ライフサイエンスコーパス: high dose

1 er, opening the door next for testing of the high dose.

2 hemia-reperfusion injury when delivered in a high dose.

3 very low doses, and suppressing function at high doses.

4 lacebo), arthritis (5.1% combined lots, 4.2% high-dose, 0.0% placebo), and rash (3.8% combined lots,

5 d low-dose (1 x 10(10) vector genomes) and 3 high-dose (1 x 10(11) vector genomes) rAAV.sFLT-1 via su

6 Melanin afforded protection against high-dose (1.5 kGy) deuterons for both CN and CA (p-valu

7 placebo), and rash (3.8% combined lots, 3.8% high-dose, 1.5% placebo).

8 , there was no induction of disease, even at high doses (10(6) HAD50).

9 In human whole blood, PAV coating at high dose (100 microg/ml) induced elevated complement, l

10 Of the 12 patients who had received the high dose, 11 sat unassisted, 9 rolled over, 11 fed oral

11 ose; 145 patients), or 280 mg every 2 weeks (high dose; 146 patients) resulted in annualized asthma e

12 kilogram of body weight), and 12 received a high dose (2.0x10(14) vg per kilogram).

13 were arthralgia (17.1% combined lots, 20.4% high-dose, 3.0% placebo), arthritis (5.1% combined lots,

14 lots (3.2% with >/=39.0 degrees C), 32.2% of high-dose (4.3% with >/=39.0 degrees C), and 0.8% of pla

15 Treatment of established infection with a high dose (50 mug) of CpG ameliorated disease and lowere

16 gamma2Vdelta2 T cells at weeks 1 and 3 after high-dose (500 CFU) M. tuberculosis infection exhibited

17 Although repelling at high doses, 6-MHO/GA mixtures were not active at the lev

18 Confirming in vitro results, high-dose (80-mg) simvastatin improved neutrophil migrat

19 Compared with low dose, high-dose ACEI or ARBs decreased all-cause mortality mod

20 cells showed increased CCR5 expression after high-dose allergen exposure while CXCR4, CXCR5, CCR6, an

21 Prolonged high-dose anabolic-androgenic steroid (AAS) use has been

22 We studied 1039645 recipients of high-dose and 1683264 recipients of standard-dose vaccin

23 -dose vaccines during 2012-2013, and 1508176 high-dose and 1877327 standard-dose recipients during 20

24 h were 0.028 and 0.038/10000 person-weeks in high-dose and standard-dose recipients, respectively.

25 doses of antibiotics can be as effective as high doses, and (iii) neither phenotypic nor inherited a

26 High-dose araC (HD-araC) was used in the second inductio

27 aspirin (50 to 150 mg/d); 914 (20%) received high-dose aspirin (300 to 600 mg/d), dipyridamole, or ot

28 Here we report that high dose atorvastatin increased the phagocytic function

29 owever, adverse events, postdose nausea with high-dose azithromycin, effectiveness of single-dose rif

30 The high-dose beta-radiation penetrates an average of only 2

31 mation) in the mandibular defect by applying high dose BMP2.

32 INTERPRETATION: High-dose bolus vitamin D supplementation of 100 000 IU

33 Low-dose CDKi outperforms high-dose CDKi in controlling tumour burden and resistan

34 High-dose cefepime-tazobactam (1:1; WCK 4282), a novel a

35 In a single, high-dose challenge study, only the Ad/Env vaccine affor

36 d against the acquisition of DENV2 following high-dose challenge.

37 t survival outcomes of patients treated with high-dose chemotherapy (HDCT) and peripheral-blood stem-

38 melphalan should thus be considered standard high-dose chemotherapy and ongoing randomised studies wi

39 cell transplantation (HCT), patients receive high-dose chemotherapy before transplantation and experi

40 High-dose chemotherapy plus autologous stem-cell transpl

41 cluded an open-label randomised arm in which high-dose chemotherapy regimens were compared.

42 We aimed to assess event-free survival after high-dose chemotherapy with busulfan and melphalan compa

43 High-dose chemotherapy with haemopoietic stem-cell rescu

44 ea under the curve >/= 4 mg/mL per minute or high-dose chemotherapy, and for pediatric patients who r

45 cell rescue was given after the last dose of high-dose chemotherapy, at least 24 h after melphalan in

46 nd inferior responses to both induction- and high-dose chemotherapy.

47 treated with standard-fractionation RT plus high-dose cisplatin vs accelerated-fractionation RT plus

48 the two cohorts and motor milestones in the high-dose cohort with scores in studies of the natural h

49 In the high-dose cohort, a rapid increase from baseline in the

50 In the high-dose cohort, the factor VIII activity level was mor

51 In the high-dose cohort, the median annualized bleeding rate am

52 that low-dose colchicine is as effective as high-dose colchicine and causes fewer gastrointestinal a

53 n in this setting prompted us to study a new high-dose combination of infused gemcitabine, busulfan,

54 receptor antagonist, dose-dependently and at high doses completely blocked ethanol-induced NREM sleep

55 tially help avoid unnecessary morbidity from high-dose corticosteroid therapy and allow the most appr

56 ients with eosinophilic asthma maintained on high-dose corticosteroids, prednisone, or both.

57 izumab (2.5 mg per kilogram of body weight), high-dose crizanlizumab (5.0 mg per kilogram), or placeb

58 e first crisis was significantly longer with high-dose crizanlizumab than with placebo (4.07 vs. 1.38

59 median rate of crises per year was 1.63 with high-dose crizanlizumab versus 2.98 with placebo (indica

60 rate of sickle cell-related pain crises with high-dose crizanlizumab versus placebo.

61 uncomplicated crises per year was 1.08 with high-dose crizanlizumab, as compared with 2.91 with plac

62 placebo (indicating a 45.3% lower rate with high-dose crizanlizumab, P=0.01).

63 placebo (indicating a 62.9% lower rate with high-dose crizanlizumab, P=0.02).

64 tant predictors that a patient would undergo high-dose CT.

65 ant conditioning can be safely combined with high-dose cyclophosphamide after transplantation, and th

66 We hypothesized that high-dose cyclophosphamide given after G-CSF-mobilized b

67 ased combination (CLARA) versus conventional high-dose cytarabine (HDAC) as postremission chemotherap

68 ree (HR) consolidation courses that included high-dose cytarabine and anthracycline, and maintenance

69 nd cytarabine and consolidation therapy with high-dose cytarabine) plus either midostaurin or placebo

70 ing factor, mitoxantrone plus cytarabine, or high-dose cytarabine).

71 se (HR, 0.78; 95% CI, .55-.90; P = .012) and high-dose daptomycin (HR, 0.70; 95% CI, .41-.84; P = .00

72 High-dose daptomycin was associated with improved surviv

73 Compared to high-dose daptomycin, both standard-dose (hazard ratio [

74 -day mortality was significantly lower among high-dose daptomycin-treated patients compared with othe

75 We find that i) middle- and high-dose data do not constrain the low-dose response, a

76 High doses decreased Ca(2+) currents through an ERbeta-m

77 performed a credible control condition, with high dose delivery yielding the best outcomes.

78 wed no detectable viral RNA after subsequent high-dose DENV2 challenge at 19 weeks postvaccination.

79 High-dose DHA supplementation in APOE4 carriers before t

80 curring VDR agonist, VDR 4-1 therapy even at high doses did not induce hypercalcemia.

81 For example, high-dose duloxetine outperformed escitalopram in treati

82 .VA supplementation administered in a single high dose during the first month after birth is readily

83 High-dose elamipretide resulted in favorable changes in

84 s (n = 4) and during intravenous infusion of high-dose erlotinib (10 mg/kg/h, n = 4) or elacridar (12

85 During high-dose erlotinib infusion, (11)C-erlotinib brain dist

86 62 212) who underwent single-phase CT had a high-dose examination (adjusted relative risk, 6.20 [95%

87 who underwent multiphase abdominal CT had a high-dose examination, 8% of patients (4977 of 62 212) w

88 on after log transformation of doses and (b) high-dose examinations (top 25% of dose within anatomic

89 h single-phase CT, 69% (18 208 of 26 388) of high-dose examinations would have been eliminated.

90 nce injection doses are above 15 mg kg(-1) : high dose expedited the renal excretion and shortened th

91 for the autoantibody and treating them with high-dose folinic acid along with other interventions to

92 We sought to determine whether high-dose folinic acid improves verbal communication in

93 D) are positive for these autoantibodies and high-dose folinic acid is beneficial in treating these c

94 asthma remain symptomatic despite prolonged, high-dose glucocorticoid therapy.

95 ion with avacopan was effective in replacing high-dose glucocorticoids in treating vasculitis.

96 were randomly allocated into 5 groups: BSJYD high dose group, middle dose group, low dose group, capt

97 r child was 1.05 (95% CI, 0.91-1.19) for the high-dose group and 1.03 (95% CI, 0.90-1.16) for the sta

98 48.7 ng/mL (95% CI, 46.9-50.5 ng/mL) in the high-dose group and 36.8 ng/mL (95% CI, 35.4-38.2 ng/mL)

99 95 months (95% CI, 3.02-5.95 months) for the high-dose group vs 3.29 months (95% CI, 2.66-4.14 months

100 2000 IU/d of vitamin D oral supplementation (high-dose group) vs 354 participants who were randomized

101 f rVSVDeltaG-ZEBOV-GP (1 x 108 pfu, n = 264; high-dose group), or placebo (n = 133).

102 ] in the low-dose group, and 20 [34%] in the high-dose group).

103 patients in the medium-dose group, 3 in the high-dose group, and 1 in the placebo group discontinued

104 ) to the low-dose group, and 58 (34%) to the high-dose group.

105 ) in the low-dose group, and two (3%) in the high-dose group; only one (an acute allergic skin reacti

106 41 patients in low-dose and 4330 patients in high-dose groups) were included.

107 medium-dose (8 mg/kg total body weight), or high-dose (>/=10 mg/kg total body weight) daptomycin for

108 none, low-dose (</=5 mug/kg per minute), and high-dose (>5 mug/kg per minute).

109 re divided into "low-dose" (</= 100 mg) and "high-dose" (>100 mg) aspirin groups.

110 yes were divided into apex low-dose (LD) and high-dose (HD) groups (</= or > median apex dose 84.35 G

111 h-type immunoassays are often limited by the high-dose hook effect, which causes falsely low results

112 -daily tiotropium Respimat add-on therapy to high-dose ICS with 1 or more controller medications, or

113 rt of the Eastern Cooperative Oncology Group high-dose IFN regimen is not better than OBS alone for p

114 ly transduced with MAGE-A3 TCR plus systemic high-dose IL-2.

115 elper type 1 (Th1) immune responses, whereas high-dose immunization primes responses characterized by

116 ge and during mild to moderate infection, at high dose in older adults, but not during more severe se

117 se findings should be considered, when using high doses in rat models for neurological diseases.

118 s (most are drugs) at two doses (control and high dose) in a repeated schedule containing four separa

119 High-dose infection and persistence were also associated

120 During high-dose infection, the multiple peptide resistance fac

121 N: When compared with standard-dose vaccine, high-dose influenza vaccine can reduce risk of respirato

122 were not already planning to administer the high-dose influenza vaccine to residents.

123 lower in facilities where residents received high-dose influenza vaccines than in those that received

124 nths before screening despite regular use of high-dose inhaled corticosteroids plus other controller

125 sthma (AA) that remains uncontrolled despite high-dose inhaled corticosteroids plus other controller

126 f MG defined by a low-dose stimulation and a high-dose inhibition of tumour growth.

127 h short-term, low-titer colonization whereas high-dose inocula were associated with acute bacterial r

128 eriarrest, we recommend incremental doses of high-dose insulin (1D) and IV lipid-emulsion therapy (1D

129 d based on desired effect), IV calcium (1D), high-dose insulin therapy (1D-2D), and norepinephrine an

130 treatments, we suggest incremental doses of high-dose insulin therapy if myocardial dysfunction is p

131 f 4 weeks of intravenous (IV) induction with high-dose interferon (IFN) as part of the Eastern Cooper

132 intravenous infusion of autologous TILs and high-dose interleukin-2 [720 000 IU/kg] every 8 h).

133 Inverse correlation with high-dose interleukin-2 outcomes was also observed for t

134 characterized by reduced lethality following high-dose intradermal infection, an altered cytokine res

135 In that model, relatively high-dose intraperitoneal rapamycin extended lifespan an

136 There is increasing interest in using high-dose intravenous ascorbate (IVC) in treating this d

137 function) at 3-week intervals, PPH (6x), and high-dose intravenous immunoglobulin (1.5 g/kg).

138 o treat inflammatory diseases in the form of high-dose intravenous immunoglobulin (IVIG).

139 ensitization protocol starting at day 0 with high-dose intravenous immunoglobulin, plasma exchanges,

140 High-dose intravenous NAC administered with low-dose int

141 High-dose ionising radiation is associated with circulat

142 After high-dose IR, when both matrix and hair bulb cells were

143 ve: To examine safety and effects of monthly high-dose IV pulse MTX in EF.

144 l saline), low-dose ketamine (0.5 mg/kg), or high dose ketamine (1.0 mg/kg) after induction of anaest

145 These data suggest that administration of high-dose loop diuretics to patients with HF yields mean

146 fu], n = 797; combined-lots group), a single high-dose lot of rVSVDeltaG-ZEBOV-GP (1 x 108 pfu, n = 2

147 culating HDL and increased liver damage upon high-dose LPS challenge.

148 rticoid receptor antagonists administered at high doses may relieve congestion, overcome diuretic res

149 High-dose melphalan is of little benefit as a regimen fo

150 e additional cycles of RVD (350 patients) or high-dose melphalan plus stem-cell transplantation follo

151 ofound voriconazole dose reductions whenever high-dose meropenem was added.

152 mmencement of fosfomycin in conjunction with high-dose meropenem.

153 High-dose metformin inhibited GM-CSF and MMP9 release fr

154 d effective as consolidation therapies after high-dose methotrexate-based chemoimmunotherapy in patie

155 ng the last decades with the introduction of high-dose methotrexate.

156 radiotherapy (WBRT), as consolidation after high-dose-methotrexate-based chemoimmunotherapy.

157 After treatment with high-dose methylprednisolone (1 g/day, intravenously, fo

158 Using full-dose proton-pump inhibitor and high-dose Metronidazole in group A, and full-dose proton

159 rticipants were randomly assigned to receive high-dose MTX with leucovorin rescue or escalating dose

160 venously injected with nanoparticles using a high-dose multiple injection scheme exhibit reduced grow

161 tandard dose, n = 709; medium dose, n = 142; high dose, n = 60).

162 r study evaluated the effects of intravenous high-dose NAC (29 g over 2 days) with background low-dos

163 y weight associated with roots immersed in a high dose nanoparticle suspension of 1.75 mg NP/mL at 10

164 limited because of cost, determined from the high doses needed to compensate for its relatively low n

165 High-dose NOACs provide overall efficacy and safety simi

166 nd a significantly higher response rate than high-dose octreotide LAR among patients with advanced mi

167 ination with primaquine, either the standard high dose of 0.5 mg base/kg/day for 14 d or a higher dos

168 ed cocaine-induced reinstatement only at the high dose of 100 mg/kg.

169 E1-vaccinated baboons were challenged with a high dose of a highly virulent B. pertussis isolate, the

170 We find that a high dose of AAV9-Tert targets the bone marrow compartme

171 occupancy similar to the one obtained with a high dose of AZ10419369.

172 nuated hypothermia in rats challenged with a high dose of bacterial lipopolysaccharide (LPS) in a the

173 were performed in animals receiving a single high dose of bevacizumab (45 mg/kg 2 d before PET; n = 9

174 ce confers long lasting protection against a high dose of BoNT/A.

175 traarterial therapy allows the delivery of a high dose of chemotherapy or radiation into liver tumors

176 Similarly, a high dose of CTGF/TGFbeta3-microS yielded significantly

177 For the high dose of CuO NPs, the amount of DTPA-extractable Cu

178 wever, retinal photosensitization requires a high dose of DENAQ and disappears within several days af

179 E4ORF1 lowered nonfasting blood glucose at a high dose of expression.

180 When exposed to a high dose of mating pheromone, the yeast cell undergoes

181 hich volunteers underwent CHMI with a low or high dose of Plasmodium falciparum sporozoites.

182 as effectively as a single treatment with a high dose of rapamycin alone.

183 fore being rectally challenged with a single high dose of SHIV-327c.

184 In animals given a single high dose of STZ causing severe and rapid development of

185 In the article by Scott et al, a high dose of vitamin D attenuated the inflammatory respo

186 re randomized to receive either placebo or a high dose of vitamin D3 (cholecalciferol) one hour after

187 the general motor-decreasing effects of the high dose of WAY.

188 ratory toxicology investigations showed that high doses of 5-NIdR did not produce the side effects co

189 Randomized controlled trials that compared high doses of ACEI or ARB against low doses among patien

190 gies are based on systemic administration of high doses of antibiotics, which result in side effects

191 High doses of AZ10419369 exerted an extracranial tissue

192 reatment consisted of plasma exchanges (PE), high doses of calcineurin inhibitors, and steroids.

193 h vasodilatory shock that did not respond to high doses of conventional vasopressors.

194 persistence of eosinophils in sputum despite high doses of corticosteroids indicates disease severity

195 oth fast-growing and slow-growing fungi from high doses of deuterons under physiological conditions.

196 ne enables their male offspring to cope with high doses of either, which suggests that such paternal

197 roduction feasibility and safety of infusing high doses of ex vivo-expanded NK cells after haploident

198 The patient was managed conservatively with high doses of glucocorticoids, which resulted in prompt

199 Using a prime/boost strategy, high doses of GP/VSVDeltaG partially or fully denuded of

200 (CSU) patients with angioedema refractory to high doses of H1 -antihistamines.

201 with long-acting beta-agonists and medium-to-high doses of inhaled glucocorticoids, those who receive

202 with long-acting beta-agonists and medium-to-high doses of inhaled glucocorticoids.

203 High doses of ionizing radiation induce acute damage to

204 essing BAT-PET/CT-as it requires exposure to high doses of ionizing radiation.

205 g to the low radiation absorption of tumors, high doses of ionizing radiations are often needed durin

206 nt humans and animals, however, can tolerate high doses of L. monocytogenes without developing system

207 The observation that high doses of Lipopolysaccharide (LPS) drove rapid monoc

208 dazolam, especially after the application of high doses of midazolam, and in case of impaired drug me

209 Feeding high doses of peanut before sensitization decreased perc

210 Feeding high doses of peanut to pups induced tolerance to peanut

211 Among older patients using medium to high doses of prednisolone, alendronate treatment was as

212 However, injection of high doses of the vector induced a decrease of alphaDG g

213 infected 39 macaques by feeding them single high doses of the virulent Mahoney strain of wild type 1

214 ne layer, such that Earth's surface receives high doses of UV radiation for about a year once the soo

215 However, upon prompt treatment with high doses of vitamin B6, affected patients can have a n

216 In contrast, a high-dose of MAGL inhibitors produces pro- or antidepres

217 outcomes in the placebo group.Six months of high-dose omega-3 supplementation raised plasma and adip

218 standard of care for the residents of either high dose or standard dose as the vaccine for the 2013-1

219 beneficiaries aged >/=65 years who received high-dose or standard-dose vaccines in community-located

220 mal estrogen formulations are preferred over high-dose oral formulations.

221 articipants with HFrEF with iron deficiency, high-dose oral iron did not improve exercise capacity ov

222 dium dose [P=0.02], and 0.15 liters with the high dose [P=0.002]).

223 Coating of high dose PAV with CHC significantly reduced these respo

224 study evaluating concurrent chemotherapy and high-dose PBT to treat unresectable stage III NSCLC.

225 To evaluate low- vs high-dose plaque brachytherapy for juxtapapillary choroi

226 similar to the renal benefits observed with high-dose prednisolone in control mice.

227 tagonism, which was at least as effective as high-dose prednisolone with potentially fewer adverse ef

228 ne also attenuated disease as effectively as high-dose prednisolone without the systemic immunosuppre

229 Moreover VIN, especially at high dose, preserved non-anthocyanin phenolic compounds

230 em, tranexamic acid (during menstrual flow), high-dose progestin-only therapy, or combined hormonal c

231 o 27OHC was hormetic, such that low, but not high, doses promoted AICD transactivation of microtubule

232 cally reduced lung inflammation in mice upon high-dose pulmonary challenge with S. pneumoniae The cPL

233 djunctive immunomodulatory intervention with high dose pulse corticosteroids, affording causal infere

234 ptoms and showed improvement with adjunctive high dose pulse corticosteroids.

235 To determine whether adaptive RT can target high-dose radiation to the FDG-avid tumor on midtreatmen

236 ementia (1 trial, low strength of evidence); high-dose raloxifene decreased risk for MCI but not for

237 All 39 macaques fed with single high doses ranging from 10(7) to 10(9) TCID50 Mahoney ty

238 ivation therapy, brachytherapy boost (LDR or high-dose rate [HDR]) should be offered to eligible pati

239 acytoid dendritic cells (pDCs) under low and high doses, respectively, through CD91.

240 apy (FACT)-Lung Cancer Subscale (LCS) in the high-dose RT arm at 3 months.

241 ]) on low-dose SCIg, and 19 (33% [22-46]) on high-dose SCIg had a relapse or were withdrawn from the

242 As an alternative to high-dose sedatives and controlled mechanical ventilatio

243 linded dosing strategy, we demonstrated that high dose sertraline monotherapy provided no benefit for

244 t], intermediate dose [one participant], and high dose [seven participants]) and were followed throug

245 -month MS-STAT phase 2 trial, we showed that high-dose simvastatin significantly reduced the annualis

246 ein boost is critical for protecting against high-dose SIVsmE660 challenge and for blocking neutraliz

247 However, at this high dose some organoleptic properties were affected.

248 High-dose spironolactone (100 mg) vs placebo or 25 mg sp

249 groups (-0.55 [95% CI, -0.92 to -0.18] with high-dose spironolactone and -0.49 [95% CI, -0.98 to -0.

250 697-9596) pg/mL among the group treated with high-dose spironolactone and 3753 (1968-7633) pg/mL amon

251 To assess the effect of high-dose spironolactone and usual care on N-terminal pr

252 Adding treatment with high-dose spironolactone to usual care for patients with

253 High-dose SSRS provides durable tumor control when used

254 At high doses, staple dissociation increases which causes s

255 tion, 22% dual-antiplatelet therapy, and 71% high-dose statin therapy versus 0.8%, 1.6%, and 31% amon

256 (PBMC) transcriptomics in patients receiving high-dose statin therapy.

257 Overall, 58.4% received high-dose statins (atorvastatin 40-80 mg, rosuvastatin 2

258 1), bendamustine (22% versus 0%; P < 0.001), high-dose steroids (57% versus 21%; P = 0.001), or purin

259 ituximab (odds ratio = 9.52; P = 0.001), and high-dose steroids (odds ratio = 5.05; P = 0.01) retaine

260 High-dose steroids and calcineurin inhibitors are ineffe

261 High viral load, high-dose steroids, and myeloablative conditioning were

262 s suggested that high viral load, receipt of high-dose steroids, and myeloablative conditioning were

263 ht eyes of 14 rats (low dose; study group I, high dose; study group II).

264 min(-1) x g(-1), P < 0.05 vs. controls) and high-dose subgroups (37.2 +/- 7.8 nmol x min(-1) x g(-1)

265 in aquatic environments and are perceived at high doses that are not compatible with their transport

266 y low efficacy in vivo, requiring the use of high doses that often cause adverse effects, such as con

267 ic outcomes, such as dosimetric estimations, high-dose therapies, multiple fractionated administratio

268 ble patients to proceed toward consolidative high-dose therapy and autologous stem cell rescue with i

269 Cardiac events were relatively common after high-dose thoracic RT and were independently associated

270 efficacy was limited, with the need for very high doses to block receptor activation.

271 However, expanding its use to include high-dose treatment of other cancers is severely hampere

272 f ROS scavengers to control ROS bursts after high-dose treatment with carbonyl cyanide m-chlorophenyl

273 compared the effect of the more immunogenic high-dose trivalent influenza vaccine with a standard-do

274 e evaluated the comparative effectiveness of high-dose vaccine in preventing postinfluenza deaths dur

275 High-dose vaccine was significantly more effective in pr

276 ies were randomised for residents to receive high-dose vaccine, and 414 facilities for residents to r

277 is not responsive to fluid and moderate- to high-dose vasopressor therapy (conditional, low quality

278 Vasodilatory shock that does not respond to high-dose vasopressors is associated with high mortality

279 VC, we tested how erythrocytes might impact high dose VC therapies.

280 t human polyclonal antisera against low- and high-dose VEEV challenges.

281 Limiting the comparison to high dose versus no primaquine in the period during and

282 us placebo (p=0.001), and 6% (-11 to 23) for high-dose versus low-dose (p=0.32).

283 se versus placebo (p=0.007), 30% (12-46) for high-dose versus placebo (p=0.001), and 6% (-11 to 23) f

284 r between groups, so analyses focused on the high-dose versus standard-dose vaccine comparison.

285 ose tissue function.We tested the effects of high-dose, very-long-chain omega-3 fatty acids on adipos

286 ollow-up phase of an interventional trial of high-dose vitamin D given during pregnancy.

287 t, overweight or obese adults, despite using high-dose vitamin D supplementation and robust endpoint

288 Monthly high-dose vitamin D supplementation does not prevent CVD

289 e findings do not support the routine use of high-dose vitamin D supplementation in children for the

290 We aimed to assess the effect of high-dose vitamin D supplementation on fractures and fal

291 To examine whether monthly high-dose vitamin D supplementation prevents CVD in the

292 To determine the effect of high-dose vitamin D3 on response to antimicrobial therap

293 tory tract illnesses between groups (625 for high-dose vs 600 for standard-dose groups, incidence RR,

294 Recipients of high-dose vs standard-dose influenza vaccines have fewer

295 To determine whether high-dose vs standard-dose vitamin D supplementation red

296 High dosing was associated with more nephrotoxicity.

297 e when they are administered periodically at high doses, while others work best when minimizing conce

298 ment therapies and cause lethality following high-dose whole-thorax lung irradiation (WTLI).

299 in six of seven participants who received a high dose, with stabilization of hemostasis and a profou

300 Application of high-dose Zika virus directly to the tonsils of three rh