ライフサイエンスコーパス: heterozygous mice

1 ve phenotype previously described for global heterozygous mice.

2 both BACE1 null and, surprisingly, in BACE1 heterozygous mice.

3 We have now extended this result for female heterozygous mice.

4 of Prox1, as the valves are absent in Prox1 heterozygous mice.

5 dle cell sarcoma, and thymic lymphoma in p53 heterozygous mice.

6 kidney fibrosis is ameliorated in Dnmt1(+/-) heterozygous mice.

7 ppression of intestinal tumorigenesis in Apc heterozygous mice.

8 s spontaneous pituitary tumorigenesis in p27 heterozygous mice.

9 s with latency and spectrum similar to Trp53 heterozygous mice.

10 nst overall insulin resistance compared with heterozygous mice.

11 nted increase in IOP in comparison to WT and heterozygous mice.

12 rily affects the cells of the GCL in younger heterozygous mice.

13 we have generated Six3+/- ;Hesx1Cre/+ double heterozygous mice.

14 me 9 in radiation-induced lymphomas from p53 heterozygous mice.

15 ild type and C3H alpha7 receptor null mutant heterozygous mice.

16 enic response to FGF is recapitulated in Vhl-heterozygous mice.

17 the high levels of phosphorylated S6 in Tsc2-heterozygous mice.

18 generated Scn1a(+/-); Scn8a(med-jo/+) double heterozygous mice.

19 ve compliance relative to wild-type (WT) and heterozygous mice.

20 cally or overexpressed in the context of Atm heterozygous mice.

21 ect of Nras loss on tumor development in Rb1 heterozygous mice.

22 orphology, and exercise capacity in compound-heterozygous mice.

23 d2 deficient mice with p53 deficient and p53 heterozygous mice.

24 imals, but lung PtdCho mass decreased in the heterozygous mice.

25 adult liver and other tissues from Pcyt1a+/- heterozygous mice.

26 re delivered to the livers of p19Arf-null or heterozygous mice.

27 post-azoxymethane injection in wild-type and heterozygous mice.

28 feron type I receptor were similar in KO and heterozygous mice.

29 ar function in beta-isoproterenol-stimulated heterozygous mice.

30 of Mdm4 on cell growth in vitro and in Mdm4-heterozygous mice.

31 he brain that are paralleled in Gsk-3beta+/- heterozygous mice.

32 es taken from BAF53b transgenic mice but not heterozygous mice.

33 n vivo by analyzing RelB+/- x aly/+ compound heterozygous mice.

34 ant negative effect in the photoreceptors of heterozygous mice.

35 impairs heat hyperalgesia in homozygous and heterozygous mice.

36 BAF53b transgenic mice compared with BAF53b heterozygous mice.

37 e on electroretinography (ERG) in UBE3D(+/-) heterozygous mice.

38 confirmed a reduced clearing ability in the heterozygous mice.

39 e viral cyclin was dispensable in p18(INK4c) heterozygous mice.

40 limit fibrosis induced by bleomycin in mTERT heterozygous mice.

41 a4(+/+) mice and approximately 20% higher in heterozygous mice.

42 gic synaptic plasticity in the BLA from Nrg1 heterozygous mice.

43 logic features, compared with the respective heterozygous mice.

44 blasts (MEF) cells derived from wildtype and heterozygous mice.

45 ce show significantly higher incidences than heterozygous mice.

46 served analogous lymphocyte defects in Bach2-heterozygous mice.

47 ared with sister cultures from wild-type and heterozygous mice.

48 ffects of cytomegalovirus infection in Trp53 heterozygous mice.

49 hearing loss in all homozygous-null, but not heterozygous, mice.

50 induced diabetes in wild type (+/+) and CTGF heterozygous (+/-) mice.

51 oplastic stage of medulloblastoma in patched heterozygous mice, a model of the human disease.

52 lyses indicate that in Eya1 hypomorphic/null heterozygous mice, a reduction of Eya1 expression to 21%

53 removed by chromosome deletion from the E2A heterozygous mice, a result consistent with the required

54 in plasma membrane calcium ATPase 2 (PMCA2) heterozygous mice: a possible modality- and sex-specific

55 han other Atoh1-positive cell types and that heterozygous mice actually develop hearing loss late in

56 The Cbs(+/+) (wild type) and Cbs(+/-) (heterozygous) mice (aged 16 to 52 weeks) were subjected

57 Moreover, 37.5% of pol eta heterozygous mice also developed skin cancer during 5 mo

58 Type III Nrg1 heterozygous mice also have impaired performance on dela

59 +/Pcdh15(av-3J) +/Ush1g(js) double heterozygous mice also showed elevated hearing loss, sug

60 e as no homozygous embryos were observed and heterozygous mice also showed embryonic lethality (haplo

61 Smg1 heterozygous mice also showed evidence of oxidative dama

62 CD40L displayed a gene dosage effect as heterozygous mice also showed reduction of autoantibody

63 ted PDAC development of KRAS(G12D) INK4A/ARF heterozygous mice and altered the tumor phenotype; while

64 om splenocytes of Fancc null mice to that of heterozygous mice and discovered reduced CD4+ IFN-gamma

65 ally reduced in spermatocytes from testes of heterozygous mice and further reduced in homozygous null

66 receptor (IR)/IR substrate-1 (IRS-1) double heterozygous mice and liver-specific IR KO (LIRKO) mice-

67 en in the Huntington's disease (HD) FEN1 +/- heterozygous mice and myotonic dystrophy type 1 (DM1) FE

68 Parity protection was limited to p53 heterozygous mice and not found in mice with increased E

69 ted differences in PPI between type III Nrg1 heterozygous mice and their wild-type littermates.

70 l cortex and hippocampus of 6-month-old BDNF heterozygous mice and wild type littermates by using pol

71 r blood vessels were increased in Claudin 14-heterozygous mice, and in VEGF-stimulated angiogenesis e

72 layers in cbs homozygous mice and older cbs heterozygous mice, and it primarily affects the cells of

73 and myotonic dystrophy type 1 (DM1) FEN1 +/- heterozygous mice, and suggest that inefficient flap pro

74 smaller lesions compared with wild-type and heterozygous mice, and there were no significant differe

75 Adult heterozygous mice appeared normal and exhibited no evide

76 Prox1 heterozygous mice are a new model for adult-onset obesit

77 Heterozygous mice are characterized by repeated hair los

78 Heterozygous mice are fertile and have no discernible ph

79 We found that Nedd4-2 heterozygous mice are hyperactive, have increased basal

80 While single heterozygous mice are normal, double heterozygous embryo

81 Additionally, Mdm2+/- Mdm4+/- double-heterozygous mice are not viable and exhibit defects in

82 In contrast, heterozygous mice are overtly and histologically indisti

83 ynapsin, whereas the levels in wild-type and heterozygous mice are undetectable.

84 versed the increase in permeability in KRIT1 heterozygous mice as shown by intravital microscopy.

85 MYH4(L342Q) is present in muscles from heterozygous mice at only 7% of the levels of the wild-t

86 e directly on the T cell as Motheaten viable heterozygous mice autoreactive T cells are not anergized

87 In Cldn14-lacZ heterozygous mice beta-galactosidase activity was detect

88 g the dynamic changes in iron balance in Pcm heterozygous mice between 3 and 12 weeks of age.

89 We studied Bmpr2 heterozygous mice (Bmpr2(+/-)), mice with hepatocyte-spe

90 NA levels were observed in 18-month-old BDNF heterozygous mice but not in 7-day-old mice, suggesting

91 inal peptide (VIP) induced REMS responses in heterozygous mice but not in KO mice.

92 f rhabdoid tumors in vivo, we developed Ini1 heterozygous mice by targeted disruption.

93 ough precancerous lesions were found in Pten heterozygous mice, cancer progression and metastasis onl

94 Here, we report that cardiac myocytes of heterozygous mice carrying a catecholaminergic polymorph

95 We have now analyzed compound heterozygous mice carrying a duplication [Dp(11)17] in o

96 Heterozygous mice carrying a null mutation at the gamma-

97 on, homozygous fII(lox/lox) mice or compound heterozygous mice carrying one fII(lox) allele and one c

98 To do this we generated Trp53 heterozygous mice carrying the T2/Onc transposon and SB1

99 e terminal differentiation, we used compound heterozygous mice carrying the W (null) and W(v) (domina

100 Genetic ablation of CBS in CBS heterozygous mice (CBS(+/-) ) reduced the number of muta

101 In CBS heterozygous mice (cbs(+/-)) and primary neurons deplete

102 r cell-enriched transcripts in the Gfi1(Cre) heterozygous mice cochleae compared with their wild-type

103 e intolerance developed in aged (>10 months) heterozygous mice compared to littermate controls.

104 idal neuron responsivity was observed in the heterozygous mice compared to the wild type mice.

105 quences of PLAG1 deficiency in knock-out and heterozygous mice compared to wild-type mice using RNA-s

106 ) and +/Myo7a(sh1-8J) +/Pcdh15(av-3J) double heterozygous mice compared with age-matched single heter

107 o be unchanged in the Brca1-MG-Deltaex11;Atm heterozygous mice compared with Brca1-MG-Deltaex11;Atm w

108 HSC (ST-HSC) populations are expanded in Apc-heterozygous mice compared with the control littermates;

109 on and lifespan after gamma-radiation in Atm heterozygous mice compared with their wild-type control

110 eritonitis after Cx43 inhibition and in Cx43 heterozygous mice compared with untreated and wild-type

111 on for reward were also exhibited by Ank3+/- heterozygous mice compared with wild-type Ank3+/+ mice.

112 Target gene expression is normal in heterozygous mice, consistent with prior work showing th

113 on in vivo in Themis(I23N/+):Lck(-/+) doubly heterozygous mice demonstrate that functional coupling o

114 The Mtap heterozygous mice demonstrated changes in metabolic and

115 following vascular injury in vivo, GABPalpha-heterozygous mice demonstrated reduced KIS gene expressi

116 Dmrt2 heterozygous mice derived from these cells are phenotypi

117 emic diet, cystathionine beta-synthase (Cbs)-heterozygous mice develop hyperhomocysteinemia.

118 Heterozygous mice develop lymphomas at an intermediate r

119 While heterozygous mice develop normally, disruption of both C

120 The heterozygous mice develop normally, with no changes in r

121 We now report that dab2 heterozygous mice develop uterine hyperplasia and ovaria

122 These heterozygous mice developed muscle weakness and myofibri

123 ctionated by gender, however, homozygous and heterozygous mice developed spontaneous tumors more rapi

124 ciated with 22q11.2 haploinsufficiency, Tbx1 heterozygous mice did not display these behavioral abnor

125 Because prior studies of Atoh1-heterozygous mice did not examine or report on hearing l

126 Bru heterozygous mice display defects similar to Axenfeld-Ri

127 sistent with the human genetic studies, Wnk1 heterozygous mice displayed a significant decrease in bl

128 m heterozygosity, but Brca1-MG-Deltaex11;Atm heterozygous mice displayed decreased ductal branching d

129 However, and surprisingly, Claudin 14-heterozygous mice displayed several blood vessel-related

130 k-out mice, when compared with wild-type and heterozygous mice, displayed a 7-9.7% decrease in lifesp

131 Although, Pax3 heterozygous mice do not show ENS defects, compound Pax3

132 f compensating for the deleted copy and that heterozygous mice do not suffer peripheral hearing impai

133 nd null mice develop cardiomyopathy, whereas heterozygous mice do not.

134 of RNA isolated from wild-type and Tcof1+/- heterozygous mice embryos from strains that exhibit a le

135 This function was tested in endoglin heterozygous mice (Eng(+/-)) and their wild-type sibling

136 All the tumors from heterozygous mice examined retain the wild-type allele a

137 do not show ENS defects, compound Pax3;Tcof1 heterozygous mice exhibit cumulative apoptosis which sev

138 Here we show that Grb2 heterozygous mice exhibit decreased susceptibility to Fr

139 Conversely, miR-34a knockout and heterozygous mice exhibit elevated bone resorption and r

140 Myc heterozygous mice exhibit extended lifespans resulting f

141 Survived adult heterozygous mice exhibit frequent haemorrhages and incr

142 Skeletal muscles from heterozygous mice exhibit increased susceptibility to ca

143 ath between P16 and P26, whereas Scn1a(RH/+) heterozygous mice exhibit infrequent spontaneous general

144 Doubly heterozygous mice exhibit progressive hyperglycemia, hyp

145 Adult Zeb1 heterozygous mice exhibit these same corneal defects.

146 n apparent normal VMH cytoarchitecture, sf-1 heterozygous (+/-) mice exhibited diet-induced obesity w

147 NHE1(+/+) mice treated with HOE 642 or NHE1 heterozygous mice exhibited a approximately 33% decrease

148 least one of the two genes because compound heterozygous mice exhibited a prostatic phenotype that w

149 Arid1b-heterozygous mice exhibited abnormal cognitive and socia

150 ivated Protein C (aPC), plasma from Pros1+/- heterozygous mice exhibited accelerated thrombin generat

151 The surviving heterozygous mice exhibited altered glucose metabolism,

152 BDNF heterozygous mice exhibited an increase in CXCR4 mRNA co

153 mPGES-1 null and heterozygous mice exhibited decreased incidence and seve

154 Under these pathological conditions, heterozygous mice exhibited localized vascular abnormali

155 These heterozygous mice exhibited no vascular defects until ch

156 The C3H alpha7 heterozygous mice exhibited significant reductions in hi

157 itivity and tumour predisposition, with Helq heterozygous mice exhibiting a similar, albeit less seve

158 mors and pretumor cells derived from patched heterozygous mice express high levels of Mad3 compared w

159 Heterozygous mice expressing the human MH/central core d

160 f the Ccm1 gene, but an initial survey of 20 heterozygous mice failed to detect any cavernous malform

161 h was induced in cystathionine-beta synthase heterozygous mice fed a high-methionine diet for 8 weeks

162 deficient mice (Fg(-/-)) in comparison with heterozygous mice (Fg(+/-)) to point the proinflammatory

163 K18-null but not K8-null or heterozygous mice form MBs, which indicates that K8 is i

164 lyzed modifiers of an eye defect in Jag1del1 heterozygous mice from this same cross.

165 Heterozygous mice grow normally and have normal total ad

166 Heterozygous mice had a twofold increase in these projec

167 ce were devoid of type XIV collagen, whereas heterozygous mice had reduced synthesis.

168 e-body exposure to ionizing radiation, Brca1 heterozygous mice have a 3-5-fold higher incidence speci

169 Trim21 heterozygous mice have a haploinsufficiency phenotype in

170 Fos mice have no multinucleated osteoclasts, heterozygous mice have a reduction in the number of oste

171 IFIH1 heterozygous mice have a regulatory rather than effector

172 tic metabolomic analyses revealed that SIRT1 heterozygous mice have elevated gluconeogenesis and oxid

173 ependence in cells, intestine-specific Sirt1 heterozygous mice have enhanced intestinal tumor formati

174 EPAS1-null as well as heterozygous mice have impaired renal erythropoietin ind

175 Heterozygous mice have less extensive ICC hyperplasia an

176 ars embryonic-lethal in homozygous mice, but heterozygous mice have no alterations at baseline.

177 Whereas Ctla4 heterozygous mice have no obvious phenotype, human CTLA4

178 The Mmp20 heterozygous mice have normal-appearing enamel, with Vic

179 Herein, using Hhip heterozygous mice (Hhip(+/-)), we observed increased lun

180 neered mice, with human P2X7R, revealed that heterozygous mice (i.e., they coexpress the disease-asso

181 roximal to the Sod2 start site in PGC-1alpha heterozygous mice, implicating PGC-1alpha in facilitatio

182 vivo and in vitro, and it is also reduced in heterozygous mice in the absence of cellular ectopia.

183 We also studied compound heterozygous mice in which one ACE allele was null (no A

184 or muscle defects, and the same was true of heterozygous mice in which one Fgf4 allele carried the H

185 in-A1 is a feature of tumors arising in Hic1 heterozygous mice in which the remaining wild-type allel

186 evidence that the smaller volume of ROS from heterozygous mice is most likely responsible for observe

187 e these defects, rod-mediated sensitivity in heterozygous mice is not decreased to the extent seen in

188 e show that on a C57BL/6 background, jagged1 heterozygous mice (Jag1(+/-) ) exhibit impaired intrahep

189 Compound-heterozygous mice lacking 1 copy of Pkd1 and Taz exhibit

190 xclusively progerin (Lmna HG) and found that heterozygous mice (Lmna HG/+) exhibit many phenotypes of

191 Heterozygous mice (Lrat(+/L3)) were crossed with mice ex

192 s study is to determine whether Zeb1 null or heterozygous mice may provide an animal model for PPCD.

193 Since the expression profile in the heterozygous mice mimicked viral transduction, we conclu

194 In vitro, islets of NHA2-deficient and heterozygous mice, NHA2-depleted Min6 cells, or islets t

195 udied Prkar2a and Prkar2b knock out (KO) and heterozygous mice; none of these mice developed bone les

196 We have previously shown that male Npc1 heterozygous mice (Npc1(+/-)), as compared to homozygous

197 We also found that Atoh1 heterozygous mice of both sexes (Atoh1(lacZ/+)) have adu

198 s in genetic background, we crossed Jag1del1 heterozygous mice onto the same genetic background as th

199 heterozygous (+/-) mice, Pten and Fyn double heterozygous (+/-) mice, or Fyn knockout (-/-) mice conf

200 Moreover, double-heterozygous mice (ostes/+, Tg(Pkd1l2)/0) suffer from my

201 d1(m1Bei) and Runx2-II mice to create double heterozygous mice (Pkd1(+/m1Bei)/Runx2-II(+/-)) deficien

202 Tbx1(-/+)/Pitx2(-/+) double heterozygous mice present with an extra premolar-like to

203 ing to demonstrate that the PVN of germ line heterozygous mice projects normally to the dorsal vagal

204 Thus, Nedd4-2 heterozygous mice provide a new genetic model to study i

205 By combining SB mutagenesis with Patched1 heterozygous mice (Ptch1(lacZ/+)), we observed an increa

206 cytes from Fyn heterozygous (+/-) mice, Pten heterozygous (+/-) mice, Pten and Fyn double heterozygou

207 interfering RNA and (b) astrocytes from Fyn heterozygous (+/-) mice, Pten heterozygous (+/-) mice, P

208 However, in patched1 heterozygous mice, putative tumor precursors form with c

209 mice show more severe defects compared with heterozygous mice reflecting the dominant and dose-depen

210 eover, loss of one allele of Notch1 in Prox1 heterozygous mice rescued embryonic lethality due to Pro

211 gical activation of CREB in the female Mecp2 heterozygous mice rescued several behavioral defects.

212 ration of Trps1(DeltaGT/+);Runx2(+/-) double heterozygous mice rescued the opposite growth plate phen

213 7beta-estradiol pellets in adult female Pten heterozygous mice, resulting in increased carcinoma inci

214 y deficits observed in the alpha2 and alpha3 heterozygous mice reveal the Na,K-ATPase to be an import

215 Magnetic resonance imaging of type III Nrg1 heterozygous mice revealed hypofunction in the medial pr

216 cardiac skinned fibers isolated from WT and heterozygous mice revealed that the WT cTnI was complete

217 ved from WT/Delta locus control region (LCR) heterozygous mice reveals no significant H3 K79 dimethyl

218 zygous animals and alpha7 nicotinic receptor heterozygous mice reveals that the sustained phase of po

219 To this end, SERCA2 heterozygous mice (S2HET) were challenged with a high-fa

220 UPR acting in pro-survival mode, Enamp.S55I heterozygous mice secreted structurally normal enamel.

221 The complete loss of Hic1 function in the heterozygous mice seems to involve dense methylation of

222 Both homozygous and heterozygous mice show a decline in survival compared to

223 In vivo, Akt3-null and heterozygous mice show dose-dependent decreases in angio

224 NeuroD2 heterozygous mice show profound deficits in emotional le

225 In contrast, P30 Jag1/Rumi double-heterozygous mice show well-developed portal triads arou

226 Arid1b-heterozygous mice showed a decreased number of cortical

227 In addition, mPGES-1 null and heterozygous mice showed a marked reduction of serum IgG

228 s reduced by 80-90% in SAP-1-deficient mice; heterozygous mice showed a moderate defect.

229 O mice were early embryonic lethal, but Smg1 heterozygous mice showed a predisposition to a range of

230 Primary hippocampal cells derived from heterozygous mice showed an attenuated calcium uptake up

231 In this study, we found that: (i) Mecp2 heterozygous mice showed deficiency of GABA perisomatic

232 Fbw7(Delta/+) heterozygous mice showed haploinsufficiency for Notch de

233 Finally, endothelial Notch1 heterozygous mice showed higher diet-induced atheroscler

234 Lastly, BDNF heterozygous mice showed higher levels of CCR5 and CXCR3

235 nsistent with this ex vivo observation, KLF2 heterozygous mice showed increased microvessel density i

236 We found that Nf1 heterozygous mice showed increased neovascularization in

237 Both homozygous and heterozygous mice showed reduced glutamatergic transmiss

238 cked GnRH neurons in the hypothalamus, while heterozygous mice showed substantial decreases in the nu

239 specific expression of Cdkn2b transcripts in heterozygous mice showed that the deletion affects expre

240 a exhibits a strong gene dosage effect, with heterozygous mice showing approximately 2-fold reduction

241 of bdnf I and IV in the VMH were reduced in heterozygous mice similar to levels observed in fasted w

242 a3+/+ and alpha3-/- littermates delivered by heterozygous mice soon after their exposures to ETS or e

243 ough partial reduction of GRP78 in the Grp78 heterozygous mice substantially reduces the tumor microv

244 Cdk2 wild-type or heterozygous mice succumbed to mammary tumors with mean

245 A144E heterozygous mice, such as TACI(+/-) mice, expressed hal

246 In contrast to Ptch1 heterozygous mice, Sufu heterozygotes had no development

247 itioning and novel object recognition in I-2 heterozygous mice suggest that I-2 is a memory suppresso

248 The neurobehavioral changes seen in heterozygous mice suggest that these mouse models may be

249 d TGCT frequencies in Mgf(Sl-J)-M19 compound heterozygous mice suggest that these mutations exacerbat

250 equent higher mortality were not observed in heterozygous mice, suggesting that one allele of betaArr

251 Heterozygous mice tended to have thicker corneas (3.4%).

252 ting ADIPOQ protein level were lower in Brd4 heterozygous mice than in wild-type mice at 21 days afte

253 To address this question, we generated heterozygous mice that persistently expressed the full-l

254 enewal capacity with progressive breeding of heterozygous mice that was indistinguishable from that o

255 mice that received vehicle alone or control (heterozygous) mice that received vehicle.

256 Heterozygous mice (the same frizzled 9 genotype as Willi

257 However, in contrast to global heterozygous mice, the behavioral changes induced by gam

258 Compared with wild-type or Rac1 heterozygous mice, the hearts of c-Rac1(-/-) mice showed

259 In Arc-positive GFP heterozygous mice, the pattern of GFP-positive cells exh

260 1.2(I1624E) mutation were generated in adult heterozygous mice through inactivation of the floxed WT

261 We used 3T3-L1 adipocytes and Brd4 heterozygous mice to investigate whether the induction o

262 NR1-/- ES cells were derived from matings of heterozygous mice under feeder-free conditions.

263 prospero-related homeobox protein 1 (Prox1) heterozygous mice, using pressure-volume loop and microm

264 In VMD2-Cre heterozygous mice variable progressive age-dependent RPE

265 Notably, seizure induction in heterozygous mice was accompanied by enhanced reporter e

266 -induced B-cell lymphoma development in Mtbp heterozygous mice was profoundly delayed.

267 Hearing in doubly heterozygous mice was similar to age-matched singly hete

268 social communication and interaction in TSC2 heterozygous mice, we recorded ultrasonic vocalizations

269 In vivo, wild-type and Ngn-3-heterozygous (+/-) mice were subjected to 3,5-diethoxyca

270 Mammary tumors from Brca1-MG-Deltaex11;Atm heterozygous mice were anaplastic and undifferentiated i

271 Pmm2(R137H/F115L) mice, but their levels in heterozygous mice were comparable to wild-type (WT) litt

272 lethal renal phenotype, Aqp11-/sjds compound heterozygous mice were generated from Aqp11 +/sjds and A

273 Heterozygous mice were healthy, fertile, and normolipide

274 tic bile duct cells from Tsc1, Tsc2 and Pkd1 heterozygous mice were highly misoriented.

275 l IOPs of C57Bl/6x129SvJ WT, SPARC-null, and heterozygous mice were measured.

276 richment of mannosyl compounds and glycogen, heterozygous mice were normal, arguing against possible

277 ced more tumors than wild-type mice, whereas heterozygous mice were not statistically different.

278 Levels of TERT mRNA in heterozygous mice were one-third to one-half the levels

279 Heterozygous mice were phenotypically normal and in situ

280 Skeletal myoblasts derived from SIRT1+/- heterozygous mice were resistant to the effects of eithe

281 Wildtype, COX-2 knockout and COX-2 heterozygous mice were subjected to a model of colonic a

282 When Tert(+/-) heterozygous mice were successively cross-bred through 1

283 ncy induced hematopoietic dysplasia, and Eed heterozygous mice were susceptible to malignant transfor

284 , Atm heterozygous as well as Atm/P53 double heterozygous mice were treated with ionizing radiation.

285 onstrated early embryonic lethality, whereas heterozygous mice were viable, but developed signs of hy

286 genetic model of breast cancer in the Grp78 heterozygous mice where GRP78 expression level was reduc

287 Motheaten viable heterozygous mice, which contain a mutation in the SHP-1

288 Heterozygous mice, which correspond to the human occurre

289 w medulloblastoma model by crossing Patched1 heterozygous mice, which develop medulloblastomas with l

290 ator of the HCM response, and compound VM/RC heterozygous mice, which developed a severe HCM phenotyp

291 The bone phenotype of the heterozygous mice, which have 79-84% of wild-type Runx2

292 We generated Arid1b heterozygous mice, which showed social behavior impairme

293 Tumour growth/angiogenesis is reduced in heterozygous mice, which was associated with reduced act

294 Here we show that treatment of p18 null and heterozygous mice with a chemical carcinogen resulted in

295 Heterozygous mice with a different CDP mutation that eli

296 esizing MEE cells following mating Tgf-beta3 heterozygous mice with Keratin 14 promoter directed Smad

297 were induced by the transduction of p53(+/-) heterozygous mice with lentiviral vectors containing onc

298 Our results show that heterozygous mice with mutations in the myosin motor or

299 e cellular phenotype and barrier function in heterozygous mice with simvastatin, a drug known to inhi

300 We generated compound heterozygous mice with the R137H and F115L mutations in