to support S

192 N-methyl-d-aspartate receptors (NMDARs) are heterotetrameric ion channels assembled as diheteromeric

193 etween the heterotetrameric chromogranin and heterotetrameric IP3 receptor but also appears to reflec

194 hosphate (IP3) receptor and the existence of heterotetrameric IP3 receptor in the cell, the heterotet

195 Thus, how the subunit composition of heterotetrameric IP3R channels contributes to shaping th

196 In summary, we demonstrate that heterotetrameric IP3R do not necessarily behave as the s

197 ide the first insight into the regulation of heterotetrameric IP3R of defined composition.

198 omains bound to two JAK2 molecules, creating heterotetrameric JAK2-(SH2-B)2-JAK2 or JAK2-(APS)2-JAK2

199 ata were compared with [125I]MgTX binding to heterotetrameric K(V) channels in rat brain synaptic pla

200 In contrast, exogenously-expressed heterotetrameric Kv7.4/7.5 channels in A7r5 cells or nat

201 yl-D-aspartate (NMDA) receptors are obligate heterotetrameric ligand-gated ion channels that play cri

202 Although the structure of the heterotetrameric maize endosperm AGPase remains unsolved

203 GPIT is a minimally heterotetrameric membrane protein complex composed of Ga

204 In budding yeast, the heterotetrameric MIND complex (Mtw1, Nnf1, Nsl1, Dsn1),

205 ependent isocitrate dehydrogenase (IDH) is a heterotetrameric mitochondrial enzyme with 2alpha:1beta:

206 The second step is catalyzed by the heterotetrameric MPT synthase protein consisting of two

207 etween individual domains of E1p relative to heterotetrameric multienzyme complex E1 components opera

208 and antibody labeling, demonstrates that the heterotetrameric Ndc80 complex is an approximately 570-A

209 Membrane-associated Hyd-2 is an unusual heterotetrameric [NiFe]-hydrogenase that lacks a typical

210 t dimer dissociation is critical for forming heterotetrameric NMDA-Rs containing GluN2 subunits, defi

211 ive AdoCbl-dependent PCM with an alpha2beta2 heterotetrameric organization similar to that of isobuty

212 The heterotetrameric phosphodiesterase (PDE) 6 complex, made

213 patients that alter function of Kv2.1/Kv8.2 heterotetrameric potassium channels.

214 sidue in the large and small subunits of the heterotetrameric potato (Solanum tuberosum) tuber enzyme

215 factor XIII (FXIII) exists in circulation as heterotetrameric proenzyme FXIII-A2B2 Effectively all FX

216 ed by actin-capping protein at one end and a heterotetrameric protein complex containing the p62 subu

217 showed that the X. sagittifolium lectin is a heterotetrameric protein composed of four 12-kDa subunit

218 ne oxidase from Corynebacterium sp. P-1 is a heterotetrameric protein containing three different enzy

219 In this report, we identify the heterotetrameric protein kinase, casein kinase 2 (CK2),

220 The A(2)B(2) heterotetrameric protein reflects ligand-directed elemen

221 hetase (PheRS) is a multidomain (alphabeta)2 heterotetrameric protein responsible for synthesizing Ph

222 ing through the extracellular annexin a2-p11 heterotetrameric protein, can mediate vascular endotheli

223 The atrial KACh channels are heterotetrameric proteins that consist of two pore-formi

224 The structure reveals a new heterotetrameric quaternary organization for the Type II

225 rent TGFbeta isoforms induce assembly of the heterotetrameric receptor complex in the same general ma

226 or (GDNF) is a ligand for RET and acts via a heterotetrameric receptor complex that includes GDNF rec

227 he insulin receptor, the IGF-1 receptor is a heterotetrameric receptor tyrosine kinase, whereas the I

228 R) are structurally and functionally related heterotetrameric receptors.

229 ors of excitatory synaptic transmission, are heterotetrameric receptors.

230 The heterotetrameric recombination complex contains two mole

231 NasS and NasT proteins co-purify as a stable heterotetrameric regulatory complex, NasS-NasT.

232 The heterotetrameric sarcoglycan complex, composed of alpha-

233 synthase (GltB2), large subunit of putative heterotetrameric sarcosine oxidase (SoxA) and glutamine

234 The crystal structure of heterotetrameric sarcosine oxidase (TSOX) from Pseudomon

235 Heterotetrameric sarcosine oxidase (TSOX) is a complex b

236 The reaction of heterotetrameric sarcosine oxidase (TSOX) of Arthrobacto

237 homologous but oxygen-unreactive FAD site in heterotetrameric sarcosine oxidase.

238 owledge, the functional properties of single heterotetrameric species having 2:2 stoichiometry.

239 All PIP2-PIP1 heterotetrameric species localize at the plasma membrane

240 Here we used heterotetrameric species of SecB to understand the sourc

241 s dimerization to initially form an inactive heterotetrameric species, followed by conversion to acti

242 -containing tRNAs requires the action of the heterotetrameric splicing endonuclease, which is compose

243 nken2 (Sh2) encodes the large subunit of the heterotetrameric starch synthetic enzyme adenosine dipho

244 nomic locations suggest that the alpha2beta2 heterotetrameric structural motif has evolved to enable

245 The presence of the heterotetrameric structure in the crystals is significan

246 This accounts for the common heterotetrameric structure of native receptor heterocomp

247 In the bacterial GA crystals, we observe a heterotetrameric structure similar to that found in the

248 two MoaE subunits and two MoaD subunits in a heterotetrameric structure with the two MoaE subunits fo

249 y that different TRPC subunits coassemble as heterotetrameric structures to form smooth muscle SOCs.

250 rogrammed arrangement of the subunits in the heterotetrameric synapse.

251 e mammalian immune response is mediated by a heterotetrameric transcriptional control complex, called

252 ked SSR4 gene which encodes a protein of the heterotetrameric translocon-associated protein (TRAP) co

253 smooth muscle results from the formation of heterotetrameric TRPC structures in different smooth mus

254 l and adult homeostatic events through their heterotetrameric type I and type II receptor complexes.

255 Thus, a heterotetrameric type II topoisomerase can be converted

256 Gyrase, a prokaryotic heterotetrameric type IIA topo, introduces negative supe

257 sarcoglycan complex in striated muscle is a heterotetrameric unit integrally associated with sarcosp

258 lution are required for the formation of the heterotetrameric Vestigial-Scalloped complex on DNA.