ライフサイエンスコーパス: hibernation

1 lex pathophysiology (e.g., myocyte death vs. hibernation).

2 l to promote fat accumulation and facilitate hibernation.

3 reasing adipose stores prior to the onset of hibernation.

4 omote wakefulness and to induce arousal from hibernation.

5 Mammals encounter constant darkness during hibernation.

6 emission tomography correlate of myocardial hibernation.

7 ctivity and spatial navigation skills during hibernation.

8 glycogen, recapitulating the changes during hibernation.

9 s-associated cardiac dysfunction may reflect hibernation.

10 ity and the possible of such interactions in hibernation.

11 irrel, Spermophilus tridecemlineatus, during hibernation.

12 t phosphorylation plays a regulatory role in hibernation.

13 etitive ischemia reproducing the features of hibernation.

14 can recapitulate the phenotype of myocardial hibernation.

15 hose related to ischemic preconditioning and hibernation.

16 ow and oxygen limitation such as seen during hibernation.

17 res and winter lengths permitting successful hibernation.

18 elongation phase of protein synthesis during hibernation.

19 ay be useful in the assessment of myocardial hibernation.

20 ions fell slightly or remained stable during hibernation.

21 evaluate myocardial perfusion, function, and hibernation.

22 ibernation and reperfusion upon arousal from hibernation.

23 seen in clinical and experimental models of hibernation.

24 ctive adaptations may work in concert during hibernation.

25 nts, ascorbate and glutathione (GSH), during hibernation.

26 ccessfully adapted to this challenge through hibernation.

27 sociated with profound CNS depression during hibernation.

28 t play a major role in CNS depression during hibernation.

29 rom a physiological phenotype of stunning to hibernation.

30 scular tone and peripheral resistance during hibernation.

31 the differential expression of genes during hibernation.

32 ozyme 4 are up-regulated in the heart during hibernation.

33 incided with the early transition phase into hibernation.

34 the responses to NA were not altered during hibernation.

35 ith the traditional definition of myocardial hibernation.

36 nd O2 consumption compatible with myocardial hibernation.

37 ocardiography (DE) in identifying myocardial hibernation.

38 be relevant to conditions such as myocardial hibernation.

39 therefore be useful in predicting myocardial hibernation.

40 od flow and oxygen consumption indicative of hibernation.

41 undergo torpor lasting up to 63 h, that is, hibernation.

42 spectrum of adaptive responses that include hibernation.

43 xygen consumption consistent with myocardial hibernation.

44 cose during a 3-4-h period of acute ischemic hibernation.

45 g the techniques used to identify myocardial hibernation.

46 ssue function at low body temperature during hibernation.

47 100S particles in a process called ribosome hibernation.

48 ed significantly among the defined states of hibernation.

49 unforeseen parallels to mammalian temperate hibernation.

50 of insulated hibernacula on the evolution of hibernation.

51 ery disease, many of whom exhibit myocardial hibernation.

52 ther seasonal adaptations, such as mammalian hibernation.

53 adverse effects on memories formed prior to hibernation.

54 ic cell death is independent of the stage of hibernation.

55 her protection was dependent on the stage of hibernation.

56 growing season and larger body masses before hibernation.

57 concentrations similar to those that induce hibernation.

58 2)S elicits physiological effects similar to hibernation.

59 uding ischemic cardiomyopathy and myocardial hibernation (5, 6).

60 Hibernation, a natural model of tolerance to cerebral is

61 dy mass increases were often observed during hibernation--a phenomenon never observed in control anim

62 and short photoperiods and from hamsters in hibernation all showed at least 40% increases in fEPSP s

63 ity rates, specifically low mortality during hibernation, allows long-term bat population viability.

64 m in the presence of infarction, stunning or hibernation, alone or in combination.

65 Cooling and hibernation also induce a number of cold-shock proteins

66 Both hibernation, also called multiday torpor, and daily torp

67 sis of adaptive behaviors like migration and hibernation and advance our understanding of fundamental

68 ations in concentrations of ascorbate during hibernation and arousal in two species of hibernating gr

69 ange of biological processes, such as animal hibernation and cell survival, and is particularly relev

70 We demonstrate how earlier emergence from hibernation and earlier weaning of young has led to a lo

71 bear adaptations to the extreme condition of hibernation and have implications for our understanding

72 ium, both in patients surgically treated for hibernation and in a chronic swine model of repetitive i

73 inserted in some animals after they entered hibernation and in others while they remained euthermic.

74 munity, cell differentiation, organogenesis, hibernation and insulin-resistant obesity.

75 ore myocardium affected by hibernation or by hibernation and ischaemia had a greater increase in LVEF

76 t species, together with adaptations such as hibernation and low reproductive rate, contribute to the

77 ransplantation may have substantial zones of hibernation and may still be candidates for coronary byp

78 amatically (3-4-fold) in both species during hibernation and rapidly returned to prehibernation level

79 ioxidant could play a protective role during hibernation and reperfusion upon arousal from hibernatio

80 Hibernation and short daily torpor are states of energy

81 s allow enough infected individuals to enter hibernation and survive until the following year, and he

82 neurochemistry of the cerebral mechanisms of hibernation and tolerance to cerebral ischemia exhibited

83 , ectotherms, endotherms (including those in hibernation), and plants in temperatures ranging from 0

84 e cycles, drive metabolic rhythms (including hibernation), and time annual reproduction.

85 gen-based matrix restored perfusion, reduced hibernation, and improved myocardial wall motion.

86 cardial viability in patients with suspected hibernation, and it can predict recovery of function sim

87 bility in patients with suspected myocardial hibernation, and it compared this index to currently est

88 ology, such as those affecting reproduction, hibernation, and metabolism, are controlled by pituitary

89 To identify myocardial ischemia, hibernation, and scar, the resting and stress (82)rubidi

90 Mating occurs shortly after emergence from hibernation, and the lipid cycle begins again with the c

91 the frequency of arousals from torpor during hibernation, and were emaciated after 3-4 mo.

92 During hibernation, animals cycle between torpor and arousal.

93 both constrictor and dilator actions during hibernation are described.

94 that myocardial adaptations consistent with hibernation are most pronounced in the subendocardial la

95 Although the biological roles of ribosome hibernation are not completely understood, this process

96 ic trait, theoretically this could mean that hibernation as an overwintering strategy was lost in all

97 90% reductions in cerebral blood flow during hibernation as well as rapid reperfusion upon periodic a

98 adaptations consistent with echolocation and hibernation, as well as altered metabolism, reproduction

99 evidence for an effect of climate change on hibernation behavior; yellow-bellied marmots are emergin

100 Interestingly, mammalian hibernation biology closely parallels the altered cardia

101 In patients with myocardial hibernation, biphasic response during dobutamine is less

102 go a severe hypometabolic state analogous to hibernation borders on science fiction.

103 Our observations indicate that the hibernation bout is closely regulated and orchestrated b

104 activated during six different phases of the hibernation bout.

105 ticipating in phase-change regulation of the hibernation bout.

106 The number of hibernation bouts in SCNx squirrels increased by 159%, t

107 aking during the arousal phase of individual hibernation bouts.

108 d not change significantly during individual hibernation bouts.

109 e quantified the biochemical adaptations for hibernation by comparing the proteome, metabolome, and h

110 any structural changes accompany short-term hibernation caused by a moderate flow reduction maintain

111 sought to determine whether CI and WI during hibernation caused caspase-3 activation, tubular apoptos

112 Hibernation causes reduced synaptic activity and experim

113 mained higher 3 h after induced arousal from hibernation compared with euthermic controls.

114 es seasonally, with higher expression during hibernation compared with the summer active state.

115 orresponding to various stages of the annual hibernation cycle.

116 dial blood flow had increased (P</=0.01) and hibernation decreased (P<0.01) in the cells+matrix group

117 During myocardial hibernation, decreases in coronary perfusion elicit inhi

118 hey spend too much time out of torpor during hibernation, depleting vital fat reserves required to su

119 n sex hormone-binding globulin levels during hibernation draws, for the first time, attention to its

120 ogrammed manner by undergoing deep torpor or hibernation during which the hypothalamic setpoint for b

121 Conclusion: This "hepatic hibernation" during prolonged moderate hypoxia may repre

122 days per year, over a 20-year period) in the hibernation emergence date of adult females in a wild po

123 s, suggesting that the thermal dependence of hibernation energetics constrains the biogeography of th

124 As an example, we use the well-quantified hibernation energetics of the little brown bat (Myotis l

125 lasma protein concentration increased during hibernation, even though the concentrations of most indi

126 was the identification of mRNAs for ribosome hibernation factors (the rmf and PA4463 genes) at the bo

127 We examined the effect of diet on pre-hibernation fattening and the gut microbiota of captive

128 Our results demonstrate that pre-hibernation fattening of arctic ground squirrels is robu

129 sumably are related to disrupted patterns of hibernation, food intake, and metabolism.

130 edge and suggest possible roles in mammalian hibernation for peroxisome proliferator-activated recept

131 Thus, hibernation has been retained in at least one primate ou

132 to climate change in some analyses, whereas hibernation, heterothermy, burrowing, nesting, and study

133 n, extremely high metabolic rates, nocturnal hibernation, high brain-to-body size ratio and a remarka

134 We used a combination of artificial hibernation, hormonal treatments, gene expression analys

135 The hibernation hypothesis predicts that nova eruptions stro

136 -like growth factor signaling pathway during hibernation (i.e., phosphorylated FKHR was significantly

137 tion trigger (HIT), has been shown to induce hibernation in active animals and afford myocardial prot

138 n fact, most patients have both scarring and hibernation in different regions.

139 bolic status that occur during the course of hibernation in European hamsters cause structural change

140 cation of regulatory mechanisms that control hibernation in ground squirrels can guide efforts to dev

141 cation of regulatory mechanisms that control hibernation in ground squirrels may guide efforts to dev

142 Their relevance to myocardial hibernation in humans is unknown.

143 h intravenous contrast identifies myocardial hibernation in humans.

144 indicating that HPF is required for ribosome hibernation in L. monocytogenes.

145 Hibernation in mammals is a remarkable state of heteroth

146 Hibernation in mammals is a reversible state of suspende

147 hocardiography (MCE) in detecting myocardial hibernation in man and its comparative accuracy to dobut

148 e and underweight male hibernators terminate hibernation in spring when aboveground food becomes avai

149 ble for the physiological characteristics of hibernation in the heart of the thirteen-lined ground sq

150 can enter a severe hypothermic state during hibernation in which metabolic activity is extremely low

151 Microbiome alterations may contribute to hibernation-induced changes in the intestinal immune sys

152 zed factor derived from hibernating animals, hibernation induction trigger (HIT), has been shown to i

153 udy undertook to test whether treatment with hibernation induction triggers could improve myocardial

154 The use of hibernation induction triggers is promising for organ pr

155 Furthermore, hibernation-induction triggers extend organ preservation

156 other physiological variables that accompany hibernation involve only modest reprogramming of gene ex

157 Central functions in hibernation involving the coagulation response and prote

158 Hibernation is a physiological adaptation characterized

159 Mammalian hibernation is a temporary suspension of euthermia allow

160 ration or progressive fibrosis suggests that hibernation is adaptive rather than an unstable physiolo

161 Myocardial hibernation is an adaptive response to ischemia and hypo

162 Hibernation is an energy-conserving state, now known to

163 Hibernation is an extreme response to a seasonal environ

164 Myocardial hibernation is associated with an inflammatory response

165 Myocardial hibernation is associated with structural myocardial cha

166 Since hibernation is commonly viewed as an ancient, plesiomorp

167 the majority of metabolic suppression during hibernation is independent of lowered body temperature.

168 Typically, hibernation is observed in cold-adapted mammals, though

169 Hibernation is one of the most dramatic examples of phen

170 ith a chronic stenosis and hypothesized that hibernation is preceded by chronic stunning with normal

171 One of the characteristics of animals in hibernation is reduced behavioral activity.

172 Hibernation is studied because it represents a unique st

173 suggested that chronic stunning rather than hibernation is the principal cause of regional wall moti

174 An integral aspect of hibernation is the profound decrease of cerebral perfusi

175 An integral aspect of hibernation is tolerance to a profound decrease of cereb

176 creased for 12 weeks in spring, from minimal hibernation levels (mean 20-25 beats/minute [bpm]; min 1

177 The Caenorhabditis elegans dauer state is a hibernation-like state of diapause that displays a drama

178 ocks somatic growth and sensitizes mice to a hibernation-like state of torpor.

179 Torpor is a short-term hibernation-like state that allows conservation of metab

180 ortedly minimize energy losses by entering a hibernation-like state when deprived of food.

181 suprachiasmatic nucleus, abolishes torpor, a hibernation-like state, implicating the circadian clock

182 The hibernation mass loss phase begins after the body mass p

183 anding of how renal protection occurs during hibernation may help in understanding the pathophysiolog

184 anisms underlying neuroprotective aspects of hibernation may lead to novel therapeutic strategies for

185 However, hibernation may represent persistent myocardial stunning

186 We hypothesized that myocardial hibernation may underlie sepsis-associated myocardial de

187 sumo-2/3-ylation may also be associated with hibernation-mediated neuroprotection.

188 In myocardial hibernation, methods evaluating rest perfusion (MCE, Tl-

189 cumflex artery territory (both P<0.001), and hibernation (mismatch) was observed.

190 asticity, silent yet intact circuits enter a hibernation mode marked by reduction of presynaptic axon

191 The hibernation model predicts cyclical evolution of catacly

192 A pig model of myocardial hibernation of 24 hours to 7 days was created through se

193 Short-term myocardial hibernation of 3 hours resulting from a moderate resting

194 pose a novel concept of inflammatory-induced hibernation of the fetus.

195 Recanalization of CTO is followed by a hibernation of vascular wall at distal coronary segments

196 We hypothesize that the slowing effects of hibernation on metabolic and viral activity maintains in

197 n the renal artery, the long term effects of hibernation on perivascular nerve activity, and the resp

198 The first report of the effect of hibernation on the gut microbiota of bears reveals trend

199 that it could play a protective role during hibernation or arousal.

200 r, patients with more myocardium affected by hibernation or by hibernation and ischaemia had a greate

201 To date, the underlying mechanism for hibernation or similar behaviors remains an enigma.

202 body temperatures of animals can drop during hibernation or torpor covering a large range of temperat

203 levels, with timing of animal reproduction, hibernation, or migration becoming detached from peak fo

204 eu5-enkaphalin (DADLE), which mimics natural hibernation, or preperfusion with DADLE, administered fo

205 that a good candidate species for the use of hibernation, outside of Madagascar should be the pygmy s

206 Interestingly, the subcellular changes in hibernation parallel the altered biology of induced card

207 Hibernation patterns were monitored continuously for 2.5

208 ectrum of delayed recognition where both the hibernation period and the awakening intensity are taken

209 Its citation history exhibits a long hibernation period followed by a sudden spike of popular

210 a thousand to a million years, starting the hibernation phase.

211 Given that lipids are integral in the hibernation phenotype they may play important regulatory

212 However, several other aspects of hibernation physiology are also consistent with toleranc

213 significant but unknown role in maintaining hibernation physiology.

214 ated by ribosome modulation factor (RMF) and hibernation promoting factor (HPF), or alternatively, th

215 genes in Synechococcus, including ribosomal hibernation promoting factor (hpf), which causes ribosom

216 oteins, ribosome modulation factor (RMF) and hibernation promoting factor (HPF), while most Gram-posi

217 onstrate that the P. aeruginosa gene PA4463 [hibernation promoting factor (HPF)], but not the ribosom

218 aphylococcus aureus and most other bacteria, hibernation-promoting factor (HPF) homodimerizes the 70S

219 These proteins include hibernation-promoting factor (HPF), which dimerizes ribo

220 taphylococcus aureus, a small protein called hibernation-promoting factor (HPFSa) is sufficient to di

221 revealed unexpected homology with bacterial hibernation-promoting factors that bind to ribosomes and

222 This study demonstrates that hibernation protection with DADLE is beneficial for prol

223 ition cycles of the living material (active, hibernation, reactivation).

224 Myocardial hibernation refers to a state of persistent left ventric

225 Myocardial hibernation refers to a state of prolonged impairment of

226 ll bears, including an individual denned for hibernation, responded to UAV flights with elevated hear

227 proach, investigating expression of putative hibernation-responsive genes by Northern analysis, revea

228 Hibernation results in dramatic changes in body temperat

229 mechanism that controls the duration of the hibernation season and the temporal structure of individ

230 Samples were collected during the hibernation season from arctic ground squirrels (AGS; Sp

231 Furthermore, torpid squirrels during the hibernation season keep their brain temperature signific

232 In order to survive the multi-month hibernation season many species engage in hyperphagy, dr

233 n thermoregulation and metabolism during the hibernation season than at other times of year, thereby

234 CHA-induced torpor within the hibernation season was specific to A(1)AR activation; th

235 season, two of six AGSs tested early in the hibernation season, and none of the six AGSs tested duri

236 Throughout the hibernation season, bouts of deep torpor are punctuated

237 por in six of six AGSs tested during the mid-hibernation season, two of six AGSs tested early in the

238 squirrel, Spermophilus lateralis, during the hibernation season.

239 AGS), display torpor only during the winter, hibernation season.

240 As such, hibernation serves as a model for studying natural toler

241 cient lipid reserves spontaneously terminate hibernation several weeks before females and independent

242 ble on molecular changes that correlate with hibernation state, and what has been done focused mainly

243 s the stability of mRNA as a function of the hibernation state, we examined the poly(A) tail lengths

244 ctic ground squirrels sacrificed during four hibernation states (early and late during a torpor bout

245 some small differences were observed across hibernation states, none of the 29 had significant chang

246 d both active (eating) and waiting (dormant, hibernation) states with additional recovery for reiniti

247 ntly to 67+/-15 g after 7 days of myocardial hibernation subtending the severe LAD stenosis.

248 prolonged partial occlusions (ie, short-term hibernation), the time course of functional recovery var

249 During hibernation, the 13-lined ground squirrel (GS) cycles th

250 For true hibernation, the geographical restriction was absolute.

251 In myocardial hibernation, the majority of recovery of rest function o

252 he Leydig cells in a state of steroidogenic "hibernation," the reductions in Leydig cell testosterone

253 nt as the patient's physiology moves toward "hibernation." The agents we utilize as sedative and pres

254 el was decreased by approximately 50% during hibernation thereby suggesting that an increase in [GABA

255 The seasonal character of hibernation thus provides a clue to its regulation.

256 s in SCNx squirrels increased by 159%, total hibernation time increased by 58%, and periodic arousals

257 lude suspended animation-like states such as hibernation, torpor, and estivation.

258 otential role of the CNS in the induction of hibernation/torpor, since CNS-driven changes in organ ph

259 This study reveals how hibernation triggers the production of new queens in Pog

260 level of metabolic shutdown (analogous to a hibernation-type response), seems to be crucial in deter

261 l that predicts the feasibility of mammalian hibernation under different climatic conditions.

262 sess whether the adaptations consistent with hibernation varied across the myocardial wall.

263 rels maintained in the laboratory and affect hibernation via an SCN-independent mechanism.

264 tunning (rest asynergy with normal flow) and hibernation was present in 15 of 23 (65%) patients.

265 increased by 58%, and periodic arousals from hibernation were 47% longer in SCNx than in control squi

266 GS kidneys at various stages of hibernation were subjected to ex vivo CI.

267 ces, were less likely to survive their first hibernation, were more likely to disperse and were less

268 e as a source of electrons during periods of hibernation when food supplies are low.

269 atty acids may be preferentially used during hibernation, whereas polyunsaturated fatty acids may be

270 ther regional LV dysfunction with myocardial hibernation without transmural or extensive infarction c