ライフサイエンスコーパス: high level of

1 However, CRPH-containing emulsions had high levels of 2-methyl-1-butanol, 3-methyl-1-butanol, a

2 flammatory response when they are exposed to high levels of a potentially harmful microorganism.

3 te progenitors, but not neuroblasts, express high levels of a T3-inactivating deiodinase, Dio3.

4 d internal Ags while simultaneously inducing high levels of Abs toward hemagglutinin.

5 imited sandwich lateral flow assay and has a high level of accuracy even in the hook effect range.

6 -specific CD4(+) T cells in combination with high levels of activated CD8(+) T cells was significantl

7 ding the helicase gene, showing consistently high levels of adaptive evolution, suggesting that they

8 IT achieved about 90%, suggesting relatively high level of adherence.

9 There was a high level of agreement between participants in defining

10 permeation at the in vitro level, finding a high level of agreement with experimental permeation mea

11 elopment in Hong Kong, China, an area with a high level of air pollution compared with other similarl

12 vation in the kidney cortex characterized by high levels of aldose reductase, sorbitol and endogenous

13 f approximately 1 per 50 bases suggestive of high levels of allelic diversity.

14 k-2 loss-of-function strains have abnormally high levels of AMX-2 compared with wild-type nematodes.

15 These swellings contain high levels of amyloid precursor protein processing enzy

16 whose tumor cells characteristically show a high level of aneuploidy and genomic instability.

17 Furthermore, we found a high level of aneuploidy in post-mitotic differentiated

18 first-principles calculations, which show a high level of anisotropy up to the melting point, where

19 ed with lifetime reproductive output up to a high level of annual effort.

20 lated recombinant allergens in patients with high levels of anti-CCD IgE antibodies.

21 e poorly protective against reinfection, and high levels of antibodies do not always correlate with p

22 ntibodies, low levels of IgA antibodies, and high levels of antibody-dependent cellular cytotoxicity

23 -resistant VCaP (CR-VCaP) xenografts express high levels of AR and retain intratumoral androgen conce

24 rogens in prostate cancer cells that express high levels of AR.

25 Marine animals, however, contain extremely high levels of arsenic (typically 2000-20000 mug As kg(-

26 WHO guidelines (2004-2013) and had achieved high levels of ART uptake in HIV-diagnosed individuals f

27 Human and mouse HSCs had unusually high levels of ascorbate, which decreased with different

28 treatment may blunt the harm associated with high levels of AT1RaAb.

29 The co-opted PK generates high levels of ATP within the viral replication compartm

30 cells stimulated with TLR2 agonists released high levels of ATP.

31 al significance of B7-H4 is supported by the high levels of B7-H4 expression found in numerous tumor

32 mission from nasally colonized pups required high levels of bacterial shedding in nasal secretions an

33 ssion to castration-resistant PCa (CRPC) and high levels of Bag-1L in primary PCa associate with a re

34 Both human and mouse lung ILC2s express high levels of beta1 and beta2 integrin adhesion recepto

35 ort that samples of hairy cell leukemia with high levels of Bim protein responded with a greater decr

36 ey are highly activated effectors expressing high levels of binding to P-selectin, T-bet, and Blimp-1

37 overed that the noisy spiking is linked to a high level of binocular suppression in visual cortex dur

38 opical montane cloud forests (TMCFs) harbour high levels of biodiversity and large carbon stocks.

39 dy suggests a neural substrate for producing high levels of both combinatorial and temporal diversity

40 They contain high levels of both HREE and light REE, but are strongly

41 ediate, and near visual acuity, resulting in high levels of both spectacle independence and patient s

42 As high levels of c-di-GMP are associated with the biofilm

43 Men and women reported similar, high levels of career satisfaction, with women reporting

44 We noted a high level of Cavin-2 expression in the neovascular tuft

45 DCs recruited at the diseased tissue produce high levels of CCL-2 and IL-8 and contribute to the infl

46 showed that these TREM-2(+) cells expressed high levels of CCR-7 and CD86 suggesting a potential rol

47 The high levels of CD62L expression suggests this molecule c

48 ells are tissue resident memory T cells with high levels of CD69 and CD103 expression, proteins that

49 tivation of Hh signaling was associated with high levels of CDK6, pointing to CDK6 as a direct transc

50 enerally exhibit restricted tropism, produce high levels of cell-free virus, and develop susceptibili

51 abolite pro-drug esters, suggesting that the high levels of cellular 2OG may preclude inhibition.

52 n MF input selectivity will be attenuated by high levels of CGC inhibition providing further flexibil

53 rse events, including death, in persons with high levels of circulating Loa loa microfilariae.

54 Fungal disease diagnosis requires a high level of clinical suspicion and specialised laborat

55 A high level of clinical suspicion is key for early diagno

56 Treatment models that maintain high levels of clinical effectiveness but allow for incr

57 ly (HHI value of 2500, indicating relatively high levels of competition), duopoly (HHI value of 5000)

58 red by the presence of peri-implantitis with high level of concern and low level of therapeutic satis

59 d primary tumors and metastases, and found a high level of concordance (85.7%; 6 out of 7 patients),

60 All 6 antibodies had high levels of concordance (R2 = 0.76-0.99) when using c

61 e social-emotional stimuli, adolescents with high levels of conduct or hyperactivity/inattention symp

62 discrimination of the target species with a high level of confidence (99.3%).

63 The high level of consensus shows that there is good agreeme

64 f these orphan receptors, characterized by a high level of conservation among vertebrates and a predo

65 Site-versus-site comparisons demonstrated a high level of consistency for the Carba NP assay, with j

66 of sexual partners in the last 7 days, with high levels of consistent condom use with clients and lo

67 heterometallic bicyclic architectures with a high level of constitutional control.

68 ng organizational culture scale demonstrated high level of construct validity and internal consistenc

69 foldamer secondary structure coupled to the high level of control over the primary sequence results

70 One explanation may be an unusually high level of convergent and parallel evolution (homopla

71 his new public health challenge; and (3) the high level of coordination and collaboration between dif

72 Lastly, we showed that high levels of copper (previously shown to elevate CUP1

73 The high level of cross-reactivity among flaviviruses and th

74 ostate tissue from obese HiMyc mice revealed high levels of CXCL12 in the stromal compartment as well

75 s other cancers driven by SHH that coexpress high levels of CXCR4.

76 ciated kinase operates in tumours expressing high levels of cyclin D3-CDK6 complexes.

77 High levels of DAF-16 (in the daf-16 (mu86); muIs61 stra

78 High levels of DDIT4 were significantly associated with

79 removal of condensin I, chromosomes present high levels of de novo Topoisomerase II (TopoII)-depende

80 ls, arising both from experimental noise and high levels of degeneracy or codependency in parameters,

81 immature and mature granulocytes expressing high levels of degranulation markers, were specifically

82 High levels of depression, anxiety and social anxiety oc

83 euterated products in good yields and with a high level of deuterium incorporation.

84 Some GBS cases do not exhibit a high level of diagnostic certainty.

85 conditions at room temperature proceeds with high levels of diastereocontrol, leading to beta-amino k

86 Thus, TRalpha absence with high levels of Dio3 provides double-pronged blockage of

87 ficient for efficient diRNA generation and a high level of diRNAs is not necessary for DSB repair.

88 ervoir of circulating HIV strains exhibiting high levels of diversity and recombination.

89 ne feature of high-risk neuroblastoma is the high level of DNA methylation of putative tumor suppress

90 al furanyl ether in a single transformation, high levels of double diastereoselectivity have been ach

91 that responders to antidepressants show a) a high level of EEG-vigilance (an indicator of brain arous

92 at combines high levels of step economy with high levels of efficiency and scalability has remained e

93 [4+2] cycloaddition to provide lactams with high levels of enantio- and diastereoselectivity.

94 inyl chlorides are difficult to prepare with high levels of enantiopurity and are prone to undergo de

95 ncluded the flexibility of the approach, the high levels of engagement and responsiveness of patients

96 Our study reveals a high level of enteric coinfections with diverse viruses

97 Generalist pollinators experience a high level of environmental variation, which we suggest

98 High levels of ERBB2/HER2 and low levels of ESR1 were as

99 ly for aligning long reads contaminated by a high level of errors.

100 pus tropicalis as a model, we show here that high levels of EVI and MDS/EVI are expressed in the inte

101 atterns, as well as the need to preserve the high levels of exclusive and critically endangered biodi

102 Not unexpectedly, saliva samples have high levels of exogenous sequence that can be traced to

103 nce with (68)Ga-DOTATATE PET/CT; n = 4) or a high level of experience (>/=500 scans or >/=5 y experie

104 g is consistent among observers with low and high levels of experience.

105 These results, in combination with the high levels of exposure, indicate a potentially serious

106 ESCd display a high level of expression of genes implicated in migratio

107 Search criteria included high levels of expression, conservation in all parasite

108 as predicted jointly by low levels of SA and high levels of FCA-that is a level of SA lower than woul

109 Importantly, in cancer cells expressing high levels of FGF13, the depletion of FGF13 elicits inc

110 deficient CMD patients, all of which present high levels of fibrosis.

111 Engineered escape variants had high levels of fitness.

112 e number of prominent cell groups expressing high levels of FMRP at the subcortical levels, in partic

113 ons between measurements of OVOCs, including high levels of formic acid, in the atmosphere (measured

114 also HNSCC patients with TP53 mutations and high levels of FOXM1 expression have the poorest surviva

115 nalogues obtained by any method and reveal a high level of functional group tolerance for metal-catal

116 ty may become even more important to support high levels of functioning in European forests.

117 High levels of G6 dendrimers were found in cerebrospinal

118 d in genetic information processing, but the high level of gene loss experienced by all genomes sugge

119 n between subpopulations was low, indicating high levels of gene flow, probably due to cross-pollinat

120 Despite this species' potential for high levels of gene flow, questions have been raised reg

121 We show that gAHB retains high levels of genetic diversity after evolution of gent

122 ylogeographic studies have found evidence of high levels of genetic variation structured across the G

123 amyloid beta-peptide, hydrogen peroxide, and high levels of glutamate.

124 e number of mature granulocytes expressing a high level of Gr1 (Gr1(hi) cells).

125 Patients demonstrated high levels of HCC-related knowledge (summary score, 77.

126 cted regions may suggest that a sufficiently high level of herd immunity was reached during the first

127 Therein, high levels of HIF2alpha, but not HIF1alpha, significant

128 Strong product binding and high levels of holo-ACPP in the cell identify a potentia

129 loid genome identity of S. spontaneum with a high level of homology among its eight sub-genomes.

130 ng hematopoietic cells from a pig expressing high levels of human CD47.

131 High levels of human DNA contamination were seen despite

132 In plasma, high levels of human T helper 2-type inflammatory cytoki

133 These cells express high levels of ICOS, and the blockade of ICOS/ICOSL inte

134 TH1 polarization, which is characterized by high levels of IFN-gamma.

135 d CD4(+) T cells increase in number and show high levels of IFNgamma after transfer of the commensal

136 redominant poly-functional profile producing high levels of IFNgamma and Granzyme B.

137 Tolerant Treg cell produced high levels of IL-10 and had diverse T cell receptor Vbe

138 High levels of IL-10 and IL-12/23p40 were significantly

139 Moreover, the association of high levels of IL-15 expression with inflammatory and au

140 ly driven by pathogenic T cells that produce high levels of IL-17 in response to IL-23.

141 ve increased expression of NLRP3, leading to high levels of IL-1beta production.

142 In contrast, classical monocytes secreted high levels of IL-6, the blockade of which resulted in i

143 In co-culture systems, MFs secreted high levels of IL-6, while cancer cells produced high le

144 tion of immunological tolerance, because the high levels of immunosuppression otherwise required woul

145 ere the most abundant genera associated with high levels of inflammation in healthy feet.

146 ociated with mononuclear cell infiltrate and high levels of inflammatory cytokine production.

147 the muscle fiber atrophy was associated with high levels of inflammatory cytokines: tumor necrosis fa

148 do not induce pro-inflammatory cytokines and high levels of interferons can be used as scaffolds to c

149 ng from day 15 after HSCT and favored by the high levels of interleukin-15 present in patients' sera,

150 ession of the GLUT5 fructose transporter and high levels of ketohexokinase were identified as molecul

151 EK signaling increased expression of KLF5; a high level of KLF5 increased proliferation.

152 ne of the European blood donors tested, have high levels of LAIR1-containing antibodies that dominate

153 To determine whether the high level of LCN2 in the CNS is protective or deleterio

154 ted depth penetration of light caused by the high level of light scattering.

155 um conditions, the calibration curves showed high levels of linearity (R(2)>0.9993) for acrylamide in

156 s within the 530 bp that are responsible for high-levels of ltxA expression.

157 by an activity trough at dusk followed by a high level of male courtship during the night.

158 The malodor was attributable to high levels of methanethiol and dimethylsulfide, the mai

159 re epithelial carcinoma cell lines expressed high levels of MHC-I, low levels of PD-L1, and contained

160 Here, we report that high levels of microRNA-128-3p (miR-128-3p) is key to co

161 Histopathological analysis revealed high levels of microvascular nestin immunoreactivity in

162 tients with HTR metastatic disease expressed high levels of miR-221.

163 d not be included in our analysis because of high levels of missing data.

164 In this setting, the data have a high-level of missingness or uncertainty, and are thus m

165 tin-resistant ovarian cancer cells expressed high levels of MKP-1 and PARP-1 proteins, and that silen

166 Thus, FOXO1 drives high levels of MMP9 expression in diabetic wound healing

167 High levels of moesin were also observed in muscle biops

168 of complex macromolecule synthesis, where a high level of molecular precision or monomer sequence co

169 Because these diseases have high levels of morbidity and can be lethal, it is import

170 We first discuss how, given plants' high levels of morphological plasticity, crop phenomics

171 remarkable dietary plasticity and consuming high levels of moss, which is exceptionally high in fibr

172 6 mice with hypha-defective strains attained high levels of mucosal colonization but failed to induce

173 ses demonstrate that quiescent MuSCs express high levels of Myogenic Differentiation 1 (MyoD) transcr

174 area of nanofibrous reservoir layers allows high levels of nanoparticle loading.

175 hage than has previously been described with high level of neurologically intact survival.

176 a tetravalent vaccine, DENV1-4 VLPs elicited high levels of neutralization activity against all four

177 gs provide a framework for rationalizing the high levels of noise in metazoan signaling networks and

178 The set of TADs that are associated with high levels of noncoding conservation exhibit distinct p

179 nd two ancient Irish genomes, we demonstrate high levels of North-West French-like and West Norwegian

180 The high level of orthogonality between FAIMS and MS provide

181 High levels of OTUD1 inhibit cancer stemness and shut of

182 vel of programmed cell death protein 1 and a high level of OX40 were associated with reduced patient

183 stressed siblings showed reduced body size, high levels of oxidative damage in lipids and proteins,

184 60 degrees C with 60 s of activation), and a high level of ozone (13 ppm with 60 s of activation).

185 High levels of PalC localised to sites within the MLNs w

186 Patients reported high levels of patient-centered care: 90% easily underst

187 trongly occupied by CBP and GAGA factor have high levels of paused Pol II, a unique chromatin signatu

188 borted fetuses from sows with PDNS contained high levels of PCV3 (7.57 x 10(7) genome copies/ml), and

189 l subpopulation of human NK cells expressing high levels of PD-1.

190 g EMT markers expressed low levels of MHC-I, high levels of PD-L1, and contained within their stroma

191 Conversely, high levels of PDK1 enhance BCSC properties and are corr

192 adverse birth outcomes is observed with very high levels of pesticide exposure.

193 lication is kinetic modeling, which requires high levels of PET quantitative stability.

194 We also find that evolved high levels of phenotypic diversity can occasionally col

195 B cells of Cdkn1a (-/-) Ezh2 (-/-) mice have high levels of phospho-Rb, indicating that loss of Cdkn1

196 , when Ambra1 cannot bind to FAK, abnormally high levels of phospho-Src and phospho-FAK accumulate at

197 We present evidence demonstrating that high levels of physical activity predict metabolic flexi

198 is relationship is disrupted in infants with high levels of physiological stress.

199 yonic development, a period characterized by high levels of plasma T3.

200 High levels of PM2.5 probably contribute to increased T2

201 stripping the polyphenols from oil 'A', with high levels of polyphenols and oleic acid, and oil 'B',

202 omes cope with oxidative stress by producing high levels of polyunsaturated fatty acids, oxylipins, a

203 about four or five, but only at moderate-to-high levels of population coverage (>65%) and if systema

204 l Vt, low plateau and driving pressures, and high levels of positive end-expiratory pressure.

205 intimate molecular contacts that explain the high levels of potency and selectivity we have measured.

206 High levels of PPIA were found in the CSF of SOD1(G93A)

207 Low, medium and high levels of predicted extractable total anthocyanin c

208 h Plasmodium yoelii nigeriensis N67C display high levels of pro-inflammatory cytokines and chemokines

209 rway spruce will contribute to maintaining a high level of productivity across many Central European

210 lso suppress T cell activation via producing high level of prostaglandin E2 (PGE2) due to their thous

211 f tumor-associated macrophages and expressed high levels of prostaglandin E2 (PGE2)-forming enzymes m

212 vered that not only does vaccination provide high levels of protection against lethal aerosol challen

213 trongly activated by hypercapnia and express high levels of proton sensors (Kcnk5 and Gpr4).

214 High levels of PSY and several other carotenogenic enzym

215 tical for top-down emotional processing with high levels of psychosocial stress in individuals with g

216 Shh-dependent cell populations that express high levels of Ptchd1 mRNA: cerebellar granule cell prec

217 haracterized by low membrane potential and a high level of reactive oxygen species.

218 s with closed neural tubes (nSR-BI(-/-)) had high levels of reactive oxygen species (ROS), intermedia

219 r its activation, leads to the production of high levels of reactive oxygen species in a p38 mitogen-

220 , which counteract the effects of relatively high levels of reactive oxygen species.

221 ealing that P2P networks display exceedingly high levels of reciprocity.

222 onstrate that North American EEEV exhibits a high level of redundancy in using host factors in replic

223 einitiation on translation and show that, at high levels of reinitiation, protein synthesis rates are

224 However, there is a high level of reported missing heritability, where only

225 tested, RAS at amino acids 28 and 93 led to high levels of resistance.

226 d they coincide with local concentrations of high levels of Reynolds shear stress, enstrophy, and tem

227 Finally, we show that sustaining high levels of Rph1 during DNA damage stress results in

228 AML patient samples with FLT3-ITD express high levels of RUNX1, a transcription factor with known

229 Especially given the high level of safety of (177)Lu-PSMA radioligand therapy

230 trace metals, organic compounds, and often, high levels of salts.

231 se Gmsacpd-c mutants were identified to have high levels of seed, nodule, and leaf stearic acid conte

232 The uptake carrier exhibits a very high level of selectivity towards small substrates inclu

233 e nanomolar inhibition of NaV1.7 and exhibit high levels of selectivity over other sodium channel iso

234 for VEGF and 1-100ng/mL for PSA), as well as high levels of sensitivity and selectivity (i.e., resist

235 at uninfected Irgm1-deficient mice displayed high levels of serum cytokines typifying profound autoin

236 re capable of IL-17 production and expressed high levels of signature genes of the TH17 pathway, RORg

237 Rs, containing 50 nM or 100 nM siRNA, showed high levels of silencing, particularly in primary airway

238 ther low levels of the dual-stained cells or high levels of single-stained cells, and such patterns d

239 but it is difficult to achieve exceptionally high levels of site-selectivity.

240 For Hispanics, moderate and high levels of social integration were equally protectiv

241 ow levels of C3, and nine (60%) patients had high levels of soluble C5b9.

242 Unexpectedly, we discover high levels of somatic hypermutation in infants as young

243 Consistently, restoring high levels of SOX5/6/21 in human primary glioblastoma c

244 table for targeted therapeutics demonstrated high levels of spatial heterogeneity in MB, malignant gl

245 of progression that appeared to guarantee a high level of specificity by accounting for normal aging

246 atients with persistent villous atrophy with high levels of specificity: 0.83 for the tTG IgA assay (

247 Acute myeloid leukemia (AML) cells exhibit a high level of spontaneous apoptosis when cultured in vit

248 nomical syntheses, a synthesis that combines high levels of step economy with high levels of efficien

249 , and the most useful syntheses will combine high levels of step-economy with efficiency and scalabil

250 enantioenriched form for the first time with high levels of stereocontrol, and this technology is app

251 ote nitrogen and sulfur functionalities with high levels of stereocontrol.

252 tereogenic alpha-keto esters was achieved in high levels of stereoselectivity, affording versatile te

253 Extremely high levels of Streptococcus mutans were detected in the

254 ccordingly, C. cohnii was characterised by a high level of sulfur compounds (dimethyl sulfide, ethane

255 A high level of synteny was found with pine genetic maps,

256 erleukin 17 (IL-17) production as well as by high levels of T-bet and related orphan receptor 3 expre

257 In contrast, high levels of TBP did not complement Taf1 depletion in

258 tional chemotherapy for cancer patients with high levels of TCTP expression.

259 Ecological theory predicts that high levels of temporal autocorrelation in the environme

260 Developmentally, males are exposed to high levels of testosterone and its byproduct, estradiol

261 levels of IL-6, while cancer cells produced high levels of TGF-beta.

262 Populations with high levels of the 2L+(a) allele may form reservoirs of

263 Circulating monocytes uniformly express high levels of the canonical E-selectin binding determin

264 n immature NK cell population that expressed high levels of the coinhibitory molecules PD-1, Lag-3, a

265 We record high levels of the dung fungus Sporormiella, a proxy for

266 vasive brain tumors, which are known to show high levels of the eukaryotic initiation factor, eIF4E,

267 ient Mtb cultured on fatty acids accumulated high levels of the ICL aldehyde endproduct, glyoxylate,

268 dings show that human melanoma cells express high levels of the immune checkpoint molecule CTLA4, wit

269 engaging the T cell receptor (TCR), express high levels of the immunosuppressive cytokine IL-10, but

270 tissues, we find that cancer cells depend on high levels of the iron-sulfur cluster biosynthetic enzy

271 Relatively high levels of the main regulated mycotoxins and presenc

272 ry tumor, tumor cell cultures expressed very high levels of the Myc protein and, in contrast to all o

273 rice, is highly nutritious but contains very high levels of the non-threshold carcinogen inorganic ar

274 osis, extensive CD4 T cell accumulation, and high levels of the proinflammatory factors IFN-gamma, TN

275 bolomic profiling and uncovered unexpectedly high levels of the sesquiterpene volatile beta-selinene

276 We found that Twist1-null cells expressed high levels of the T cell chemoattractant CXCL12.

277 Treg cell precursors expressed high levels of the tumor necrosis factor receptor superf

278 context of applications that require a very high level of threshold voltage stability, such as activ

279 High levels of TNF were detected in cocultures with nonc

280 genotypes like Nonabokra and Pokkali show a high level of tolerance towards salinity stress compared

281 Milk from vitamin D deficient mothers showed high levels of TRAIL (alpha and beta) proteins compared

282 t adipose-derived mesenchymal cells secreted high levels of transforming growth factor-beta1, which d

283 r prognosis in PDAC especially combined with high levels of Treg cells.

284 ivers of MAT1A-KO mice were characterized by high levels of triglycerides, diglycerides, fatty acids,

285 tation was characterized by three stages: i) high levels of tryptamine, phenolics, and scavenging cap

286 er lesions in biopsy specimens or persistent high levels of tTGA.

287 ISG15 deficiency also leads to persistently high levels of type I IFN-stimulated gene expression and

288 in TNBCs with CSC-like properties is due to high levels of U-ISGF3 and that treatment with IFN-beta

289 neoplasia in mouse prostate with aberrantly high levels of Ube2e1 in the cytoplasm.

290 ased trabeculectomy surgery, although with a high level of uncertainty owing to low event rates.

291 tion levels and excitatory synaptic weights, high levels of uncorrelated background activity among pr

292 The CSC-like properties were correlated with high levels of unphosphorylated IFN-stimulated gene fact

293 itted parameters to make predictions shows a high level of variability in the modelled number of pand

294 Feeding with ADM leads to high levels of viable egg production, but also does not

295 Mice with high levels of viremia had HBV-infected liver progenitor

296 EVD is characterized by high levels of virus replication and dissemination, dysr

297 vestigated factors mediating these extremely high levels of VSG expression by inserting ectopic VSG11

298 ES nanostructure is retained to a remarkably high level of water (ca. 42 wt % H2 O) because of solvop

299 ival curves and log-rank tests revealed that high levels of WIF1 methylation were associated with low

300 , we generated a stable cell line expressing high levels of ZIKV prM-E proteins that constitutively p