ライフサイエンスコーパス: hiPSC

1 hiPSC-BAPs expressed the molecular identity of adult-UCP

2 hiPSC-CM treated with T3+Dex, but not with either T3 or

3 hiPSC-CMs derived from individuals with breast cancer wh

4 hiPSC-derived adipocytes are insulin sensitive and displ

5 hiPSC-derived cardiomyocytes from both patients recapitu

6 hiPSC-derived cardiomyocytes integrated into host myocar

7 hiPSC-differentiated SE cells expressed markers suggesti

8 hiPSC-EHTs achieved maximum peak stress of 6.5 mN/mm(2)

9 hiPSCs and hESCs form interspecies chimeras with high ef

10 hiPSCs can be differentiated into mature and functional

11 put pluripotent cell and was effective in 11 hiPSC lines tested.

12 cardiomyocyte differentiation derived from 2 hiPSC lines and 2 hESC lines at 4 stages: pluripotent st

13 mtDNA next-generation sequencing (NGS) on 84 hiPSC clones derived from a cohort of 19 individuals, in

14 fferentiation capacity in 23 out of 25 (92%) hiPSC lines.

15 this study demonstrates the versatility of a hiPSC-based panel spanning the mutational heterogeneity

16 chromatin accessibility were similar across hiPSC and hESC cell lines.

17 s a tool for large scale differentiation and hiPSC banking studies.

18 is needed to reliably differentiate hESC and hiPSC into neural-restricted multipotent derivatives or

19 s goal, we tested the transition of hESC and hiPSC lines onto xeno-free (XF) / feeder-free conditions

20 onstrate the transition of multiple hESC and hiPSC lines onto XF substrate and media conditions, and

21 Here we use genetically matched hESC and hiPSC lines to assess the contribution of cellular origi

22 ly derived, larger set of unmatched hESC and hiPSC lines.

23 Subsequently, XF transitioned hESC and hiPSC were induced with epidermal growth factor (EGF) an

24 induced pluripotent stem cells (hiPSCs) and hiPSC-derived oligodendrocytes from 12 individuals with

25 f human embryonic stem cell (hESC) lines and hiPSC lines and have shown that hiPSCs are inferior in t

26 METHODS AND hiPSC cardiomyocytes were derived from a CPVT2 patient (

27 METHODS AND hiPSC-CM were generated using a standard chemical differ

28 These convergent findings from mouse and hiPSC SZ models provide evidence for STEP61 dysfunction

29 hUCMSCs, hESC-MSCs, and hiPSC-MSCs in CPC generated new bone and blood vessels s

30 and in three isogenic human heart tissue and hiPSC-CM pairs showed greater inter-patient variation th

31 VPs from human embryonic stem cells and hiPSCs were generated with an optimized vascular differe

32 We conclude that hESCs and hiPSCs are molecularly and functionally equivalent and c

33 neuroectodermal differentiation of hESCs and hiPSCs by binding and sequestering SMAD4 to the mitochon

34 Using this system, hESCs and hiPSCs can be easily and stably passaged by dissociating

35 HLCs differentiated from hESCs and hiPSCs could be engrafted in the liver parenchyma of imm

36 nt neural progenitors derived from hESCs and hiPSCs in a sonic hedgehog-independent manner.

37 detect between genetically matched hESCs and hiPSCs neither predict functional outcome nor distinguis

38 re useful matrices for maintaining hESCs and hiPSCs when used in combination with a completely xeno-f

39 ially expressed candidates between hESCs and hiPSCs, we identified a mitochondrial protein, CHCHD2, w

40 nces between genetically unmatched hESCs and hiPSCs.

41 or delivering cells; (2) hUCMSCs, hESCs, and hiPSCs are promising alternatives to hBMSCs, which requi

42 As hiPSC-BAPs display similarities with adult-BAPs, it open

43 In this context, autologous hiPSC-derived smooth muscle cells (SMCs) appear to be hi

44 r to be highly immunogenic, while autologous hiPSC-derived retinal pigment epithelial (RPE) cells are

45 issues from hiPSCs using a single autologous hiPSCs as source and generates a range of stromal cells

46 We predict a growing convergence between hiPSC and post-mortem studies as both approaches expand

47 16) show that expression differences between hiPSC-cardiomyocytes provide a personalized drug testing

48 fferentiation were highly concordant between hiPSCs and hESCs, and clustering of 4 cell lines within

49 Both hiPSCs and hESCs share similar transcriptional regulator

50 luripotent stem cell-derived cardiomyocytes (hiPSC-CM) are increasingly being used for modeling heart

51 luripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are a powerful platform for uncovering diseas

52 luripotent stem cell-derived cardiomyocytes (hiPSC-CMs) can recapitulate the predilection to DIC of i

53 luripotent stem cell-derived cardiomyocytes (hiPSC-CMs) could be used to model the pathogenic process

54 luripotent stem cell-derived cardiomyocytes (hiPSC-CMs) for drug development and disease modeling stu

55 luripotent stem cell derived cardiomyocytes (hiPSC-CMs) offer a novel in vitro platform for pre-clini

56 luripotent stem cell-derived cardiomyocytes (hiPSC-CMs) provide new possibilities for evaluating drug

57 luripotent stem cell-derived cardiomyocytes (hiPSC-CMs), but D-ala,RP produgs, including MK-3682, did

58 luripotent stem cell-derived cardiomyocytes (hiPSC-CMs), fibroblasts (FB) and endothelial cells (EC)

59 luripotent stem cell-derived cardiomyocytes (hiPSC-CMs), Tbx20 enhanced human KCNH2 gene expression a

60 ods for human induced pluripotent stem cell (hiPSC) cardiac differentiation are efficient but require

61 rrected human induced pluripotent stem cell (hiPSC) clones in three different disease models.

62 heteroplasmic induced pluripotent stem cell (hiPSC) clones.

63 pendent human induced pluripotent stem cell (hiPSC) lines could be reverted to stable human preimplan

64 notyped human induced pluripotent stem cell (hiPSC) lines revealed unidirectional loss (Deltabeta=13%

65 rs into human induced pluripotent stem cell (hiPSC) lines.

66 pecific human induced pluripotent stem cell (hiPSC) model of CPVT2 and to use the generated hiPSC-der

67 enerate human induced pluripotent stem cell (hiPSC) models of JLNS, covering splice site (c.478-2A>T)

68 ll (hESC) and induced pluripotent stem cell (hiPSC) seeding with CPC for bone regeneration.

69 Human induced pluripotent stem cell (hiPSC) utility is limited by variations in the ability o

70 hogonal human induced pluripotent stem cell (hiPSC)-based RPE reporter assay.

71 ower of human induced pluripotent stem cell (hiPSC)-based studies to resolve the smaller effects of c

72 124, in human-induced pluripotent stem cell (hiPSC)-derived cardiomyocytes bearing nonsense mutations

73 l as in human induced pluripotent stem cell (hiPSC)-derived forebrain neurons and Ngn2-induced excita

74 lls and human-induced pluripotent stem cell (hiPSC)-derived neurons from NO-induced hypersensitivity

75 uding human inducible pluripotent stem cell (hiPSC)-derived neurons, that sulfide inhibited complex I

76 ipotent stem cell-derived endothelial cells (hiPSC-ECs) adopted a well-spread morphology within three

77 n of hiPSC-derived hepatic progenitor cells (hiPSC-HPCs) in a 3D environment that depicts the physiol

78 s (hESC) and induced pluripotent stem cells (hiPSC) can differentiate into many cell types and are im

79 d from human-induced pluripotent stem cells (hiPSC) exhibit an outwardly rectifying chloride current

80 Human induced pluripotent stem cells (hiPSC) represent a powerful tool for bone regeneration b

81 SC and human induced pluripotent stem cells (hiPSC) was demonstrated by flow cytometry, immunohistoch

82 fluent human induced pluripotent stem cells (hiPSC), bypassing embryoid body formation and the use of

83 em cells and induced pluripotent stem cells (hiPSC).

84 ags in human induced pluripotent stem cells (hiPSC).

85 d from human induced pluripotent stem cells (hiPSC-CMs), 41 were accurately quantified.

86 med to human induced pluripotent stem cells (hiPSCs) and differentiated to beating cardiomyocytes (CM

87 els of human induced pluripotent stem cells (hiPSCs) and hiPSC-derived oligodendrocytes from 12 indiv

88 h that human induced pluripotent stem cells (hiPSCs) and human embryonic stem cells (hESCs) have the

89 nce of human induced pluripotent stem cells (hiPSCs) and human embryonic stem cells (hESCs) remains c

90 s from human induced pluripotent stem cells (hiPSCs) and human embryonic stem cells (hESCs).

91 Human induced pluripotent stem cells (hiPSCs) are a robust source for cardiac regenerative the

92 d from human induced pluripotent stem cells (hiPSCs) are essential to personalized in vitro drug scre

93 o from human-induced pluripotent stem cells (hiPSCs) are immature relative to those in the human brai

94 Human induced pluripotent stem cells (hiPSCs) are invaluable to study developmental processes

95 Human induced pluripotent stem cells (hiPSCs) are useful in disease modeling and drug discover

96 Human-induced pluripotent stem cells (hiPSCs) can be differentiated into CMs (hiPSC-CMs) that

97 d that human induced pluripotent stem cells (hiPSCs) contained functional gap junctions partially con

98 o from human induced pluripotent stem cells (hiPSCs) derived from patients carrying a non-sense HNF4A

99 sed of human induced pluripotent stem cells (hiPSCs) derived multiple lineage cardiac cells with vari

100 ng the human induced pluripotent stem cells (hiPSCs) differentiation system, we fully characterized m

101 detect human induced pluripotent stem cells (hiPSCs) down to a spiked level of 0.05% of hiPSCs in a h

102 Human induced pluripotent stem cells (hiPSCs) enable the study of pharmacological and toxicolo

103 use of human-induced pluripotent stem cells (hiPSCs) for modelling gliomagenesis.

104 ses in human induced pluripotent stem cells (hiPSCs) from a healthy donor and patients with SVs.

105 ion of human-induced pluripotent stem cells (hiPSCs) from patients with diagnosed AMD, including two

106 Human induced pluripotent stem cells (hiPSCs) have potential for personalized and regenerative

107 Human induced pluripotent stem cells (hiPSCs) hold promise for myocardial repair following inj

108 ient-derived induced pluripotent stem cells (hiPSCs) into hepatocyte-like cells (HLCs) holds great pr

109 (hESCs) and induced pluripotent stem cells (hiPSCs) is fundamental for realising their promise in di

110 (hESCs) and induced pluripotent stem cells (hiPSCs) manifests key properties of naive state cells.

111 ing of human induced pluripotent stem cells (hiPSCs) offers unprecedented opportunities for in vitro

112 onvert human induced pluripotent stem cells (hiPSCs) or embryonic stem cells (hESCs) into cells simil

113 s into human induced pluripotent stem cells (hiPSCs) provides a new tool that supplies live human neu

114 an clones of induced pluripotent stem cells (hiPSCs) remains a limitation in assembling high-quality

115 ion of human induced pluripotent stem cells (hiPSCs) result in low yields, cellular heterogeneity, an

116 Human induced pluripotent stem cells (hiPSCs) show great promise for obesity treatment as they

117 (hESCs) and induced pluripotent stem cells (hiPSCs) to regenerative medicine, the cells should be pr

118 ciated human induced pluripotent stem cells (hiPSCs) was developed.

119 uch as human induced pluripotent stem cells (hiPSCs), is therefore attractive for engineering cartila

120 n from human induced pluripotent stem cells (hiPSCs).

121 (hESCs), and induced pluripotent stem cells (hiPSCs).

122 (hESCs) and induced pluripotent stem cells (hiPSCs).

123 ion of human induced pluripotent stem cells (hiPSCs).

124 t from human induced pluripotent stem cells (hiPSCs).

125 s from human induced pluripotent stem cells (hiPSCs).

126 g from human induced pluripotent stem cells (hiPSCs).

127 s and to primary cells, including CHO cells, hiPSC-CMs, and human astrocytes derived in 3D cortical s

128 osis, indicating immune rejection of certain hiPSC-derived cells.

129 lls (hiPSCs) can be differentiated into CMs (hiPSC-CMs) that model cardiac contractile mechanical out

130 ear bundles, ML) and a gel matrix containing hiPSC-derived cardiomyocytes, endothelial, and vascular

131 the rapid generation of robustly contracting hiPSC-CMs and enhances maturation.

132 <0.1-mm thick 1:60 diluted Matrigel, control hiPSC-CMs).

133 e are numerus protocols which aim to control hiPSC differentiation.

134 Unlike control hiPSC-CMs, mattress hiPSC-CMs display robust contractile

135 Compared with control hiPSC-CMs, mattress hiPSC-CMs had more rod-shape morphol

136 ersion of a broad repertoire of conventional hiPSCs reduced lineage-primed gene expression and signif

137 ous in efficiently reprogrammed conventional hiPSCs.

138 d-induced Ca(2+)-release events in the CPVT2-hiPSC cardiomyocytes when compared with healthy control

139 PSC-CMs were consistent across cryopreserved hiPSC-CMs generated independently at another institution

140 After 28 days of in vitro culture, hiPSC-derived progenitor cells differentiate into a mono

141 taneous implantation in rodents, co-cultured hiPSC-MSC/-macrophage on such scaffolds showed mature bo

142 To date hiPSC-CMs used for cardiotoxicity testing display an imm

143 We applied the platform to DMD-derived hiPSCs where successful deletion and non-homologous end

144 and human dermal fibroblasts (hDFs) derived hiPSCs.

145 ndings support the feasibility of developing hiPSC-derived RPEs for treating macular degeneration.

146 h for generating and then co-differentiating hiPSC-derived progenitors.

147 th factor-based protocol for differentiating hiPSCs into articular-like chondrocytes (hiChondrocytes)

148 round-bottom microwells to host dissociated hiPSCs.

149 Not only do hiPSCs offer unprecedented opportunities to study cellul

150 ing component expression and function during hiPSC-CM maturation.

151 CD140(low) prechondrogenic population during hiPSC differentiation.

152 In "early" hiPSC-CMs (less than or equal to d 30), beta2-ARs are a

153 hydrogel-based triculture model that embeds hiPSC-HPCs with human umbilical vein endothelial cells a

154 A NGS as a new selection criterion to ensure hiPSC quality for drug discovery and regenerative medici

155 potent stem cell-retinal pigment epithelium (hiPSC-RPE) derived from patients with three dominant MDs

156 This study features the first hiPSC model of RBM20 familial DCM.

157 atomas formed by autologous integration-free hiPSCs exhibit local infiltration of antigen-specific T

158 d techniques for generating integration-free hiPSCs.

159 ency of RPCs generated from integration-free hiPSCs.

160 s and osteoclasts can be differentiated from hiPSC-mesenchymal stem cells and macrophages when co-cul

161 Thus, large-format ECTs generated from hiPSC-derived cardiac cells may be feasible for large an

162 and multiple vascular lineages derived from hiPSCs and incorporated into ECTs promotes functional ma

163 Excitatory neurons derived from hiPSCs with CRISPR/Cas9-edited rs1198588 or a rare proxi

164 scular mural cells (MCs) differentiated from hiPSCs.

165 global OCRs in neurons differentiating from hiPSCs, a cellular model for studying neurodevelopmental

166 ing early cardiomyocyte differentiation from hiPSCs and hESCs.

167 ncreased, cardiomyocyte differentiation from hiPSCs.

168 roducing human mesencephalic DA neurons from hiPSCs.

169 sistent hPGCLCs can be readily produced from hiPSCs after transition of their pluripotency from the p

170 onstrates derivation of complex tissues from hiPSCs using a single autologous hiPSCs as source and ge

171 ication of reprogramming methods to generate hiPSCs.

172 PSC) model of CPVT2 and to use the generated hiPSC-derived cardiomyocytes to gain insights into patie

173 We generated hiPSC from 2 patients carrying the mutations R1638X and

174 gs present a favorable method for generating hiPSC-derived articular-like chondrocytes.

175 typic analyses demonstrated that these hESCs/hiPSCs are similar in their osteogenic differentiation e

176 col starting from embryoid bodies of hiPSCs (hiPSC-EBs) for robust mass production of human hepatocyt

177 However, hiPSC-BAPs display a low adipogenic capacity compared to

178 structs using biomaterials as an implantable hiPSC-derived myocardium provides a path to realize sust

179 normal expression of immunogenic antigens in hiPSC-derived SMCs, but not in hiPSC-derived RPEs.

180 to cardiotoxicity, and functional assays in hiPSC-CMs using tacrolimus and rosiglitazone, drugs targ

181 C Tbx20 did not increase KCNH2 expression in hiPSC-CMs, which led to decreased IhERG and increased AP

182 c antigens in hiPSC-derived SMCs, but not in hiPSC-derived RPEs.

183 cue of the electrophysiological phenotype in hiPSC-derived cardiomyocytes from the patients.

184 Transcriptome profiling in hiPSC-CMs from seven individuals lacking known cardiovas

185 pacity to abrogate CVB3-Luc proliferation in hiPSC-CMs in vitro.

186 ompounds to reduce CVB3-Luc proliferation in hiPSC-CMs was consistent with reported drug effects in p

187 Viral proliferation in hiPSC-CMs was quantified using bioluminescence imaging.

188 This current is severely reduced in hiPSC-RPE cells derived from macular dystrophy patients

189 beta-AR functionalvs remodeling signaling in hiPSC-CMs has important implications for their use in di

190 Dysregulation of RTK and p53 signalling in hiPSC-derived NPCs (iNPCs) recapitulates GTIC properties

191 ntly increased gene-correction efficiency in hiPSCs.

192 pment, neurogenesis and synapse formation in hiPSCs-derived cortical neurons.

193 Knockdown of SOX2 in hiPSCs led to decreased HBL1 expression and increased ca

194 fferences between in vitro models, including hiPSC-derived neural progenitors from multiple laborator

195 Indeed, hiPSC-CMs recapitulate RBM20 familial DCM phenotype in a

196 g were used to characterize virally infected hiPSC-CMs for alterations in cellular morphology and cal

197 the immunogenicity of autologous human iPSC (hiPSC)-derived cells is not well understood.

198 lop a strategy to differentiate human iPSCs (hiPSCs) into CD200(+)/ITGA6(+) EpSCs that can reconstitu

199 and clinical constraints currently limiting hiPSC-based studies.

200 ivation/characterization of gene-manipulated hiPSC clones.

201 Mattress hiPSC-CMs exhibit molecular changes that include increas

202 Unlike control hiPSC-CMs, mattress hiPSC-CMs display robust contractile responses to positi

203 Compared with control hiPSC-CMs, mattress hiPSC-CMs had more rod-shape morphology and significantl

204 ick mattress of undiluted Matrigel (mattress hiPSC-CMs) and compared with hiPSC-CMs maintained on a c

205 Contractile parameters of mattress hiPSC-CMs measured with video-based edge detection were

206 gical and contractile properties of mattress hiPSC-CMs were consistent across cryopreserved hiPSC-CMs

207 rm consisting of either fetal-like or mature hiPSC-CM monolayers.

208 Our MFS-hiPSC-derived smooth muscle cells (SMCs) recapitulated t

209 om human induced pluripotent stem cells (MFS-hiPSCs).

210 he cardiac function of single micropatterned hiPSC-CMs and determine contractile parameters that can

211 e mechanical output of single micropatterned hiPSC-CMs from microscopy videos.

212 Whole-genome sequencing of Cas9-modified hiPSC clones detects neither gross genomic alterations n

213 To date, we have generated multiple hiPSC lines with monoallelic green fluorescent protein t

214 ugh nuclear reprogramming, generating mutant hiPSCs with a detrimental effect in their differentiated

215 as called into question the applicability of hiPSC-CM findings to the adult heart.

216 Electrophysiological comparison of hiPSC-derived cardiomyocytes (CMs) from homozygous JLNS,

217 nd mature excitation-contraction coupling of hiPSC-CM when cultured on extracellular matrix with phys

218 l arterial disease, MITCH-PEG co-delivery of hiPSC-ECs and VEGF was found to reduce inflammation and

219 Upon differentiation of hiPSC into hepatocyte-like cells, the sialyl-lactotetra

220 Engraftment of hiPSC-derived adipocytes in mice produces well-organized

221 However, long-term in vivo engraftment of hiPSC-derived VPs into the retina has not yet been repor

222 that reducing the clinical heterogeneity of hiPSC-based studies, by selecting subjects with common c

223 lete structural and functional maturation of hiPSC-CM, including lack of T-tubules, immature excitati

224 h" platform for 3D culture and maturation of hiPSC-CMs that after 5 weeks of differentiation show rob

225 d to the indices of phenotypic maturation of hiPSC-CMs.

226 have demonstrated the in vitro maturation of hiPSC-derived hepatic progenitor cells (hiPSC-HPCs) in a

227 The clonal nature of hiPSC lines allows a high-resolution analysis of the gen

228 g mutations and demonstrate the potential of hiPSC-CMs in drug evaluation.

229 genetic disorders, to maximize the power of hiPSC cohorts currently feasible, in most cases and when

230 ic analyses via gene expression profiling of hiPSC-CMs infected with CVB3-Luc revealed an activation

231 reater senescence, and poor proliferation of hiPSC-derived vascular cells.

232 Here we show that maturation state of hiPSC-CMs determines the absolute pro-arrhythmia risk sc

233 Thus, the maturation state of hiPSC-CMs should be considered prior to pro-arrhythmia a

234 Cell transplantation of hiPSC-EB-HLC in a rat model of acute liver failure signi

235 us one step closer to the anticipated use of hiPSC for disease modelling and open possibilities for f

236 e maturation method could advance the use of hiPSC-CM for disease modeling and cell-based therapy.

237 rovide enabling technology for future use of hiPSC-CM tissues in human heart repair.

238 (hiPSCs) down to a spiked level of 0.05% of hiPSCs in a heterogeneous population and can prevent ter

239 These results demonstrate the ability of hiPSCs cardiomyocytes to recapitulate CPVT2 disease phen

240 on protocol starting from embryoid bodies of hiPSCs (hiPSC-EBs) for robust mass production of human h

241 independent replication cohort consisting of hiPSCs reprogrammed from different cell types and differ

242 Differentiation of hiPSCs to cortical neurons with extended period demonstr

243 ther, our results highlight the potential of hiPSCs for studying human tumourigenesis.

244 Use of hiPSCs allowed evaluation of dystrophin in disease-relev

245 otent cells is a prerequisite for the use of hiPSCs to study disease mechanisms, for drug discovery,

246 cal role of TGFbeta pathway in switching off hiPSC-brown adipogenesis and revealed novel factors to u

247 effect of cardiomyocyte maturation state on hiPSC-CM drug responsiveness.

248 Moreover, the photoreceptors in our hiPSC-derived retinal tissue achieve advanced maturation

249 an brain, gene expression comparisons of our hiPSC-derived neurons to the Allen BrainSpan Atlas indic

250 eneath both control (unaffected) and patient hiPSC-RPE cells.

251 al complement genes was also seen in patient hiPSC-RPE cultures of all three MDs (SFD, DHRD, and ADRD

252 Importantly basal deposits in patient hiPSC-RPE cultures were more abundant and displayed a li

253 mposition of drusen-like deposits in patient hiPSC-RPE cultures.

254 ved in ECM isolated from control vs. patient hiPSC-RPE cultures.

255 ion, being a potential cause of intra-person hiPSC variability.

256 , there has been modest success in producing hiPSC-derived organotypic tissues or organoids.

257 corbic acid and EGF were required to promote hiPSCs-BAP differentiation at a level similar to adult-B

258 All methods generated high-quality hiPSCs, but significant differences existed in aneuploid

259 Indeed, RBM20 hiPSC-CMs exhibited increased sarcomeric length (RBM20:

260 eletal muscle myotubes derived from reframed hiPSC clonal lines had restored dystrophin protein.

261 The development of clinically relevant hiPSC derivation methods from patients and demonstration

262 en at the expense of the number of replicate hiPSC clones.

263 The resultant hiPSC-EB-HLCs expressed liver-specific genes, secreted h

264 n, comparable to that accumulated in routine hiPSC culture.

265 Automated and selective hiPSC-elimination was achieved by controlling puromycin

266 Single hiPSC-CMs were cultured for 5 to 7 days on a 0.4- to 0.8

267 METHODS AND We micropatterned single hiPSC-CMs on deformable polyacrylamide substrates contai

268 Specifically, hiPSC-derived cardiomyocytes with expanded mtDNA mutatio

269 SZ hiPSC-derived neurons is conserved in SZ hiPSC neural progenitor cells (NPCs).

270 alyses-to identify cellular phenotypes in SZ hiPSC NPCs from four SZ patients.

271 gration and increased oxidative stress in SZ hiPSC NPCs.

272 ificant fraction of the gene signature of SZ hiPSC-derived neurons is conserved in SZ hiPSC neural pr

273 From our findings that SZ hiPSC NPCs show abnormal gene expression and protein lev

274 n in a large case/control schizophrenia (SZ) hiPSC-derived cohort of neural progenitor cells and neur

275 ing the late features of schizophrenia (SZ), hiPSC-based models may be better suited for the study of

276 more sensitive to doxorubicin toxicity than hiPSC-CMs from patients who did not experience DIC, with

277 We provide evidence that hiPSC variability with respect to CHCHD2 expression and

278 Taken together, our data indicate that hiPSC-CMs are a suitable platform to identify and charac

279 Here we report that hiPSC can, in a highly autonomous manner, recapitulate s

280 Our data suggest that hiPSC-CMs can be used in vitro to predict and validate p

281 These results indicate that hiPSCs can be generated and maintained under this novel

282 C) lines and hiPSC lines and have shown that hiPSCs are inferior in their ability to undergo neuroect

283 The hiPSC-derived CD200(+)/ITGA6(+) cells show a similar gen

284 The hiPSC-derived RPE cells produce several AMD/drusen-relat

285 Both the hiPSC- and hESC-derived hEBs expressed key proteins char

286 as a marker for assessing and comparing the hiPSC clonal and/or line differentiation potential provi

287 henotypic and functional enhancements in the hiPSC-HPCs over weeks of in vitro culture.

288 Our results suggest that the hiPSC-CM/CVB3-Luc assay is a sensitive platform that can

289 RPE cells differentiated from these hiPSCs contained morphologically abnormal mitochondria a

290 a staining on all seven hESC lines and three hiPSC lines analyzed, whereas no staining of hESC-derive

291 gineered nucleases with no donor template to hiPSCs, and genotyping and derivation/characterization o

292 The transplanted hiPSC-EB-HLCs secreted human albumin into the host plasm

293 cardiomyocytes, T-tubules in T3+Dex-treated hiPSC-CM were less organized and had more longitudinal e

294 Using hiPSCs derived under chemically defined conditions on sy

295 I model highlight the potential of utilizing hiPSC-derived cells for cardiac repair.

296 he contribution of cellular origin (hESC vs. hiPSC), the Sendai virus (SeV) reprogramming method and

297 However, the accuracy with which hiPSC-CMs recapitulate the contractile and remodeling si

298 rigel (mattress hiPSC-CMs) and compared with hiPSC-CMs maintained on a control substrate (<0.1-mm thi

299 potential upstroke velocities compared with hiPSC-derived cardiomyocytes from 2 unrelated control in

300 entially activated in SE cells compared with hiPSCs.