ライフサイエンスコーパス: heterotypic

1 small RNA transfer can be both homotypic and heterotypic.

2 y VP7/VP4 homotypic and, to a lesser degree, heterotypic.

3 d for a further oligomeric state involving a heterotypic A:B interaction.

4 Niche interactions are mediated by heterotypic adherens junctions (hAJs) involving cancer-d

5 engage osteogenic niches in the bone through heterotypic adherins junctions.

6 binding proteins FGF-1 and BACE, and for the heterotypic adhesion molecules JAM-B and JAM-C.

7 is expressed by epidermal cells and mediates heterotypic adhesion to lymphocytes expressing class 1-r

8 he inhibitory effects of 1,25-VD on PCa cell heterotypic adhesion were further confirmed using microv

9 ves poor prognosis by promoting survival and heterotypic adhesion.

10 Platelets form heterotypic aggregates with neutrophils, and we hypothes

11 en and Fn had different abilities to enhance heterotypic aggregation between PMNs and Lu1205 melanoma

12 AKT2 inhibition reduced heterotypic aggregation of neutrophils and platelets iso

13 ring revealed specific associations for both heterotypic and homotypic motif-pairs with particular ha

14 We classified strains as homotypic, partly heterotypic, and fully heterotypic based on the amount o

15 Preexisting heterotypic antibodies markedly reduced but did not elim

16 Preexisting heterotypic antibodies, via their Fc-gamma receptor (Fcg

17 ndividual CSMG postganglionics formed mixed, heterotypic arbors that coinnervated extensively (>15% o

18 nism for pseudokinases whereby homotypic and heterotypic association is used to assemble scaffolding

19 recruitment of adaptor protein CIKS/Act1 via heterotypic association of their respective SEFIR domain

20 associations among wave 1 diagnoses and for heterotypic associations from wave 1 to wave 2 diagnoses

21 ence, and participates in both homotypic and heterotypic associations with itself and LDAP3, respecti

22 hagosomes and/or their clearance through the heterotypic autophagosomal/lysosomal fusion process.

23 as homotypic, partly heterotypic, and fully heterotypic based on the amount of antigen-matching betw

24 P. gingivalis to SAPP, while monospecies and heterotypic biofilm formation, and invasion of oral epit

25 s assemble in living cells to produce mixed (heterotypic) bipolar filaments or whether filaments cons

26 Heterotypic bivalent binding enhanced neutralization com

27 Addition of Dss1 to the heterotypic Brh2-Dss1 complex attenuates DNA binding act

28 T cells were required for protection against heterotypic, but not homotypic, reinfection.

29 ated cancer antigen 125 (CA-125) can lead to heterotypic cell adhesion and tumor metastasis within th

30 Our results illustrate a novel heterotypic cell contact-mediated signaling role for Rho

31 A heterotypic cell fusion assay resulting in productive fu

32 roenvironment of tumours is characterized by heterotypic cell interactions and physiological gradient

33 These data render a new understanding of how heterotypic cell interactions may increase cellular forc

34 Heterotypic cell interactions were also studied.

35 vascular network assembly and cell fate; and heterotypic cell interactions were explored by targeted

36 lly increase cell power by 22x by maximizing heterotypic cell interactions.

37 howed that tensile forces can be enhanced by heterotypic cell interactions.

38 to quantify the effects of TGF-beta1 vs. the heterotypic cell interface on the power exerted by pure

39 mesenchymal stem cells drive condensation of heterotypic cell mixtures to create buds from diverse or

40 The MSCs initiated condensation within these heterotypic cell mixtures, which was dependent upon subs

41 pproach enables the large-scale formation of heterotypic cell pairs with controlled morphology and al

42 Notch receptors and ligands mediate heterotypic cell signaling that is required for normal v

43 Tissues comprise multiple heterotypic cell types (e.g., epithelial, mesenchymal, a

44 Communication between heterotypic cell types is essential for biological cohes

45 We model homotypic cell-cell adhesion and heterotypic cell-basement membrane (BM) adhesion with th

46 Heterotypic cell-cell adhesion and aggregation mediate v

47 f cell-cell signalling networks, we prepared heterotypic cell-cell interaction arrays using DNA-progr

48 AC to explore the impact of ECM composition, heterotypic cell-cell interactions and patterns of signa

49 cell adhesion molecule Cdh2 toward mediating heterotypic cell-cell interactions between neurons and C

50 Recreating heterotypic cell-cell interactions in vitro is key to di

51 Precise reconstruction of heterotypic cell-cell interactions in vitro requires the

52 however, the regulatory mechanisms of these heterotypic cell-cell interactions remain unclear.

53 ool for various biological studies involving heterotypic cell-cell interactions.

54 EphA4 signaling involving both homotypic and heterotypic cell-cell interactions.

55 tal cancer (CRC) as an example, I review how heterotypic cells differentially communicate to support

56 med cell-cell adhesion between homotypic and heterotypic cells via sequence-specific DNA hybridizatio

57 mensional (3D) tumor models that incorporate heterotypic cellular communication are gaining interest

58 g lies in capturing the panoply of homo- and heterotypic cellular interactions within the context of

59 rmeability; and 3) no claudin hemichannel or heterotypic channel made of claudin-16 and -19 trans int

60 chanisms of channel gating with concatenated heterotypic channels should be interpreted with care, as

61 A chemical approach to the production of heterotypic chromatin that can be used in such studies i

62 Heterotypic chronic stress (HeCS) was applied to male Wi

63 nflammatory cytokines through a mechanism of heterotypic claudin-binding incompatibility.

64 rol-independent clusters, resulting in mixed heterotypic clusters of Ras proteins that normally are s

65 robe the mechanisms involved, we developed a heterotypic coculture methodology, allowing simultaneous

66 ced recruitment of endothelial cells (EC) in heterotypic cocultures.

67 with comparable efficiency in all homo- and heterotypic combinations, but only the homotypic pairs w

68 ingivalis, and the two species assemble into heterotypic communities.

69 work that controls P. gingivalis-S. gordonii heterotypic communities.

70 ial and neuronal cells, indicating efficient heterotypic complementation.

71 in bacterial clearance through formation of heterotypic complexes with salivary constituents that bi

72 transmembrane proteins possessing homo- and heterotypic contact sites in their ectodomains.

73 At heterotypic contacts with E-cadherin, unbound N-cadherin

74 nd SaHV-1 gB homologs retained function in a heterotypic context.

75 0.54 [range, 0.41-0.79]) and for nearly all heterotypic continuities (median tetrachoric correlation

76 ifested both concurrently and in patterns of heterotypic continuity across time.

77 DHD), and oppositional defiant disorder, and heterotypic continuity between depression and anxiety, b

78 Furthermore, the relative magnitudes of heterotypic continuity closely mirrored the relative mag

79 Heterotypic continuity is inconsistent with a view of me

80 s of disorders and patterns of homotypic and heterotypic continuity similar to those observed in samp

81 For these prevalent mental disorders, heterotypic continuity was nearly universal and not an a

82 Significant heterotypic continuity was widespread even when all wave

83 (homotypic continuity) and other disorders (heterotypic continuity).

84 s and mechanisms, predict both homotypic and heterotypic continuity.

85 Heterotypic cooperation-two populations exchanging disti

86 Two mechanisms can stabilize heterotypic cooperation.

87 Here, cooperators and their heterotypic cooperative partners (partners) exchanged di

88 ation of this component removes the need for heterotypic culture.

89 of GJ channel (homotypic Cx43 and Cx45, and heterotypic Cx43/Cx45 and Cx45/Cx43).

90 The pK(a) of heterotypic Cx45/Cx43-EGFP GJs was lower, approximately

91 In homotypic Cx45 and heterotypic Cx45/Cx43-EGFP GJs, pH(i) changes from 7.2 t

92 ly related (homotypic defence) or unrelated (heterotypic defence) to the prophage.

93 sk for severe dengue occurs during a second, heterotypic Dengue virus infection.

94 g antibodies capable of enhancing subsequent heterotypic Dengue virus infections, the greatest risk f

95 mediating cross-protection against secondary heterotypic DENV infection is not well understood.

96 likelihood of severe disease with a second, heterotypic DENV infection.

97 cells provide protection against a secondary heterotypic DENV infection.

98 tes the role of T cells during homotypic and heterotypic DENV reinfection.

99 were sequentially infected with homotypic or heterotypic DENV serotypes, and T cell subsets were depl

100 mablasts produced Ab that cross-reacted with heterotypic DENV serotypes, but with a 3-fold greater re

101 immunity (only several months duration) to a heterotypic DENV.

102 lity of Hax-1 proteins to form homotypic and heterotypic dimers with binding affinities ranging from

103 macrophages is phagosomal maturation through heterotypic endosomal fusion.

104 Both heterotypic endothelial smooth muscle cell interactions

105 ndary, rather than by differential homo- and heterotypic energies of cell-cell interaction.

106 Heterotypic enhancers are stronger than their homotypic

107 ntrast, neither gD nor gH/gL functioned with heterotypic entry glycoproteins, indicating that gD and

108 th untreated H35 cells demonstrated that the heterotypic environment and TGF-beta1 synergistically in

109 e NHF and pure H35 microtissues, whereas the heterotypic environment resulted in a 5-fold increase in

110 Rather, we observed that, in ADAM23-heterotypic environments, ADAM23-negative cells promote

111 n as a PtdIns-presentation scaffold requires heterotypic exchange of phosphatidylcholine (PtdCho) for

112 clude a single-subunit restriction system, a heterotypic exclusion system and a predicted (p)ppGpp sy

113 homotypic [(F(C))(E(C)) and (F(N))(E(N))] or heterotypic [(F(C))(E(N)) and (F(N))(E(C))] recombinants

114 th co-assemble with collagen I or II to form heterotypic fibrils and have been implicated in regulati

115 Tumor cell KRAS(G12D) engages heterotypic fibroblasts, which subsequently instigate re

116 We show that NM II isoforms coassemble into heterotypic filaments in a variety of settings, includin

117 d XLF form homodimers that can polymerize as heterotypic filaments independently of DNA Ligase IV.

118 rans intermolecular interactions can also be heterotypic-for example, between thrombospondin-1 and th

119 m de novo continuously in wild-type cells by heterotypic fusion of endoplasmic reticulum-derived vesi

120 fusion (F) protein but can also activate the heterotypic fusion proteins.

121 Macropinosomes mature through homotypic and heterotypic fusion with endosomes and ultimately merge w

122 o recycling endosomes, where VAMP3-dependent heterotypic fusions occur.

123 es contained in the vaccine than against the heterotypic G8P[6] and G8P[1] rotavirus strains of which

124 the distribution of some Cx subtypes in the heterotypic gap junctions is not symmetrical; in the mur

125 Avidities to heterotypic genogroup I VLPs were not sustained at day 3

126 escribing gating properties of homotypic and heterotypic GJ channels each composed of two hemichannel

127 ent Cx isoforms and forming homotypic and/or heterotypic GJ channels.

128 cribe the gating properties of homotypic and heterotypic GJ channels.

129 se to transjunctional voltage (Vj) Cx43/Cx45 heterotypic GJs exhibit both Vj-gating and dye transfer

130 The model was used to predict V(j)-gating of heterotypic GJs from characteristics of corresponding ho

131 Astrocyte connexins also form heterotypic GJs with oligodendrocytic somata and lamella

132 For example, heterotypic GPC complexes are unable to support virion e

133 evious biochemical data, the majority of the heterotypic H3K27M-K27ac nucleosomes colocalize with bro

134 g the recruitment of bromodomain proteins by heterotypic H3K27M-K27ac nucleosomes in DIPG cells, we p

135 lderly subjects developed significantly less heterotypic H5 T cell boosting, predominantly for T cell

136 or 90 microg) had no effect on magnitude of heterotypic H5 T cell responses.

137 modulated both the magnitude and duration of heterotypic H5 T cell responses.

138 intermolecular (also known as noncognate or heterotypic) help to generate robust Ab responses agains

139 herein the spontaneous in vitro formation of heterotypic hybrids between human bone marrow-derived mu

140 s for the relative strength of homotypic vs. heterotypic immunity and compared model predictions agai

141 the 3 subtypes and investigated evidence for heterotypic immunity through multivariable logistic regr

142 ity to the infecting serotype is long-lived, heterotypic immunity wanes a few months after infection.

143 the expected impacts of homotypic immunity, heterotypic immunity, and immune enhancement of disease

144 Better understanding of homotypic vs. heterotypic immunity, both natural and vaccine-induced,

145 impairment in viral clearance or functional heterotypic immunity.

146 ds on the relative strength of homotypic vs. heterotypic immunity.

147 tricate process of tissue assembly involving heterotypic inductive interactions between tendons, musc

148 DENV-specific avidity during acute secondary heterotypic infection is mediated by cross-reactive memo

149 02) and previous influenza infection against heterotypic infections (OR, 0.32; P = .045) were protect

150 Epidemiological studies link secondary heterotypic infections with more severe symptoms, and cr

151 vaccination and impaired lung T(CD8) during heterotypic influenza virus challenge infection.

152 required both DEDs and represents an unusual heterotypic interaction between domains of the death fol

153 We also show heterotypic interaction between NPs from both closely (L

154 al evidence for an alpha565 protomer and its heterotypic interaction with the alpha121 protomer.

155 Rsr1 also exhibits heterotypic interaction with the Cdc42 GTPase in vivo.

156 Upon heterotypic interaction, exosomes are transferred from s

157 understand the molecular components of this heterotypic interaction, we used a 3D model of angiogene

158 action of single cells acting as partners in heterotypic interactions (e.g., effectors and targets of

159 gan-like tissues; however, it is unclear how heterotypic interactions affect lineage identity.

160 These events are fueled by heterotypic interactions among glomerular, tubular, and

161 ues in the C'C" loop necessary for homo- and heterotypic interactions are dispensable for MeV-induced

162 at this domain determines the preference for heterotypic interactions at one specific interface durin

163 In this context, we investigate the heterotypic interactions between Abeta and fatty acids (

164 revealed by this study, including bilateral heterotypic interactions between Aga1p and Fig2p and a h

165 Our data reveal that heterotypic interactions between epithelial subpopulatio

166 This result illustrates an example where heterotypic interactions between pre-amyloid oligomers p

167 Heterotypic interactions between Smc1 and Smc3 dimerizat

168 These interactions include three favorable heterotypic interactions between TFs.

169 These motifs can facilitate homotypic and heterotypic interactions between TM helices, activities

170 current efforts are focused on understanding heterotypic interactions between tumor cells and surroun

171 gene regulation that can be dictated through heterotypic interactions exemplified by the Elk-1-SRF co

172 Information gained on heterotypic interactions has further clarified the influ

173 TMD2 alone lines the pinhole, making heterotypic interactions involving two surfaces, A and B

174 The heterotypic interactions of endothelial cells and mural

175 her the PLAD mediates only homotypic or also heterotypic interactions remained inconclusive until now

176 erse group of phenomena in which short-range heterotypic interactions result in the selective elimina

177 , respectively) engage in both homotypic and heterotypic interactions to create the capsid.

178 utonomously in endothelium, independently of heterotypic interactions with nonendothelial cells.

179 oth homotypic interactions between iHeps and heterotypic interactions with stromal fibroblasts signif

180 tively promote tumor progression via complex heterotypic interactions with the nearby carcinoma cells

181 interactions with other ALCAM molecules and heterotypic interactions with the surface receptor CD6 e

182 conserved C-termini mediating homotypic and heterotypic interactions within and between both protein

183 s suggest that higher order homotypic and/or heterotypic interactions within distinct sub-populations

184 is necessary for the efficient homotypic and heterotypic interactions, selection of a proper growth s

185 motifs participating in either homotypic or heterotypic interactions.

186 nsures tiling of the lamina neuropil through heterotypic interactions.

187 ophages is explored using drugs that inhibit heterotypic interactions.

188 gagement with their ligands via homotypic or heterotypic interactions.

189 ts a powerful yet simple system to elucidate heterotypic intercellular interactions mediating diverse

190 regates that adhere to one another through a heterotypic interface.

191 of these breast cell lines in homotypic and heterotypic invasion assays.

192 rential distribution of NMII isoforms across heterotypic junctions and evidence for compensation betw

193 of holding potentials between cells forming heterotypic junctions effectively modulates cell-to-cell

194 tricted to postsynaptic hemiplaques, forming heterotypic junctions.

195 diated conditional mutagenesis is enabled by heterotypic lox sites that delete Citrine and "flip" in

196 Here we describe a heterotypic mechanism by which one afferent controls syn

197 specific lipid milieu that is maintained by heterotypic membrane-mitochondrial interactions.

198 We observed that dissociation of heterotypic membranes from mitochondria inhibited BAK/BA

199 functionally and physically associated with heterotypic membranes, yet little is known about how the

200 m can be transdifferentiated on the basis of heterotypic mesenchymal induction.

201 We demonstrate that heterotypic MFN1-MFN2 trans complexes possess greater ef

202 ial only becomes evident in the context of a heterotypic microbial community.

203 B. thailandensis stimulated the formation of heterotypic MNGCs in a T6SS-5-dependent manner.

204 Taken together, these studies suggest a heterotypic model wherein Notch signaling in vSMCs provi

205 portant interacting cellular compartments in heterotypic models of cancer.

206 Here, we examine how additional heterotypic modifications influence BPTF binding.

207 -d-aspartate receptors in homotypic, but not heterotypic, MSNs.

208 n homotypic (one chain type per polymer) and heterotypic (multiple linkage types per polymer) chains

209 thereof of cellular bodies assembled through heterotypic multivalent interactions.

210 wever, the association between homotypic and heterotypic NAb titers and protection against symptomati

211 The heterotypic nature of chromatin presents a formidable ob

212 et- and neutrophil-associated AKT2 regulates heterotypic neutrophil-platelet aggregation under shear

213 the JCI, Li et al. explore the regulation of heterotypic neutrophil-platelet contacts in response to

214 on, one H2A.Z-H2B dimer at a time, producing heterotypic nucleosomes as intermediates and homotypic H

215 nucleosomes at specific cell cycle points or heterotypic nucleosomes containing both CENP-A and histo

216 ifferent studies as hemisomes, canonical, or heterotypic nucleosomes.

217 ves the transition of S105 from homotypic to heterotypic oligomeric interactions.

218 at both connexins form homotypic rather than heterotypic or heteromeric gap junctions.

219 Heterotypic pairing with Cx32 WT showed that the absence

220 ions and 70-90% of branches of homotypic and heterotypic pairs are non-overlapping.

221 incorporated in the same nucleosome to form heterotypic particles.

222 d/or adolescence, yet specific homotypic and heterotypic patterns of prediction have not been firmly

223 We have previously described heterotypic peptides from parainfluenza virus that poten

224 Heterotypic Ping-Pong between Aub and Ago3 ensures that

225 We propose that Qin enforces heterotypic Ping-Pong between Aub and Ago3, ensuring tha

226 e A or B influenza virus with its cognate or heterotypic polymerase.

227 s described here are dynamic and accommodate heterotypic polymerization.

228 onjugates, the physiological significance of heterotypic polymers remained poorly understood.

229 d proteins and to assess the architecture of heterotypic polyubiquitin chains.

230 lular communication in several homotypic and heterotypic populations by visualizing the transfer of f

231 Stringent tests of homotypic and heterotypic prediction patterns suggest a more developme

232 bust neutralizing antibody response, whereas heterotypic priming elicited binding, but nonneutralizin

233 H5 heterotypic priming prior to onset of an A(H5N1) pandemi

234 ate TFRE activities in varying homotypic and heterotypic promoter architectures.

235 h polyanionic phosphoinositides and homo and heterotypic protein interactions.

236 These heterotypic Ras nanoclusters showed impaired Raf recruit

237 nockdown of PPARgamma and PTEN and performed heterotypic recombination experiments using embryonic bl

238 effect of IVIG on leukocyte recruitment and heterotypic red blood cell (RBC) interactions with adher

239 leukocyte rolling and adhesion and decreased heterotypic red blood cell-leukocyte interactions, coupl

240 osophila dominant mutation reveals that this heterotypic region regulates the recruitment of dynein t

241 ional Ago2*microRNA complexes that may exert heterotypic regulation of gene expression in endothelial

242 rs of functional miR-4443, which might exert heterotypic regulation of PTPRJ gene expression in MCs,

243 n contribute crucially to protection against heterotypic reinfection in situations where humoral resp

244 reinfection is less clear, especially during heterotypic reinfection.

245 rtant statistical correlate of homotypic and heterotypic response and may limit severity of influenza

246 Thus, a detrimental effect of previous heterotypic responses might not be due to dysfunctional

247 similar effectiveness against homotypic and heterotypic rotavirus strains.

248 ough severe disease has been associated with heterotypic secondary DENV infection, most secondary DEN

249 During heterotypic secondary DENV infection, subneutralizing an

250 -17/20 in breast cancer, but also identify a heterotypic secreted signal that mediates the microRNA r

251 r migration and invasion of nearby cells via heterotypic secreted signals.

252 s helix as a common structural signature for heterotypic SEFIR-SEFIR association.

253 Our results support a model in which the heterotypic segment is part of a molecular switch that p

254 of segment homologs, a lack of processing of heterotypic segments by influenza virus RNA-dependent RN

255 or an inability to specifically incorporate heterotypic segments into budding virions.

256 Heterotypic seroresponses observed between PIVs and pers

257 ainst reinfection with either a homotypic or heterotypic serotype 2 weeks later.

258 ng/priming factor and Ca(2+) sensor for both heterotypic SG-plasma membrane and homotypic SG-SG fusio

259 repertoire of signaling states that promote heterotypic signaling between distinct cell types, provi

260 al/stromal separation, and identification of heterotypic signaling networks underlying microdomains.

261 As in control of cell cycle, stem cells, and heterotypic signaling, as well as the role of these proc

262 to expansion of breast tumor stem cells and heterotypic signals that enhance TAM and vasculogenesis,

263 complex organs through collaboration between heterotypic stem cell populations.

264 of a unique niche in the bone marrow made of heterotypic stem-cell pairs.

265 gainst severe rotavirus diarrhea caused by a heterotypic strain in Guatemala.

266 ine type strains, 82% (70-89) against partly heterotypic strains, and 75% (47-88) against single-anti

267 ine type strains, 37% (10-56) against partly heterotypic strains, and 87% (38-97) against single-anti

268 omotypic strains, 71% (39-86) against partly heterotypic strains, and 87% (76-93) against fully heter

269 homotypic strains and weakest against fully heterotypic strains, with an intermediate immunity among

270 typic strains, and 87% (76-93) against fully heterotypic strains.

271 ss of homotypic strains with fully or partly heterotypic strains.

272 h an intermediate immunity amongst partially heterotypic strains.

273 In singly housed rats, chronic heterotypic stress significantly delayed gastric emptyin

274 ved in singly housed rats induced by chronic heterotypic stress was significantly improved by paired

275 s delayed gastric emptying following chronic heterotypic stress, via down-regulating CRF expression a

276 measured after 7 consecutive days of chronic heterotypic stress.

277 uced in paired housed rats following chronic heterotypic stress.

278 ed rats (33.2+/-4.1%, n=6) following chronic heterotypic stress.

279 sion, a prediction supported biologically by heterotypic stromal interleukin-1beta signaling between

280 l and functional basis of these connections, heterotypic supramolecular aggregates were isolated from

281 Using this heterotypic system and a dual lentiviral reporter system

282 gen/deuterium exchange mass spectrometry and heterotypic TcpB and TIRAP interaction by co-immunopreci

283 NP-A nucleosomes are organized as asymmetric heterotypic tetramers, rather than canonical octamers.

284 In the developing heart, heterotypic TF interactions, such as between the T-box T

285 ibution and define a combinatorial logic for heterotypic TF regulation of differentiation.

286 Furthermore, in vitro and in vivo heterotypic tissue regeneration models with embryonic bl

287 An uncommon G12P[8] strain, partially heterotypic to strains in both vaccines, was identified

288 uced immunity against infection with strains heterotypic to the vaccine, in the absence of significan

289 n Africa, including against a serotype fully heterotypic to the vaccine.

290 ption factors often function in concert with heterotypic transcription factors to specify distinct tr

291 virus, influenza B virus cannot incorporate heterotypic transgenes due to packaging signal incompati

292 This heterotypic tumor cell - macrophage interaction results

293 parametric readouts of treatment effects for heterotypic tumor cultures that enables advanced analyse

294 cells is higher if they are incorporated in heterotypic tumor-stroma cell fragments.

295 cell-cycle and quality control, we establish heterotypic ubiquitin conjugates as important carriers o

296 plication, safety, and immunogenicity of the heterotypic vaccine virus was compared with that of Deng

297 were randomly chosen to receive placebo or a heterotypic vaccine.

298 seen during both secondary infection with a heterotypic virus and during primary DENV infection in l

299 e, an inhibitory effect of viral proteins on heterotypic virus function, or an inability to specifica

300 ith Cx50 expressed in both pairing cells and heterotypic with Cx50 in only one pairing cell, and this