ライフサイエンスコーパス: heterozygosity

1 roduct (or two genetic variants for compound heterozygosity).

2 on or high percentage of genome-wide loss of heterozygosity.

3 tigmatic pollen loads, outcrossing rates and heterozygosity.

4 l for chromosomal rearrangements and loss of heterozygosity.

5 om the normal meiotic program that maintains heterozygosity.

6 and cell-free DNA samples revealing loss of heterozygosity.

7 duals, we also explored the role of compound heterozygosity.

8 idence of other somatic mutations or loss of heterozygosity.

9 where human cancers frequently show loss of heterozygosity.

10 genic annotation scores, total LD scores and heterozygosity.

11 and evolution toward permanent translocation heterozygosity.

12 vidual with sporadic SRNS exhibited compound heterozygosity.

13 ss closely related and showed a low level of heterozygosity.

14 We also assessed APC gene loss of heterozygosity.

15 -promoting repair pathways, prevents loss of heterozygosity.

16 determining homozygous deletions and loss of heterozygosity.

17 cytological mechanism retains high levels of heterozygosity.

18 itutions appear attributable to variation in heterozygosity.

19 tions with limited branching through loss of heterozygosity.

20 h allelic diversity, mainly due to very high heterozygosity.

21 d fitness as a result of reduced genome-wide heterozygosity.

22 expose deleterious mutations through loss of heterozygosity.

23 orrelating STR genotypes with local sequence heterozygosity.

24 h 1p and 16q copy number loss and/or loss of heterozygosity.

25 ce, self-incompatibility, and high levels of heterozygosity.

26 versity, pedigree analysis, and detection of heterozygosity.

27 number of alleles (2.1 to 2.9) and observed heterozygosities (0.330 to 0.388) per vineyard-sites.

28 S. commersonii shows a striking reduction in heterozygosity (1.5% versus 53 to 59%), and differences

29 associated relapse (20% relapse with loss of heterozygosity, 25% with loss of imprinting, and 3.3% re

30 that such females have significantly higher heterozygosity (a measure of within-individual genetic v

31 otype, and combined Ripk3 deletion and Casp8 heterozygosity almost completely suppressed it, even res

32 This genetic approach involves detecting heterozygosity along chromosomes in segregating populati

33 with reduced Oct4 expression resulting from heterozygosity also exhibit a stabilized pluripotent sta

34 ngle population, every standard deviation of heterozygosity an individual has over the mean decreases

35 equencing to accurately estimate genome-wide heterozygosity, an approach transferrable to any organis

36 homozygous after copy number-neutral loss-of-heterozygosity and amplified through a chromosomal gain;

37 sease, we computed the regression of average heterozygosity and average allele frequency of the risk

38 Loss of heterozygosity and decreased copy number delimited inter

39 ly to regenerate the diploid form, restoring heterozygosity and fitness.

40 mutant mice and mice with pan-cellular Tcf4 heterozygosity and found that they exhibited hippocampal

41 pecific hybrids often increase the levels of heterozygosity and hybrid vigor, but some interspecific

42 excessive genetic risk imposed by HLA-DQ2/8 heterozygosity and may assist immune monitoring of disea

43 d varieties, respectively, and discover high heterozygosity and millions of single-nucleotide variati

44 ers and cell lines, we find frequent loss of heterozygosity and mutations in BCL9L in aneuploid tumor

45 ic stability in all species, with no loss of heterozygosity and no shifts in allele frequencies over

46 We propose that D. pachys preserves heterozygosity and produces diploid embryos without fert

47 To investigate interactions between heterozygosity and recombination we crossed Arabidopsis

48 g pollinator reliability, outcrossing rates, heterozygosity and relevant floral traits across populat

49 mphomas at higher incidence with p53 loss-of-heterozygosity and severe genome aneuploidy, suggesting

50 a significant association between increased heterozygosity and survival (P = 0.03).

51 how TGCTs gain additional reciprocal loss of heterozygosity and that this is associated with loss of

52 urther characterize the link between loss of heterozygosity and the typical CALMs that appear over th

53 egression model trained on both X chromosome heterozygosity and Y chromosome missingness, that consis

54 Slit2 heterozygosity and Yap deletion both restore callosal fo

55 CA mutant or BRCA wild-type and high loss of heterozygosity), and the intention-to-treat population,

56 A homozygosity, 35% of SD patients having AG heterozygosity, and 56% of SD patients having GG homozyg

57 of evidence of activating mutations, loss of heterozygosity, and a mass forming proliferation, we pro

58 996 knockouts are strongly enhanced by Notch heterozygosity, and activated nuclear Notch is impaired

59 ony membership, mother-offspring similarity, heterozygosity, and genetic relatedness are all chemical

60 be protective against TALEN-induced loss of heterozygosity, and indeed Apc gene editing was less eff

61 pecific hybridization, high levels of strain heterozygosity, and prion transmission suggest that outb

62 novo variant calling, inference of compound heterozygosity, and the identification of inheritance an

63 d, these results illustrate that genome-wide heterozygosity, and therefore HFCs, are best measured by

64 ed regions of copy-number-neutral absence of heterozygosity (AOH) in subjects with multiple congenita

65 SNPs had similar correlations to genome-wide heterozygosity as microsatellites in both populations.

66 t the Wrangel mammoth has a 20% reduction in heterozygosity as well as a 28-fold increase in the frac

67 oci are needed to adequately measure genomic heterozygosity assuming different levels of identity dis

68 The genome-wide heterozygosity at 9590 genes, all heterozygous in a sing

69 Homo- or heterozygosity at Ars1127354 or Crs7270101 , entailing r

70 olume; response to chemotherapy; and loss of heterozygosity at chromosomes 1p and 16q.

71 me-wide functional inference of advantageous heterozygosity at cis-regulatory regions.

72 Maximal heterozygosity at HLA-I loci ("A," "B," and "C") improve

73 e (including HLA-B*15:01) or somatic loss of heterozygosity at HLA-I was associated with poor outcome

74 f chromosomes from each parent, with loss of heterozygosity at some loci, and uniparental retention o

75 Furthermore, loss of heterozygosity at the Chr.16q24.3 locus in breast cancer

76 line genotype misclassification from loss of heterozygosity at the CYP2D6 locus.

77 Preferential loss of heterozygosity at the rs1042522 locus of the tumor prote

78 t tumors revealed that 23% displayed loss of heterozygosity at the SPEN locus and that 3% to 4% harbo

79 lective advantage resulting from the loss of heterozygosity at the TP53 locus.

80 HD patients were genotyped for heterozygosity at three SNP sites, before phasing each S

81 markers, we observed high levels of allelic heterozygosity (average He, 0.586 to 0.842).

82 Proxy measures of genome-wide heterozygosity based on approximately 10 microsatellites

83 enabled the study of haplotype structure and heterozygosities between homologous chromosomes, includi

84 es may be correlated with the maintenance of heterozygosity by mechanisms that rearrange genomes and

85 d with intrinsic noise reduction, regulatory heterozygosity can contribute to the suppression of extr

86 sms between homologous chromosomes, that is, heterozygosity, can influence meiotic recombination path

87 The relationship between CCR5-Delta32 heterozygosity, CCR5 expression, and markers of HIV-1 pe

88 The estimation of observed heterozygosity clearly suggests that P. formosa is not c

89 ad evidence of acquired copy-neutral loss of heterozygosity (CN-LOH) of chromosome 1p in granulocytes

90 In addition, three copy-neutral loss of heterozygosity (CN-LOH) regions greater than 1 Mb were o

91 , monosomy 7) or copy number neutral loss of heterozygosity (CN-LOH).

92 ng TNFRSF14, but copy-number neutral loss of heterozygosity (CNN-LOH) of this locus was more frequent

93 Higher overall levels of genome heterozygosity correlated with faster growth rates, cons

94 ssense mutation in one allele and a 'loss of heterozygosity' deletion encompassing the other.

95 ardiac-specific inactivation and miR-106b-25 heterozygosity develop sinoatrial node dysfunction.

96 worsen TDP-43 toxicity, whereas progranulin heterozygosity did.

97 Heterozygosity, effective population sizes and gene flow

98 Msh3/p53 tumors showed increased loss of heterozygosity, elevated genome-wide copy-number variati

99 , there was no difference in the variance in heterozygosity estimates, suggesting that some blind ind

100 Sr50 contained a 2.5 mega-base pair loss-of-heterozygosity event.

101 rmalities, defined as copy number or loss of heterozygosity events that are large and present in only

102 umor sample; two of which are likely loss-of-heterozygosity events.

103 This heterozygosity excess, when detected, is often interpret

104 10 microsatellites have been used to uncover heterozygosity fitness correlations (HFCs) for a wealth

105 Heterozygosity-fitness correlations (HFCs) are often use

106 Using heterozygosity-fitness correlations, we investigated the

107 nowledge, the first report of an increase in heterozygosity following multigenerational exposure to m

108 ance population and (2) estimate genome-wide heterozygosity for 200 individuals.

109 s a common phenomenon and is correlated with heterozygosity for a frequent variant in the 3' untransl

110 This study demonstrates that heterozygosity for a Gaucher disease-associated mutation

111 erase chain reaction, we identified compound heterozygosity for a maternal splicing variant (chr5:601

112 Heterozygosity for a naturally occurring Gaucher mutatio

113 whole exome sequencing established compound heterozygosity for a non-conservative missense change af

114 tion to date, the functional consequences of heterozygosity for ACTN3 are unclear.

115 nificant increase in segregation errors, and heterozygosity for an smc1 deletion enhanced this phenot

116 ssels obstructing the bile duct and compound heterozygosity for collagen and calcium-binding epiderma

117 a recessive disorder resulting from compound heterozygosity for deleterious variants of VAC14.

118 Heterozygosity for Engrailed-1 (En1), one of the key fac

119 s, which in eusocial species usually require heterozygosity for female development.

120 family UW-AP exhibited copy-neutral loss of heterozygosity for large portions of the long arm of chr

121 is required for embryonic survival and that heterozygosity for LoF variants of Arhgap29 increases th

122 Heterozygosity for loss-of-function alleles causes an in

123 Heterozygosity for loss-of-function mutations in APOC3,

124 These neuropathies are linked to heterozygosity for missense mutations in five ARS genes,

125 cEDS can be caused by heterozygosity for missense mutations in genes COL5A2 an

126 utosomal dominant form of the disease due to heterozygosity for missense or nonsense mutations in MYH

127 In a case of SRPS we identified compound heterozygosity for mutations in IFT52, which encodes a c

128 keratosis/ichthyosis, we identified compound heterozygosity for mutations in KDSR, encoding an enzyme

129 l anemia with kernicterus caused by compound heterozygosity for null mutations in KLF1, each inherite

130 gs demonstrate that homozygosity or compound heterozygosity for null mutations of FIG4 is responsible

131 ariation in humans and mice, we predict that heterozygosity for R36C, G175R, R17S, and R17H will prov

132 cardiomyopathy, this study reveals compound heterozygosity for recessive MYH6 mutations in patients

133 is, because disease onset was accelerated by heterozygosity for Suz12 or by short hairpin RNA-mediate

134 Among the extensive miR-124 target network, heterozygosity for targets in the BMP pathway substantia

135 This study provides strong evidence that heterozygosity for the c.643_663del21 deletion in CAPN3

136 In female mice, heterozygosity for the deletion manifests cleft palate,

137 or genetic risk factors such as steatosis or heterozygosity for the HAMP non-sense mutation p.Arg59*

138 Heterozygosity for the KI mutation decreased production

139 , in a background of either wild-type Gba or heterozygosity for the L444P GBA mutation associated wit

140 263+1G --> A) in the 3 symptomatic siblings, heterozygosity for the mutation in the 2 parents, and no

141 n of GJB2 encoding connexin (Cx) 26 revealed heterozygosity for the recurrent de novo germline mutati

142 Heterozygosity for the variant allele caused a strong mu

143 These results indicate that heterozygosity for the wild-type P2X7R and its mood diso

144 ation of LAM cells identified by the loss of heterozygosity for TSC2.

145 epistatic variance depends critically on the heterozygosity, for models where frequencies are widely

146 Here we sequence the genome of a low-heterozygosity Fraxinus excelsior tree from Gloucestersh

147 enital amaurosis than predicted based on its heterozygosity frequency in the European American popula

148 The expected pattern of heterozygosity from theoretical calculations and simulat

149 expected, the partial contribution to total heterozygosity gave high priority to Criollo pig breeds,

150 This study therefore shows how loss of heterozygosity, hallmarked by VHL deletion in ccRCC, may

151 Thus, breeding female heterozygosity has increased by 8.5% per generation over

152 nonneoplastic proliferation, albeit loss of heterozygosity has long been reported in a part of these

153 ies: sickle cell trait (HbAS) 220 (14%), HbC heterozygosity (HbAC) 103 (7%), alpha thalassaemia 438 (

154 ns, each accession still possesses extensive heterozygosity, highlighting the inherent differences be

155 homologous recombination deficiency-loss of heterozygosity/homologous recombination deficiency-large

156 Most regions show significant heterozygosity; homozygosity is largely concentrated to

157 que genetic flatlining that is punctuated by heterozygosity hotspots, enriched for olfactory receptor

158 mbination deficiency was assessed by loss of heterozygosity (HRD-LOH) in pretreatment core breast bio

159 Higher observed heterozygosities in adults compared with progeny may rel

160 ith compound heterozygosity in 7 and digenic heterozygosity in 14.

161 ene that has been shown to undergo a loss of heterozygosity in 40-75% of human breast, ovarian, and p

162 s (16%) had a complex genotype with compound heterozygosity in 7 and digenic heterozygosity in 14.

163 isincorporation resulted in complete loss of heterozygosity in a large region of chromosome V.

164 We observed a decline in heterozygosity in admixed Africans and found that the Eu

165 nges in tissue organisation that result from heterozygosity in Apc, a precancerous situation, are com

166 ed to be associated with significant loss of heterozygosity in breast cancer.

167 ata also provided the opportunity to analyze heterozygosity in crocodilians, which indicates a likely

168 results underscore the significance of mDia1 heterozygosity in deregulated innate immune responses in

169 quencies of examined L1 insertions indicated heterozygosity in genomes of DLPFC cells.

170 Here, we present loss of heterozygosity in human leukocyte antigen (LOHHLA), a co

171 The excess heterozygosity in metal-selected populations that we obs

172 As few as ten SNPs are capable of revealing heterozygosity in more than 97% of European HD subjects.

173 havior is recapitulated by recurrent loss of heterozygosity in multiple metabolic genes adjacent to V

174 ay explain the high incidence of p53 loss of heterozygosity in mutant tumors.

175 We tested the effects of heterozygosity in mutants where the balance of interferi

176 e screened for somatic mutations and loss of heterozygosity in mutL homolog 1 (MLH1) and mutS homolog

177 t kidney, one from the right) showed loss of heterozygosity in one tumor, and four different TSC2 poi

178 o predict the optimal variants for capturing heterozygosity in personalized allele-specific gene-sile

179 the effect on B-cell function of TACI A181E heterozygosity in reportedly healthy subjects and of the

180 ltaneously deletes one copy of BAP1, loss of heterozygosity in the corresponding Vhl region in the mo

181 in allelic richness, and showed an excess in heterozygosity in the Cu- and Zn-selected populations co

182 Mapping the distribution of heterozygosity in these half-tetrad individuals allowed

183 n particular, somatic mutations with loss of heterozygosity in TP53 were strongly associated with leu

184 ncoded in 16q24.3 for which there is loss of heterozygosity in various solid tumors, is responsible f

185 a germ line FAS mutation and somatic loss of heterozygosity, in whom biallelic mutant cells can be tr

186 ith tumour formation in the context of Trp53 heterozygosity, including AB041803 and the Jun dimerizat

187 Ctbp2 heterozygosity increased the median survival of Apc(min/

188 ly 110 years of captivity, revealing reduced heterozygosity, increased inbreeding, and variable intro

189 with 14,585 SNPs, the deviance explained by heterozygosity increasing almost fivefold to a remarkabl

190 s and the most private alleles, and observed heterozygosity indicates outcrossing.

191 CHEK2*1100delC heterozygosity is associated with 15% to 82% increased r

192 we tested the hypothesis that CHEK2*1100delC heterozygosity is associated with increased risk for oth

193 otype, suggesting that susceptibility to En1 heterozygosity is genetically regulated.

194 amino acid changing heterozygosity to silent heterozygosity is higher in dogs than in wolves and, on

195 s via automixis with central fusion and that heterozygosity is lost extremely slowly.

196 Along these chromatids, heterozygosity is maximal at the centromeres, and homolo

197 Nonetheless, as heterozygosity is not inherited from mothers to daughter

198 cy, providing an explanation for why loss of heterozygosity is not required for the development of Po

199 rs and to determine to what extent increased heterozygosity is preserved after genetic recombination

200 Crossover remodeling at homozygosity-heterozygosity junctions requires interference, and non-

201 datasets with a wide range in genome sizes, heterozygosity levels and error rates.

202 = 0.002), and increased frequency of loss of heterozygosity (LOH) across the genome (median 913 vs. 4

203 anced losses and gains, copy-neutral loss-of-heterozygosity (LOH) and tetraploidy.

204 ome (chr) 8p with a common region of loss of heterozygosity (LOH) at chr8p22 locus.

205 with stage III FHWT without combined loss of heterozygosity (LOH) at chromosomes 1p and 16q treated i

206 ithelial cell model and show that 8p loss of heterozygosity (LOH) attenuates the action of several ge

207 tudied the frequency and location of loss-of-heterozygosity (LOH) events on chromosome III in Sacchar

208 Many cancers are initiated by loss-of-heterozygosity (LOH) events that lead to the replacement

209 s (SNPs), copy-number variations and loss-of-heterozygosity (LOH) events.

210 a(m/m);tp53(w/m) zebrafish displayed loss of heterozygosity (LOH) for the wildtype tp53 locus.

211 served point mutations, deletions or loss of heterozygosity (LOH) in beta-2-microglobulin (B2M), an e

212 ); Cdk4(-/-) mice showed no signs of loss of heterozygosity (LOH) in the Men1 locus, whereas tumors i

213 1 and BRCA2 (BRCA) mutations genomic loss of heterozygosity (LOH) might also represent homologous rec

214 Most cases (91%) show loss of heterozygosity (LOH) of chromosome 11p, with uniform sel

215 est events, followed by deletions or loss of heterozygosity (LOH) of chromosomes carrying TP53, BRCA1

216 h recombination events often lead to loss of heterozygosity (LOH) of SNPs that are centromere distal

217 Loss of heterozygosity (LOH) of the hDMP1 locus was found in 42%

218 issue-specific, large copy-number or loss-of-heterozygosity (LOH) variants involving multiple Shh gen

219 A2 allele (absence of locus-specific loss of heterozygosity (LOH)) is observed in 7% of BRCA1 ovarian

220 heterozygous deletions, copy-neutral loss-of-heterozygosity (LOH), allele-specific gains/amplificatio

221 d information of copy number status, loss of heterozygosity (LOH), and event break points, which is e

222 rsions, subtelomeric hypervariation, loss of heterozygosity (LOH), and whole or partial chromosome an

223 mosomal rearrangements and extensive loss of heterozygosity (LOH), hallmarks of cancer cells.

224 s in one TP53 allele are followed by loss-of-heterozygosity (LOH), so tumors express only mutant p53.

225 on of HR in G1 cells can lead to the loss-of-heterozygosity (LOH), which is potentially carcinogenic.

226 rome detected four shared regions of loss of heterozygosity (LOH).

227 nt number of copies and copy-neutral loss-of-heterozygosity (LOH).

228 fine estimates of continent-wide patterns of heterozygosity, long- and short-distance gene flow, arch

229 The heterozygosity maintained in this experiment allowed for

230 This effect was enhanced for a compound heterozygosity marker constructed from four pre-selected

231 The burden of E161K heterozygosity may be a forme fruste of dRTA.

232 y also suggest that under some circumstances heterozygosity may explain far more variation in fitness

233 dance between the inbreeding coefficient and heterozygosity measured at 13,198 single-nucleotide poly

234 and losses, and several copy neutral loss-of-heterozygosity mutations at a genome-wide level, includi

235 ch, due to chromosomal deletions and loss of heterozygosity, necessitate the development of inference

236 Recent murine studies demonstrate that Nf1 heterozygosity (Nf1(+/-)) in monocytes/macrophages signi

237 f wild-type TRPC6 and TRPC6 G757D, mimicking heterozygosity observed in patients, revealed a dominant

238 Significant, tumour-specific loss of heterozygosity occurs in nine genes (ATM, BAP1, BRCA1/2,

239 4q32 amplification, and copy-neutral loss of heterozygosity of 9p were gained in the B-LBL cells.

240 Here, we assess the impact of germline heterozygosity of a novel, oxygen-independent ubiquitin

241 Heterozygosity of Atoh1 reduced tumor occurrence and pro

242 parib pretreatment, PARP1 knockdown or Parp1 heterozygosity of Brca2(cko/ko) mouse embryonic stem cel

243 ltamir females, and substantially rescued by heterozygosity of Deltamir targets, especially within th

244 Subsequent loss of heterozygosity of Dpc4 restores metastatic competency wh

245 tion, which is frequently caused by compound heterozygosity of low-frequency promoter deletions in co

246 Accordingly, compound germline heterozygosity of mouse Sdhb/Sdhc/Sdhd null alleles blun

247 Deltaexon3/+) BALB/c mice to develop SCC, as heterozygosity of p63 but not p53 prevents them from dev

248 Here, we asked whether genetic heterozygosity of PGC-1alpha modulates gene expression f

249 Among those with SHH-MB, loss of heterozygosity of PTCH1 was associated with prolonged PF

250 Population heterozygosity of single nucleotide polymorphisms has be

251 DNA-PK inhibition by gene heterozygosity of the 450-kDa catalytic subunit of the k

252 Loss of heterozygosity of the TRIM3 locus in approximately 20% o

253 eltamir mutants was substantially rescued by heterozygosity of these genes.

254 of KRAS and PIK3CA and mutation and loss of heterozygosity of tumor suppressor genes, such as APC an

255 rther affect oncogenic signaling and loss of heterozygosity of tumor-suppressor genes.

256 The functional consequence of Parp1 heterozygosity on BRCA2 loss is demonstrated by a signif

257 correlations, we investigated the effect of heterozygosity on six diverse fitness measures (ulna len

258 plates has the potential to generate loss of heterozygosity or genome rearrangements.

259 splaying a mild disease progression, whereas heterozygosity or homozygosity for the major alleles (CT

260 ethnicity (OR: 1.8; P = 0.001) and HFE C282Y heterozygosity (OR: 1.9; P = 0.003) were associated with

261 Strikingly, we found that p53 heterozygosity partially rescued the phenotypes in Chd7-

262 or performance status score, age, 1p loss of heterozygosity, presence of oligodendroglial elements, a

263 f the F(ST) divergence statistic, their high heterozygosities produce greater ancestry inference pote

264 oma (OSCC) samples in the absence of loss-of-heterozygosity, promoter methylation, and mutations, we

265 Additionally, the estimation of observed heterozygosity provides support for the hypothesis that

266 rom 6 to 24 per locus, observed and expected heterozygosity ranged from 0.133 to 0.9 and 0.183 to 0.9

267 Heterozygosity ranged from 52-79%, averaging 65.5%, much

268 eristics of a genome, including genome size, heterozygosity rate and repeat content from unprocessed

269 These studies confirm FLI1 heterozygosity results in pleiotropic defects similar to

270 These results suggest that TACI A181E heterozygosity results in TACI haploinsufficiency with i

271 780CP/Cl-24 cells, which express loss of p53 heterozygosity, retained the p53(V172F) mutation and hig

272 rs12203592, P=1.8 x 10(-27)), MC1R (compound heterozygosity score, P=2.3 x 10(-24)), and RALY/ASIP (r

273 ence in GWAS that assesses only X chromosome heterozygosity, seXY achieved marginally better male cla

274 id not suppress inflammation, although Casp8 heterozygosity significantly delayed dermatitis.

275 As with heterozygosity, SNPs performed similarly to microsatelli

276 stricted to neurons by these miRNAs, and its heterozygosity strongly suppresses ectopic peripheral ne

277 s in chromosomal copy number and patterns of heterozygosity, suggesting complex and heterogeneous gen

278 utation in a MMR gene, with possible loss of heterozygosity that could lead to MMR deficiency, 6 were

279 CTVT first arose in a dog with low genomic heterozygosity that may have lived about 11,000 years ag

280 sion or loss, somatic mutagenesis or loss-of-heterozygosity (the first three also in a tumor-specific

281 total linkage disequilibrium (LD) scores and heterozygosity to construct enrichment scores for improv

282 nulocytes, consistent with a transition from heterozygosity to homozygosity for the MPL mutation in c

283 e find that the ratio of amino acid changing heterozygosity to silent heterozygosity is higher in dog

284 o detects differences in somatic and loss of heterozygosity variants between paired samples.

285 and reciprocal deletions (reciprocal loss of heterozygosity), variations that are significantly enric

286 PiMZ heterozygosity was associated with an adjusted odds rati

287 Expected heterozygosity was estimated to evaluate the genetic div

288 Evidence for loss of heterozygosity was found in 100 and 76% of cases with ge

289 Low level of heterozygosity was observed for both SNPs in all populat

290 Heterozygosity was seen in 4/27 (14.8%) mutations, sugge

291 In both populations, heterozygosity was significantly correlated across marke

292 rs measured by chiasmata were unchanged when heterozygosity was varied, consistent with homeostatic c

293 ) such aneuploidies have resulted in loss of heterozygosity, where a chromosomal region is represente

294 a germline FAS mutation and somatic loss-of-heterozygosity, which allows comparing the fate of B cel

295 y organism and show large regions of loss of heterozygosity, which we hypothesise to be a short-term

296 r, is described in 13 patients, including in heterozygosity with ABCB4(A286V), ABCB4(A953D), and null

297 ed study of the associations of CCR5-Delta32 heterozygosity with human immunodeficiency virus type 1

298 Loss of heterozygosity with retention of an LZTR1 mutation was p

299 -somatic copy number alterations and loss of heterozygosity-within a unified probabilistic framework.

300 ity for exon 1 mutations [YO/YO] or compound heterozygosity [XA/YO]; YA/YO and XA/XA genotypes were d