ライフサイエンスコーパス: high affinity

1 viral mRNA 5' untranslated region (UTR) with high affinity.

2 d with Ala residues fails to bind hemin with high affinity.

3 Pin((R)) proteins recognize FcgammaRIIB with high affinity.

4 d the entropic advantage driving aprotinin's high affinity.

5 ed, and reduced holomycin chelates zinc with high affinity.

6 Both CopZ chaperones could bind Cu(+) with high affinity.

7 r but also binds the mature 30S subunit with high affinity.

8 competitively bind to a cullin scaffold with high affinity.

9 ein that binds to the Kv1.3 ion channel with high affinity.

10 ly bind the shared receptor IL-12Rbeta1 with high affinity.

11 HB is shown to bind and inhibit SULT1A3 with high affinity, 23 (+/-2) nM, and to bind weakly, if at a

12 ing domain (ABD) of beta-III-spectrin causes high-affinity actin binding and decreased thermal stabil

13 Our data suggest that high-affinity actin binding by SCA5 beta-spectrin interf

14 d the identification of a previously unknown high-affinity AICE2 motif at a human single-nucleotide p

15 m in (periportal) hepatocytes represents the high-affinity ammonia-detoxifying system of the body.

16 orter and the phoB-phoR regulatory system, a high-affinity ammonium amtB transporter, urea and taurin

17 onium concentrations in the rhizosphere, the high-affinity ammonium transporters (AMTs) in Arabidopsi

18 The compounds show high affinities and a diverse range of kinetic profiles

19 Many compounds showed high affinities and a diverse range of kinetic profiles.

20 s is difficult owing to competition with the high affinity and abundance of its endogenous nucleotide

21 ated binding of endothelial cells (ECs) with high affinity and also induced endothelial cell capillar

22 identify UbVs that bound USP7 or USP10 with high affinity and inhibited deubiquitination activity.

23 ranscription factors challenges the basis of high affinity and selective interactions.

24 oordination sites to capture phosphates with high affinity and selectivity directly in water at neutr

25 ion of 5-HT6 receptor antagonist 7 indicates high affinity and selectivity over a panel of receptors

26 stimated to be 6.35x10(-11)M, indicating the high affinity and sensitivity of anti-CEA-GFET.

27 he plasma membrane, bind membranes with very high affinity and slow dissociation dynamics.

28 The characterisation of high affinity and specific transporters has implications

29 onstrated the selection of DNA aptamers with high affinity and specificity against S.

30 mergence of antibody mimetics that offer the high affinity and specificity associated with antibodies

31 High affinity and specificity DNA aptamers against carbe

32 The CIPs had high affinity and specificity for bacterial detection an

33 d aptamers, BLG14 aptamer sequence has shown high affinity and specificity to both beta-LG A and B wi

34 ally optimized BAX activator that binds with high affinity and specificity to the N-terminal activati

35 ain of an inner membrane protein, RodZ, with high affinity and specificity.

36 that interact with a variety of targets with high affinity and specificity.

37 Although all these antibodies bound D8 with high affinity and were moderately neutralizing in the pr

38 Our goal was to investigate a high-affinity and scalable method for isolating E1E2.

39 High-affinity and selective antagonists that are able to

40 We found that DDX21 can bind to the RRE with high affinity, and this binding stimulates ATPase activi

41 s must be designed to generate long-lasting, high-affinity, and broadly neutralizing Ab responses aga

42 enantiomer UCB35625, initially identified as high affinity antagonists for CCR1 and CCR3, also bind w

43 AIL, FasL or CD40L is genetically fused to a high-affinity anti-fluorescein scFv antibody fragment (s

44 This is in contrast to the high-affinity anti-IgE mAbs that trigger anaphylactic de

45 ived from germinal centers (GCs) secrete the high-affinity antibodies required for long-term serologi

46 The potential therapeutic usefulness of high-affinity antibodies to cell wall carbohydrates is u

47 lar helper (Tfh) cells and the generation of high affinity antibody-producing B cells.

48 ulation is contained to ensure generation of high-affinity antibody is unknown.

49 High-affinity antibody production through the germinal c

50 Protective high-affinity antibody responses depend on competitive s

51 High-affinity arrestin binding requires receptor phospho

52 with favorable spectroscopic properties and high affinity, as determined by bioluminescence resonanc

53 l antibody (DX-2507) that binds to FcRn with high affinity at both neutral and acidic pH, prevents th

54 contrast, a number of other antagonists with high affinity at the D3R, did not alter the dimer/monome

55 to PCs is induced among a discrete subset of high-affinity B cells residing within the light zone of

56 result of an age-related subunit switch from high affinity beta2-containing nAChRs to low affinity be

57 are stable and can be engineered to develop high-affinity binders against specific targets of intere

58 howed that enrichment of indel mutations for high-affinity binders was three times that of non-synony

59 to folding and binding, and identified 2,618 high-affinity binders.

60 licity changes was essential to achieve both high affinity binding and a stringent targeted absorptio

61 potentially providing access by TERT to this high affinity binding site during an early step in TERT-

62 procapsid (PC-portal) that is competent for high affinity binding to the large terminase packaging p

63 with WDR5 provide structural basis for their high affinity binding to WDR5.

64 ly functional homodimer (or "lysibody") with high-affinity binding and specificity for carbohydrate d

65 es in BabA and on pH reversible formation of high-affinity binding BabA multimers.

66 d pulsed-EPR measurements, demonstrates that high-affinity binding caused by the CH2-localized mutati

67 side chain, the pH effect is abolished, and high-affinity binding is observed until LacY is destabil

68 reliably predict those mutated peptides with high-affinity binding of autologous human leukocyte anti

69 l virulence factors, relying on specific and high-affinity binding of zinc by a periplasmic solute-bi

70 ly coordinate zinc and then convey it to the high-affinity binding site.

71 y of Sox2 and Pax6 demands the relaxation of high-affinity binding sites and is enabled by alternativ

72 we used these advances to rapidly mutate 10 high-affinity binding sites for the nucleoid occlusion p

73 ffold and preorganizes CPSF-30 and WDR33 for high-affinity binding to AAUAAA.

74 or the chaperone/GEF Ric-8A], while favoring high-affinity binding to all known GBA motifs.

75 ar enzymes, composed of discrete domains for high-affinity binding to cell wall carbohydrates and cle

76 , and eight of the nine candidates exhibited high-affinity binding to human chemokines.

77 s conformational changes in gp120 that allow high-affinity binding to its coreceptors.

78 my virus long terminal repeat (LTR) that has high-affinity binding to the CCCTC-binding factor.

79 gnizes a receptor on the host cell, enabling high-affinity binding to the cell surface, after which t

80 identified molecular features important for high-affinity binding, with high predictive validity.

81 agonist (+)-pentazocine did not compete for high-affinity binding.

82 minazene is an interesting lead compound for high-affinity blockers of ASICs.

83 ay differentially influence the evolution of high-affinity bnAbs.

84 atrix; the popular dogma is that long-lived, high-affinity bonds to both species facilitate optimal t

85 Ks for CaM binding and found that CPK28 is a high affinity Ca(2+)/CaM-binding protein.

86 A common mechanism for high affinity carbohydrate uptake in microbial species i

87 varied in affinity, and determined that the high-affinity CD3 arms were up to 100-fold more potent i

88 High-affinity cdN binding inhibited RECON enzyme activit

89 ere we report the development of DI-591 as a high-affinity, cell-permeable small-molecule inhibitor o

90 radisulfide between Cys117 and Cys195 in the high affinity cGMP-binding site.

91 When supplied chloride, NPF6.4 switched to a high-affinity chloride selective transporter, while NPF6

92 The presynaptic, high-affinity choline transporter is a critical determin

93 er T cells, antigen-specific GC B cells, and high-affinity class-switched antibody production.

94 ubiquitin orientation in NCP-ubme to form a high-affinity complex.

95 nslational entropy accompanying formation of high-affinity complexes.

96 In physiological high-affinity conditions using a multivalent immunogen,

97 , the expression of OsCOPT1, which encodes a high-affinity copper transport protein, as well as other

98 n rice and overexpression of the Arabidopsis high-affinity copper transporter COPT1 slightly increase

99 cAMP-dependent membrane binding required the high-affinity cyclic nucleotide-binding (CNB) and Ras as

100 enetic screen around E. coli that identified high-affinity cytochrome bd oxidase as an essential bact

101 avels along DNA occupied by tandem arrays of high-affinity DNA binding proteins.

102 o conversion to a [2Fe-2S] form with loss of high-affinity DNA binding.

103 subset of the C-terminal ZBTB38 ZFs exhibit high-affinity DNA interactions and that preferential tar

104 ne heterocyclic appendage led to a series of high-affinity dopamine receptor partial agonists.

105 ssion, in a preclinical model, using a small high-affinity engineered protein scaffold (HAC-PD1).

106 All compounds were high affinity estrogen receptor alpha (ERalpha) ligands

107 PIs through basic and nonpolar residues with high affinity, favoring a more ordered structure.

108 d to restrict cancer cell growth by engaging high-affinity Fc receptors on monocytes and macrophages;

109 All 3 mAbs had high affinities for EphA2 but exhibited different intern

110 escribe includes (i) selection of scFvs with high affinity for Abeta42 fibrils after removal of scFvs

111 While several protein based inhibitors with high affinity for activated FXII (FXIIa) were developed,

112 d evaluated (18)F-JNJ64349311, a tracer with high affinity for aggregated tau (inhibition constant va

113 itro DNA binding assays suggest that Zta has high affinity for all four sequences examined, whereas A

114 xanthus PilB possesses conserved motifs with high affinity for c-di-GMP binding, the findings here su

115 low stoichiometry relative to cohesin, and a high affinity for chromosomal cohesin enables Scc2 to mo

116 multiple regions in the pre-genomic RNA with high affinity for core protein dimers.

117 as a recognition layer led to a sensor with high affinity for CT26 cancer cells, compared to control

118 ding loop of aprotinin, a small protein with high affinity for DENV protease.

119 protected by Ku, a DNA repair factor with a high affinity for DNA ends.

120 se the content of isoflavones, especially of high affinity for ERbeta.

121 n-dependent local transition to a state with high affinity for GPIbalpha.

122 is a novel DOTA-coupled GRPR antagonist with high affinity for GRPR and excellent in vivo stability.

123 Compounds with relatively high affinity for HSA (</=2 muM) showed high and sustain

124 c binding experiments [(3)H]RO6957022 showed high affinity for human CB2R with fast association (kon)

125 These functions require high affinity for nonspecific amino acid sequences that

126 nd Mo, that is, elements with a particularly high affinity for organic matter or oxides.

127 The cbb3 oxidase has a high affinity for oxygen and is required for growth of b

128 mbrane-binding properties, with particularly high affinity for phosphatidylethanolamine lipids.

129 that dual-target binding ligands displaying high affinity for PSMA and appropriate affinity for huma

130 Finally, UL8 has a very high affinity for replication fork structures containing

131 T cells bearing T cell receptors (TCRs) with high affinity for self-antigen are eliminated.

132 ght chains were cloned as IgG1, and those of high affinity for specific SAEs, assayed by means of ELI

133 able in only one allosteric state, that with high affinity for substrate.

134 ry bioactive thyroid hormone (TH) due to its high affinity for TH nuclear receptors (TRs), new data s

135 ure-selective DNA-binding protein exhibiting high affinity for the Holliday junction and promoting DN

136 Insight into the origin of the high affinity for the in state is obtained from spin-rel

137 nein, being capable of inducing both low and high affinity for the microtubule.

138 uscular acetylcholine (ACh) receptors have a high affinity for the neurotransmitter ACh and a low aff

139 radiolabeled sst receptor antagonist with a high affinity for the sst2 receptor, has the potential t

140 tically modified mutant activated PC, with a high affinity for VLA-3, shows significantly improved bi

141 PVP's high affinity for water and the nifedipine-polymer inter

142 terization and ligand identification for the high-affinity GHB binding sites.

143 tein Csr2/Art8 at multiple levels to trigger high-affinity glucose transporter endocytosis.

144 ique subpopulation based on addiction to the high-affinity glucose transporter, Glut3.

145 ersed the cocaine-induced suppression of the high-affinity glutamate transporter 1 (EAAT2/GLT-1) in t

146 ough an induced-fit disease pathway enabling high-affinity GPIbalpha binding and firm platelet adhesi

147 anges the conformation of the A1 domain to a high-affinity GPIbalpha binding competent state.

148 In-, and (nat)Lu-NeoBOMB1 bound to GRPR with high affinity (half maximal inhibitory concentration, 1-

149 its head domains, further stabilized by two high-affinity head-tail interfaces.

150 lex through a complementary interaction with high affinity, high specificity and high stability.

151 t conformations are amenable to cooperative, high-affinity histone binding.

152 Fluorosulfate is a high-affinity hNIS substrate.

153 otide-hydrolysis cycle but can still adopt a high-affinity homodimer when bound to a transition-state

154 Tildrakizumab is a high-affinity, humanised, IgG1 kappa antibody targeting

155 nd B*0801 and only 3 of 97 bound A*0101 with high affinity (IC50 < 500 nM).

156 thermore, repertoire analysis indicates that high affinity IgE and IgG1 plasma cells differentiate fr

157 By identifying the cellular origin of high affinity IgE and the clonal selection of high affin

158 munity as well as allergic reaction, but how high affinity IgE antibodies are produced in memory resp

159 naphylaxis was assessed, and the role of the high-affinity IgE Fc receptor (FcepsilonRI) in allergic

160 receptor-like 1[EMR1](+)MPs), mast cell MPs (high-affinity IgE receptor [FcepsilonRI](+)c-kit(+)MPs),

161 E-dependent activation mediated through both high-affinity IgE receptors (FcepsilonRI) on mast cells

162 T follicular helper cells and production of high-affinity IgG.

163 associated with decreased expression of the high affinity IL-2 receptor (CD25).

164 Neutralisation of the high-affinity IL-15 receptor binding subunit, IL-15ralph

165 om other genotypes, JFH-1 NS3 binds RNA with high affinity in a functionally active form that is capa

166 ue and 3 clones (CSP3, CSP4 and CSP6) showed high affinity in binding alpha-amylase.

167 nd the target protein beta-tubulin with both high affinity in vitro and high specificity in living ce

168 e Rac1); however, CXCL14 bound to CXCR4 with high affinity, induced redistribution of cell-surface CX

169 se inhibitor 2 (SGPI-2) to select reversible high affinity inhibitors of human CELA3A, CELA3B, and po

170 r, we show that targeting FimH with M4284, a high-affinity inhibitory mannoside, reduces intestinal c

171 oreceptors prior to inducing fusion and when high-affinity inhibitory peptides are used, a condition

172 strate a selective loss of clones expressing high-affinity iNKT-TCRs from the iNKT repertoire of peop

173 ion model in which the previously identified high-affinity interaction acts as a molecular tether, ho

174 y that was further supported by modeling the high-affinity interaction between the optimized sequence

175 That there is a high-affinity interaction is now clear, and its molecula

176 f Pd(en)Cl2 (en, ethylenediamine) promotes a high-affinity interaction with exquisite selectivity for

177 lar cytotoxicity and cytokine secretion upon high-affinity interaction with the cognate CTLR keratino

178 High-affinity interactions with MED25 are specific for t

179 MglA-SspA must be bound to ppGpp to mediate high-affinity interactions with PigR.

180 4G by the poliovirus 2A protease generates a high-affinity IRES binding truncation of eIF4G that stim

181 The GO-peptide-based chip (1mM) had a high affinity (KA) of 6.37x10(12)M(-1), limit of detecti

182 ains to DNA creates amphiphiles that exhibit high-affinity (Kd in low nanomolar range) binding to HSA

183 e identified and optimized a novel series of high affinity KMO inhibitors with favorable physicochemi

184 toward binding input molecules in water with high affinity leading to displacement of CB7 from includ

185 on Coro1A by regulating the accumulation of high-affinity LFA-1 in focal zones of adherent cells.

186 dless of ligand density, like a low density, high affinity ligand in all these parameters.

187 Cs might determine local availability of its high-affinity ligand APRIL, because sBCMA has been shown

188 6-alpha7 loop and alpha7-helix, required for high-affinity ligand binding.

189 VACV-138 also abrogated D8 binding to the high-affinity ligand CS-E, but we observed residual CS-E

190 ration-inducing ligand" (APRIL) is a natural high-affinity ligand for BCMA and transmembrane activato

191 , Pachymedusa dacnicolor, and validated as a high-affinity ligand for CRF receptor studies.

192 ethylpyrrolidinyl analogues were found to be high affinity ligands for the CB1 and CB2 cannabinoid re

193 Antisense oligonucleotides may be coupled to high-affinity ligands (triantennary N-acetyl galactosami

194 al its functional interaction interface with high-affinity ligands.

195 novel binder [S14R, W50Pra]Ts1 for Nav with high affinity, low dissociation rate and reduced toxicit

196 This finding should also hold for other high-affinity mAbs and short-lived alpha-emitters.

197 d by reexpression, which has identified many high-affinity mAbs.

198 Our workflow uses high-affinity magnetic immunocapture to rapidly purify H

199 Finally, hydroxymethylation of a high-affinity mCA site does not alter the binding proper

200 e PIP molecules by PH domains contributes to high-affinity membrane interactions, informing our under

201 igh affinity IgE and the clonal selection of high affinity memory B cells into the plasma cell fate,

202 cells differentiate from rare CD80(+)CD73(+) high affinity memory clones without undergoing further m

203 ction; the ene-dithiol group of DTPs enables high-affinity metal binding as a central mechanism to in

204 and interleukin (IL)-2, but not IL-17A; iii) high-affinity MHC class II interaction with SAgs, but no

205 Rhizobium leguminosarum has two high-affinity Mn(2+) transport systems encoded by sitABC

206 in switching, allows FIN219 to switch to its high-affinity mode and thereby enhances JA signaling und

207 ified view of the general role of entropy in high-affinity molecular recognition by proteins.

208 We selected a high-affinity monkey cross-reactive anti-CLL-1 arm and t

209 In this study, a collection of high-affinity monoclonal antibodies was generated to bos

210 The primary, high-affinity motif is conserved.

211 ted at kappa and mu receptors and yield very high affinity multifunctional (e.g. 12) or highly select

212 mmunogens can overcome these challenges with high-affinity multimeric designs.

213 ine endometrial epithelial cells express the high affinity Na(+)-coupled glucose carrier SGLT1.

214 ts biological and immunological activity via high-affinity neurokinin 1 receptor (NK1R).

215 combination and clonal selection to generate high affinity neutralizing antibodies.

216 Tyr-370 to His (Y370H) resulted in saturable high-affinity nitrate transport activity and nitrate sel

217 hat Zm-NPF6.6 was a pH-dependent nonbiphasic high-affinity nitrate-specific transport protein.

218 iation constant or affinity unit (KD) showed high affinity of both AP and AS to BSA.

219 paradoxical situation develops in which the high affinity of Pt for CO helps to decrease the overpot

220 The high affinity of SA to BSA was demonstrated by a binding

221 Due to a high affinity of the catalyst to silica gel, a simple ch

222 functional ligands characterized in vitro as high-affinity partial agonists of D2R, antagonists of 5-

223 ntribute distinctively to the repertoires of high affinity pathogenic IgE and low affinity non-pathog

224 y determining pockets in a way that leads to high-affinity peptide binding and efficient antigen pres

225 led CB-TE1A1P-PEG4-LLP2A ([(64)Cu]-LLP2A), a high affinity peptidomimetic ligand for very late Ag-4 (

226 eas the other phylotype consistently carry a high-affinity phosphate pst transporter and the phoB-pho

227 XRCC1 and PNKP interact via a high-affinity phosphorylation-dependent interaction site

228 PHT1;1, 1;2, 1;3, 1;7 and 1;8 to function as high affinity Pi transporters.

229 aromyces cerevisiae pho2 mutant defective in high-affinity Pi transport rescues growth in low-Pi envi

230 ganism Saccharomyces cerevisiae are the Trk1 high affinity potassium transporter and the functionally

231 smon resonance we demonstrate that Rif1 is a high-affinity PP1 adaptor, able to out-compete the well-

232 with other popular techniques for measuring high-affinity protein-protein interactions, such as bios

233 (11)C-JNJ-42491293, a novel high-affinity radioligand (human 50% inhibitory concentr

234 nt species and is only suitable for studying high affinity reactions.

235 ngle nucleotide polymorphisms (SNPs) for the high affinity receptor for IgG, FcgammaRI.

236 for leukotriene B4 have been identified: the high-affinity receptor BLT1 and the low-affinity recepto

237 Binding of allergen-specific IgE to its high-affinity receptor FcepsilonRI on basophils and mast

238 orphan member of the GFR-alpha family, is a high-affinity receptor for GDF15.

239 tients with atopic dermatitis (AD) carry the high-affinity receptor for IgE, FcepsilonRI, and are cru

240 an neutrophils constitutively express Sema3E high-affinity receptor, PlexinD1.

241 the inhibitory LIR1 revealed similarities to high-affinity recognition of the viral MHC-I mimic UL18

242 and UG-rich RNA motifs, binding with low and high affinity, respectively.

243 one branched domain (domain II) containing a high-affinity Rev-binding site, and two or three additio

244 d Kir6.2(V64M) mutations essentially abolish high-affinity sensitivity to the KATP blocker glibenclam

245 her dehydroepiandrosterone or fluvoxamine, a high-affinity sigma1-receptor agonist, improved survival

246 -) mice exhibited comparable accumulation of high-affinity signaled CD4(+)CD8(+) double-positive thym

247 Here, we engineered a series of ultra-high affinity siRNA binders based on the viral protein p

248 E2 approximately ubiquitin-binding sites: a high-affinity Site 1 required for E6AP Cys(820) approxim

249 ogether, these findings demonstrate that the high-affinity site is inaccessible because of either a c

250 tion of toluene by competitive adsorption to high-affinity sorption sites while acknowledging that to

251 s are appealing drug candidates due to their high affinity, specificity, and favorable pharmacologica

252 immunoassays rely on antibodies that provide high affinity, specificity, and selectivity against a ta

253 n-like motion was confined by DNA binding to high-affinity spots, suggesting a two-step mechanism for

254 in metabolically stressed cancer cells using high-affinity STAT3 inhibitors.

255 and to trigger allostery that stabilizes the high affinity state under force.

256 hough alpha4beta1 is easier to activate, its high-affinity state binds vascular cell adhesion molecul

257 called catch-bond mechanism from the low- to high-affinity state.

258 rom the bent (low affinity) to the extended (high affinity) state.

259 ed component and are responsible for initial high-affinity substrate binding.

260 bacteria, these transporters partner with a high-affinity substrate-binding protein (SBP) to import

261 A key question remains: how are high-affinity substrates transferred across the membrane

262 a protein-engineering approach, we generated high-affinity SUMO2 variants by phage display that bind

263 is to describe the recent progress in making high affinity synthetic association partners that operat

264 ased therapies, such as chimeric antigen and high-affinity T-cell receptors to deepen the adaptive im

265 i) M.HhaII triggers Mrr activity by creating high affinity target sites on the chromosome, which pull

266 Here we exploit a high-affinity TCR (B4.2.3) to examine the structural cha

267 Two high-affinity TCRs (KD values of approximately 50 and 25

268 l CD4(+) T cell responses mediated by shared high-affinity TCRs.

269 s bind FZD cysteine-rich domains (CRDs) with high affinity through a palmitoylated N-terminal "thumb"

270 ulin-specific T cells and prevents escape of high-affinity thymocytes.

271 SPI-1 was characterized as a high-affinity, tight-binding inhibitor of Arabidopsis su

272 ts of the IL18R1 and IL18RAP genes, and with high affinity to a separate IL-18 binding protein (IL-18

273 ine and a number of compounds that bind with high affinity to alpha2-ARs.

274 h the peptide sequence RGD, which binds with high affinity to alphaVbeta3 integrins present in both t

275 a near infrared probe was fabricated to have high affinity to apoptotic cells.

276 rms a hydrogen bond with E353 to mediate its high affinity to beta1-integrin.

277 the key to achieving colloidal stability and high affinity to biomolecules as well as support materia

278 ated cavities in the polymer matrix led to a high affinity to CO2.

279 cationic bolaamphiphile that binds TFDs with high affinity to form self-assembled complexes (nanoplex

280 Furthermore, we find that GDF15 binds with high affinity to GDNF family receptor alpha-like (GFRAL)

281 ecule tracer for PET imaging that binds with high affinity to GPIIb/IIIa receptors and has suitable p

282 tagonist, [(3)H]G9543, was able to bind with high affinity to GPR84, this was not competed for by inc

283 s unidentified, we show that FplA binds with high affinity to host phosphoinositide-signaling lipids,

284 In skeletal muscle, agrin binds with high affinity to laminin(s) and alpha-dystroglycan (alph

285 (SSB) wraps single-stranded DNA (ssDNA) with high affinity to protect it from degradation and prevent

286 ion of RBM25 spanning Lys-77 that binds with high affinity to serine- and arginine-rich splicing fact

287 We report that CHD6 and CHD7 both bind with high affinity to short linker DNA, whereas CHD8 requires

288 tein that, when unphosphorylated, binds with high affinity to the complex of betagamma-subunits of G

289 (18)F-GP1 binds specifically with high affinity to the GPIIb/IIIa receptor involved in pla

290 o identify the few variants that bind with a high affinity to the target structure.

291 RNP A2 proteins that bind specifically (with high affinity) to A2RE sequences or nonspecifically (wit

292 was due to the mislocalisation of CTR1, the high affinity transporter that imports copper into the c

293 een the new compounds stands out 12b for its high affinity value (Ki = 0.27 nM) and for its anxiolyti

294 gion of Notch1 complexed with an engineered, high-affinity variant of Jagged1 (Jag1) reveals a bindin

295 nists, namely compounds 21 and 22, displayed high affinity versus the EphA2 receptor and resulted end

296 mechanism to retain substrate proteins with high affinity while also generating functional switches

297 aused by the reduction of CO2 into CO, whose high affinity with platinum triggers the formation of a

298 to study protein interactions of medium- and high-affinities with a limit of detection down to 1 pM,

299 ty due to its ability to bind PPARgamma with high affinity without stimulating adipocyte differentiat

300 re characterized by a flexible loop near the high-affinity zinc-binding site.