ライフサイエンスコーパス: heterotrimeric G-protein

1 or (GPCR), the 2AR, which signals via a G(q) heterotrimeric G protein.

2 DP/GTP exchange on the G(alpha) subunit of a heterotrimeric G protein.

3 efficiently, and is capable of activating a heterotrimeric G protein.

4 ive Fus3 binding to the alpha-subunit of the heterotrimeric G-protein.

5 moting neurons, and likely couples to a Gi/o heterotrimeric G-protein.

6 hosphorylated GPCRs and uncoupling them from heterotrimeric G proteins.

7 ong binding affinities observed for multiple heterotrimeric G proteins.

8 ange of GDP for GTP on the Galpha subunit of heterotrimeric G proteins.

9 nal and posttranslational suppression of rod heterotrimeric G proteins.

10 efficiently regulate the cellular levels of heterotrimeric G proteins.

11 signal transduction processes by activating heterotrimeric G proteins.

12 ross-linking did not require the presence of heterotrimeric G proteins.

13 eby preventing the interaction of GPCRs with heterotrimeric G proteins.

14 y receptors coupled to the G(q/11) family of heterotrimeric G proteins.

15 aARs) become desensitized and uncoupled from heterotrimeric G proteins.

16 of these receptors along with their cognate heterotrimeric G proteins.

17 te signalling through nucleotide exchange on heterotrimeric G proteins.

18 ling by receptors coupled to the Gq/11 class heterotrimeric G proteins.

19 ecruitment of arrestin but not activation of heterotrimeric G proteins.

20 on of insulin secretion is the activation of heterotrimeric G proteins.

21 first example of a calcium-dependent GDI for heterotrimeric G proteins.

22 eotide exchange factors (GEFs) that activate heterotrimeric G proteins.

23 serve as the direct downstream effectors of heterotrimeric G proteins.

24 lated by the actions of different classes of heterotrimeric G proteins.

25 on of these recently recognized effectors of heterotrimeric G proteins.

26 own as GTPase-activating proteins (GAPs) for heterotrimeric G proteins.

27 es through Galphai2- and Galphai3-containing heterotrimeric G proteins.

28 d GNAQ, genes that encode Galpha subunits of heterotrimeric G proteins.

29 mpounds are available that directly modulate heterotrimeric G proteins.

30 ontrol bundle polarity cell-autonomously via heterotrimeric G proteins.

31 cterized based on their ability to couple to heterotrimeric G proteins.

32 or-activating protein receptors (SNAREs) and heterotrimeric G-proteins.

33 ed glutamine residue in the alpha subunit of heterotrimeric G-proteins.

34 PR126 directly increases cAMP by coupling to heterotrimeric G-proteins.

35 pendent ERK1/2 activation without activating heterotrimeric G-proteins.

36 ation via intracellular cascades mediated by heterotrimeric G-proteins.

37 receptors (GPCRs) with other GPCRs and with heterotrimeric G-proteins.

38 RGS proteins stimulate the deactivation of heterotrimeric G-proteins.

39 We examine the possible roles of heterotrimeric G-proteins activated by the PPR.

40 Gsalpha, the stimulatory subunit of heterotrimeric G proteins, activates downstream signalin

41 G protein-coupled receptor-mediated heterotrimeric G protein activation is a major mode of s

42 Interestingly, this mechanistic model for heterotrimeric G protein activation is similar to that s

43 eptide agonist permitting receptor-dependent heterotrimeric G protein activation.

44 Mutations that increase heterotrimeric G-protein activity expand the bending-gro

45 8 (Ric-8) proteins regulate an early step of heterotrimeric G protein alpha (Galpha) subunit biosynth

46 Mice lacking the heterotrimeric G protein alpha subunit Gialpha2 develop

47 ty and is a chaperone for several classes of heterotrimeric G protein alpha subunits in vertebrates.

48 ng RhoGEFs (RGS-RhoGEFs) that link activated heterotrimeric G protein alpha subunits of the G12 famil

49 ne nucleotide exchange (GEF) activity toward heterotrimeric G protein alpha subunits of the i, q, and

50 GNAQ and GNA11 are heterotrimeric G protein alpha subunits, which are mutat

51 rts suggested that NUCB1 might interact with heterotrimeric G protein alpha subunits.

52 ial genes that encode positive regulators of heterotrimeric G protein alpha subunits.

53 mice with a loss-of-function mutation in the heterotrimeric G protein alpha-subunit gene Gnai3 have f

54 ed to both members of the Galpha12 family of heterotrimeric G proteins alpha subunits, Galpha12 and G

55 ype that resembles the one described for the heterotrimeric G-protein alpha subunit (GPA1) null mutan

56 s dynein recruitment to the cell cortex by a heterotrimeric G-protein alpha subunit in complex with a

57 s Columbia accession (Col) wild type and the heterotrimeric G-protein alpha subunit mutant, gpa1, whi

58 asured by activation of the alpha subunit of heterotrimeric G protein and cAMP accumulation.

59 nctional scaffolding protein that integrates heterotrimeric G protein and H-Ras signaling pathways.

60 st pheromone pathway consists of a canonical heterotrimeric G protein and MAP kinase cascade.

61 spective inhibitors of the Galpha subunit of heterotrimeric G proteins and adenylyl cyclases.

62 ies in plant immunity provide a link between heterotrimeric G proteins and an MAPK cascade via the RA

63 receptors (7TMRs) classically signal through heterotrimeric G proteins and are commonly referred to a

64 -protein-coupled receptors (GPCRs) activates heterotrimeric G proteins and downstream signaling.

65 rs (GPCRs) and the interaction of GPCRs with heterotrimeric G proteins and effector molecules.

66 ich agonist stimulation leads to coupling of heterotrimeric G proteins and generation of second messe

67 Both heterotrimeric G proteins and GPCR kinases are well know

68 Recent structural studies now suggest that heterotrimeric G proteins and GPCR kinases identify acti

69 gand binding to GPCRs, activating associated heterotrimeric G proteins and intracellular signaling pa

70 al/lysosomal compartment are associated with heterotrimeric G proteins and mediate signal transductio

71 Heterotrimeric G proteins and other regulators are impor

72 ent a direct link between the G(12) class of heterotrimeric G proteins and the monomeric GTPases.

73 These signaling pathways are modulated by heterotrimeric G proteins and the scaffold proteins beta

74 iple waves of signaling that are mediated by heterotrimeric G proteins and the scaffolding proteins b

75 ed receptors (GPCRs) allosterically activate heterotrimeric G proteins and trigger GDP release.

76 suggesting a role for Bni1 downstream of the heterotrimeric G-protein and Cdc42 during gradient sensi

77 Upstream of PKCzeta, heterotrimeric G-proteins and phosphatidylinositol-3-kin

78 Heterotrimeric G-proteins and the regulator of G-protein

79 , (ii) binding of the Gbetagamma subunits of heterotrimeric G proteins, and (iii) phosphorylation of

80 GPCRs signal through heterotrimeric G proteins, and among the different types

81 ghly homologous alpha subunits of Galphaq/11 heterotrimeric G proteins, and in PLCB4 (phospholipase C

82 1 matrix metalloprotease (MMP14, MT1-MMP) by heterotrimeric G proteins, and in turn, the generation o

83 to promote arrestin binding, decoupling from heterotrimeric G proteins, and internalization.

84 Arrestin recruitment uncouples GPCRs from heterotrimeric G proteins, and targets the proteins for

85 eta2.PLCdelta1 is disrupted by activation of heterotrimeric G proteins, and that the major cytosolic

86 ling complexes, which may include receptors, heterotrimeric G proteins, and/or effectors, is gaining

87 Heterotrimeric G proteins are activated by exchange of G

88 Heterotrimeric G proteins are conformational switches th

89 Heterotrimeric G proteins are critical signal-transducin

90 Heterotrimeric G proteins are critical transducers of ce

91 Heterotrimeric G proteins are crucial for the perception

92 Heterotrimeric G proteins are localized to the plasma me

93 Heterotrimeric G proteins are molecular switches modulat

94 Heterotrimeric G proteins are molecular switches that co

95 Heterotrimeric G proteins are molecular switches that co

96 Heterotrimeric G proteins are molecular switches that re

97 Heterotrimeric G proteins are quintessential signalling

98 Although small and heterotrimeric G proteins are subjects of intensive stud

99 Although most heterotrimeric G proteins are thought to dissociate into

100 Heterotrimeric G proteins are usually activated by the g

101 Heterotrimeric G proteins are well known to transmit sig

102 Heterotrimeric G-proteins are essential cellular signal

103 Heterotrimeric G-proteins are implicated in several plan

104 ggers signal transduction cascades involving heterotrimeric G proteins as key players.

105 Heterotrimeric G proteins become activated after they fo

106 -coupled receptor (GPCR) kinase 2 (GRK2) and heterotrimeric G protein beta(1)gamma(2) subunits (Gbeta

107 kinase 1 (RACK1), a novel binding protein of heterotrimeric G protein betagamma (G betagamma) subunit

108 A role for heterotrimeric G protein betagamma subunits was shown by

109 Rs, CNO-activated DREADDs not only couple to heterotrimeric G proteins but can also recruit proteins

110 n upon cAMP stimulation occurs downstream of heterotrimeric G proteins but is independent of guanylyl

111 e structure of Smo implies interactions with heterotrimeric G proteins, but the degree to which G pro

112 cells by catalyzing nucleotide release from heterotrimeric G proteins, but the mechanism underlying

113 Activation of heterotrimeric G proteins by cytoplasmic nonreceptor pro

114 T based sensor for detecting activation of a heterotrimeric G-protein by G-protein coupled receptors.

115 cur indirectly via cross-talk from canonical heterotrimeric G protein cascades, it has recently been

116 betagamma dimers of the Arabidopsis thaliana heterotrimeric G protein complex are differentially loca

117 onstrate that cone Talpha forms a functional heterotrimeric G protein complex in rods and that rod an

118 and phosphorylates the alpha subunit of the heterotrimeric G protein complex, Galphaq, resulting in

119 d Ggamma proteins of a soybean (Glycine max) heterotrimeric G-protein complex are involved in regulat

120 1 Gbeta and 3 Ggamma proteins represent the heterotrimeric G-protein complex in Arabidopsis, and a s

121 Arabidopsis heterotrimeric G-protein complex modulates pathogen-asso

122 The heterotrimeric G-protein complex provides signal amplifi

123 B2 encodes the beta2 subunit (Gbeta2) of the heterotrimeric G-protein complex that is being released

124 for the signaling processes mediated by the heterotrimeric G-protein complex.

125 dently modulated by the Gbeta subunit of the heterotrimeric G-protein complex.

126 Heterotrimeric G protein complexes are conserved from pl

127 The manner in which the heterotrimeric G protein complexes Gbeta1gamma2 and Galp

128 Plants and some protists have heterotrimeric G protein complexes that activate spontan

129 Signaling pathways mediated by heterotrimeric G-protein complexes comprising Galpha, Gb

130 ng the Galpha, Gbeta, and Ggamma subunits of heterotrimeric G-protein complexes, which function upstr

131 Heterotrimeric G proteins composed of alpha, beta and ga

132 Heterotrimeric G proteins composed of alpha, beta, and g

133 GPCRs transmit signals through heterotrimeric G proteins composed of Galpha and Gbetaga

134 Heterotrimeric G proteins, composed of alpha, beta, and

135 Heterotrimeric G proteins, composed of Galpha and Gbetag

136 Heterotrimeric G-proteins comprised of Galpha, Gbeta and

137 Heterotrimeric G proteins comprising Galpha, Gbeta, and

138 Heterotrimeric G-proteins (comprising Galpha and Gbetaga

139 In animals, heterotrimeric G proteins, comprising Ga, Gb, and Gg sub

140 The G12/13 class of heterotrimeric G proteins, comprising the alpha-subunits

141 Heterotrimeric G-proteins, comprising Galpha and Gbetaga

142 Heterotrimeric G-proteins, comprising Galpha, Gbeta, and

143 -gated channel via a cascade that includes a heterotrimeric G-protein, cone transducin, comprising Ga

144 a signaling cascade, which is mediated by a heterotrimeric G-protein consisting of alpha, beta, and

145 Heterotrimeric G proteins, consisting of Galpha, Gbeta,

146 Heterotrimeric G proteins, consisting of Galpha, Gbeta,

147 Heterotrimeric G proteins couple external signals to the

148 ere the very first genes for agonist-binding heterotrimeric G protein-coupled receptors (GPCRs) to be

149 The heterotrimeric, G protein-coupled receptor-associated G

150 A, specifically binds to the AT(1)R, reduces heterotrimeric G-protein coupling, and inhibits IP(3) (i

151 , transient autophosphorylation of T176 in a heterotrimeric G protein-dependent and PI3K- and TorC2-i

152 e therefore diagnoses in the group of mosaic heterotrimeric G-protein disorders, joining McCune-Albri

153 tem to drive expression of dominant-negative heterotrimeric G-proteins (DNG) in retinal ganglion cell

154 ins, which form the alpha subunit of certain heterotrimeric G proteins, drive uveal melanoma oncogene

155 Signaling pathways regulated by heterotrimeric G-proteins exist in all eukaryotes.

156 applications to dihydrofolate reductase and heterotrimeric G-protein families along with a discussio

157 he histamine receptor subtypes for different heterotrimeric G-protein families with single-cell resol

158 the catalytic core and scaffolding inactive heterotrimeric G proteins, forming a preassembled comple

159 Here we show that the Galphaq/11 subunit of heterotrimeric G proteins forms a complex with platelet-

160 lel pathways simultaneously, such as through heterotrimeric G proteins from different families, or, a

161 we report the functional characterization of heterotrimeric G-proteins from a nonvascular plant, the

162 GDD and provide insights how perturbation in heterotrimeric G protein function contributes to the dis

163 Clearly, Ric-8 has a profound influence on heterotrimeric G protein function.

164 Additionally we show that heterotrimeric G-protein function is required for DA mor

165 nventional receptor-independent regulator of heterotrimeric G-protein function, influences renal tubu

166 s that inhibit beta-adrenergic signaling via heterotrimeric G proteins, function in hippocampal pyram

167 renoreceptor (beta(2)AR) signals through the heterotrimeric G proteins G(s) and G(i) and beta-arresti

168 -coupled receptors transduce signals through heterotrimeric G protein Galpha and Gbetagamma subunits,

169 The heterotrimeric G protein Galpha(13) stimulates the guani

170 Heterotrimeric G-protein Galpha subunits and GoLoco moti

171 neutrophil cell surface receptors triggering heterotrimeric G-protein Galpha(i) subunits to exchange

172 ortex during mitosis by the alpha subunit of heterotrimeric G protein (Galpha)/mammalian homologue of

173 Heterotrimeric G protein Galpha13 is known to transmit G

174 The heterotrimeric G protein Galpha13 transduces signals fro

175 Heterotrimeric G proteins (Galphabetagamma) transmit sig

176 GPCRs) relay extracellular signals mainly to heterotrimeric G-proteins (Galphabetagamma) and they are

177 Pharmacological inhibition of heterotrimeric G protein Galphai or PI3K signaling and s

178 e B lymphocyte surface receptors, triggering heterotrimeric G protein Galphai subunit guanine nucleot

179 t chemoattractants rely on activation of the heterotrimeric G-protein Galphai to regulate directional

180 opic glutamate receptor mGluR6 activates the heterotrimeric G-protein Galphaobeta3gamma13, and this l

181 muscarinic acetylcholine receptor GAR-3, the heterotrimeric G protein Galphaq, and its effector, Trio

182 ta is the canonical downstream target of the heterotrimeric G protein Galphaq.

183 from EEA1 endosomes and is regulated by the heterotrimeric G protein Galphas through interaction wit

184 Interestingly, a mutant lacking the heterotrimeric G protein Gbeta-subunit exhibited a remar

185 red an interaction between PP1calpha and the heterotrimeric G protein Gbeta1 subunit.

186 proteins that bind the betagamma subunits of heterotrimeric G-proteins (Gbetagamma).

187 naling triad analogous to the core triad for heterotrimeric G proteins (GEF + G proteins + effector).

188 ts thrombin signal through activation of the heterotrimeric G proteins, Gi, Gq, and G12/13.

189 showed that interactions between APP and the heterotrimeric G protein Goalpha-regulated Goalpha activ

190 ortholog [APPL (APP-Like)] directly bind the heterotrimeric G-protein Goalpha, supporting the model t

191 agonist-promoted interactions of GPCRs with heterotrimeric G proteins, GPCR kinases (GRKs), and arre

192 ivates several signaling pathways, including heterotrimeric G proteins Gq and G12, as well as the ext

193 R40 is known to signal predominantly via the heterotrimeric G proteins Gq/11.

194 adrenoceptor (beta(2)AR) in complex with the heterotrimeric G protein Gs (Galphasbetagamma).

195 Gbeta subunits from heterotrimeric G-proteins (guanine nucleotide-binding pr

196 ivative, was validated using cell-free aGPCR/heterotrimeric G protein guanosine 5'-3-O-(thio)triphosp

197 TAS1R taste receptors and their associated heterotrimeric G protein gustducin are involved in sugar

198 Although several non-receptor activators of heterotrimeric G proteins have been identified, the stru

199 versity of functions and phenotypes in which heterotrimeric G proteins have been implicated.

200 The basic schemes of heterotrimeric G-proteins have been outlined.

201 (GNB1) gene, encoding the Gbeta1 subunit of heterotrimeric G proteins, have recently been identified

202 The lack of heterotrimeric G-protein homologs in the sequenced genom

203 These enzymes are regulated by stimulatory heterotrimeric Gs proteins; however, the presence of Gs

204 ced activation of RhoA or Gi, Gq, and G12/13 heterotrimeric G proteins, implicating a novel signaling

205 aces and on stimulation forms a complex with heterotrimeric G protein in 2:1 stoichiometry.

206 We have found that the alpha-subunit of the heterotrimeric G protein in Arabidopsis (Arabidopsis tha

207 f the C terminus of the alpha subunit of the heterotrimeric G protein in G protein-coupled receptor (

208 signaling and point to an important role for heterotrimeric G proteins in modulating the cellular eff

209 is direct evidence that Smoothened relies on heterotrimeric G proteins in order to transduce the Hedg

210 Accordingly, XLGs expand the repertoire of heterotrimeric G proteins in plants and reveal a higher

211 receptors (GPCRs), in addition to activating heterotrimeric G proteins in the plasma membrane, appear

212 Additionally, we studied the role of heterotrimeric G proteins in Wnt-5a-dependent synaptic d

213 n be activated by the Gbetagamma subunits of heterotrimeric G-proteins in a manner that depends on th

214 s (Rac1, RhoA/B/C, and Cdc42) as well as for heterotrimeric G-proteins in a series of live-cell imagi

215 o examine the role of Galpha13, a G12 family heterotrimeric G protein, in regulating cellular invasio

216 (AGS3), a receptor-independent regulator of heterotrimeric G proteins, in rodents and humans with bo

217 Heterotrimeric G proteins, including combinations believ

218 eptor activation, and alpha subunits of some heterotrimeric G-proteins, including Galpha(s) bind to t

219 rs and also direct receptor signaling toward heterotrimeric G protein-independent signaling pathways.

220 coupled receptors and Galpha subunits of the heterotrimeric G-proteins, induce contraction of smooth

221 RGS4, a heterotrimeric G-protein inhibitor, localizes to plasma

222 studies have questioned the idea that plant heterotrimeric G proteins interact with canonical GPCRs,

223 ceptors (GPCRs) leads to the dissociation of heterotrimeric G-proteins into Galpha and Gbetagamma sub

224 Our data show that the G(12/13) family of heterotrimeric G proteins is centrally involved in press

225 -protein-coupled receptor (GPCR) coupling to heterotrimeric G proteins is confined to the plasma memb

226 The time course of signaling via heterotrimeric G proteins is controlled through their ac

227 Activation of heterotrimeric G proteins is generally believed to induc

228 is transient (<10 minutes) and initiated by heterotrimeric G proteins, is followed by a second wave

229 eIF2, a heterotrimeric G-protein, is activated by guanine nucleo

230 l transduction system through its associated heterotrimeric G protein leading to the arrest of cell g

231 dissociation of the Galpha subunit from the heterotrimeric G protein, leading to downstream signalin

232 gand histamine by activating three canonical heterotrimeric G-protein-mediated signaling pathways wit

233 its activation depends on integrin beta1 and heterotrimeric G proteins of the G12/13 family.

234 Heterotrimeric G proteins of the Galpha(i) family have b

235 not essential for the initial activation of heterotrimeric G proteins or Ras by uniform chemoattract

236 nterestingly, neither receptor is coupled to heterotrimeric G proteins or to beta-arrestin when stimu

237 These results indicate that heterotrimeric G-protein, phosphatidylinositol (PI) 3-ki

238 Heterotrimeric G proteins play a pivotal role in the sig

239 Heterotrimeric G proteins play an essential role in cell

240 Heterotrimeric G proteins play an essential role in the

241 Heterotrimeric G-proteins play a crucial role in the con

242 Our findings reveal that FZD9 and heterotrimeric G proteins regulate Wnt-5a signaling and

243 activation of MMP14 and identify MMP14 as a heterotrimeric G protein-regulated effector.

244 inatorial complexity of the role of GPSM3 in heterotrimeric G-protein regulation.

245 Heterotrimeric G proteins relay extracellular cues from

246 mediated activation of the Galpha subunit of heterotrimeric G proteins requires allosteric communicat

247 A long-held tenet of heterotrimeric G protein signal transduction is that it

248 les in G protein-coupled receptor (GPCR) and heterotrimeric G protein signal transduction.

249 Heterotrimeric G proteins signal at a variety of endomem

250 Heterotrimeric G-protein signal transduction initiated b

251 on of chemoattractant sensing occurs between heterotrimeric G protein signaling and Ras activation.

252 Heterotrimeric G protein signaling cascades are one of t

253 ne nucleotide exchange factor that activates heterotrimeric G protein signaling downstream of RTKs an

254 intermediate molecule(s) that could activate heterotrimeric G protein signaling in a calcium-dependen

255 The activation of heterotrimeric G protein signaling is a key feature in t

256 Heterotrimeric G protein signaling is essential for norm

257 integrin activation in platelets is through heterotrimeric G protein signaling regulating hemostasis

258 ts and reveal a higher level of diversity in heterotrimeric G protein signaling.

259 or beta-arrestin binding and uncoupling from heterotrimeric G-protein signaling and that the presence

260 Our studies demonstrate that targeting heterotrimeric G-protein signaling offers opportunities

261 Loss of myosin II asymmetry by perturbing heterotrimeric G-protein signaling results in symmetric

262 oxygen species, cytosolic Ca2+ (Ca2+c), and heterotrimeric G-protein signaling.

263 ling (RGS) proteins are potent inhibitors of heterotrimeric G-protein signaling.

264 city, in which it is functionally coupled to heterotrimeric G-protein signaling.

265 Though the heterotrimeric G-proteins signaling system is one of the

266 Galpha12/13 but not representatives of other heterotrimeric G protein subfamilies, such as Galphai1,

267 PAR1 is promiscuous and couples to multiple heterotrimeric G-protein subtypes in the same cell and p

268 Activated PAR2 couples to multiple heterotrimeric G-protein subtypes including G alpha(q),

269 Previous work showed that the heterotrimeric G protein subunit alpha(q) contains a pol

270 cible sequestration system to inactivate the heterotrimeric G protein subunit Gbeta and find that thi

271 re we report that signal transduction by the heterotrimeric G protein subunit Gbeta1 is essential for

272 The heterotrimeric G protein subunit Gsalpha stimulates cAMP

273 onfirmation of expected interactions such as heterotrimeric G protein subunit interactions and aquapo

274 XB motif of APP intracellular domain and the heterotrimeric G-protein subunit Galpha(S), and demonstr

275 Putative functions of the heterotrimeric G-protein subunit Galphai2-dependent sign

276 C-beta (PLC-beta) isoforms are stimulated by heterotrimeric G protein subunits and members of the Rho

277 elial cell adhesion molecule-1 (PECAM-1) and heterotrimeric G protein subunits Galphaq and 11 (Galpha

278 of the AC NT for mechanisms of regulation by heterotrimeric G protein subunits is isoform-specific.

279 its own spectrum of activators that includes heterotrimeric G protein subunits, protein tyrosine kina

280 rect control over the activity of endogenous heterotrimeric G protein subunits.

281 ulin-like (CML) protein, and by showing that heterotrimeric G-protein subunits Galpha (GPA1) and Gbet

282 age the 7TM receptors occur independently of heterotrimeric G-proteins, suggesting the prevalence of

283 Ste4 is the beta subunit of a heterotrimeric G protein that mediates mating responses

284 for the G-alpha-q and G-alpha-i subunits of heterotrimeric G-proteins that turns off signaling by G-

285 modulated by three families of proteins: the heterotrimeric G proteins, the G-protein-coupled recepto

286 inactive and active conformations of several heterotrimeric G proteins, the molecular underpinnings o

287 tein Signaling (RGS) promote deactivation of heterotrimeric G proteins thus controlling the magnitude

288 binding protein)-coupled receptors couple to heterotrimeric G proteins to relay extracellular signals

289 cytoplasmic NUCB1 might function to regulate heterotrimeric G protein trafficking and G protein-coupl

290 pled receptor (GPCR) rhodopsin activates the heterotrimeric G protein transducin (Gt) to transmit the

291 atalyzing the exchange of GDP for GTP on the heterotrimeric G protein transducin (GT).

292 pigments couple to distinct variants of the heterotrimeric G protein transducin.

293 of this G protein-coupled receptor with the heterotrimeric G protein, transducin (Gt).

294 The Gbetagamma subunits of heterotrimeric G proteins transmit signals to control ma

295 between receptor tyrosine kinases (RTKs) and heterotrimeric G proteins, two major and distinct signal

296 oupling to any of the four major subtypes of heterotrimeric G proteins was found.

297 Smo couples to members of the G(i) family of heterotrimeric G proteins, which in some cases are integ

298 PKA and upstream of the Galphai component of heterotrimeric G proteins, which itself localizes to cil

299 investigated the inactive-state assembly of heterotrimeric G proteins with FZD4, a receptor importan

300 hat Galphaolf exclusively forms a functional heterotrimeric G-protein with Gbeta1 and Ggamma13 in OSN