ライフサイエンスコーパス: high specificity

1 P688, which binds to an allosteric site with high specificity.

2 nstrate subpicomolar limit of detection with high specificity.

3 mentary nucleic acids with high affinity and high specificity.

4 cket in the other, thereby rationalizing the high specificity.

5 osphorylate ~15000 different substrates with high specificity.

6 a rapid isothermal amplification method with high specificity.

7 ismissing benign variants with exceptionally high specificity.

8 an element with a very high sensitivity and high specificity.

9 ng pocket and that FES binds to ERalpha with high specificity.

10 exhibits excellent DNA binding affinity with high specificity.

11 han current 2-tier serology, while retaining high specificity.

12 sion on B cells captured seroconversion with high specificity.

13 sing high levels of novel genetic tools with high specificity.

14 than these programs while maintaining a very high specificity.

15 ble off/on fluorescence response to H2Sn and high specificity.

16 istinguish TNT versus different chemicals in high specificity.

17 oth the abdomen and pelvis while maintaining high specificity.

18 erum while binding to cells of interest with high specificity.

19 , sulfate esters, and carboxylic acids, with high specificity.

20 fferentiate varying biomarker amounts with a high specificity.

21 patiotemporally at the site of interest with high specificity.

22 nucleotide resolution, high sensitivity, and high specificity.

23 or separation, isothermal amplification, and high specificity.

24 agnosis, and so the algorithms were tuned at high specificity.

25 dase genes into endogenous genomic loci with high specificity.

26 the ammonium and methylammonium cation with high specificity.

27 otein complexes whose subunits interact with high specificity.

28 e can be targeted to uncover inhibitors with high specificity.

29 49 dB/m rules in liver steatosis with a very high specificity.

30 beta-glycoside ligands while still achieving high specificity.

31 mysial antibodies tests were associated with high specificity.

32 affinities (Kd approximately 10(-12) m) and high specificity.

33 novel substrates of kinases while retaining high specificity.

34 ty tissue can show perivesical invasion with high specificity.

35 ploid cotton genome with high-efficiency and high-specificity.

36 lts than did traditional RIDTs, with equally high specificities.

37 lin-resistant S. aureus nasal carriage had a high specificity (0.96; 95% CI, 0.90-0.98) but low sensi

38 A reasonably high specificity (100.0%) and a high sensitivity (53.8%)

39 sitivity (98.5% vs. 53.7%) while maintaining high specificity (86.7% vs. 93.3%) in the detection of o

40 n Assessment Method for the ICU maintained a high specificity (87%) and sensitivity (78%) in post hoc

41 NanoDisk-MS also exhibited high specificity (87.1-100%) in both healthy and high-ri

42 -level methods had low sensitivity (20-63%), high specificity (89-100%), and low proportion of false

43 (27.3% [95% confidence limit 16.6-41.4]) and high specificity (89.8% [82.3-94.4]) for prediction of t

44 tive biomarker of in vivo drug response with high specificity (92%) and strong positive predictive va

45 83%) and positive predictive value (40%) but high specificity (94%) and negative predictive value (99

46 T-PCR had low clinical sensitivity (75%) but high specificity (96%).

47 ocedure codes for mechanical ventilation had high specificity (96.0%; 95% CI, 95.8-96.2), but only mo

48 nstrated the highest sensitivity (87.5%) and high specificity (96.8%).

49 The algorithm and the physicians had high specificity (97% (95% CI 96% to 98%) and 90% (95% C

50 The assays exhibited high specificities (98.6%) when tested against an animal

51 This process modifies with high specificity a conserved Pro, shares with the deacet

52 in the last years owing to features such as high specificity, a broad range of analytes and a high d

53 aptasensor showed high stability as well as high specificity against common cynaobacterial toxins.

54 u to P-tau ratios in CJD patients has a very high specificity against important differential diagnose

55 indices showed overall low sensitivities and high specificities (among them myocardial contraction fr

56 The diagnostic accuracy was similarly high (specificity and PPV > 90%) for parkinsonian subjec

57 The H3R and H4R activated Galphai with high specificity and a high potency.

58 subunits: an aptamer domain that binds with high specificity and affinity to a target ligand and an

59 (mAbs) are a major class of medicines, with high specificity and affinity towards targets spanning m

60 We show that the binding is of high specificity and affinity with dissociation constant

61 Eight nanobodies, recognizing BBMV with high specificity and affinity, were retrieved after phag

62 cted for their ability to bind proteins with high specificity and affinity.

63 y that target their respective antigens with high specificity and affinity.

64 d from the development set, one selected for high specificity and another for high sensitivity.

65 talloinsertors that bind DNA mismatches with high specificity and are preferentially cytotoxic to MMR

66 f DSB hotspots - they bind DSB hotspots with high specificity and are required for DSB formation ther

67 gainst deamidated gliadin peptides (DGP) has high specificity and better sensitivity than IgG anti-tT

68 89)Zr-labeled mAb to galectin-3, which shows high specificity and binding affinity in vitro Reliable

69 , only this newly developed CLIA test showed high specificity and correlated with the "gold standard"

70 ies (mAbs) for internalization and exhibited high specificity and cytotoxicity against A20 murine B-c

71 ive and quantitative with 93.3% sensitivity, high specificity and detection limit of 4.57IU/microl.

72 e apoferritin molecules in vitreous ice with high specificity and determines their orientation and lo

73 Novel protein-based antifibrotic drugs show high specificity and efficacy, but their use in the trea

74 ues to manipulate microbial communities with high specificity and efficacy.

75 l region than to PAM-proximal region and the high specificity and efficiency for shorter protospacers

76 e development of potent antiviral drugs with high specificity and efficiency.

77 chanism combines structural promiscuity with high specificity and enables discrimination between bact

78 monstrated that this developed method showed high specificity and excellent recovery for the human se

79 this platform exhibits pM-range sensitivity, high specificity and good reproducibility, making it wel

80 was also investigated and the results showed high specificity and great stability in detecting of p53

81 n real time in living cells, demonstrating a high specificity and high degree of colocalization in th

82 cilitated antigen clasping and achieved both high specificity and high potency.

83 omplementary interaction with high affinity, high specificity and high stability.

84 The SPR biosensor demonstrated high specificity and long shelf life thus, pointing towa

85 t growing class of therapeutics due to their high specificity and low incidence of side effects.

86 All PFPs exhibited high specificity and negative predictive values for iden

87 have been identified that target ASICs with high specificity and potency.

88 Conclusion FDG PET/CT demonstrates high specificity and PPV for detecting distant metastasi

89 opulation cases at a threshold that also has high specificity and PPV, and could be used as a screeni

90 n of these goals will require reactions with high specificity and precise control.

91 disorder patients and control subjects with high specificity and predictive value compared with diag

92 The aptasensor also presents high specificity and reproducibility for thrombin, which

93 y to study the surfaces of living cells with high specificity and resolution down to 10-20 nm.

94 (11)C-Lu AE92686 displayed high specificity and selectivity for PDE10A-expressing r

95 A fragments mixed with samples, revealed the high specificity and selectivity in methylation analysis

96 binding and 2-8 for Con A mediated binding), high specificity and selectivity, and an extraordinary r

97 ssay that is capable of resolving 5 hmC with high specificity and sensitivity and demonstrate its uti

98 ay can be used to immunophenotype NLHPL with high specificity and sensitivity and rapidly purify LP c

99 s (BV); this subtype could be predicted with high specificity and sensitivity based on the Nugent sco

100 nant nuts which could then be monitored with high specificity and sensitivity by selective reaction m

101 portable and low-cost sensor devices with a high specificity and sensitivity for a number of applica

102 come (P= .009); a ratio of >/=0.55 pg/mL had high specificity and sensitivity for a poor outcome (100

103 l infections given its unique combination of high specificity and sensitivity for bacteria.

104 ive showed predominantly renal clearance and high specificity and sensitivity for detecting low level

105 Detecting target analytes with high specificity and sensitivity in any fluid is of fund

106 resulting catalog of TCRbeta sequences with high specificity and sensitivity in both the original co

107 Detection of SNPs with high specificity and sensitivity is essential for effect

108 robe to the surface of electrode, as well as high specificity and sensitivity of aptamer toward its t

109 microarray analysis protocol, eRIP, that has high specificity and sensitivity was developed to test e

110 diagnose acute cellular rejection (ACR) with high specificity and sensitivity would significantly adv

111 The performance assessment shows very high specificity and sensitivity, due to the corroborati

112 Due to its high specificity and sensitivity, SPARK has the potentia

113 nd diagnosis of syphilis require assays with high specificity and sensitivity.

114 ction in photoreceptor cells is derived with high specificity and sensitivity.

115 s and validation resulted in a gold set with high specificity and sensitivity.

116 i.e., human serum albumin and lysozyme, with high specificity and sensitivity.

117 iplexed and quantitative miRNA analysis with high specificity and sensitivity.

118 des may identify the seizure onset zone with high specificity and sensitivity.

119 nes in tens of thousands of individuals with high specificity and sensitivity.

120 silico, bound the minimal FLAG sequence with high specificity and sensitivity.

121 ic PWV, and aortic bifurcation diameter with high specificity and sensitivity.

122 ttice within the tumor microenvironment with high specificity and soft-tissue contrast-to-background

123 tegy relying on "immutable ligands" with the high specificity and speed of Raman microspectroscopy.

124 bit cytosolic sulfotransferases (SULTs) with high specificity and therapeutically relevant affinities

125 These agents target cartilage with high specificity and this property is inherent to the ch

126 This high-specificity and high-affinity binding by NC consequ

127 ecause of its favorable reversible kinetics, high specificity, and absence of brain radiometabolites

128 y (low limit of quantification at amol/muL), high specificity, and broad linear dynamics range (2500-

129 UAAs are incorporated with high specificity, and functionally active transporters h

130 signal amplification have high sensitivity, high specificity, and good correlation with HCV RNA leve

131 em detects single nucleotide mismatches with high specificity, and has a limit of detection of 1.5 fe

132 that this apoptosis probe has low toxicity, high specificity, and high affinity to apoptotic cells.

133 ieve sufficient signal-to-background levels, high specificity, and high labeling efficiency.

134 The high sensitivity, high specificity, and rapid detection capacity of the SE

135 s thaliana were analyzed simultaneously with high specificity, and the sensitivity of the method was

136 Furthermore, the nanobiosensor showed high Specificity, and was able to discriminate sharply b

137 omopentamer in complex with a high affinity, high-specificity antagonist, strychnine.

138 e conventional wisdom that high affinity and high specificity are coupled.

139 nts, we show that toxins and antitoxins with high specificity are frequently connected in sequence sp

140 ns from complex cell and tissue lysates with high specificity as confirmed by SDS-PAGE analysis with

141 nucleic acid probe systems with consistently high specificity as they enable the discovery of an opti

142 QMC is characterized by high specificity, as even a single-nucleotide modificati

143 ding proteins such as fimbrin and espin show high specificity between these two bundle types within t

144 Cy3-labeled tilmanocept exhibited high specificity binding to macrophages that was nearly

145 tematically evolved to create high-affinity, high-specificity binding peptides to a protein target in

146 Gemin5 binds with high specificity, both in vitro and in vivo, to sequence

147 s such as rapid antigen detection tests have high specificity but do not have high sensitivity.

148 lure by caregivers at time of extubation had high specificity but low sensitivity.

149 s tightly to DNA to recognize promoters with high specificity but then releases these contacts during

150 e capable of detecting single molecules with high specificity, but achieving single-molecule sensitiv

151 onditions, ACD have moderate sensitivity and high specificity, but evidence for detection of other HA

152 sion criteria currently used in the GPA have high specificity, but some patients are more likely to s

153 be identified by HLA class II tetramers with high specificity, but unexpected low sensitivity.

154 inding affinity by 2 (41-nt, KD = 45 pM) and high specificity by 10, was used successfully to constru

155 target their DNA-recognition sequences with high specificity by binding with resident times of up to

156 ple markers while simultaneously maintaining high specificity by requiring positive results for two m

157 sphorylated at the plasma membrane, and with high specificity by the apically localized kinase LOK.

158 ut appendicitis and are distinguishable with high specificity by using a PSV greater than 10 cm/sec a

159 This assay demonstrated high specificity, correctly identifying 218 of 221 presu

160 We believe that high specificity could be obtained by implementing near-

161 High-specificity-designed proteins that selectively kill

162 Importantly, it also displays high specificity, detecting the other three prolamins to

163 etection [LODs] ranging from 1 to 30 fM) and high specificity (distinguishing miRNAs with a single nu

164 mechanical cantilever sensor system that has high specificity, fast response time and is easily appli

165 s and in source fragmentation in addition to high specificity feature LC-MS detection to improve the

166 with GXP provided reasonable sensitivity and high specificity for active TB while dramatically reduci

167 The immunosensor exhibited high specificity for AFP detection, extremely short incu

168 t receptor association constants, and showed high specificity for alpha V beta 3 in HUVECs (K d 35

169 ve disclosed the structural basis for PllA's high specificity for alpha-galactoside-containing ligand

170 s, and evaluation of fluorogenic probes with high specificity for BlaC, a biomarker expressed by Mtb,

171 LPAT2 from microsomal LPAT class A that has high specificity for C18 fatty acids containing Delta9 u

172 The T2 dark spot sign has high specificity for chronic hemorrhage and is useful to

173 It has high specificity for cisplatin and potentially other Pt(

174 ually well on different platforms, exhibited high specificity for crab over other types of crustacean

175 tified that is efficiently processed and has high specificity for CTB over other cysteine cathepsins.

176 Although LS-IVCM has a high specificity for diagnosing filamentous fungal kerat

177 ds provided moderate to high sensitivity and high specificity for diagnosis of grade 1 or higher, gra

178 y and PF LAM assays have low sensitivity but high specificity for diagnosis of TBP.

179 ited by high glucose concentration and shows high specificity for glucose, with no activity for other

180 both LI-RADS category 4 and category 5 have high specificity for HCC.

181 aptamers that exhibited high sensitivity and high specificity for hemoglobin and HbA1c to perform a s

182 tralis and Cirrus reference databases have a high specificity for identifying healthy eyes and good a

183 LLL12 exhibits high specificity for inhibiting STAT3 phosphorylation an

184 YAMAT-seq has high specificity for mature tRNAs and high sensitivity t

185 This SMC mHTT immunoassay demonstrated high specificity for mHTT, high sensitivity with a femto

186 igating potential interference and affording high specificity for modulation sites.

187 FS50 exhibits high specificity for NaV1.5, since 10 muM FS50 had no di

188 BLM helicase has a high specificity for non-canonical G-quadruplex (G4) DNA

189 ncrease specific binding affinity and impart high specificity for PDAC cells.

190 These modifications all revealed high specificity for Psi.

191 ption of REEs compared to cells lacking LBT, high specificity for REEs, and an adsorption preference

192 hat these cycles of positive feedback enable high specificity for substrates with short recognition m

193 olding assistant or autoinhibitor, revealing high specificity for the SBT3-SBT3PP interaction.

194 We identified 4 probes that had high specificity for tumor vs non-tumor tissues; we call

195 (64)Cu-LLP2A and LLP2A-Cy5 demonstrated high specificity for VLA-4-positive mouse 5TGM1-GFP myel

196 utoffs (0.3 for high sensitivity and 2.0 for high specificity) for the development of AKI were evalua

197 Using the first operating cut point with high specificity, for EyePACS-1, the sensitivity was 90.

198 mit of detection (79 cells mL(-1), S/N = 3), high specificity, good inter-and intra-assay reproducibi

199 ing, in simulated wound fluid which exhibits high specificity, good linearly from 0 to 800microM, and

200 ging results demonstrate that this probe has high specificity, good selectivity, and appropriate kine

201 Combination of high sensitivity (>95%) and high specificity (>90%) was found in 5 tests only: polys

202 182030 (10 pg/mL, corresponding 453 fM) with high specificity has been achieved, employing the newly

203 Live-cell labeling techniques require high specificity, high labeling density, and cell permea

204 chnologies to isolate these tumor cells with high specificity; however, there are limited techniques

205 Given its high specificity, Ig-HTS from plasma has potential clini

206 Our new bioassay exhibited high specificity, improved speed (assay time:</= 20 min)

207 BAF displays high specificity in controlling the open chromatin lands

208 The proposed strategy exhibits high specificity in discriminating cognate miRNAs, and t

209 tubulin with both high affinity in vitro and high specificity in living cells, exhibited substantial

210 eraction constitutes the chemical essence of high specificity in natural systems, which inspires us t

211 nsors offer large signal-to-noise ratios and high specificity in single molecule binding measurements

212 lial breast cells revealed that MAD-28 had a high specificity in the selective killing of cancer cell

213 intermolecular complementation, and achieved high specificity in tumor targeting.

214 gnition often leads to moderate affinity but high specificity, in contradiction with the conventional

215 The HA complex recognizes E-cadherin with high specificity involving extensive intermolecular inte

216 gle aaRS binds distinct anticodon loops with high specificity is not well understood.

217 affinity protein-protein interactions retain high specificity is still poorly understood.

218 The RCEA assay had high specificity, it was insensitive to non-specific bin

219 vesting of inorganic semiconductors with the high specificity, low cost, and self-replication and -re

220 ombined observations lead us to propose that high-specificity, low-affinity attachment of MERS-CoV to

221 An evolved and reengineered high-specificity M6P/IGF2R domain 11 binding site for IG

222 proach takes advantage of sandwich assay for high specificity, MBs for fast separation, and electroch

223 ted EGFR and KRAS mutations rapidly with the high specificity needed to select therapy and avoid repe

224 ation of Cas9-treated cells further confirms high specificity of Cas9.

225 The high specificity of CHMFL-BTK-11 makes it a useful pharm

226 However, the high specificity of Cry toxins can also prove to be a li

227 y investigations, many studies point out the high specificity of imaging studies, and particularly ul

228 rom synergy between spacer diversity and the high specificity of infection, which greatly increases o

229 Our results confirm the high specificity of many members of the OTU and JAB/MPN/

230 e tools for live-cell imaging because of the high specificity of peptide sequences for their biomolec

231 The high specificity of PFI-3 for family VIII was achieved t

232 The results obtained showed high specificity of polymeric antibodies to template Mb,

233 accharomyces cerevisiae) microsomes showed a high specificity of RcsPLA2alpha for ricinoleic acid, su

234 Flow cytometry revealed high specificity of rHDL for TAMs, which had the highest

235 The high specificity of Rif1 for cruciform structures is sig

236 We confirmed that high specificity of Rnl2 ligation and TaqMan RT-PCR towa

237 hat enterotropism may be correlated with the high specificity of spike proteins for such glycans expr

238 Combining the high specificity of TALENs with efficient lentiviral gen

239 A method confirmed the nM-level affinity and high specificity of the aptamers against AMACR.

240 The high specificity of the coherent (Rayleigh), as well as

241 specific antibody surface that confirmed the high specificity of the developed immunoassays.

242 Due to the high specificity of the displayed octapeptides and avidi

243 lutination unit due to the high affinity and high specificity of the H1N1-specific aptamers.

244 The high specificity of the mapA-ceuE assay was the result o

245 ethylpyrrole derivatives, demonstrating the high specificity of the process.

246 utions at low Sur concentrations confirm the high specificity of the proposed biosensor and good disc

247 A high specificity of the sensor chip to detect cortisol w

248 The high sensitivity and very high specificity of the Xpert MTB/RIF assay supports its

249 The high specificity of this distinguished structure was als

250 ed as belonging to the SCZ group, suggesting high specificity of this measurement in predicting brain

251 The high specificity of ubiquitination is regulated by the i

252 Our results confirm the high-specificity of CRISPR endonucleases and demonstrate

253 inds to MDM2 with K(i) = 0.88 nmol/L and has high specificity over other proteins.

254 There is a clear clinical need for high-specificity plasma biomarkers for predicting risk o

255 This equation has a high specificity, PPV with a moderate NPV and sensitivit

256 a high sensitivity (range, 87.6%-100%) and a high specificity (range, 97.2%-100%).

257 sensor displayed desired properties such as high specificity, relatively low detection limit (30 nM

258 technique to image endogenous proteins with high specificity, resolution, and contrast in single cel

259 e degree of processing it has undergone with high specificity, sensitivity and rapidity.

260 In particular, despite relatively high specificity, sensitivity was poor in both pipelines

261 As a universal detector, VUV also provides high specificity, sensitivity, and a fast data acquisiti

262 from Mk exosomes (MkExos), target HSPCs with high specificity since they have no effect on other onto

263 a graphene field effect transistor (FET) for high-specificity, single-nucleotide mismatch detection.

264 diagnostics and therapeutics owing to their high specificity, small size ( approximately 15 kDa) and

265 al structures while simultaneously achieving high specificity so that diverse bitter toxins can be de

266 ding broad and potent neutralizing activity, high specificity, stability, solubility, and affinity fo

267 (71.4%; 95% CI, 47.8%-88.7%), the extremely high specificity supports using the assay to screen for

268 heir ability to bind long DNA sequences with high specificity, TALEs have been used in many applicati

269 we demonstrate labeling of fixed cells with high specificity that correlates well with fluorescent l

270 ies are now needed to further validate these high-specificity thresholds.

271 class of therapeutic drugs, because of their high specificities to target cells.

272 combination drugs are explored which demand high specificity to avoid combined-drug side effects.

273 roscopy (CFM) analyses, which exhibited very high specificity to BR+ cancer cells.

274 The eFBG sensors show high specificity to CRP even in the presence of other in

275 cal diagnosis had high sensitivity to AD and high specificity to dementia with Lewy body/Parkinson de

276 This proposed immunosensor revealed high specificity to detect ApoB-100, acceptable intra-as

277 high sensitivity to detect small tumors and high specificity to distinguish malignant from benign ti

278 ains accounts for IgG's ability to bind with high specificity to essentially any antigen.

279 calcium-independent lectin, which binds with high specificity to O-linked alpha1,4-GlcNAc-capped hexa

280 on analyses of BCAA-raising alleles revealed high specificity to the BCAA pathway and an accumulation

281 C. guilliermondii) simultaneously with very high specificity to the species level in less than 80 mi

282 with the participation of the N-lobe, endows high specificity to this protein.

283 n sequence is matched to domain models using high-specificity tools and only then unmatched segments

284 gmL(-1), wide linearity (50-500ngmL(-1)) and high specificity toward NGAL detection from small sample

285 Moreover, the aptasensor showed high specificity toward other coexistent cyanobacterial

286 Thus, CCP/CSGMA electrodes provide high specificity toward thrombin detection and mechanist

287 d that the developed biosensing system had a high specificity towards adenovirus (less than 20% signa

288 ates the detection of peritoneal tumors with high specificity upon intraperitoneal tumor targeting an

289 Diagnostic tests of high specificity used at an early stage of active infect

290 TP family of proteins, TIS11d binds RNA with high specificity using a pair of CCCH-type tandem zinc f

291 nsferase activity in Enterobacteriaceae with high specificity using the standard disk susceptibility

292 e further engineered this system to create a high-specificity variant and minimized the system to fac

293 Moreover, high specificity was demonstrated, together with success

294 29 x 10(5) ng/mul bacterial genomic DNA, and high specificity was indicated by the absence of reactiv

295 Although most showed high specificity, we applied a deconvolution method base

296 tural protein 3 (NS3):1406-1415 epitope with high specificity when presented by HLA-A2.

297 The biosensor showed a high specificity which could discriminate between comple

298 n CEA protein and anti-CEA in real-time with high specificity, which revealed selective electrical de

299 were shown to detect various quinolones with high specificity, while specific binding activities to s

300 detect intracellular cancer RNA markers with high specificity within 30 minutes post treatment, while