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1 viral mRNA 5' untranslated region (UTR) with high affinity.
2 d with Ala residues fails to bind hemin with high affinity.
3 Pin((R)) proteins recognize FcgammaRIIB with high affinity.
4 d the entropic advantage driving aprotinin's high affinity.
5 ed, and reduced holomycin chelates zinc with high affinity.
6 Both CopZ chaperones could bind Cu(+) with high affinity.
7 r but also binds the mature 30S subunit with high affinity.
8 competitively bind to a cullin scaffold with high affinity.
9 ein that binds to the Kv1.3 ion channel with high affinity.
10 ly bind the shared receptor IL-12Rbeta1 with high affinity.
11 HB is shown to bind and inhibit SULT1A3 with high affinity, 23 (+/-2) nM, and to bind weakly, if at a
12 ing domain (ABD) of beta-III-spectrin causes high-affinity actin binding and decreased thermal stabil
14 d the identification of a previously unknown high-affinity AICE2 motif at a human single-nucleotide p
15 m in (periportal) hepatocytes represents the high-affinity ammonia-detoxifying system of the body.
16 orter and the phoB-phoR regulatory system, a high-affinity ammonium amtB transporter, urea and taurin
17 onium concentrations in the rhizosphere, the high-affinity ammonium transporters (AMTs) in Arabidopsi
20 s is difficult owing to competition with the high affinity and abundance of its endogenous nucleotide
21 ated binding of endothelial cells (ECs) with high affinity and also induced endothelial cell capillar
22 identify UbVs that bound USP7 or USP10 with high affinity and inhibited deubiquitination activity.
24 oordination sites to capture phosphates with high affinity and selectivity directly in water at neutr
25 ion of 5-HT6 receptor antagonist 7 indicates high affinity and selectivity over a panel of receptors
30 mergence of antibody mimetics that offer the high affinity and specificity associated with antibodies
33 d aptamers, BLG14 aptamer sequence has shown high affinity and specificity to both beta-LG A and B wi
34 ally optimized BAX activator that binds with high affinity and specificity to the N-terminal activati
37 Although all these antibodies bound D8 with high affinity and were moderately neutralizing in the pr
40 We found that DDX21 can bind to the RRE with high affinity, and this binding stimulates ATPase activi
41 s must be designed to generate long-lasting, high-affinity, and broadly neutralizing Ab responses aga
42 enantiomer UCB35625, initially identified as high affinity antagonists for CCR1 and CCR3, also bind w
43 AIL, FasL or CD40L is genetically fused to a high-affinity anti-fluorescein scFv antibody fragment (s
45 ived from germinal centers (GCs) secrete the high-affinity antibodies required for long-term serologi
52 with favorable spectroscopic properties and high affinity, as determined by bioluminescence resonanc
53 l antibody (DX-2507) that binds to FcRn with high affinity at both neutral and acidic pH, prevents th
54 contrast, a number of other antagonists with high affinity at the D3R, did not alter the dimer/monome
55 to PCs is induced among a discrete subset of high-affinity B cells residing within the light zone of
56 result of an age-related subunit switch from high affinity beta2-containing nAChRs to low affinity be
57 are stable and can be engineered to develop high-affinity binders against specific targets of intere
58 howed that enrichment of indel mutations for high-affinity binders was three times that of non-synony
60 licity changes was essential to achieve both high affinity binding and a stringent targeted absorptio
61 potentially providing access by TERT to this high affinity binding site during an early step in TERT-
62 procapsid (PC-portal) that is competent for high affinity binding to the large terminase packaging p
64 ly functional homodimer (or "lysibody") with high-affinity binding and specificity for carbohydrate d
66 d pulsed-EPR measurements, demonstrates that high-affinity binding caused by the CH2-localized mutati
67 side chain, the pH effect is abolished, and high-affinity binding is observed until LacY is destabil
68 reliably predict those mutated peptides with high-affinity binding of autologous human leukocyte anti
69 l virulence factors, relying on specific and high-affinity binding of zinc by a periplasmic solute-bi
71 y of Sox2 and Pax6 demands the relaxation of high-affinity binding sites and is enabled by alternativ
72 we used these advances to rapidly mutate 10 high-affinity binding sites for the nucleoid occlusion p
75 ar enzymes, composed of discrete domains for high-affinity binding to cell wall carbohydrates and cle
79 gnizes a receptor on the host cell, enabling high-affinity binding to the cell surface, after which t
80 identified molecular features important for high-affinity binding, with high predictive validity.
84 atrix; the popular dogma is that long-lived, high-affinity bonds to both species facilitate optimal t
87 varied in affinity, and determined that the high-affinity CD3 arms were up to 100-fold more potent i
89 ere we report the development of DI-591 as a high-affinity, cell-permeable small-molecule inhibitor o
91 When supplied chloride, NPF6.4 switched to a high-affinity chloride selective transporter, while NPF6
97 , the expression of OsCOPT1, which encodes a high-affinity copper transport protein, as well as other
98 n rice and overexpression of the Arabidopsis high-affinity copper transporter COPT1 slightly increase
99 cAMP-dependent membrane binding required the high-affinity cyclic nucleotide-binding (CNB) and Ras as
100 enetic screen around E. coli that identified high-affinity cytochrome bd oxidase as an essential bact
103 subset of the C-terminal ZBTB38 ZFs exhibit high-affinity DNA interactions and that preferential tar
105 ssion, in a preclinical model, using a small high-affinity engineered protein scaffold (HAC-PD1).
108 d to restrict cancer cell growth by engaging high-affinity Fc receptors on monocytes and macrophages;
110 escribe includes (i) selection of scFvs with high affinity for Abeta42 fibrils after removal of scFvs
111 While several protein based inhibitors with high affinity for activated FXII (FXIIa) were developed,
112 d evaluated (18)F-JNJ64349311, a tracer with high affinity for aggregated tau (inhibition constant va
113 itro DNA binding assays suggest that Zta has high affinity for all four sequences examined, whereas A
114 xanthus PilB possesses conserved motifs with high affinity for c-di-GMP binding, the findings here su
115 low stoichiometry relative to cohesin, and a high affinity for chromosomal cohesin enables Scc2 to mo
117 as a recognition layer led to a sensor with high affinity for CT26 cancer cells, compared to control
122 is a novel DOTA-coupled GRPR antagonist with high affinity for GRPR and excellent in vivo stability.
124 c binding experiments [(3)H]RO6957022 showed high affinity for human CB2R with fast association (kon)
129 that dual-target binding ligands displaying high affinity for PSMA and appropriate affinity for huma
132 ght chains were cloned as IgG1, and those of high affinity for specific SAEs, assayed by means of ELI
134 ry bioactive thyroid hormone (TH) due to its high affinity for TH nuclear receptors (TRs), new data s
135 ure-selective DNA-binding protein exhibiting high affinity for the Holliday junction and promoting DN
138 uscular acetylcholine (ACh) receptors have a high affinity for the neurotransmitter ACh and a low aff
139 radiolabeled sst receptor antagonist with a high affinity for the sst2 receptor, has the potential t
140 tically modified mutant activated PC, with a high affinity for VLA-3, shows significantly improved bi
145 ersed the cocaine-induced suppression of the high-affinity glutamate transporter 1 (EAAT2/GLT-1) in t
146 ough an induced-fit disease pathway enabling high-affinity GPIbalpha binding and firm platelet adhesi
148 In-, and (nat)Lu-NeoBOMB1 bound to GRPR with high affinity (half maximal inhibitory concentration, 1-
150 lex through a complementary interaction with high affinity, high specificity and high stability.
153 otide-hydrolysis cycle but can still adopt a high-affinity homodimer when bound to a transition-state
156 thermore, repertoire analysis indicates that high affinity IgE and IgG1 plasma cells differentiate fr
158 munity as well as allergic reaction, but how high affinity IgE antibodies are produced in memory resp
159 naphylaxis was assessed, and the role of the high-affinity IgE Fc receptor (FcepsilonRI) in allergic
160 receptor-like 1[EMR1](+)MPs), mast cell MPs (high-affinity IgE receptor [FcepsilonRI](+)c-kit(+)MPs),
161 E-dependent activation mediated through both high-affinity IgE receptors (FcepsilonRI) on mast cells
165 om other genotypes, JFH-1 NS3 binds RNA with high affinity in a functionally active form that is capa
167 nd the target protein beta-tubulin with both high affinity in vitro and high specificity in living ce
168 e Rac1); however, CXCL14 bound to CXCR4 with high affinity, induced redistribution of cell-surface CX
169 se inhibitor 2 (SGPI-2) to select reversible high affinity inhibitors of human CELA3A, CELA3B, and po
170 r, we show that targeting FimH with M4284, a high-affinity inhibitory mannoside, reduces intestinal c
171 oreceptors prior to inducing fusion and when high-affinity inhibitory peptides are used, a condition
172 strate a selective loss of clones expressing high-affinity iNKT-TCRs from the iNKT repertoire of peop
173 ion model in which the previously identified high-affinity interaction acts as a molecular tether, ho
174 y that was further supported by modeling the high-affinity interaction between the optimized sequence
176 f Pd(en)Cl2 (en, ethylenediamine) promotes a high-affinity interaction with exquisite selectivity for
177 lar cytotoxicity and cytokine secretion upon high-affinity interaction with the cognate CTLR keratino
180 4G by the poliovirus 2A protease generates a high-affinity IRES binding truncation of eIF4G that stim
182 ains to DNA creates amphiphiles that exhibit high-affinity (Kd in low nanomolar range) binding to HSA
183 e identified and optimized a novel series of high affinity KMO inhibitors with favorable physicochemi
184 toward binding input molecules in water with high affinity leading to displacement of CB7 from includ
185 on Coro1A by regulating the accumulation of high-affinity LFA-1 in focal zones of adherent cells.
187 Cs might determine local availability of its high-affinity ligand APRIL, because sBCMA has been shown
189 VACV-138 also abrogated D8 binding to the high-affinity ligand CS-E, but we observed residual CS-E
190 ration-inducing ligand" (APRIL) is a natural high-affinity ligand for BCMA and transmembrane activato
192 ethylpyrrolidinyl analogues were found to be high affinity ligands for the CB1 and CB2 cannabinoid re
193 Antisense oligonucleotides may be coupled to high-affinity ligands (triantennary N-acetyl galactosami
195 novel binder [S14R, W50Pra]Ts1 for Nav with high affinity, low dissociation rate and reduced toxicit
200 e PIP molecules by PH domains contributes to high-affinity membrane interactions, informing our under
201 igh affinity IgE and the clonal selection of high affinity memory B cells into the plasma cell fate,
202 cells differentiate from rare CD80(+)CD73(+) high affinity memory clones without undergoing further m
203 ction; the ene-dithiol group of DTPs enables high-affinity metal binding as a central mechanism to in
204 and interleukin (IL)-2, but not IL-17A; iii) high-affinity MHC class II interaction with SAgs, but no
206 in switching, allows FIN219 to switch to its high-affinity mode and thereby enhances JA signaling und
211 ted at kappa and mu receptors and yield very high affinity multifunctional (e.g. 12) or highly select
216 Tyr-370 to His (Y370H) resulted in saturable high-affinity nitrate transport activity and nitrate sel
219 paradoxical situation develops in which the high affinity of Pt for CO helps to decrease the overpot
222 functional ligands characterized in vitro as high-affinity partial agonists of D2R, antagonists of 5-
223 ntribute distinctively to the repertoires of high affinity pathogenic IgE and low affinity non-pathog
224 y determining pockets in a way that leads to high-affinity peptide binding and efficient antigen pres
225 led CB-TE1A1P-PEG4-LLP2A ([(64)Cu]-LLP2A), a high affinity peptidomimetic ligand for very late Ag-4 (
226 eas the other phylotype consistently carry a high-affinity phosphate pst transporter and the phoB-pho
229 aromyces cerevisiae pho2 mutant defective in high-affinity Pi transport rescues growth in low-Pi envi
230 ganism Saccharomyces cerevisiae are the Trk1 high affinity potassium transporter and the functionally
231 smon resonance we demonstrate that Rif1 is a high-affinity PP1 adaptor, able to out-compete the well-
232 with other popular techniques for measuring high-affinity protein-protein interactions, such as bios
236 for leukotriene B4 have been identified: the high-affinity receptor BLT1 and the low-affinity recepto
237 Binding of allergen-specific IgE to its high-affinity receptor FcepsilonRI on basophils and mast
239 tients with atopic dermatitis (AD) carry the high-affinity receptor for IgE, FcepsilonRI, and are cru
241 the inhibitory LIR1 revealed similarities to high-affinity recognition of the viral MHC-I mimic UL18
243 one branched domain (domain II) containing a high-affinity Rev-binding site, and two or three additio
244 d Kir6.2(V64M) mutations essentially abolish high-affinity sensitivity to the KATP blocker glibenclam
245 her dehydroepiandrosterone or fluvoxamine, a high-affinity sigma1-receptor agonist, improved survival
246 -) mice exhibited comparable accumulation of high-affinity signaled CD4(+)CD8(+) double-positive thym
248 E2 approximately ubiquitin-binding sites: a high-affinity Site 1 required for E6AP Cys(820) approxim
249 ogether, these findings demonstrate that the high-affinity site is inaccessible because of either a c
250 tion of toluene by competitive adsorption to high-affinity sorption sites while acknowledging that to
251 s are appealing drug candidates due to their high affinity, specificity, and favorable pharmacologica
252 immunoassays rely on antibodies that provide high affinity, specificity, and selectivity against a ta
253 n-like motion was confined by DNA binding to high-affinity spots, suggesting a two-step mechanism for
256 hough alpha4beta1 is easier to activate, its high-affinity state binds vascular cell adhesion molecul
260 bacteria, these transporters partner with a high-affinity substrate-binding protein (SBP) to import
262 a protein-engineering approach, we generated high-affinity SUMO2 variants by phage display that bind
263 is to describe the recent progress in making high affinity synthetic association partners that operat
264 ased therapies, such as chimeric antigen and high-affinity T-cell receptors to deepen the adaptive im
265 i) M.HhaII triggers Mrr activity by creating high affinity target sites on the chromosome, which pull
269 s bind FZD cysteine-rich domains (CRDs) with high affinity through a palmitoylated N-terminal "thumb"
272 ts of the IL18R1 and IL18RAP genes, and with high affinity to a separate IL-18 binding protein (IL-18
274 h the peptide sequence RGD, which binds with high affinity to alphaVbeta3 integrins present in both t
277 the key to achieving colloidal stability and high affinity to biomolecules as well as support materia
279 cationic bolaamphiphile that binds TFDs with high affinity to form self-assembled complexes (nanoplex
280 Furthermore, we find that GDF15 binds with high affinity to GDNF family receptor alpha-like (GFRAL)
281 ecule tracer for PET imaging that binds with high affinity to GPIIb/IIIa receptors and has suitable p
282 tagonist, [(3)H]G9543, was able to bind with high affinity to GPR84, this was not competed for by inc
283 s unidentified, we show that FplA binds with high affinity to host phosphoinositide-signaling lipids,
285 (SSB) wraps single-stranded DNA (ssDNA) with high affinity to protect it from degradation and prevent
286 ion of RBM25 spanning Lys-77 that binds with high affinity to serine- and arginine-rich splicing fact
287 We report that CHD6 and CHD7 both bind with high affinity to short linker DNA, whereas CHD8 requires
288 tein that, when unphosphorylated, binds with high affinity to the complex of betagamma-subunits of G
291 RNP A2 proteins that bind specifically (with high affinity) to A2RE sequences or nonspecifically (wit
292 was due to the mislocalisation of CTR1, the high affinity transporter that imports copper into the c
293 een the new compounds stands out 12b for its high affinity value (Ki = 0.27 nM) and for its anxiolyti
294 gion of Notch1 complexed with an engineered, high-affinity variant of Jagged1 (Jag1) reveals a bindin
295 nists, namely compounds 21 and 22, displayed high affinity versus the EphA2 receptor and resulted end
296 mechanism to retain substrate proteins with high affinity while also generating functional switches
297 aused by the reduction of CO2 into CO, whose high affinity with platinum triggers the formation of a
298 to study protein interactions of medium- and high-affinities with a limit of detection down to 1 pM,
299 ty due to its ability to bind PPARgamma with high affinity without stimulating adipocyte differentiat
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