ライフサイエンスコーパス: hibernating myocardium

1 ta4 in a translational large animal model of hibernating myocardium.

2 rapeutic efficacy in a large animal model of hibernating myocardium.

3 nctional recovery after revascularization in hibernating myocardium.

4 nse to dobutamine have been used to identify hibernating myocardium.

5 ventricular arrhythmias, and reperfusion of hibernating myocardium.

6 ustained, the result is necrosis rather than hibernating myocardium.

7 gh-dose dobutamine from inducing ischemia in hibernating myocardium.

8 has been increasingly used for detection of hibernating myocardium.

9 stenosis and to 78+/-17 mL 7 days later with hibernating myocardium.

10 th through myocyte apoptosis in hypoperfused hibernating myocardium.

11 inducing deterioration of wall thickening in hibernating myocardium.

12 s using a clinically relevant swine model of hibernating myocardium.

13 ncreasing myocardial perfusion in swine with hibernating myocardium.

14 resting myocardial blood flow is reduced in hibernating myocardium.

15 d stability of sympathetic dysinnervation in hibernating myocardium.

16 d for at least 2 mo after the development of hibernating myocardium.

17 ) to improve flow and function in swine with hibernating myocardium.

18 titative CMR perfusion imaging is reduced in hibernating myocardium.

19 beta-receptor adenylyl cyclase signaling in hibernating myocardium.

20 ion is attenuated in patients and swine with hibernating myocardium.

21 mpathetic norepinephrine uptake in pigs with hibernating myocardium.

22 survival of medically treated patients with hibernating myocardium.

23 entricular dysfunction are features of human hibernating myocardium.

24 ative to revascularisation for patients with hibernating myocardium.

25 lic adjustments could facilitate survival of hibernating myocardium.

26 r non-hibernators according to the volume of hibernating myocardium.

27 the excess mortality seen in the setting of hibernating myocardium.

28 the observed depression of function seen in hibernating myocardium.

29 l, molecular, and morphological phenotype of hibernating myocardium.

30 pinephrine uptake-1 mechanism is impaired in hibernating myocardium.

31 injected transendocardially in the areas of hibernating myocardium.

32 he result of a mixture of scarred as well as hibernating myocardium.

33 tural adaptations was evaluated in pigs with hibernating myocardium.

34 ntadecanoic acid (IPPA), to identify viable, hibernating myocardium.

35 EGF(165) GTx may successfully rescue foci of hibernating myocardium.

36 n PET has been used successfully to diagnose hibernating myocardium.

37 cardium having the physiological features of hibernating myocardium.

38 t persistent myocardial stunning can lead to hibernating myocardium, 13 pigs were chronically instrum

39 ly perfused remote regions from animals with hibernating myocardium (32+/-7%).

40 coronary artery (LAD) stenosis that produced hibernating myocardium after 3 months.

41 nal myocardium with reduced resting flow, or hibernating myocardium, after 3 mo.

42 licits a gene program of survival protecting hibernating myocardium against cell death.

43 emodeling in the cardiac interstitium of the hibernating myocardium, an important predictor of recove

44 ibitory cytokines are elevated in regions of hibernating myocardium and account in part for the depre

45 GF-5 may afford a way to restore function in hibernating myocardium and ameliorate heart failure in c

46 renergic receptor densities occur in viable, hibernating myocardium and may account in part for the o

47 period (P<0.05 versus untreated animals with hibernating myocardium and normal shams).

48 There was no lactate production in hibernating myocardium, and lactate uptake increased dur

49 Swine with hibernating myocardium arising from a chronic left anter

50 that can accurately determine the amount of hibernating myocardium as well as the presence and degre

51 identification of candidates with regions of hibernating myocardium, because these patients stand to

52 re is evidence to suggest that patients with hibernating myocardium benefit most from revascularizati

53 measured the expression of survival genes in hibernating myocardium, both in patients surgically trea

54 coplasmic reticulum proteins were present in hibernating myocardium but absent in stunned myocardium

55 hat dobutamine echocardiography can identify hibernating myocardium, but laboratory studies suggest t

56 thickening at low-dose DSE may be limited in hibernating myocardium by severe hypoperfusion.

57 reas of nonfunctional but viable (stunned or hibernating) myocardium can also contribute to the devel

58 umented with a proximal LAD stenosis develop hibernating myocardium characterized by relative reducti

59 Hibernating myocardium, characterized by reductions in f

60 ysiological and molecular characteristics of hibernating myocardium develop rapidly after a critical

61 Hibernating myocardium developed a significant downregul

62 Previous studies have suggested that hibernating myocardium eventually results in progressive

63 proved clinically useful for distinguishing hibernating myocardium from irreversibly injured myocard

64 nuclear density to 995+/-100 nuclei/mm(2) in hibernating myocardium from the instrumented group versu

65 fter 2 weeks, when physiological features of hibernating myocardium had developed.

66 acked necrosis, might have been mistaken for hibernating myocardium had only histology been evaluated

67 rsibility of protein changes that develop in hibernating myocardium have an impact on functional reco

68 Although humans and swine with hibernating myocardium have an increased risk of sudden

69 In hibernating myocardium, icMSCs increased function (perce

70 ion in coronary BF in conscious pigs induced hibernating myocardium, ie, perfusion-contraction matchi

71 al function and heart failure, dysfunctional hibernating myocardium improves after pravastatin.

72 Hibernating myocardium in patients with collateral-depen

73 ced flow and increased FDG characteristic of hibernating myocardium in similarly instrumented pigs af

74 Delayed recovery of hibernating myocardium in the absence of scar may reflec

75 Previous studies of hibernating myocardium in the fasting state have shown r

76 cyte >10%) and increased glycogen typical of hibernating myocardium in the LAD region (33+/-3% of myo

77 New modalities to detect hibernating myocardium include 99mTc-sestamibi, contrast

78 lts indicate that icMSCs improve function in hibernating myocardium independent of coronary flow or r

79 Several models purported to represent hibernating myocardium involve a coronary stenosis (CS)

80 The diagnosis of hibernating myocardium involves (a) documenting left ven

81 These data support the notion that hibernating myocardium is a pathophysiological substrate

82 Hibernating myocardium is a state of persistently impair

83 Hibernating myocardium is accompanied by a downregulatio

84 his study was performed to determine whether hibernating myocardium is adaptive or is destined to und

85 lation of oxygen consumption and function in hibernating myocardium is an adaptive response that prev

86 Hibernating myocardium is associated with persistent red

87 ata indicate that the proteomic phenotype of hibernating myocardium is dynamic and has similarities t

88 Hibernating myocardium, ischemic myocardium, and scarred

89 In hibernating myocardium, MIBG deposition was decreased in

90 Using an established model of chronic hibernating myocardium, mini-swine underwent 90% proxima

91 0.65+/-0.08 (mean+/-SEM) mL.min(-1).g(-1) in hibernating myocardium of instrumented pigs compared wit

92 F-A improves contractile function of chronic hibernating myocardium of pigs to a level comparable to

93 on tomography identified ischemia, scar, and hibernating myocardium on the survival benefit associate

94 20+/-77 myocytes per 10(6) myocyte nuclei in hibernating myocardium (P<0.05).

95 Swine with chronic hibernating myocardium received autologous intracoronary

96 Hibernating myocardium refers to chronically dysfunction

97 Thus, physiologic and structural features of hibernating myocardium remain constant for at least two

98 ster and more precise method for determining hibernating myocardium remains the holy grail of noninva

99 , can be initiated by regional dysfunctional hibernating myocardium resulting from a severe coronary

100 in function and oxygen consumption at rest, hibernating myocardium retains the ability to increase m

101 Many of these patients have "hibernating" myocardium secondary to chronic ischemia wi

102 and the presence of ischemia and/or stunned/hibernating myocardium should be assessed for optimal ma

103 designed to study apoptosis in hypoperfused hibernating myocardium subtending severe coronary stenos

104 tricular dysfunction (LVD) may have areas of hibernating myocardium that improve functionally after r

105 this preclinical swine model of ischemic and hibernating myocardium, the combined delivery of circula

106 t in perfusion reserve is well recognized in hibernating myocardium, there is substantial controversy

107 gene expression is regionally upregulated in hibernating myocardium to a level intermediate between t

108 te the serial changes in the response of the hibernating myocardium to dobutamine stimulation after r

109 is heterogeneous, varying from predominantly hibernating myocardium to irreversible scarring.

110 f contractile reserve and thallium uptake in hibernating myocardium to myocardial structure in humans

111 descending artery (LAD) stenosis to produce hibernating myocardium underwent percutaneous revascular

112 egion (33+/-3% of myocytes from animals with hibernating myocardium versus 15+/-4% of myocytes from s

113 nt in LVEF was associated with the volume of hibernating myocardium (viable myocardium with contracti

114 ascularization in the setting of significant hibernating myocardium was associated with improved surv

115 Human hibernating myocardium was characterized by an upregulat

116 Hibernating myocardium was characterized by severe regio

117 n the fasting state, FDG uptake in pigs with hibernating myocardium was heterogeneous and was increas

118 Although, originally, hibernating myocardium was identified by a mismatch betw

119 After 3 months (n=8), hibernating myocardium was present as reflected by reduc

120 The physiological substrate of hibernating myocardium was present before SCD, with redu

121 An interaction between treatment and hibernating myocardium was present such that early revas

122 At 3 months, physiological features of hibernating myocardium were confirmed, with depressed LA

123 MCE parameters of perfusion in hibernating myocardium were similar to segments with nor

124 n reversible loss of cardiomyocyte function (hibernating myocardium), which is amenable to therapeuti

125 The improvement of wall thickening of hibernating myocardium with NTG and dobutamine, from 23.

126 We previously produced hibernating myocardium with reduced resting flow in pigs

127 ing artery (LAD) stenosis to produce chronic hibernating myocardium with regional contractile dysfunc

128 tensive defects in HED uptake were found for hibernating myocardium, with regional retention approxim