ライフサイエンスコーパス: hibernate

1 squirrels before any of the animals began to hibernate.

2 utside of Madagascar was previously known to hibernate.

3 Toolkit, and server-side data storage using Hibernate.

4 axis, increases its body weight, and finally hibernates.

5 The bacterial hibernating 100S ribosome is a poorly understood form of

6 584 segments, 24% (n = 140) were labeled as hibernating; 23% (n = 136) as stunned; 30% (n = 177) as

7 mine, was observed in 83% of stunned, 59% of hibernating, 35% of remodeled and 13% of scarred myocard

8 l because only 55% of segments classified as hibernating actually improved resting function after rev

9 Ascorbate levels in the CSF doubled in hibernating AGS (not determined in TLS), while brain asc

10 osmolarity and pH outside the incubator with Hibernate and density gradient separation of neurons fro

11 -altitude inhabitants, as well as those that hibernate and interrupt their development when exposed t

12 but kinase-knockout clones still are able to hibernate and recover, indicating that this pathway does

13 me, and hematological features of blood from hibernating and active free-ranging subadult brown bears

14 The brain tissue from hibernating and euthermic animals was examined 3 days af

15 utyric acid ([GABA](ecf)) in striatum of non-hibernating and hibernating arctic ground squirrels to t

16 se-3-like activity was not different between hibernating and summer kidneys.

17 nconsistent bloodstream amino acid supply by hibernating and waiting for more nutrient to be provided

18 d by fibrosis from that arising from viable (hibernating and/or stunned) myocardium has important imp

19 ptable mammals, spending up to half the year hibernating, and the remainder of the year attempting to

20 It may also be induced in nonhibernators via hibernating animal serum factors or delta-opiate peptide

21 emical findings were compared with untreated hibernating animals (n = 7), sham-normal animals (n = 5)

22 amatically attenuated around probe tracks in hibernating animals compared to euthermic controls.

23 respect from nature: Diving, burrowing, and hibernating animals living in diverse environments are m

24 similarities between calorie-restricted and hibernating animals suggest the effects of CR may be par

25 shutdown of cellular functions that permits hibernating animals to tolerate severe reductions in cer

26 Kidneys from both summer and hibernating animals tolerated ex vivo CI, confirming tha

27 SCs were observed postsynaptic to cones from hibernating animals, although depolarized cones were abl

28 An uncharacterized factor derived from hibernating animals, hibernation induction trigger (HIT)

29 34 interactions were disrupted in brain from hibernating animals, in which eIF-2alpha was highly phos

30 imer-like phosphorylation is also present in hibernating animals, mitosis, or during embryonic develo

31 In hibernating animals, reduction of immunoreactive phospho

32 tolerance to cerebral ischemia exhibited by hibernating animals.

33 BA](ecf)) in striatum of non-hibernating and hibernating arctic ground squirrels to test the hypothes

34 neural microstructure from groups of animals hibernating at different ambient temperatures revealed t

35 ose syndrome (WNS) is an emerging disease of hibernating bats associated with cutaneous infection by

36 drome (WNS) is an emerging disease affecting hibernating bats in eastern North America that causes ma

37 We show, in hibernating bats infected with Geomyces destructans, tha

38 ts a pronounced northward range expansion of hibernating bats within the next 80 years.

39 proliferates at low temperatures and targets hibernating bats, resulting in their premature arousal f

40 uctans on the skin (including the muzzle) of hibernating bats.

41 on and delayed recovery of metabolic rate in hibernating bears suggest that the majority of metabolic

42 hat fast during lactation, such as seals and hibernating bears.

43 w temperatures, and perhaps their ability to hibernate below the permafrost, might explain the abilit

44 sured metabolic rate and body temperature in hibernating black bears and found that they suppress met

45 Administration of serum derived from hibernating black bears to rabbits affords protection ag

46 ranscription-PCR products from euthermic and hibernating brain and compared them using differential d

47 as reduced 3-fold in cell-free extracts from hibernating brain at 37 degreesC, eliminating hypothermi

48 rpose of this study was to determine whether hibernating brain tissue is tolerant to penetrating brai

49 of the catalytic subunit of PP2A (PP2A/C) in hibernating brains and livers.

50 Among patients with ischemic cardiomyopathy, hibernating, but not ischemic, myocardium identifies whi

51 Hibernating cardiomyocytes are reversibly hypocontractil

52 approximately 124% and 99%, respectively, in hibernating compared with cold control preparations with

53 The remaining SCNx squirrels that did not hibernate continuously displayed CARs in body mass withi

54 ether animals prepare to develop, reproduce, hibernate, enter dormancy, or migrate.

55 Thus, the torpid/awakening cycle of the hibernating European hamster causes a rapid and reversib

56 Black bears hibernate for 5 to 7 months a year and, during this time

57 Brown bears (Ursus arctos) hibernate for 5-7 months without eating, drinking, urina

58 Unlike normal squirrels that hibernate for about 6 months during each circannual cycl

59 ts during the migratory season and sometimes hibernate for an entire winter.

60 Western fat-tailed dwarf lemurs are known to hibernate for seven months per year inside tree holes.

61 rrels that did not hibernate or had not been hibernating for several weeks.

62 one of euthermic (control), cold control and hibernating golden hamsters.

63 Isolated hibernating ground squirrel and mouse RTECs were subject

64 d for weeks in brain and other organs of the hibernating ground squirrel, Spermophilus tridecemlineat

65 uirrels (T(b) range 34.7-38.9 degrees C) and hibernating ground squirrels (T(b) range 2.9-3.9 degrees

66 BA](ecf) was determined in unrestrained, non-hibernating ground squirrels (T(b) range 34.7-38.9 degre

67 , suggest that light can reach the retina of hibernating ground squirrels maintained in the laborator

68 rites, and spines from several cell types in hibernating ground squirrels retract on entry into torpo

69 ng hibernation and arousal in two species of hibernating ground squirrels suggest that it could play

70 d shutdown of cellular function that permits hibernating ground squirrels to tolerate "trickle" blood

71 bular epithelial cells (RTECs) isolated from hibernating ground squirrels would be protected against

72 eriments, we looked at mlEPSCs from cones of hibernating ground squirrels, which exhibit dramatically

73 -2) was observed in the brains and livers of hibernating ground squirrels.

74 everal types of neurons in fixed slices from hibernating ground squirrels.

75 n cold controls and markedly enhanced in the hibernating group at all frequencies tested.

76 In the hibernating group, NTG alone improved wall thickening in

77 ificantly enhanced in both cold controls and hibernating groups, while vasoconstriction in response t

78 ificantly increased in the renal arteries of hibernating hamsters compared with controls, but not com

79 The ultrastructure of MFT in hibernating hamsters showed a significant reduction in s

80 y in the pancreas, but when expressed in the hibernating heart it liberates fatty acids from triglyce

81 val underlies the sustained viability of the hibernating heart.

82 on after revascularization in these areas of hibernating heart.

83 In hibernating hearts, icMSCs increased Ki67+ cardiomyocyte

84 y be related to the temperature range of its hibernating host.

85 teristics of the cardiac interstitium in the hibernating human myocardium and evaluate whether active

86 ular necrosis and apoptosis did not occur in hibernating kidneys.

87 g perfusion was significantly reduced in the hibernating LAD region in comparison with the normal rem

88 increased from 2.4+/-0.04 to 4.7+/-0.7 mm in hibernating LAD regions (P<0.05) whereas remote wall-thi

89 and a long-term (1976-2008) data set from a hibernating mammal (the yellow-bellied marmot) inhabitin

90 of the dynamics of the body temperature of a hibernating mammal is presented.

91 d cardiac ischemia but are well tolerated by hibernated mammalian myocardium.

92 Hibernating mammals are remarkable for surviving near-fr

93 shortage and/or reduced ambient temperatures hibernating mammals become heterothermic, allowing their

94 Torpor in hibernating mammals defines the nadir in mammalian metab

95 Neurons in hibernating mammals exhibit a dramatic form of plasticit

96 Hibernating mammals possess a unique ability to reduce t

97 Hibernating mammals survive for periods up to 6 mo in th

98 In hibernating mammals, cooling induces loss of synaptic co

99 ypothermic and hypometabolic torpid state in hibernating mammals, we investigated the potential for t

100 uction and energy expenditure in infants and hibernating mammals-also exists in adult humans.

101 has been shown to be cerebral protective in hibernating mammals.

102 Apoptotic myocytes were observed in the hibernating myocardial region in all pigs (4.8 +/- 2.3%)

103 vidence for a local inflammatory reaction in hibernating myocardial segments from patients undergoing

104 sion imaging detects impaired resting MBF in hibernating myocardial segments.

105 ly perfused remote regions from animals with hibernating myocardium (32+/-7%).

106 20+/-77 myocytes per 10(6) myocyte nuclei in hibernating myocardium (P<0.05).

107 nt in LVEF was associated with the volume of hibernating myocardium (viable myocardium with contracti

108 coronary artery (LAD) stenosis that produced hibernating myocardium after 3 months.

109 licits a gene program of survival protecting hibernating myocardium against cell death.

110 ibitory cytokines are elevated in regions of hibernating myocardium and account in part for the depre

111 GF-5 may afford a way to restore function in hibernating myocardium and ameliorate heart failure in c

112 renergic receptor densities occur in viable, hibernating myocardium and may account in part for the o

113 period (P<0.05 versus untreated animals with hibernating myocardium and normal shams).

114 Swine with hibernating myocardium arising from a chronic left anter

115 that can accurately determine the amount of hibernating myocardium as well as the presence and degre

116 re is evidence to suggest that patients with hibernating myocardium benefit most from revascularizati

117 coplasmic reticulum proteins were present in hibernating myocardium but absent in stunned myocardium

118 thickening at low-dose DSE may be limited in hibernating myocardium by severe hypoperfusion.

119 umented with a proximal LAD stenosis develop hibernating myocardium characterized by relative reducti

120 ysiological and molecular characteristics of hibernating myocardium develop rapidly after a critical

121 Hibernating myocardium developed a significant downregul

122 Previous studies have suggested that hibernating myocardium eventually results in progressive

123 proved clinically useful for distinguishing hibernating myocardium from irreversibly injured myocard

124 nuclear density to 995+/-100 nuclei/mm(2) in hibernating myocardium from the instrumented group versu

125 fter 2 weeks, when physiological features of hibernating myocardium had developed.

126 acked necrosis, might have been mistaken for hibernating myocardium had only histology been evaluated

127 rsibility of protein changes that develop in hibernating myocardium have an impact on functional reco

128 Although humans and swine with hibernating myocardium have an increased risk of sudden

129 al function and heart failure, dysfunctional hibernating myocardium improves after pravastatin.

130 Hibernating myocardium in patients with collateral-depen

131 ced flow and increased FDG characteristic of hibernating myocardium in similarly instrumented pigs af

132 Delayed recovery of hibernating myocardium in the absence of scar may reflec

133 Previous studies of hibernating myocardium in the fasting state have shown r

134 cyte >10%) and increased glycogen typical of hibernating myocardium in the LAD region (33+/-3% of myo

135 New modalities to detect hibernating myocardium include 99mTc-sestamibi, contrast

136 lts indicate that icMSCs improve function in hibernating myocardium independent of coronary flow or r

137 Several models purported to represent hibernating myocardium involve a coronary stenosis (CS)

138 The diagnosis of hibernating myocardium involves (a) documenting left ven

139 These data support the notion that hibernating myocardium is a pathophysiological substrate

140 Hibernating myocardium is a state of persistently impair

141 Hibernating myocardium is accompanied by a downregulatio

142 his study was performed to determine whether hibernating myocardium is adaptive or is destined to und

143 lation of oxygen consumption and function in hibernating myocardium is an adaptive response that prev

144 Hibernating myocardium is associated with persistent red

145 ata indicate that the proteomic phenotype of hibernating myocardium is dynamic and has similarities t

146 0.65+/-0.08 (mean+/-SEM) mL.min(-1).g(-1) in hibernating myocardium of instrumented pigs compared wit

147 F-A improves contractile function of chronic hibernating myocardium of pigs to a level comparable to

148 on tomography identified ischemia, scar, and hibernating myocardium on the survival benefit associate

149 Swine with chronic hibernating myocardium received autologous intracoronary

150 Hibernating myocardium refers to chronically dysfunction

151 Thus, physiologic and structural features of hibernating myocardium remain constant for at least two

152 ster and more precise method for determining hibernating myocardium remains the holy grail of noninva

153 , can be initiated by regional dysfunctional hibernating myocardium resulting from a severe coronary

154 in function and oxygen consumption at rest, hibernating myocardium retains the ability to increase m

155 and the presence of ischemia and/or stunned/hibernating myocardium should be assessed for optimal ma

156 designed to study apoptosis in hypoperfused hibernating myocardium subtending severe coronary stenos

157 tricular dysfunction (LVD) may have areas of hibernating myocardium that improve functionally after r

158 gene expression is regionally upregulated in hibernating myocardium to a level intermediate between t

159 te the serial changes in the response of the hibernating myocardium to dobutamine stimulation after r

160 is heterogeneous, varying from predominantly hibernating myocardium to irreversible scarring.

161 f contractile reserve and thallium uptake in hibernating myocardium to myocardial structure in humans

162 descending artery (LAD) stenosis to produce hibernating myocardium underwent percutaneous revascular

163 egion (33+/-3% of myocytes from animals with hibernating myocardium versus 15+/-4% of myocytes from s

164 ascularization in the setting of significant hibernating myocardium was associated with improved surv

165 Human hibernating myocardium was characterized by an upregulat

166 Hibernating myocardium was characterized by severe regio

167 n the fasting state, FDG uptake in pigs with hibernating myocardium was heterogeneous and was increas

168 Although, originally, hibernating myocardium was identified by a mismatch betw

169 After 3 months (n=8), hibernating myocardium was present as reflected by reduc

170 The physiological substrate of hibernating myocardium was present before SCD, with redu

171 An interaction between treatment and hibernating myocardium was present such that early revas

172 At 3 months, physiological features of hibernating myocardium were confirmed, with depressed LA

173 MCE parameters of perfusion in hibernating myocardium were similar to segments with nor

174 The improvement of wall thickening of hibernating myocardium with NTG and dobutamine, from 23.

175 We previously produced hibernating myocardium with reduced resting flow in pigs

176 ing artery (LAD) stenosis to produce chronic hibernating myocardium with regional contractile dysfunc

177 n reversible loss of cardiomyocyte function (hibernating myocardium), which is amenable to therapeuti

178 t persistent myocardial stunning can lead to hibernating myocardium, 13 pigs were chronically instrum

179 nal myocardium with reduced resting flow, or hibernating myocardium, after 3 mo.

180 emodeling in the cardiac interstitium of the hibernating myocardium, an important predictor of recove

181 There was no lactate production in hibernating myocardium, and lactate uptake increased dur

182 identification of candidates with regions of hibernating myocardium, because these patients stand to

183 measured the expression of survival genes in hibernating myocardium, both in patients surgically trea

184 hat dobutamine echocardiography can identify hibernating myocardium, but laboratory studies suggest t

185 Hibernating myocardium, characterized by reductions in f

186 In hibernating myocardium, icMSCs increased function (perce

187 ion in coronary BF in conscious pigs induced hibernating myocardium, ie, perfusion-contraction matchi

188 Hibernating myocardium, ischemic myocardium, and scarred

189 In hibernating myocardium, MIBG deposition was decreased in

190 Using an established model of chronic hibernating myocardium, mini-swine underwent 90% proxima

191 this preclinical swine model of ischemic and hibernating myocardium, the combined delivery of circula

192 t in perfusion reserve is well recognized in hibernating myocardium, there is substantial controversy

193 tensive defects in HED uptake were found for hibernating myocardium, with regional retention approxim

194 ta4 in a translational large animal model of hibernating myocardium.

195 titative CMR perfusion imaging is reduced in hibernating myocardium.

196 beta-receptor adenylyl cyclase signaling in hibernating myocardium.

197 ion is attenuated in patients and swine with hibernating myocardium.

198 mpathetic norepinephrine uptake in pigs with hibernating myocardium.

199 survival of medically treated patients with hibernating myocardium.

200 rapeutic efficacy in a large animal model of hibernating myocardium.

201 entricular dysfunction are features of human hibernating myocardium.

202 ative to revascularisation for patients with hibernating myocardium.

203 lic adjustments could facilitate survival of hibernating myocardium.

204 r non-hibernators according to the volume of hibernating myocardium.

205 the excess mortality seen in the setting of hibernating myocardium.

206 the observed depression of function seen in hibernating myocardium.

207 l, molecular, and morphological phenotype of hibernating myocardium.

208 pinephrine uptake-1 mechanism is impaired in hibernating myocardium.

209 he result of a mixture of scarred as well as hibernating myocardium.

210 tural adaptations was evaluated in pigs with hibernating myocardium.

211 ntadecanoic acid (IPPA), to identify viable, hibernating myocardium.

212 EGF(165) GTx may successfully rescue foci of hibernating myocardium.

213 n PET has been used successfully to diagnose hibernating myocardium.

214 cardium having the physiological features of hibernating myocardium.

215 nctional recovery after revascularization in hibernating myocardium.

216 nse to dobutamine have been used to identify hibernating myocardium.

217 ventricular arrhythmias, and reperfusion of hibernating myocardium.

218 ustained, the result is necrosis rather than hibernating myocardium.

219 gh-dose dobutamine from inducing ischemia in hibernating myocardium.

220 has been increasingly used for detection of hibernating myocardium.

221 stenosis and to 78+/-17 mL 7 days later with hibernating myocardium.

222 th through myocyte apoptosis in hypoperfused hibernating myocardium.

223 inducing deterioration of wall thickening in hibernating myocardium.

224 injected transendocardially in the areas of hibernating myocardium.

225 s using a clinically relevant swine model of hibernating myocardium.

226 ncreasing myocardial perfusion in swine with hibernating myocardium.

227 resting myocardial blood flow is reduced in hibernating myocardium.

228 d stability of sympathetic dysinnervation in hibernating myocardium.

229 d for at least 2 mo after the development of hibernating myocardium.

230 ) to improve flow and function in swine with hibernating myocardium.

231 Many of these patients have "hibernating" myocardium secondary to chronic ischemia wi

232 reas of nonfunctional but viable (stunned or hibernating) myocardium can also contribute to the devel

233 he reversibility of molecular adaptations of hibernating myocytes.

234 olonged torpor and in squirrels that did not hibernate or had not been hibernating for several weeks.

235 EF might be mediated by improved function of hibernating or ischaemic myocardium, or both.

236 ntractile myocardium, which is distinct from hibernating or stunned myocardium.

237 ersibly hypocontractile myocardium as simply hibernating or stunned.

238 factors ribosome modulation factor (RMF) and hibernating promoting factor (HPF) were shown to directl

239 arvester ants, in which only colonies with a hibernated queen produce new queens.

240 ed transmural variation in FDG uptake in the hibernating region (LAD/normal), which averaged 2.5 +/-

241 p, NTG alone improved wall thickening in the hibernating region modestly from 11.4+/-7.2% at baseline

242 in(-1)) dobutamine on wall thickening in the hibernating region.

243 zation may be an adaptive mechanism in such "hibernating" regions.

244 cterize dysfunctional myocardium as stunned, hibernating, remodeled and nonviable.

245 Hibernating ribosomes are formed by the activity of one

246 peratures for brief intervals throughout the hibernating season.

247 a marker of active remodeling, was higher in hibernating segments than in segments with persistent dy

248 duced a torpor-like state similar to that in hibernating species and characterized by a marked fall i

249 y plays a primary adaptive role which allows hibernating species to tolerate such phenomena.

250 iod of snow cover also have implications for hibernating species.

251 The results show that [GABA](ecf) in non-hibernating squirrels was 73 nM and this level was decre

252 the changes from a state of activity to the hibernating state are poorly understood; however, the se

253 itiation, regulation, and maintenance of the hibernating state.

254 Myocardial segments were defined as hibernating, stunned, remodeled or scarred.

255 yzes the regulation of ischemic tolerance in hibernating thirteen-lined ground squirrels (Spermophilu

256 cantly reduced as was its kinase activity in hibernating thirteen-lined ground squirrels.

257 e observation that eastern dwarf lemurs also hibernate, though in self-made underground hibernacula.

258 The tissue was shipped overnight in Hibernate transport medium.

259 Our findings that dwarf lemurs can hibernate underground in tropical forests draw unforesee