1 alues of both positive and negative dP/dt in
heterozygous mutants.
2 bosis response was severely reduced for both
heterozygous mutants.
3 e dental epithelium and mesenchyme of double
heterozygous mutants.
4 cient to obtain gene conversion in initially
heterozygous mutants.
5 ignificantly reduced in Clock homozygous and
heterozygous mutants.
6 that was no more severe than that of single
heterozygous mutants.
7 of wild-type alpha1beta2gamma2 receptors or
heterozygous mutant alpha1(A322D)beta2gamma2 receptors,
8 rafficking and/or accelerated endocytosis of
heterozygous mutant alpha1beta2gamma2 receptors containi
9 Heterozygous mutants also exhibited delayed recovery of
10 cartilage from the knee joints of the double-
heterozygous mutant and surgically treated mice were exa
11 copy numbers in ovulated oocytes from EndoG
heterozygous mutant and wild-type mice are similar, sugg
12 e strain but decreasing catalase activity in
heterozygous mutants and no detectable catalase in a hom
13 We used
heterozygous mutants and targeted RNA interference-media
14 between those persons who were homozygous or
heterozygous mutants and wildtype/pseudo-wildtype (p = 0
15 e 73.3% for p53 wild-type fetuses, 52.5% for
heterozygous mutants,
and 2.2% for p53-null mutants.
16 our onset, incidence and progression in Pten-
heterozygous mutants,
and leads to female sterility with
17 In
heterozygous mutant animals, we observed a relative decr
18 We also show that Xpc Trp53 double
heterozygous mutants are more predisposed to skin cancer
19 Prior to seizure onset,
heterozygous mutants are not defective in motor learning
20 enes expressed during wing development in 27
heterozygous mutants,
as well as their co-isogenic wild
21 Here we show that aged
heterozygous mutant (
Atp2a2(+/-)) mice develop squamous
22 ables instant germline modifications, making
heterozygous mutants available within 18 wk.
23 res from E12.5 homozygous mutant (bcl-x-/-),
heterozygous mutant (
bcl-x+/-), and wild-type (bcl-x+/+)
24 one morphogenetic protein receptor-2 (BMPR2)-
heterozygous, mutant (
BMPR2(+/-)) mice have a genetic tr
25 In contrast to all
heterozygous mutants,
both systolic and diastolic functi
26 Heterozygous mutant BRCA1 cell clones also showed a high
27 We found that even the
heterozygous mutant cell lines showed cell survival defe
28 We show that Apex
heterozygous mutant cells and animals are abnormally sen
29 While
heterozygous mutant cells had diminished signaling in re
30 When compared with Ptch1
heterozygous mutants,
compound Ptch1/Hic1 heterozygotes
31 nctionally independent domains, we undertook
heterozygous mutant crossing between Phr1(Delta8,9) and
32 Interestingly, the MK2
heterozygous mutants display an intermediate level of pr
33 Ventricles of
heterozygous mutants displayed a 50% reduction in mlc-2v
34 In mouse, Hnf1b
heterozygous mutants do not exhibit any phenotype, where
35 Myocardial hypoplasia in GATA4/GATA6 double
heterozygous mutant embryos is associated with reduced p
36 finding of exencephaly in about 15% of rybp
heterozygous mutant embryos, and by Rybp's distinct neur
37 misexpressed in engrailed cells in hedgehog
heterozygous mutant embryos, larvae show a dominant phen
38 Using p53
heterozygous mutant epithelial cells from Li-Fraumeni sy
39 Although the
heterozygous mutant ES cells were able to generate low c
40 Heterozygous mutants exhibited cardiac function comparab
41 Finally, BIR1
heterozygous mutants exhibited grossly altered cell morp
42 Compound Cdc42, tinman
heterozygous mutant flies exhibited impaired cardiac out
43 phenotypic characterization of mice that are
heterozygous mutants for the Apex gene (Apex+/-).
44 Heterozygous mutants (
Foxc1(+/-) and NC-Foxc1(+/-)) exhi
45 s knockout (SR-/-) and glycine transporter 1
heterozygous mutant (
GlyT1-/+).
46 coding PMCA1 caused embryolethality, whereas
heterozygous mutants had no overt disease phenotype.
47 The
heterozygous mutant has no overt phenotype, and its leaf
48 Heterozygous mutants have 67% of the enzyme activity of
49 Heterozygous mutants have axonal defects in the adult ey
50 hus, heterozygous and homozygous or compound
heterozygous mutants have very different clinical phenot
51 t of WT KRAS with a mutant allele sensitized
heterozygous mutant HCT116 cells to treatment.
52 CA2 mRNA was reduced by approximately 45% in
heterozygous mutant hearts and that SERCA2 protein and m
53 crog/L; 24 had homozygous mutant or compound
heterozygous mutant HFE genotypes.
54 can affect muscle function, we have analyzed
heterozygous mutants in depth.
55 f chondrogenesis and osteogenesis, while the
heterozygous mutant is dwarfed.
56 mal gene can be disrupted, and the resulting
heterozygous mutant is unlikely to display a phenotype.
57 s, the phenotype of the lymph gland of Zfpr8
heterozygous mutants is dominantly enhanced by the l(1)d
58 ciliary ganglion and we find that in Phox2b
heterozygous mutants it is highly atrophic.
59 By contrast, kinesin-8
heterozygous mutant (
KIP3/kip3) spindles exhibited the s
60 Heterozygous mutant Kit(V558Delta)/+ mice that develop s
61 Heterozygous mutant KitV558Delta/+ mice develop symptoms
62 comparison with wild-type alphaA protein of
heterozygous mutant lenses.
63 The
heterozygous mutant (
LPAT2/lpat2) had minimal altered ve
64 Heterozygous mutant (
luxoid.Zbtb16(LU)/J) mice deficient
65 The
heterozygous mutant mice (Acc1(+/-)) had normal fertilit
66 e phenotypes in growth plate chondrocytes of
heterozygous mutant mice (Gnas(+/E2-)).
67 Heterozygous mutant mice (ngf+/-) have reduced levels of
68 The
heterozygous mutant mice also developed similar prostati
69 in the mammalian heart, we examined compound
heterozygous mutant mice and found conduction system and
70 The abnormal EEG patterns in
heterozygous mutant mice and the influence of genetic ba
71 Snf2h
heterozygous mutant mice are born at the expected freque
72 In addition, both homozygous and
heterozygous mutant mice are highly resistant to the sei
73 oints was dramatically reduced in the double-
heterozygous mutant mice compared with that in the type
74 nally, we propose that soluble KITL in Sld/+
heterozygous mutant mice complements a dosage effect of
75 We report here that
heterozygous mutant mice develop into adulthood without
76 We report here that
heterozygous mutant mice develop into adulthood without
77 The
heterozygous mutant mice display insulin hypersensitivit
78 The
heterozygous mutant mice do not develop seizures.
79 The Chd2
heterozygous mutant mice exhibit increased extramedullar
80 nterestingly, we found that cells from EndoG
heterozygous mutant mice exhibit increased resistance to
81 ectrophysiological studies demonstrated that
heterozygous mutant mice have a specific defect in hippo
82 opment, we generated, through breeding, IRF4
heterozygous mutant mice in the NZB background (NZB IRF4
83 taneous cell death of spermatogonia in EndoG
heterozygous mutant mice is significantly reduced compar
84 ed an F2 intercross between insulin receptor
heterozygous mutant mice on B6 and 129/Sv backgrounds (B
85 However, breeding of
heterozygous mutant mice on the 129 background generated
86 Closer inspection of
heterozygous mutant mice revealed a range of defects wit
87 Heterozygous mutant mice show a phenotype similar to hum
88 Fibroblasts taken from adult
heterozygous mutant mice show an apparent alteration in
89 scular endothelial cells isolated from Foxc2
heterozygous mutant mice showed a marked reduction in It
90 Heterozygous mutant mice showed postnatal growth delay w
91 The resulting compound
heterozygous mutant mice showed significantly accelerate
92 The progression in the double-
heterozygous mutant mice was delayed by approximately 6
93 , microvessel outgrowth from aortas of Foxc2
heterozygous mutant mice was reduced.
94 Heterozygous mutant mice were viable, but embryos exhibi
95 Adult
heterozygous mutant mice with a targeted disruption for
96 Heterozygous mutant mice with deletion of hypoxia-respon
97 Mating of
heterozygous mutant mice yielded wild-type and heterozyg
98 f osteoclasts were not altered in the double
heterozygous mutant mice, indicating that the defect lie
99 chanism of MHE, both Ext1(+/-) and Ext2(+/-)
heterozygous mutant mice, which mimic the genetic status
100 ciency also accelerated tumorigenesis in p53
heterozygous mutant mice.
101 ter behavioral recovery than in wild-type or
heterozygous mutant mice.
102 f the Steel locus increase TGCT incidence in
heterozygous mutant mice.
103 omal breaks as well as aneuploidy in primary
heterozygous mutant mouse embryonic fibroblasts.
104 Analysis of a
heterozygous mutant mouse in which the NF-kappaB-depende
105 which manifests as visual dysfunction in the
heterozygous mutant mouse, B6;C3-Opa1(Q285STOP).
106 , a finding relevant to our understanding of
heterozygous mutant myosins found in disease states like
107 ablated in Schwann cells in the context of a
heterozygous mutant (
Nf1+/-) microenvironment.
108 ablated in Schwann cells in the context of a
heterozygous mutant (
Nf1+/-) microenvironment.
109 trocytes from NKCC1 wild-type (NKCC1+/+) and
heterozygous mutant (
NKCC1+/-) mice.
110 When the mutations were examined in
heterozygous mutant/
nonmutant genotypes, more than half
111 the activity of the wild-type transposase in
heterozygous mutant/
nonmutant genotypes.
112 ary phase survival was prolonged in a double
heterozygous mutant of the metabolic enzyme non-quiescen
113 ductive tracts of Hoxa-10 and Hoxa-11 single
heterozygous mutants of both sexes were primarily unaffe
114 rease in deposition of AA when compared with
heterozygous mutant or wild-type animals.
115 ic mice bearing both the v-Ha-ras gene and a
heterozygous mutant p53 allele tend to retain the Ink4a
116 cted with an apparent dominant ZSD in whom a
heterozygous mutant PEX6 allele (c.2578C>T [p.Arg860Trp]
117 Heterozygous mutant plants showed no visible leaf phenot
118 Selfing of a
heterozygous mutant produced normal-sized and shrunken s
119 We found that pnr
heterozygous mutants result in defective cardiac perform
120 ient for the Bloom's syndrome helicase, such
heterozygous mutants segregate homozygous daughter cells
121 e extreme fertility observed in the compound
heterozygous mutant sheep.
122 Heterozygous mutants show a slow onset of degeneration i
123 In contrast,
heterozygous mutants show an exaggerated escape response
124 We conclude that
heterozygous mutants show neither a molecular nor a phys
125 The
heterozygous mutants showed slower growth kinetics and e
126 ice had no detectable CuZn-SOD activity, and
heterozygous mutants (
Sod1 +/-) showed a 50% decrease co
127 further suggestive of selection against the
heterozygous mutant state as tumors progress.
128 We obtained homozygous cells from 40% of the
heterozygous mutants tested.
129 Moreover, in double
heterozygous mutants,
the lower incisors were consistent
130 00(DeltaKASH), or in klar and msp-300 double
heterozygous mutants,
the MSP-300 nuclear ring and the a
131 Heterozygous mutant thymocytes had a severe defect in p5
132 nctionally complemented lpat2 in transformed
heterozygous mutants to produce the lpat2/lpat2 genotype
133 We have grown > 6000
heterozygous mutants together and exposed them to a star
134 By flow cytometry, some
heterozygous mutants were polyploid accumulating >4 N DN
135 Notch2(Q2319X)
heterozygous mutants were smaller and had shorter femurs
136 ty could be rescued by transformation of the
heterozygous mutant with a 35S:LPAAT1 construct.
137 In ephrin-B1
heterozygous mutants,
X inactivation generates ephrin-B1
138 Breeding of
heterozygous mutants yielded a normal Mendelian ratio am