ライフサイエンスコーパス: hibernating

1 The bacterial hibernating 100S ribosome is a poorly understood form of

2 584 segments, 24% (n = 140) were labeled as hibernating; 23% (n = 136) as stunned; 30% (n = 177) as

3 mine, was observed in 83% of stunned, 59% of hibernating, 35% of remodeled and 13% of scarred myocard

4 l because only 55% of segments classified as hibernating actually improved resting function after rev

5 Ascorbate levels in the CSF doubled in hibernating AGS (not determined in TLS), while brain asc

6 me, and hematological features of blood from hibernating and active free-ranging subadult brown bears

7 The brain tissue from hibernating and euthermic animals was examined 3 days af

8 utyric acid ([GABA](ecf)) in striatum of non-hibernating and hibernating arctic ground squirrels to t

9 se-3-like activity was not different between hibernating and summer kidneys.

10 nconsistent bloodstream amino acid supply by hibernating and waiting for more nutrient to be provided

11 d by fibrosis from that arising from viable (hibernating and/or stunned) myocardium has important imp

12 ptable mammals, spending up to half the year hibernating, and the remainder of the year attempting to

13 It may also be induced in nonhibernators via hibernating animal serum factors or delta-opiate peptide

14 emical findings were compared with untreated hibernating animals (n = 7), sham-normal animals (n = 5)

15 amatically attenuated around probe tracks in hibernating animals compared to euthermic controls.

16 respect from nature: Diving, burrowing, and hibernating animals living in diverse environments are m

17 similarities between calorie-restricted and hibernating animals suggest the effects of CR may be par

18 shutdown of cellular functions that permits hibernating animals to tolerate severe reductions in cer

19 Kidneys from both summer and hibernating animals tolerated ex vivo CI, confirming tha

20 SCs were observed postsynaptic to cones from hibernating animals, although depolarized cones were abl

21 An uncharacterized factor derived from hibernating animals, hibernation induction trigger (HIT)

22 34 interactions were disrupted in brain from hibernating animals, in which eIF-2alpha was highly phos

23 imer-like phosphorylation is also present in hibernating animals, mitosis, or during embryonic develo

24 In hibernating animals, reduction of immunoreactive phospho

25 tolerance to cerebral ischemia exhibited by hibernating animals.

26 BA](ecf)) in striatum of non-hibernating and hibernating arctic ground squirrels to test the hypothes

27 neural microstructure from groups of animals hibernating at different ambient temperatures revealed t

28 ose syndrome (WNS) is an emerging disease of hibernating bats associated with cutaneous infection by

29 drome (WNS) is an emerging disease affecting hibernating bats in eastern North America that causes ma

30 We show, in hibernating bats infected with Geomyces destructans, tha

31 ts a pronounced northward range expansion of hibernating bats within the next 80 years.

32 proliferates at low temperatures and targets hibernating bats, resulting in their premature arousal f

33 uctans on the skin (including the muzzle) of hibernating bats.

34 on and delayed recovery of metabolic rate in hibernating bears suggest that the majority of metabolic

35 hat fast during lactation, such as seals and hibernating bears.

36 sured metabolic rate and body temperature in hibernating black bears and found that they suppress met

37 Administration of serum derived from hibernating black bears to rabbits affords protection ag

38 ranscription-PCR products from euthermic and hibernating brain and compared them using differential d

39 as reduced 3-fold in cell-free extracts from hibernating brain at 37 degreesC, eliminating hypothermi

40 rpose of this study was to determine whether hibernating brain tissue is tolerant to penetrating brai

41 of the catalytic subunit of PP2A (PP2A/C) in hibernating brains and livers.

42 Among patients with ischemic cardiomyopathy, hibernating, but not ischemic, myocardium identifies whi

43 Hibernating cardiomyocytes are reversibly hypocontractil

44 approximately 124% and 99%, respectively, in hibernating compared with cold control preparations with

45 Thus, the torpid/awakening cycle of the hibernating European hamster causes a rapid and reversib

46 rrels that did not hibernate or had not been hibernating for several weeks.

47 one of euthermic (control), cold control and hibernating golden hamsters.

48 Isolated hibernating ground squirrel and mouse RTECs were subject

49 d for weeks in brain and other organs of the hibernating ground squirrel, Spermophilus tridecemlineat

50 uirrels (T(b) range 34.7-38.9 degrees C) and hibernating ground squirrels (T(b) range 2.9-3.9 degrees

51 BA](ecf) was determined in unrestrained, non-hibernating ground squirrels (T(b) range 34.7-38.9 degre

52 , suggest that light can reach the retina of hibernating ground squirrels maintained in the laborator

53 rites, and spines from several cell types in hibernating ground squirrels retract on entry into torpo

54 ng hibernation and arousal in two species of hibernating ground squirrels suggest that it could play

55 d shutdown of cellular function that permits hibernating ground squirrels to tolerate "trickle" blood

56 bular epithelial cells (RTECs) isolated from hibernating ground squirrels would be protected against

57 eriments, we looked at mlEPSCs from cones of hibernating ground squirrels, which exhibit dramatically

58 -2) was observed in the brains and livers of hibernating ground squirrels.

59 everal types of neurons in fixed slices from hibernating ground squirrels.

60 n cold controls and markedly enhanced in the hibernating group at all frequencies tested.

61 In the hibernating group, NTG alone improved wall thickening in

62 ificantly enhanced in both cold controls and hibernating groups, while vasoconstriction in response t

63 ificantly increased in the renal arteries of hibernating hamsters compared with controls, but not com

64 The ultrastructure of MFT in hibernating hamsters showed a significant reduction in s

65 y in the pancreas, but when expressed in the hibernating heart it liberates fatty acids from triglyce

66 on after revascularization in these areas of hibernating heart.

67 val underlies the sustained viability of the hibernating heart.

68 In hibernating hearts, icMSCs increased Ki67+ cardiomyocyte

69 y be related to the temperature range of its hibernating host.

70 teristics of the cardiac interstitium in the hibernating human myocardium and evaluate whether active

71 ular necrosis and apoptosis did not occur in hibernating kidneys.

72 g perfusion was significantly reduced in the hibernating LAD region in comparison with the normal rem

73 increased from 2.4+/-0.04 to 4.7+/-0.7 mm in hibernating LAD regions (P<0.05) whereas remote wall-thi

74 and a long-term (1976-2008) data set from a hibernating mammal (the yellow-bellied marmot) inhabitin

75 of the dynamics of the body temperature of a hibernating mammal is presented.

76 Hibernating mammals are remarkable for surviving near-fr

77 shortage and/or reduced ambient temperatures hibernating mammals become heterothermic, allowing their

78 Torpor in hibernating mammals defines the nadir in mammalian metab

79 Neurons in hibernating mammals exhibit a dramatic form of plasticit

80 Hibernating mammals possess a unique ability to reduce t

81 Hibernating mammals survive for periods up to 6 mo in th

82 In hibernating mammals, cooling induces loss of synaptic co

83 ypothermic and hypometabolic torpid state in hibernating mammals, we investigated the potential for t

84 uction and energy expenditure in infants and hibernating mammals-also exists in adult humans.

85 has been shown to be cerebral protective in hibernating mammals.

86 Apoptotic myocytes were observed in the hibernating myocardial region in all pigs (4.8 +/- 2.3%)

87 vidence for a local inflammatory reaction in hibernating myocardial segments from patients undergoing

88 sion imaging detects impaired resting MBF in hibernating myocardial segments.

89 ly perfused remote regions from animals with hibernating myocardium (32+/-7%).

90 20+/-77 myocytes per 10(6) myocyte nuclei in hibernating myocardium (P<0.05).

91 nt in LVEF was associated with the volume of hibernating myocardium (viable myocardium with contracti

92 coronary artery (LAD) stenosis that produced hibernating myocardium after 3 months.

93 licits a gene program of survival protecting hibernating myocardium against cell death.

94 ibitory cytokines are elevated in regions of hibernating myocardium and account in part for the depre

95 GF-5 may afford a way to restore function in hibernating myocardium and ameliorate heart failure in c

96 renergic receptor densities occur in viable, hibernating myocardium and may account in part for the o

97 period (P<0.05 versus untreated animals with hibernating myocardium and normal shams).

98 Swine with hibernating myocardium arising from a chronic left anter

99 that can accurately determine the amount of hibernating myocardium as well as the presence and degre

100 re is evidence to suggest that patients with hibernating myocardium benefit most from revascularizati

101 coplasmic reticulum proteins were present in hibernating myocardium but absent in stunned myocardium

102 thickening at low-dose DSE may be limited in hibernating myocardium by severe hypoperfusion.

103 umented with a proximal LAD stenosis develop hibernating myocardium characterized by relative reducti

104 ysiological and molecular characteristics of hibernating myocardium develop rapidly after a critical

105 Hibernating myocardium developed a significant downregul

106 Previous studies have suggested that hibernating myocardium eventually results in progressive

107 proved clinically useful for distinguishing hibernating myocardium from irreversibly injured myocard

108 nuclear density to 995+/-100 nuclei/mm(2) in hibernating myocardium from the instrumented group versu

109 fter 2 weeks, when physiological features of hibernating myocardium had developed.

110 acked necrosis, might have been mistaken for hibernating myocardium had only histology been evaluated

111 rsibility of protein changes that develop in hibernating myocardium have an impact on functional reco

112 Although humans and swine with hibernating myocardium have an increased risk of sudden

113 al function and heart failure, dysfunctional hibernating myocardium improves after pravastatin.

114 Hibernating myocardium in patients with collateral-depen

115 ced flow and increased FDG characteristic of hibernating myocardium in similarly instrumented pigs af

116 Delayed recovery of hibernating myocardium in the absence of scar may reflec

117 Previous studies of hibernating myocardium in the fasting state have shown r

118 cyte >10%) and increased glycogen typical of hibernating myocardium in the LAD region (33+/-3% of myo

119 New modalities to detect hibernating myocardium include 99mTc-sestamibi, contrast

120 lts indicate that icMSCs improve function in hibernating myocardium independent of coronary flow or r

121 Several models purported to represent hibernating myocardium involve a coronary stenosis (CS)

122 The diagnosis of hibernating myocardium involves (a) documenting left ven

123 These data support the notion that hibernating myocardium is a pathophysiological substrate

124 Hibernating myocardium is a state of persistently impair

125 Hibernating myocardium is accompanied by a downregulatio

126 his study was performed to determine whether hibernating myocardium is adaptive or is destined to und

127 lation of oxygen consumption and function in hibernating myocardium is an adaptive response that prev

128 Hibernating myocardium is associated with persistent red

129 ata indicate that the proteomic phenotype of hibernating myocardium is dynamic and has similarities t

130 0.65+/-0.08 (mean+/-SEM) mL.min(-1).g(-1) in hibernating myocardium of instrumented pigs compared wit

131 F-A improves contractile function of chronic hibernating myocardium of pigs to a level comparable to

132 on tomography identified ischemia, scar, and hibernating myocardium on the survival benefit associate

133 Swine with chronic hibernating myocardium received autologous intracoronary

134 Hibernating myocardium refers to chronically dysfunction

135 Thus, physiologic and structural features of hibernating myocardium remain constant for at least two

136 ster and more precise method for determining hibernating myocardium remains the holy grail of noninva

137 , can be initiated by regional dysfunctional hibernating myocardium resulting from a severe coronary

138 in function and oxygen consumption at rest, hibernating myocardium retains the ability to increase m

139 and the presence of ischemia and/or stunned/hibernating myocardium should be assessed for optimal ma

140 designed to study apoptosis in hypoperfused hibernating myocardium subtending severe coronary stenos

141 tricular dysfunction (LVD) may have areas of hibernating myocardium that improve functionally after r

142 gene expression is regionally upregulated in hibernating myocardium to a level intermediate between t

143 te the serial changes in the response of the hibernating myocardium to dobutamine stimulation after r

144 is heterogeneous, varying from predominantly hibernating myocardium to irreversible scarring.

145 f contractile reserve and thallium uptake in hibernating myocardium to myocardial structure in humans

146 descending artery (LAD) stenosis to produce hibernating myocardium underwent percutaneous revascular

147 egion (33+/-3% of myocytes from animals with hibernating myocardium versus 15+/-4% of myocytes from s

148 ascularization in the setting of significant hibernating myocardium was associated with improved surv

149 Human hibernating myocardium was characterized by an upregulat

150 Hibernating myocardium was characterized by severe regio

151 n the fasting state, FDG uptake in pigs with hibernating myocardium was heterogeneous and was increas

152 Although, originally, hibernating myocardium was identified by a mismatch betw

153 After 3 months (n=8), hibernating myocardium was present as reflected by reduc

154 The physiological substrate of hibernating myocardium was present before SCD, with redu

155 An interaction between treatment and hibernating myocardium was present such that early revas

156 At 3 months, physiological features of hibernating myocardium were confirmed, with depressed LA

157 MCE parameters of perfusion in hibernating myocardium were similar to segments with nor

158 The improvement of wall thickening of hibernating myocardium with NTG and dobutamine, from 23.

159 We previously produced hibernating myocardium with reduced resting flow in pigs

160 ing artery (LAD) stenosis to produce chronic hibernating myocardium with regional contractile dysfunc

161 n reversible loss of cardiomyocyte function (hibernating myocardium), which is amenable to therapeuti

162 t persistent myocardial stunning can lead to hibernating myocardium, 13 pigs were chronically instrum

163 nal myocardium with reduced resting flow, or hibernating myocardium, after 3 mo.

164 emodeling in the cardiac interstitium of the hibernating myocardium, an important predictor of recove

165 There was no lactate production in hibernating myocardium, and lactate uptake increased dur

166 identification of candidates with regions of hibernating myocardium, because these patients stand to

167 measured the expression of survival genes in hibernating myocardium, both in patients surgically trea

168 hat dobutamine echocardiography can identify hibernating myocardium, but laboratory studies suggest t

169 Hibernating myocardium, characterized by reductions in f

170 In hibernating myocardium, icMSCs increased function (perce

171 ion in coronary BF in conscious pigs induced hibernating myocardium, ie, perfusion-contraction matchi

172 Hibernating myocardium, ischemic myocardium, and scarred

173 In hibernating myocardium, MIBG deposition was decreased in

174 Using an established model of chronic hibernating myocardium, mini-swine underwent 90% proxima

175 this preclinical swine model of ischemic and hibernating myocardium, the combined delivery of circula

176 t in perfusion reserve is well recognized in hibernating myocardium, there is substantial controversy

177 tensive defects in HED uptake were found for hibernating myocardium, with regional retention approxim

178 ta4 in a translational large animal model of hibernating myocardium.

179 entricular dysfunction are features of human hibernating myocardium.

180 ative to revascularisation for patients with hibernating myocardium.

181 lic adjustments could facilitate survival of hibernating myocardium.

182 r non-hibernators according to the volume of hibernating myocardium.

183 the excess mortality seen in the setting of hibernating myocardium.

184 the observed depression of function seen in hibernating myocardium.

185 l, molecular, and morphological phenotype of hibernating myocardium.

186 pinephrine uptake-1 mechanism is impaired in hibernating myocardium.

187 he result of a mixture of scarred as well as hibernating myocardium.

188 tural adaptations was evaluated in pigs with hibernating myocardium.

189 ntadecanoic acid (IPPA), to identify viable, hibernating myocardium.

190 EGF(165) GTx may successfully rescue foci of hibernating myocardium.

191 n PET has been used successfully to diagnose hibernating myocardium.

192 cardium having the physiological features of hibernating myocardium.

193 nctional recovery after revascularization in hibernating myocardium.

194 nse to dobutamine have been used to identify hibernating myocardium.

195 ventricular arrhythmias, and reperfusion of hibernating myocardium.

196 ustained, the result is necrosis rather than hibernating myocardium.

197 gh-dose dobutamine from inducing ischemia in hibernating myocardium.

198 has been increasingly used for detection of hibernating myocardium.

199 stenosis and to 78+/-17 mL 7 days later with hibernating myocardium.

200 injected transendocardially in the areas of hibernating myocardium.

201 th through myocyte apoptosis in hypoperfused hibernating myocardium.

202 inducing deterioration of wall thickening in hibernating myocardium.

203 s using a clinically relevant swine model of hibernating myocardium.

204 ncreasing myocardial perfusion in swine with hibernating myocardium.

205 resting myocardial blood flow is reduced in hibernating myocardium.

206 d stability of sympathetic dysinnervation in hibernating myocardium.

207 d for at least 2 mo after the development of hibernating myocardium.

208 ) to improve flow and function in swine with hibernating myocardium.

209 titative CMR perfusion imaging is reduced in hibernating myocardium.

210 beta-receptor adenylyl cyclase signaling in hibernating myocardium.

211 ion is attenuated in patients and swine with hibernating myocardium.

212 mpathetic norepinephrine uptake in pigs with hibernating myocardium.

213 rapeutic efficacy in a large animal model of hibernating myocardium.

214 survival of medically treated patients with hibernating myocardium.

215 Many of these patients have "hibernating" myocardium secondary to chronic ischemia wi

216 reas of nonfunctional but viable (stunned or hibernating) myocardium can also contribute to the devel

217 he reversibility of molecular adaptations of hibernating myocytes.

218 EF might be mediated by improved function of hibernating or ischaemic myocardium, or both.

219 ntractile myocardium, which is distinct from hibernating or stunned myocardium.

220 ersibly hypocontractile myocardium as simply hibernating or stunned.

221 factors ribosome modulation factor (RMF) and hibernating promoting factor (HPF) were shown to directl

222 ed transmural variation in FDG uptake in the hibernating region (LAD/normal), which averaged 2.5 +/-

223 p, NTG alone improved wall thickening in the hibernating region modestly from 11.4+/-7.2% at baseline

224 in(-1)) dobutamine on wall thickening in the hibernating region.

225 zation may be an adaptive mechanism in such "hibernating" regions.

226 cterize dysfunctional myocardium as stunned, hibernating, remodeled and nonviable.

227 Hibernating ribosomes are formed by the activity of one

228 peratures for brief intervals throughout the hibernating season.

229 a marker of active remodeling, was higher in hibernating segments than in segments with persistent dy

230 duced a torpor-like state similar to that in hibernating species and characterized by a marked fall i

231 y plays a primary adaptive role which allows hibernating species to tolerate such phenomena.

232 iod of snow cover also have implications for hibernating species.

233 The results show that [GABA](ecf) in non-hibernating squirrels was 73 nM and this level was decre

234 the changes from a state of activity to the hibernating state are poorly understood; however, the se

235 itiation, regulation, and maintenance of the hibernating state.

236 Myocardial segments were defined as hibernating, stunned, remodeled or scarred.

237 yzes the regulation of ischemic tolerance in hibernating thirteen-lined ground squirrels (Spermophilu

238 cantly reduced as was its kinase activity in hibernating thirteen-lined ground squirrels.