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2 tes many cellular proteins, in the case of a heterotrimeric aminoacyl-tRNA synthetase complex, the ag
4 um, a basal chemotaxis pathway consisting of heterotrimeric and monomeric G proteins is sufficient fo
5 iverse array of processes and is part of the heterotrimeric Bag6 complex, which also includes ubiquit
10 t a thermally stable hydroxyproline-free ABC heterotrimeric collagen mimetic system composed of decap
11 ine-glutamate axial salt-bridges to design a heterotrimeric collagen triple helix, ABC-1, containing
14 inase (AMPK) is an obligatory alphabetagamma heterotrimeric complex carrying a carbohydrate-binding m
15 protein phosphatase 2A (PP2A) functions as a heterotrimeric complex composed of a catalytic (C), scaf
16 Escherichia coli DNA polymerase V (pol V), a heterotrimeric complex composed of UmuD'2C, is marginall
17 ve channel show that the SecY subunit of the heterotrimeric complex consists of two halves that form
19 ochore-associated (Ska) protein complex is a heterotrimeric complex required for timely anaphase onse
21 hat ectopically expressed cTalpha 1) forms a heterotrimeric complex with rod Gbeta(1)gamma(1), 2) sub
24 t emerged that apo GRX3 and apo BOLA2 form a heterotrimeric complex, composed by two BOLA2 molecules
29 nd HSF2 interact directly, forming HSF1-HSF2 heterotrimeric complexes recruited to a specific heat sh
31 ed ability of the G-protein subunits to form heterotrimeric complexes, including betagamma-dimers pre
32 elucidate the thermodynamic properties of a heterotrimeric DNA complex that portrays the structure o
34 AMP-activated protein kinase (AMPK) is a heterotrimeric enzyme that senses and governs changes in
36 as the Werner syndrome protein (WRN) and the heterotrimeric eukaryotic ss-DNA binding protein RPA.
38 ortex during mitosis by the alpha subunit of heterotrimeric G protein (Galpha)/mammalian homologue of
41 8 (Ric-8) proteins regulate an early step of heterotrimeric G protein alpha (Galpha) subunit biosynth
42 ty and is a chaperone for several classes of heterotrimeric G protein alpha subunits in vertebrates.
43 ne nucleotide exchange (GEF) activity toward heterotrimeric G protein alpha subunits of the i, q, and
46 nctional scaffolding protein that integrates heterotrimeric G protein and H-Ras signaling pathways.
48 and phosphorylates the alpha subunit of the heterotrimeric G protein complex, Galphaq, resulting in
51 GDD and provide insights how perturbation in heterotrimeric G protein function contributes to the dis
56 e B lymphocyte surface receptors, triggering heterotrimeric G protein Galphai subunit guanine nucleot
59 showed that interactions between APP and the heterotrimeric G protein Goalpha-regulated Goalpha activ
60 ivative, was validated using cell-free aGPCR/heterotrimeric G protein guanosine 5'-3-O-(thio)triphosp
61 TAS1R taste receptors and their associated heterotrimeric G protein gustducin are involved in sugar
63 f the C terminus of the alpha subunit of the heterotrimeric G protein in G protein-coupled receptor (
66 on of chemoattractant sensing occurs between heterotrimeric G protein signaling and Ras activation.
68 ne nucleotide exchange factor that activates heterotrimeric G protein signaling downstream of RTKs an
69 intermediate molecule(s) that could activate heterotrimeric G protein signaling in a calcium-dependen
70 integrin activation in platelets is through heterotrimeric G protein signaling regulating hemostasis
72 Galpha12/13 but not representatives of other heterotrimeric G protein subfamilies, such as Galphai1,
73 cible sequestration system to inactivate the heterotrimeric G protein subunit Gbeta and find that thi
74 re we report that signal transduction by the heterotrimeric G protein subunit Gbeta1 is essential for
75 onfirmation of expected interactions such as heterotrimeric G protein subunit interactions and aquapo
76 C-beta (PLC-beta) isoforms are stimulated by heterotrimeric G protein subunits and members of the Rho
77 elial cell adhesion molecule-1 (PECAM-1) and heterotrimeric G protein subunits Galphaq and 11 (Galpha
78 of the AC NT for mechanisms of regulation by heterotrimeric G protein subunits is isoform-specific.
79 its own spectrum of activators that includes heterotrimeric G protein subunits, protein tyrosine kina
81 pled receptor (GPCR) rhodopsin activates the heterotrimeric G protein transducin (Gt) to transmit the
83 o examine the role of Galpha13, a G12 family heterotrimeric G protein, in regulating cellular invasio
84 dissociation of the Galpha subunit from the heterotrimeric G protein, leading to downstream signalin
85 ere the very first genes for agonist-binding heterotrimeric G protein-coupled receptors (GPCRs) to be
86 rs and also direct receptor signaling toward heterotrimeric G protein-independent signaling pathways.
88 naling triad analogous to the core triad for heterotrimeric G proteins (GEF + G proteins + effector).
89 ed to both members of the Galpha12 family of heterotrimeric G proteins alpha subunits, Galpha12 and G
91 ies in plant immunity provide a link between heterotrimeric G proteins and an MAPK cascade via the RA
94 ich agonist stimulation leads to coupling of heterotrimeric G proteins and generation of second messe
96 These signaling pathways are modulated by heterotrimeric G proteins and the scaffold proteins beta
97 iple waves of signaling that are mediated by heterotrimeric G proteins and the scaffolding proteins b
114 ivates several signaling pathways, including heterotrimeric G proteins Gq and G12, as well as the ext
117 Accordingly, XLGs expand the repertoire of heterotrimeric G proteins in plants and reveal a higher
118 receptors (GPCRs), in addition to activating heterotrimeric G proteins in the plasma membrane, appear
120 studies have questioned the idea that plant heterotrimeric G proteins interact with canonical GPCRs,
121 -protein-coupled receptor (GPCR) coupling to heterotrimeric G proteins is confined to the plasma memb
124 not essential for the initial activation of heterotrimeric G proteins or Ras by uniform chemoattract
129 mediated activation of the Galpha subunit of heterotrimeric G proteins requires allosteric communicat
131 tein Signaling (RGS) promote deactivation of heterotrimeric G proteins thus controlling the magnitude
133 investigated the inactive-state assembly of heterotrimeric G proteins with FZD4, a receptor importan
135 , (ii) binding of the Gbetagamma subunits of heterotrimeric G proteins, and (iii) phosphorylation of
137 ghly homologous alpha subunits of Galphaq/11 heterotrimeric G proteins, and in PLCB4 (phospholipase C
138 1 matrix metalloprotease (MMP14, MT1-MMP) by heterotrimeric G proteins, and in turn, the generation o
140 Arrestin recruitment uncouples GPCRs from heterotrimeric G proteins, and targets the proteins for
141 e structure of Smo implies interactions with heterotrimeric G proteins, but the degree to which G pro
142 cells by catalyzing nucleotide release from heterotrimeric G proteins, but the mechanism underlying
147 ins, which form the alpha subunit of certain heterotrimeric G proteins, drive uveal melanoma oncogene
148 agonist-promoted interactions of GPCRs with heterotrimeric G proteins, GPCR kinases (GRKs), and arre
149 (GNB1) gene, encoding the Gbeta1 subunit of heterotrimeric G proteins, have recently been identified
151 is transient (<10 minutes) and initiated by heterotrimeric G proteins, is followed by a second wave
152 modulated by three families of proteins: the heterotrimeric G proteins, the G-protein-coupled recepto
153 between receptor tyrosine kinases (RTKs) and heterotrimeric G proteins, two major and distinct signal
154 PKA and upstream of the Galphai component of heterotrimeric G proteins, which itself localizes to cil
171 ype that resembles the one described for the heterotrimeric G-protein alpha subunit (GPA1) null mutan
172 s dynein recruitment to the cell cortex by a heterotrimeric G-protein alpha subunit in complex with a
173 s Columbia accession (Col) wild type and the heterotrimeric G-protein alpha subunit mutant, gpa1, whi
174 suggesting a role for Bni1 downstream of the heterotrimeric G-protein and Cdc42 during gradient sensi
175 T based sensor for detecting activation of a heterotrimeric G-protein by G-protein coupled receptors.
176 d Ggamma proteins of a soybean (Glycine max) heterotrimeric G-protein complex are involved in regulat
177 1 Gbeta and 3 Ggamma proteins represent the heterotrimeric G-protein complex in Arabidopsis, and a s
179 B2 encodes the beta2 subunit (Gbeta2) of the heterotrimeric G-protein complex that is being released
182 ng the Galpha, Gbeta, and Ggamma subunits of heterotrimeric G-protein complexes, which function upstr
183 a signaling cascade, which is mediated by a heterotrimeric G-protein consisting of alpha, beta, and
184 e therefore diagnoses in the group of mosaic heterotrimeric G-protein disorders, joining McCune-Albri
185 applications to dihydrofolate reductase and heterotrimeric G-protein families along with a discussio
186 he histamine receptor subtypes for different heterotrimeric G-protein families with single-cell resol
187 t chemoattractants rely on activation of the heterotrimeric G-protein Galphai to regulate directional
188 opic glutamate receptor mGluR6 activates the heterotrimeric G-protein Galphaobeta3gamma13, and this l
189 ortholog [APPL (APP-Like)] directly bind the heterotrimeric G-protein Goalpha, supporting the model t
197 PAR1 is promiscuous and couples to multiple heterotrimeric G-protein subtypes in the same cell and p
199 ulin-like (CML) protein, and by showing that heterotrimeric G-protein subunits Galpha (GPA1) and Gbet
200 hat Galphaolf exclusively forms a functional heterotrimeric G-protein with Gbeta1 and Ggamma13 in OSN
201 -gated channel via a cascade that includes a heterotrimeric G-protein, cone transducin, comprising Ga
203 gand histamine by activating three canonical heterotrimeric G-protein-mediated signaling pathways wit
207 tem to drive expression of dominant-negative heterotrimeric G-proteins (DNG) in retinal ganglion cell
208 GPCRs) relay extracellular signals mainly to heterotrimeric G-proteins (Galphabetagamma) and they are
215 we report the functional characterization of heterotrimeric G-proteins from a nonvascular plant, the
217 s (Rac1, RhoA/B/C, and Cdc42) as well as for heterotrimeric G-proteins in a series of live-cell imagi
220 coupled receptors and Galpha subunits of the heterotrimeric G-proteins, induce contraction of smooth
224 juana component (9)-tetrahydrocannabinol, to heterotrimeric G12/G13 proteins that triggers rapid and
228 ns in the GNAQ and GNA11 oncogenes, encoding heterotrimeric Galphaq family members, have been identif
229 receptor, in complex with peptide ligand and heterotrimeric Galphasbetagamma protein determined by Vo
230 oupled receptors that predominantly activate heterotrimeric Gi proteins and are involved in immune ce
231 sic G protein-coupled receptor by activating heterotrimeric Gi/Go proteins resulting in adenylyl cycl
232 show that activation of receptors coupled to heterotrimeric Gi/o proteins inhibits TRPM3 channels.
233 These enzymes are regulated by stimulatory heterotrimeric Gs proteins; however, the presence of Gs
235 FLJ00018 is regulated by the interaction of heterotrimeric GTP-binding protein Gbetagamma subunits o
239 translation initiation factor 2 (eIF2) is a heterotrimeric GTPase, which plays a critical role in pr
240 TPases, nuclear lamins, the gamma-subunit of heterotrimeric GTPases, and several protein kinases and
244 ocalization signal and reversible G protein (heterotrimeric guanine nucleotide-binding protein)-coupl
246 which are transcribed and replicated by the heterotrimeric IAV RNA-dependent RNA-polymerase (RdRp).
249 channels (ASICs) form both homotrimeric and heterotrimeric ion channels that are activated by extrac
251 7, osmotic avoidance abnormal-3 (OSM-3)] and heterotrimeric (KIF3) kinesin-2 motors are required to e
256 strate unexpected new roles for both ciliary heterotrimeric kinesins and IFT particle genes and clari
258 f bacteria is mediated by a highly conserved heterotrimeric membrane protein complex denoted Sec61 in
259 to a protein-conducting channel formed by a heterotrimeric membrane protein complex, the prokaryotic
264 factor C (RFC) is sufficient for loading the heterotrimeric PCNA123 [proliferating cell nuclear antig
265 ae isolate NCTC13129 produces three distinct heterotrimeric pili that contain SpaA, SpaD, and SpaH, m
266 tochondrial DNA (mtDNA) is replicated by the heterotrimeric Pol gamma comprised of a single catalytic
267 virus PB1 protein is the core subunit of the heterotrimeric polymerase complex (PA, PB1 and PB2) in w
270 mma of eukaryotes is a universally conserved heterotrimeric protein channel complex that accommodates
272 eonine phosphatase in eukaryotic cells, is a heterotrimeric protein composed of structural, catalytic
273 s in many organisms secrete laminin, a large heterotrimeric protein consisting of an alpha, beta, and
274 LE: AMPK (AMP-activated protein kinase) is a heterotrimeric protein that plays an important role in e
278 has been well studied as a component of the heterotrimeric RecBCD helicase-nuclease enzyme important
283 Here, we describe a stimulus-inducible, heterotrimeric S-nitrosylase complex consisting of induc
287 tes with the protein-conducting channel, the heterotrimeric SecYEG complex, in a so-called posttransl
291 BTR-mediated dHJ dissolution reaction by the heterotrimeric single-stranded DNA binding protein repli
292 cation protein A (RPA) is a highly conserved heterotrimeric single-stranded DNA-binding protein invol
293 the beta-adrenergic receptors coupled to the heterotrimeric stimulatory Gs protein, followed by subse
294 nal ensemble of the alpha subunit Galphas of heterotrimeric stimulatory protein Gs exhibits structura
295 heds light on the process whereby an ancient heterotrimeric TF mainly controlling cell division in an
298 binding protein contains twice the number of heterotrimeric units of SecYEG as does that for the prec
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