ライフサイエンスコーパス: heterotopia

1 near the lateral ventricles (periventricular heterotopia).

2 les lead to a more variable subcortical band heterotopia.

3 sically epileptogenic; these include FCD and heterotopia.

4 X-linked lissencephaly and subcortical band heterotopia.

5 X-linked lissencephaly and subcortical band heterotopia.

6 d the cortex overlying band and subependymal heterotopia.

7 key role in the formation of large cortical heterotopia.

8 n of terminals was present in the underlying heterotopia.

9 ed in epileptic humans with subcortical band heterotopia.

10 of labeling were observed in the underlying heterotopia.

11 and radial orientation are disturbed in the heterotopia.

12 ing cortex secondarily propagate to the band heterotopia.

13 99% for schizencephaly, and 40% and 91% for heterotopia.

14 aly, and 15 cases of periventricular nodular heterotopia.

15 ncephaly; and 73% and 92%, respectively, for heterotopia.

16 nt, especially for counseling patients about heterotopia.

17 double cortex syndrome, and periventricular heterotopia.

18 subgroup of patients with unilateral nodular heterotopia.

19 eighted images to visually assess regions of heterotopia.

20 and epilepsy with bilateral periventricular heterotopias.

21 ed to show altered neuronal connectivity and heterotopias.

22 he gene for filamin A, cause periventricular heterotopias.

23 ociated with the formation of large neuronal heterotopias.

24 tive of excessive pre-natal neurogenesis and heterotopias.

25 (3 members from 2 families), and focal band heterotopia (1 individual).

26 s consisted of focal cortical dysplasia (5), heterotopia (2), hamartoma (3), cortical duplication (1)

27 the double-cortex syndrome (subcortical band heterotopia, 30 persons), polymicrogyria with megalencep

28 megalencephaly (20), periventricular nodular heterotopia (61), and pachygyria (47).

29 e cortex (DC; also known as subcortical band heterotopia), a neuronal migration disorder causing epil

30 ral neurons and give rise to periventricular heterotopia, a disorder that leads to epilepsy and vascu

31 s to a phenotype resembling subcortical band heterotopia, also known as "double cortex," a brain malf

32 complex 1 (Tsc1) heterozygote mice leads to heterotopia and abnormal neuronal morphogenesis as seen

33 ons, polymicrogyria, periventricular nodular heterotopia and diffuse megalencephaly without cortical

34 At 19 d post-electroporation (dpe), heterotopia and ectopic cells with a neuronal morphology

35 drome, with X-linked periventricular nodular heterotopia and FG syndrome (Omim, 305450).

36 cortical dysplasias had better outcome than heterotopia and hamartoma regardless of type of surgical

37 entricular heterotopia, polymicrogyria, band heterotopia and lissencephaly, dysembryoplastic neuroepi

38 ymicrogyria, periventricular and subcortical heterotopia and lissencephaly.

39 icular nodular heterotopia, subcortical band heterotopia and lissencephaly.

40 s with epilepsy from periventricular nodular heterotopia and matched healthy controls.

41 Human cortical heterotopia and neuronal migration disorders result in e

42 Although it is clear that the band heterotopia and the overlying cortex both contribute to

43 molecular layer and overlying leptomeningeal heterotopia and within the heterotopia itself.

44 ther findings in ET cases were Purkinje cell heterotopias and dendrite swellings.

45 e often discussed, notably entorhinal cortex heterotopias and hippocampal neuronal disarray, remain t

46 These lesions include migratory heterotopias and olfactory micronodules containing neuro

47 ption of pial basal membranes underlying the heterotopias and poor organization of fibrillar laminin

48 utants showed differences in the location of heterotopias and the organization of the hippocampal str

49 n as subcortical band heterotopia or laminar heterotopia) and affected males show X-linked lissenceph

50 anized pyramidal-like neurons (e.g., nodular heterotopia) and loss of lamination in cortical and hipp

51 man PMSE brain exhibits cytomegaly, neuronal heterotopia, and aberrant activation of mammalian target

52 heterotopic bands, subependymal grey matter heterotopia, and the cortex overlying band and subependy

53 hment of radial glial endfeet, marginal zone heterotopias, and cortical dyslamination.

54 tion with heterotopic neurons, Purkinje cell heterotopias, and simplified convolutions of the dentate

55 od of neurogenesis during which cells in the heterotopia are generated is the same as in the normotop

56 we show that dyslamination and white matter heterotopia are not necessary for seizure generation in

57 Neuronal heterotopia are seen in various pathologies and are asso

58 ture, frontal polymicrogyria and gray matter heterotopia are uniformly present, whereas cerebellar dy

59 Leptomeningeal glioneuronal heterotopias are a focal type of cortical dysplasia in w

60 These heterotopias are frequently observed as microscopic abno

61 Hippocampal nodular heterotopias are prone to hyperexcitability and may cont

62 Bilateral periventricular nodular heterotopia (BPNH) is a malformation of neuronal migrati

63 that presented with both MKS and cerebellar heterotopia, caused by an unusual in-frame deletion muta

64 blast migration give rise to periventricular heterotopia (clusters of neurons along the ventricles of

65 exams in children diagnosed with gray matter heterotopia confirmed in MRI (magnetic resonance imaging

66 a, abnormal corpus callosum, and gray matter heterotopia, consistent with a CMS diagnosis, but no ven

67 RMS heterotopias contained astrocytes, neurons, and entrappe

68 Moreover, the Rfx3(-/-) VT displays heterotopias containing attractive guidance cues and exp

69 rophy, additional brain abnormalities (e.g., heterotopia, Dandy-Walker malformation), pituitary insuf

70 Sensitivity for heterotopia decreased to 44% for fetuses younger than 24

71 brain frequently resulted in periventricular heterotopia, developmental abnormalities often associate

72 vo, leading to the formation of white matter heterotopias displaying neuronal hyperexcitability.

73 We show that the band heterotopia does not constitute a primary origin for int

74 l cortical malformations, megalencephaly and heterotopia due to constitutional AKT3 mutations.

75 h cerebral ventriculomegaly, periventricular heterotopias, echogenic kidneys, and renal failure was h

76 hippocampal lamination defects, hippocampal heterotopias, enlarged dysplastic neurons and glia, abno

77 motopic neocortex; however, the cells in the heterotopia exhibit a "rim-to-core" neurogenetic pattern

78 Neurons in the heterotopia exhibit neocortical-like morphologies and se

79 useful biomarker in epilepsy in gray matter heterotopia, expand our understanding of circuit mechani

80 MAM-exposed rats the abnormal cell clusters (heterotopia) first appear postnatally in the hippocampus

81 LIS1), persons with periventricular nodular heterotopia (FLNA), and persons with pachygyria (TUBB2B)

82 We report that leptomeningeal glioneuronal heterotopias form in Emx2(-/-) mice that are equivalent

83 bnormalities in basement membrane integrity, heterotopia formation, neuronal overmigration, and menin

84 l basement membrane integrity, marginal zone heterotopia formation, neuronal overmigration, meningeal

85 Gray matter heterotopia (GMH) is a malformation of the central nervo

86 that patients with epilepsy from gray matter heterotopia have altered cortical physiology consistent

87 n the neighboring portions of the underlying heterotopia; however, these neurons did not display char

88 (i) micrencephaly without polymicrogyria or heterotopia; (ii) atrophic cerebellar hemispheres with s

89 ence and cytoarchitecture of molecular-layer heterotopia in C57BL/6J mice and related strains obtaine

90 eristic morphological changes of gray matter heterotopia in children hospitalized in our institution

91 of human FLNA causes periventricular nodular heterotopia in females and is generally lethal (cause un

92 role of the normotopic cortex over the band heterotopia in generating interictal epileptiform activi

93 he previously reported prevalence of gastric heterotopia in the cervical esophagus, also termed inlet

94 uces diffuse cortical dysplasia and neuronal heterotopia in the neocortex and hippocampus.

95 of cell migration abnormalities, gray matter heterotopia included, MR imaging remains the method of c

96 lead to hippocampal injury and white matter heterotopia is not invariably associated with hippocampa

97 The bilateral heterotopia is prominent below the frontal and parietal

98 Periventricular heterotopias is a malformation of cortical development,

99 ng leptomeningeal heterotopia and within the heterotopia itself.

100 erentiation, resulting in a subcortical band heterotopia-like phenotype, reminiscent of loss of doubl

101 ncephaly, holoprosencephaly, periventricular heterotopia, lissencephaly, and Joubert syndrome.

102 cterized by microcephaly and periventricular heterotopia maps to chromosome 20 and is caused by mutat

103 OB heterotopia, micronodules, and dendrite hypertrophy were

104 Among children with gray matter heterotopia most common clinical symptoms were: epilepsy

105 cts in the Gsh1/2 mutants, there are pallial heterotopia near the cortical/subcortical limit and defe

106 e of four patients with subependymal nodular heterotopia, nodules had lower [(11)C]FMZ-V(d) than the

107 Gray matter heterotopia occurred more often with other developmental

108 Gray matter heterotopia occurred with other developmental disorders

109 with subcortical or periventricular nodular heterotopia of different aetiologies: one with severe ep

110 are cells of endothelial lineage rather than heterotopia of epithelial cells; these cells probably ar

111 t p35-deficient mice also exhibit dysplasia/ heterotopia of principal neurons in the hippocampal form

112 cells, but not preplate cells, comprise the heterotopia of the tish cortex.

113 ons normally seen in periventricular nodular heterotopia on MRI.

114 severely thickened cortex to posterior band heterotopia only.

115 syndrome (DC; also known as subcortical band heterotopia or laminar heterotopia) and affected males s

116 %) patients additionally had schizencephaly, heterotopia, or focal cortical dysplasia.

117 Heterotopia patients with active epilepsy demonstrated a

118 Periventricular heterotopia (PH) involves dramatic malformations of the

119 Periventricular heterotopia (PH) is a disorder characterized by neuronal

120 Periventricular heterotopia (PH) is a human malformation of cortical dev

121 Periventricular heterotopia (PH) is a human neuronal migration disorder

122 Periventricular heterotopia (PH) is a malformation of cortical developme

123 nked dominant human disorder periventricular heterotopia (PH), many neurons fail to migrate and persi

124 human neurological disorder, periventricular heterotopia (PH).

125 hibit MCCs resembling severe periventricular heterotopia (PH).

126 nA) cause the human disorder periventricular heterotopia (PH).

127 and form persistent periventricular nodular heterotopia (PH).

128 ental disorders with periventricular nodular heterotopia (PNH) are etiologically heterogeneous, and t

129 microgyria (PMG) and periventricular nodular heterotopia (PNH) are two developmental brain malformati

130 D: focal cortical dysplasia, periventricular heterotopia, polymicrogyria, band heterotopia and lissen

131 Although heterotopia production is TrkB mediated, BDNF is >10-fol

132 Periventricular heterotopia (PVH) is a congenital malformation of human

133 ble in patients with periventricular nodular heterotopia (PVNH) to detect abnormal fiber projections

134 ion disorder, called periventricular nodular heterotopia (PVNH; refs. 3-6).

135 n in the whole brain produced glial/neuronal heterotopia resembling the cerebral cortex malformation

136 Heterotopias resembling those found in cobblestone lisse

137 Subcortical band heterotopia (SBH) and classical lissencephaly (LIS) resu

138 Subcortical band heterotopia (SBH) and lissencephaly (LIS), two distinct

139 Subcortical band heterotopia (SBH) are bilateral and symmetric ribbons of

140 we show, in a rat model of subcortical band heterotopia (SBH) generated by in utero RNA interference

141 Subcortical band heterotopia (SBH) is a cortical malformation formed when

142 HeCo mutant mouse exhibits subcortical band heterotopia (SBH), likely to be initiated by progenitor

143 Two of three patients with band heterotopia showed multiple increases in the overlying c

144 utant is seizure-prone and displays cortical heterotopia similar to those observed in certain epilept

145 This animal exhibits bilateral heterotopia similar to those observed in epileptic human

146 ncephaly (smooth brain) and subcortical band heterotopia (smooth brain with a band of neurons beneath

147 disorders, including periventricular nodular heterotopia, subcortical band heterotopia and lissenceph

148 polymicrogyria and overlying leptomeningeal heterotopia suggest an association between the presence

149 to confirm significant white matter neuronal heterotopia that might indicate an underlying developmen

150 we demonstrate severe neuronal dysplasia and heterotopia throughout the granule cell and pyramidal ce

151 set in the telencephalic internal structural heterotopia (tish) rat, which is a genetic model of heig

152 displays a telencephalic internal structural heterotopia (tish) that is inherited in an autosomal rec

153 ring loss of lamination and distinct nodular heterotopia to examine inhibitory synaptic function in t

154 ddition, bypassing neuronal misplacement and heterotopia using inducible vectors do not prevent seizu

155 found that the prevalence of molecular-layer heterotopia vaired according to the sex as well as the v

156 Sensitivity for heterotopia was lower for fetuses younger than 24 weeks.

157 Subependymal gray matter heterotopia was more common than subcortical GMH.

158 When heterotopia was seen in two planes, specificity was 100%

159 tracks emanating from one or more regions of heterotopia were reported by all four readers in all 14

160 Abnormal cell clusters or heterotopias were detected in the marginal zone, and dis

161 Heterotopias were detected in transgenic mice as early a

162 rely stop migrating to form subcortical band heterotopias within the intermediate zone and then white

163 larged, indented cortical plate and cellular heterotopias within the ventricular zone, similar to the