ライフサイエンスコーパス: heterotropic

1 ' shows no allostery, neither homotropic nor heterotropic.

2 r-->Ala enzymes and their importance for the heterotropic activation and inhibition of aspartate tran

3 ed 2-fold, with a corresponding reduction in heterotropic activation by dGuo.

4 la substitution on this chimera also reduced heterotropic activation by half.

5 In neither case is the heterotropic activation due to ligand-induced heterodime

6 Both homo- and heterotropic activation have been reported, and kinetic

7 ions manifested in the nearly unidirectional heterotropic activation of dAK when dGK binds deoxyguano

8 uding the Ras-like segment, in catalysis and heterotropic activation.

9 no catalytic activity in the absence of the heterotropic activator fructose 1,6-bisphosphate (FBP).

10 Saturating amounts of the heterotropic activator fructose 2, 6-bisphosphate (F26P2

11 eloma cell adhesion while decreasing myeloma heterotropic adhesion to bone marrow stromal cells.

12 vealed that TbetaRIII-mediated inhibition of heterotropic adhesion was associated with decreased dura

13 mutations are within the recently identified heterotropic allosteric activator site in the theoretica

14 olism of Nile Red (NR) is accelerated by the heterotropic allosteric effector alpha-naphthoflavone (A

15 lt hemoglobin (Hb A) due to the binding of a heterotropic allosteric effector, inositol hexaphosphate

16 affinity resulting from interactions between heterotropic allosteric effectors and hemoglobin in not

17 As heterotropic allosteric effectors we employ single-stran

18 mer of the TTF-C4Ps, thus acting as positive heterotropic allosteric effectors.

19 , which are induced by its interactions with heterotropic allosteric effectors.

20 nfluence ligand binding and not to cause the heterotropic allosteric inhibition per se.

21 To isolate a single heterotropic allosteric interaction, hybrid tetramers we

22 e-binding domain through an as yet undefined heterotropic allosteric mechanism.

23 Hsp70 chaperones are heterotropic allosteric systems in which ATP and misfold

24 We review recent data on heterotropic allostery where peptide-MHC and membrane ch

25 ulin hexamer possesses positive and negative heterotropic and homotropic interactions involving two c

26 cause of the multitude of different types of heterotropic and homotropic interactions that are possib

27 trate- and reaction-dependent homotropic and heterotropic cooperative behavior.

28 g intermediates gives rise to homotropic and heterotropic cooperative kinetics of this enzyme.

29 ding pocket that is responsible for positive heterotropic cooperativity between [Ca(2+)]o and L-Phe i

30 ng of the correct effector, rather than from heterotropic cooperativity between effector and substrat

31 This leads to apparent positive heterotropic cooperativity between substrate and alloste

32 The mechanism of the observed homotropic and heterotropic cooperativity in P450 3A4-catalyzed oxidati

33 some P450's demonstrate both homotropic and heterotropic cooperativity toward a number of substrates

34 R2(2) binding to R1(2) shows negative heterotropic cooperativity vis-a-vis effectors but posit

35 operativity vis-a-vis effectors but positive heterotropic cooperativity vis-a-vis substrates.

36 ivity and unusual patterns of homotropic and heterotropic cooperativity, for which several models hav

37 as the partial agonists but exhibit positive heterotropic cooperativity.

38 The energetics of Zn(II) binding and heterotropic coupling free energies (Hc, -TSc) of the do

39 ee energies at each pH is equal to the total heterotropic coupling free energy associated with the te

40 ted interaction contributes 20% of the total heterotropic coupling.

41 nd local conformational changes and that the heterotropic effect of the nucleotides may be exerted th

42 Thus, the Bohr effect, a heterotropic effect, depends on the intricate arrangemen

43 d allosterically, where the association of a heterotropic effector at the periphery of the molecule s

44 han for dCMP, (ii) dCTP serves as a positive heterotropic effector for the dCMP deaminase activity an

45 y, and (at most) very weak interactions with heterotropic effector ligands such as organic phosphates

46 terpret the dynamic phenomena induced by the heterotropic effector, IHP.

47 reaction is not only R-T-dependent but also heterotropic effector-dependent within a given quaternar

48 ed on human adult hemoglobin (HbA) show that heterotropic effector-linked tertiary structural changes

49 Thus, the heterotropic effector-linked tertiary structural changes

50 important components of HbA motions and that heterotropic effectors modify the overall dynamics of th

51 lity to measure the effect of homotropic and heterotropic effectors on the dissociation kinetics of t

52 otropic cooperativity and the ability of the heterotropic effectors to modulate activity.

53 h nucleotides also appear to act as positive heterotropic effectors, since the binding of one stimula

54 anions to the bound metal ions, which act as heterotropic effectors.

55 ate transcarbamoylase in the presence of the heterotropic effectors.

56 Heterotropic effects between these two substrates can fu

57 as observed, indicating that p-xylene exerts heterotropic effects by residing in the active site simu

58 that loss of cooperativity and reduction in heterotropic effects is due to the dramatic destabilizat

59 The heterotropic effects of ATP and CTP upon the Pro268-->Al

60 Heterotropic effects were observed as well, as incubatio

61 equired for homotropic cooperativity and for heterotropic effects.

62 icrotropic (1-8 Delta horizontal tropia), or heterotropic (>8 Delta horizontal tropia).

63 The magnitude of the heterotropic interaction between the metal and FBP is si

64 free energy of activation by MgADP for this heterotropic interaction is -0.58 kcal/mol at 8.5 degree

65 ubstrate reveals a detailed landscape of the heterotropic interactions and indicates negligible bindi

66 allosteric site homotropic interactions, and heterotropic interactions between active and allosteric

67 bution of each of the four unique inhibiting heterotropic interactions between the allosteric inhibit

68 sistent with stabilization of the R-state by heterotropic interactions between the phenol-binding poc

69 In this study, we explore the effects of heterotropic interactions between these sites.

70 possible interactions to a series of single heterotropic interactions by forming and isolating hybri

71 236, exhibited homotropic cooperativity, and heterotropic interactions consistent with an enzyme with

72 These values indicate that positive, heterotropic interactions exist between each of these li

73 Each of the four unique heterotropic interactions have independently been isolat

74 The unique heterotropic interactions, previously labeled by the dis

75 the protein is stabilised in the absence of heterotropic interactions.

76 to a control that has all four of the unique heterotropic interactions.

77 oloenzyme, reduced cooperativity, and normal heterotropic interactions.

78 ced cooperativity, and substantially reduced heterotropic interactions.

79 nity for aspartate, no cooperativity, and no heterotropic interactions.

80 h no homotropic coupling but all four unique heterotropic interactions.

81 lu-239 stabilizing interactions also exhibit heterotropic interactions.

82 y that is modulated by strong homotropic and heterotropic ligand binding interactions at two differen

83 e that TfR does not exhibit cooperativity in heterotropic ligand binding, suggesting that some or all

84 tor site can modulate the environment of the heterotropic ligand.

85 enzyme, although the addition of inhibitory heterotropic ligands (CTP or CTP+UTP) re-establishes co-

86 for isoleucine and valine, and suggest that heterotropic ligands can bind to the same site to promot

87 These results on the heterotropic mechanism suggest a destabilization of the

88 ay be involved in nucleotide binding and the heterotropic mechanism, especially, UTP recognition.

89 her the role of the N-terminal region in the heterotropic mechanism, the first 10 N-terminal residues

90 t for nucleotide binding and, therefore, the heterotropic mechanism.

91 electin Abs and introduce the new concept of heterotropic modulation of receptor function.

92 The strong heterotropic negative linkage in this system (DeltaG(c)(

93 solating each of the four potentially unique heterotropic pairwise allosteric interactions that exist

94 Of the four unique heterotropic PEP-Fru-6-P interactions, the 45 A interact

95 nits had essentially the same homotropic and heterotropic properties as the native catalytic subunit

96 s in part responsible for the homotropic and heterotropic properties of aspartate transcarbamoylase a

97 ence of domain closure on the homotropic and heterotropic properties of the enzyme.

98 c data of the unique but completely opposite heterotropic properties of the two mutant enzymes, it is

99 For the Ile-12r-->Ala enzyme, the heterotropic properties were reduced or eliminated.

100 The complete abolition of homotropic and heterotropic regulation from stabilizing the 240s loop i

101 Heterotropic regulation may be due to the direct transmi

102 es deep insights, with parallels between the heterotropic regulation of hemoglobin (e.g., the Bohr ef

103 ts no response to dGuo or dCyd; activity and heterotropic response are fully restored upon reassociat

104 d affinity for aspartate, and essentially no heterotropic response identical to the enzyme isolated w

105 , and CTP in the presence of UTP suggest the heterotropic response is also altered.

106 that direct pathways for transmission of the heterotropic signals are unlikely.

107 rate concentrations and a decreased level of heterotropic stimulation elicited by alpha-naphthoflavon

108 tory properties of native dAK/dCK, including heterotropic stimulation of dAK activity by deoxycytidin

109 thermodynamic linked-function analysis for a heterotropic, three ligand coupled system in order to as

110 me, previously thought to have a defect in a heterotropic transmission pathway, with a known R state-