ライフサイエンスコーパス: high-affinity antibody

1 (Tfh) cell is required for the production of high affinity antibody.

2 to produce plasma cells capable of secreting high-affinity antibody.

3 lasticity of the antigen-combining site of a high-affinity antibody.

4 necessary, indirectly, for the production of high affinity antibodies.

5 wth of B cells and plasma cells that produce high affinity antibodies.

6 es the generation of a diverse repertoire of high-affinity antibodies.

7 rm germinal centers (GC) but fail to produce high-affinity antibodies.

8 (SHM) critically underlies the generation of high-affinity antibodies.

9 (SHM)--two processes essential for producing high-affinity antibodies.

10 red for GC development and the production of high-affinity antibodies.

11 xpression, and capacities to yield IgG2c and high-affinity antibodies.

12 tion that is required for the development of high-affinity antibodies.

13 ction by cytotoxic mechanisms, cytokines and high-affinity antibodies.

14 rs of germinal center B cells and absence of high-affinity antibodies.

15 s to form germinal centers (GCs) and produce high-affinity antibodies.

16 clonal selection lead to B cells expressing high-affinity antibodies.

17 n (SHM) in V(D)J exons for the generation of high-affinity antibodies.

18 nation of which results in the production of high-affinity antibodies.

19 pecific CD4 T cell responses, in addition to high-affinity antibodies.

20 nity maturation, directing the production of high-affinity antibodies.

21 been employed to facilitate the selection of high-affinity antibodies.

22 ation, and rapid clonal expansion to produce high-affinity antibodies.

23 T follicular cells help B cells generate high-affinity antibodies.

24 ity of the natural immune system to generate high-affinity antibodies.

25 on of germinal centres and the production of high-affinity antibodies.

26 incorporated into hapten design to generate high-affinity antibodies.

27 from their CICs with fixed platelets reveals high-affinity antibody (Ab) against platelet glycoprotei

28 The generation of high-affinity antibodies (Abs) plays a critical role in

29 ed this design with nanoparticles containing high-affinity antibodies (Abs) to TfR.

30 B cells do not generate germinal centers and high-affinity antibody after protein immunization.

31 ant source of humoral immunity by generating high affinity antibodies against a pathogen.

32 High-affinity antibodies against a conserved epitope cou

33 interactions with CD4(+) T cells to develop high-affinity antibodies against proteins.

34 We generated a fully human high-affinity antibody against FasL that binds to and ne

35 l for the generation of genetically diverse, high affinity antibody and robust humoral immunity, but

36 GC functions are not sufficient to generate high-affinity antibodies and B cell memory.

37 ermutation is critical for the generation of high-affinity antibodies and effective immune responses,

38 5 for normal production of isotype-switched, high-affinity antibodies and for a memory response.

39 nity maturation, and the development of most high-affinity antibodies and memory B cells.

40 arp boundary between an outer shell of bound high-affinity antibody and an inner antibody-free core h

41 AID plays a central role in the synthesis of high affinity antibodies, and APOBEC3G inactivates human

42 e deaminase (AID) is critical for generating high-affinity antibodies, and deamination by APOBEC-3 pr

43 TFH) cells are essential in the induction of high-affinity antibodies, and their precursor memory com

44 SHM) in immunoglobulin genes is required for high affinity antibody-antigen binding.

45 Detailed analysis of factors governing high affinity antibody-antigen interactions yields impor

46 High affinity antibodies are generated in mice and human

47 High-affinity antibodies are critical for host protectio

48 B cells producing high-affinity antibodies are destined to differentiate i

49 High-affinity antibodies are generated by somatic hyperm

50 re memory B cells and plasma cells producing high-affinity antibodies are generated during T cell-dep

51 Three high-affinity antibodies are presented in this study as

52 s, particularly in subjects who did not have high affinity antibodies at baseline.

53 To produce high-affinity antibodies, B cells must undergo iterative

54 To create high-affinity antibodies, B cells target a high rate of

55 High-affinity antibodies bind effectively even with a si

56 The production of high-affinity antibodies by B cells is essential for pat

57 deadly pathogens requires the production of high-affinity antibodies by B cells, which are generated

58 This presents an opportunity for designing high-affinity antibodies by connecting via a flexible pe

59 The germinal center (GC) reaction produces high-affinity antibodies by random mutation and selectiv

60 The generation of high-affinity antibodies depends on the ability of B cel

61 The GAD autoantibodies were high affinity (antibody dissociation constant, 0.06-0.78

62 rtant anatomical site for the development of high affinity antibodies during T-cell dependent B cell

63 , coupled to selection by antigen, generates high-affinity antibodies during germinal center (GC) B c

64 licular helper cells (Tfh) and production of high-affinity antibody during a primary response are inc

65 sis of any biomolecular target for which two high-affinity antibodies exist by detecting the approxim

66 This has spurred efforts to generate high affinity antibodies for use in cancer therapy.

67 in driving the germinal centre reaction and high affinity antibody formation.

68 ers (GCs) in the generation and selection of high affinity antibody-forming cells (AFCs), we have ana

69 res central to the generation of long-lived, high-affinity, antibody-forming B cells.

70 e backbone NMR assignments for two distinct, high affinity antibody fragments (single chain variable

71 as highlighted by the development of robust high affinity antibody fragments derived from the breast

72 lone may be sufficient for the generation of high-affinity antibodies from phage-displayed libraries;

73 CVpp, and affinity studies found moderate-to-high-affinity antibodies in all domains.

74 The development of high-affinity antibodies in response to infection is an

75 The maturation process of high-affinity antibodies is a result of intricate intera

76 ivo findings demonstrate that the need for a high-affinity antibody is dependent on the density of th

77 ulation is contained to ensure generation of high-affinity antibody is unknown.

78 s significantly accelerates the discovery of high-affinity antibody leads.

79 large enough variable surface area to select high-affinity antibody mimics is significant because a s

80 immunoglobulin genes is required to produce high affinity antibody molecules.

81 R), two processes that are needed to produce high-affinity antibodies of all isotypes.

82 Somatic hypermutation generates high-affinity antibodies of different isotypes that effi

83 ing mechanisms involved in the production of high-affinity antibodies of different isotypes.

84 ecombination (CSR) enable B cells to produce high-affinity antibodies of various isotypes.

85 ectively neutralising interleukin 17A with a high affinity antibody potentially gives patients with p

86 High-affinity antibodies produced by memory B cells diff

87 lar helper (Tfh) cells and the generation of high affinity antibody-producing B cells.

88 GC) is a microanatomical compartment wherein high-affinity antibody-producing B cells are selectively

89 T follicular helper (T(FH)) cells select high-affinity, antibody-producing B cells for clonal exp

90 fferentiation of B cells to plasma cells and high affinity antibody production in germinal centers (G

91 High-affinity antibody production through the germinal c

92 eipt of the IIV reflected the specificity of high-affinity antibody production.

93 ecombination (CSR) before being selected for high-affinity antibody production.

94 High-affinity-antibody production, T-cell activation, an

95 tigen-activated B cells proliferate, express high-affinity antibodies, promote antibody class switchi

96 TRIM21 is a high-affinity antibody receptor that allows antibodies t

97 lic IgA-virion complexes colocalize with the high-affinity antibody receptor tripartite motif-contain

98 TRIM21 is a high-affinity antibody receptor uniquely expressed in th

99 he adaptive immune system relies on specific high-affinity antibody receptors that are generated from

100 ived from germinal centers (GCs) secrete the high-affinity antibodies required for long-term serologi

101 The synthesis of high affinity antibodies requires activation-induced cyt

102 The generation of high-affinity antibodies requires germinal center (GC) d

103 The generation of high-affinity antibodies requires the presence of a popu

104 regulate B cell function and development of high affinity antibody responses but little is known abo

105 and modified to yield diverse, specific, and high affinity antibody responses to antigen.

106 lls, which are required for the induction of high-affinity antibody responses and the formation of lo

107 Protective high-affinity antibody responses depend on competitive s

108 nsitization with mP/O-B elicited high-titre, high-affinity antibody responses reactive with both the

109 ctive specificities, but are unable to mount high-affinity antibody responses.

110 High affinity antibodies result from interactions betwee

111 possible to reorder the combining site of a high affinity antibody, resulting in altered specificity

112 tablishment of T-dependent B cell memory and high affinity antibody-secreting cells.

113 rs and a corresponding decrease in secondary high-affinity antibody-secreting cell formation.

114 High-affinity antibodies specific for hHepc were generat

115 Pathogen exposure elicits production of high-affinity antibodies stimulated by T follicular help

116 is an integral process in the development of high-affinity antibodies that are important for recovery

117 generation of the somatically hypermutated, high-affinity antibodies that mediate adaptive immunity.

118 une response, resulting in the production of high-affinity antibodies that neutralize pathogens and c

119 an immune system has generated high quality, high affinity antibodies to a wide range of antigens for

120 t the 14 days of observation, binding of the high affinity antibody to LD beads and of the low affini

121 The competitive assay format uses a high affinity antibody to paralytic shellfish toxins wit

122 d AZD8055 increased titers of class-switched high-affinity antibodies to a hapten-protein conjugate.

123 The potential therapeutic usefulness of high-affinity antibodies to cell wall carbohydrates is u

124 Our findings show that high-affinity antibodies to cell-bound MUC1 SEA domain e

125 e combinatorial antibody libraries to select high-affinity antibodies to every protein encoded by the

126 The discovery and optimization of high-affinity antibodies to important therapeutic target

127 rinitrophenyl (TNP)-Ficoll and production of high-affinity antibodies to TNP-keyhole limpet hemocyani

128 ighly efficient isolation of intermediate to high affinity antibodies, which preferentially reacted w

129 ide the selection of an animal that produces high affinity antibodies with a desired epitope coverage

130 gest that affinity maturation may select for high affinity antibodies with either "lock-and-key" prec

131 e most complex library, we produced multiple high-affinity antibodies with dissociation constants in

132 ntigen immunization results in production of high-affinity antibodies with long human-like complement

133 generation and selection of B cells bearing high-affinity antibodies, yet GC cell migration and inte