ライフサイエンスコーパス: high-affinity binding

1 CCL7 renders oligomerization unnecessary for high affinity binding.

2 ndertaken to elucidate the basis of the very high affinity binding.

3 vers oligomer expansion as a requirement for high affinity binding.

4 contacts but is substantially attenuated in high affinity binding.

5 ommon SUMO1-specific interactions needed for high affinity binding.

6 tion of basic charge on MAM7 is required for high affinity binding.

7 res four nucleotides adjacent to the cap for high affinity binding.

8 stant (Kd) equal to about 1 nM, indicating a high affinity binding.

9 tensions flanking the central PXXP motif for high affinity binding.

10 pR thereby contributing significantly to its high affinity binding.

11 iboswitch, divalent cations are required for high-affinity binding.

12 ional amino acids are critically involved in high-affinity binding.

13 ally grafted polar residues are critical for high-affinity binding.

14 ptimizes the surrounding contact surface for high-affinity binding.

15 e opposing minor groove and are required for high-affinity binding.

16 hese peptides are essential for the observed high-affinity binding.

17 four nucleotides adjacent to the 5' cap for high-affinity binding.

18 city in the interface composition supporting high-affinity binding.

19 ggesting that multiple solutions may support high-affinity binding.

20 agonist (+)-pentazocine did not compete for high-affinity binding.

21 d favorable interactions contributing to the high-affinity binding.

22 residues, Lys21 and Tyr22, are essential for high-affinity binding.

23 where high GTP levels are present; however, high affinity binding [(3)H]PGE(2) was observed in broke

24 tory concentration, 7.4 ng/ml), demonstrated high-affinity binding (320 pM), and was capable of thera

25 optimal syntax, whereas enhancers containing high-affinity binding affinities possess suboptimal synt

26 is (MS) shows that PBR28 binds the TSPO with high affinity (binding affinity [Ki], approximately 4 nM

27 Changes induced by high affinity binding already exist in both a constraine

28 licity changes was essential to achieve both high affinity binding and a stringent targeted absorptio

29 ptake via FRalpha and -beta, associated with high affinity binding and inhibition of de novo purine n

30 arks within the heptad repeat of the CTD for high affinity binding and provides a molecular interpret

31 ith Unc119a reveals the molecular details of high affinity binding and suggests the importance of the

32 -cGAMP revealed the structural basis of this high-affinity binding and a ligand-induced conformationa

33 tent with a two-step reaction involving fast high-affinity binding and a subsequent slower conformati

34 A fine-tuned balance between high-affinity binding and electrostatic repulsive forces

35 in Nicotiana benthamiana plants and retained high-affinity binding and potent neutralizing activity i

36 ingly, a single H830A mutation restores both high-affinity binding and signaling activity with 2'-O-m

37 following extensive washout, consistent with high-affinity binding and slow dissociation from ABL kin

38 ly functional homodimer (or "lysibody") with high-affinity binding and specificity for carbohydrate d

39 strate selection in EAATs and illustrate how high-affinity binding and the efficient transport of glu

40 TonB-dependent transporter that permits the high-affinity binding and transport of cobalamin (CBL),

41 benzothiazole moiety, which greatly enhances high-affinity binding and use-dependent block.

42 t H3R2, H3K4, H3T3, H3T6, and H3S10 disrupts high-affinity binding, and the three most N-terminal ami

43 In solution, the cyanostar shows high-affinity binding as 2:1 sandwich complexes, log bet

44 generated a panel of novel Fc variants with high affinity binding at acidic pH that vary in pH 7.4 a

45 es in BabA and on pH reversible formation of high-affinity binding BabA multimers.

46 tors, and that this coupling is critical for high affinity binding but differentially regulates activ

47 Single protein loops can mediate extremely high-affinity binding, but it is unclear whether such a

48 rboxylate of AA with Arg-120 is required for high affinity binding by COX-1 but not COX-2, suggesting

49 This high-specificity and high-affinity binding by NC consequently liberates these

50 ion of stoichiometry and free energy of such high-affinity binding can be far from trivial.

51 d pulsed-EPR measurements, demonstrates that high-affinity binding caused by the CH2-localized mutati

52 These studies indicate high affinity binding, characterized by a low micromolar

53 results in a shift from a low affinity to a high affinity binding conformation of the lectin domain.

54 First, eIF4E binding to eIF4G generates a high-affinity binding conformation of the eIF4F complex

55 a point mutant (alpha-catenin L344P) lacking high affinity binding does not activate vinculin.

56 ntain multiple occurrences of G(A/G)GGC, the high-affinity binding element for the viral initiator T-

57 The minimal high affinity binding epitope of SL2-1 was alpha1-6 fuco

58 ites on individual nucleosomes to generate a high affinity binding event and promote reorganization.

59 The cloned 12-HETER demonstrated high affinity binding for 12-(S)-[(3)H]HETE (K(d) = 4.8

60 Calcium accumulation assays and high affinity binding for [(3)H]epibatidine determined t

61 s, and patients whose HLA genetics predicted high-affinity binding had more allergy (P = 3.3 x 10(-4)

62 free and bound Zher2 structures reveals how high-affinity binding has evolved during selection and a

63 We hypothesize that selection for high-affinity binding in physiological conditions is pri

64 gnaling, all other mutant receptors retained high affinity binding, indistinguishable from wild-type

65 These modifications facilitate the high affinity binding interaction with IL-6 and provide

66 ombination of E1A aggregation propensity and high-affinity binding interactions.

67 es a basic patch that constitutes a putative high-affinity binding interface spanning both DBL domain

68 High affinity binding is destabilized by osmotic stress,

69 In both cases, high affinity binding is found to involve conformational

70 High affinity binding is mediated by Lys(415), whereas t

71 her ETS domains (e.g., Ets-1, TEL) for which high-affinity binding is driven by rapid association (>1

72 side chain, the pH effect is abolished, and high-affinity binding is observed until LacY is destabil

73 re designed to mimic the profile of ABT-089, high affinity binding ligand for the alpha4beta2 nAChR,

74 Thus, selection for high-affinity binding may automatically lead to structur

75 4-methylenedioxy-N-methylamphetamine adopt a high-affinity binding mode consistent with a transportab

76 at unmodified PARP-1 engages in at least two high-affinity binding modes with chromatin, one of which

77 d fragment of MLL, and the MBM1 represents a high affinity binding motif.

78 tor because it appears to be responsible for high affinity binding of a number of benzodiazepines to

79 They exhibit high affinity binding of a single long-chain fatty acid,

80 cated network of interactions that result in high affinity binding of all 43 S PIC components with th

81 Gel shift assays confirmed high affinity binding of CsrA to relA mRNA leader and we

82 We demonstrate that the observed high affinity binding of Fab to TNF-alpha is an enthalpy

83 RR31 is an NDH subunit that is necessary for high affinity binding of ferredoxin, indicating that chl

84 Nedd4 and ARRDC3 expressed in HEK293 cells, high affinity binding of full-length ARRDC3 and Nedd4 is

85 e relative and specific titration of IGF2 by high affinity binding of IGF2R represents a mechanism th

86 The results show that high affinity binding of NotD to FVa is membrane-indepen

87 formation on the structural requirements for high affinity binding of organic nitrates to the catalyt

88 Thus, our data (a) indicate that high affinity binding of Pg to Fn is not essential for F

89 High affinity binding of PsbO to PSII is required to pro

90 triads of SRCR domains 2 and 3 abrogates the high affinity binding of recombinant CD163 to Hp-Hb.

91 urface-bound TG2 inactive, whereas specific, high affinity binding of S-nitrosylated TG2 (SNO-TG2) to

92 High affinity binding of short peptide analogs of HVR to

93 These studies revealed high affinity binding of SHP-2 to phosphorylated forms o

94 Our studies revealed high affinity binding of the farnesylated-Cys probe to t

95 inal tail of EIIA(Glc) are essential for the high affinity binding of the protein to the transporter.

96 On the basis of the high affinity binding of trimethoprim (TMP) to Escherich

97 ses are, however, tightly linked because the high affinity binding of urokinase regulates the binding

98 tion binding assays, SET knockdown increased high-affinity binding of agonist in intact cells and mem

99 reliably predict those mutated peptides with high-affinity binding of autologous human leukocyte anti

100 Multimicrosecond simulations of NavAb reveal high-affinity binding of benzocaine to F203 that is a su

101 vity of Ad-FX and Ad-FVII complexes, despite high-affinity binding of both these coagulation factors

102 t sufficient for CaMKII activation, although high-affinity binding of calmodulin is.

103 ndings, here we have successfully introduced high-affinity binding of capsaicin and resiniferatoxin t

104 n shown that Ca(2+) binding is necessary for high-affinity binding of CBL to BtuB, and earlier simula

105 5 interaction with (NF)G proteins eliminates high-affinity binding of CCR5 chemokines but preserves r

106 nB box of the colicin cross the OM following high-affinity binding of ColIa to its primary receptor,

107 re labeling, a supramolecular assay based on high-affinity binding of cucurbit[7]uril, and two colori

108 Cellulosomes are assembled by selective high-affinity binding of enzyme-borne dockerin modules t

109 The BabA adhesin mediates high-affinity binding of Helicobacter pylori to the ABO

110 Direct high-affinity binding of hPg/plasmin to pattern D GAS is

111 and binding-based reconstitution assays show high-affinity binding of inositol pyrophosphates to the

112 recognition of 5-HT, this mutation disrupts high-affinity binding of many competitive antagonists in

113 with the role of Ser438 as a key residue for high-affinity binding of many SSRIs, including (S)-cital

114 showed that the minimal elements crucial for high-affinity binding of MLL1 to WDR5 are -CO-ARA-NH- mo

115 al N-mediated translation initiation and for high-affinity binding of N to the UTR.

116 The results show high-affinity binding of neomycin to 27-nucleotide model

117 Nicotine addiction begins with high-affinity binding of nicotine to acetylcholine (ACh)

118 into the key molecular determinants for the high-affinity binding of peptide toxins to KCa3.1, and d

119 show that native chemokines fail to prevent high-affinity binding of PSC-RANTES, analog-mediated cal

120 Here, we demonstrate specific, high-affinity binding of quinine to the complementarity-

121 High-affinity binding of RS1-Reg to ODC1 was demonstrate

122 d surface plasmon resonance studies revealed high-affinity binding of septins to the microtubule plus

123 The high-affinity binding of the AO7 clamp to UbcH5B has als

124 An apparent paradox is that the high-affinity binding of the AO7 clamp to UbcH5B, which

125 It has been shown that high-affinity binding of the BMP10 prodomain to the matu

126 condary repulsive effects contributes to the high-affinity binding of the lin-benzoguanines.

127 upancy of this site is sufficient to promote high-affinity binding of the NCS-1 monomer to the D2R pe

128 In BtuB, the high-affinity binding of TonB(33-239) was eliminated by

129 ts Rpn10 and Rpn13 contribute equally to the high-affinity binding of ubiquitin chains, but in their

130 ation of myeloid dendritic cells induced the high-affinity binding of VCAM-1/CD106 Fc chimeric protei

131 l virulence factors, relying on specific and high-affinity binding of zinc by a periplasmic solute-bi

132 luid, we find that galectin-3 is a specific, high-affinity binding partner for lubricin.

133 Our data reveal SPATA2 as a high-affinity binding partner of CYLD and HOIP, and a re

134 Loss of Munc18-1, a high-affinity binding partner of Stx1, also showed sever

135 cking of KARs, Neto1 determined both the KAR high-affinity binding pattern and the distinctively slow

136 We found that both the high-affinity binding pattern in the mouse brain and the

137 eration of new therapeutic molecules such as high affinity binding peptides or modified high affinity

138 selectivity, increased substrate access to a high affinity binding pocket, and proton transport in th

139 Sex hormone-binding globulin (SHBG) is the high-affinity binding protein for androgens and estrogen

140 eins prefer ordered structures, whereas only high-affinity binding proteins (found mostly in eukaryot

141 ing antigens or due to the lack of specific, high-affinity binding reagents and reliable assays with

142 The RNA structural context is critical: High-affinity binding requires base-paired regions flank

143 the SF1 model with a PPT model computed from high affinity binding sequences for U2AF65.

144 Our results demonstrate the presence of a high affinity binding site at the enzyme periphery.

145 potentially providing access by TERT to this high affinity binding site during an early step in TERT-

146 o regions likely act in concert to provide a high affinity binding site for Abeta42 oligomers.

147 ate-free form of the transporter generates a high affinity binding site for glutamate and is thus req

148 onal modification (PTM) is the creation of a high affinity binding site for the selective interaction

149 Cytochrome bo(3) has a high affinity binding site for ubiquinol that stabilizes

150 Calcium bound in the high affinity binding site of gamma-actin may cause a se

151 lacing multiple permeant ions, en route to a high affinity binding site that remains loosely defined.

152 proteolysis is the driving force to unveil a high affinity binding site(s) for FXa.

153 In addition to a high affinity binding site, SERT possesses a low affinit

154 ses the active state and therefore makes the high-affinity binding site accessible.

155 n may result from periodic drug-binding to a high-affinity binding site during the action potentials

156 a 15 bp inverted repeat that functions as a high-affinity binding site for BldD, as was shown by ele

157 93 collectively contribute to establishing a high-affinity binding site for SCF(Slimb).

158 -labeled analogue of stearic acid detected a high-affinity binding site for the fatty acid with stron

159 G) variant repeat predominated and created a high-affinity binding site for the nuclear receptors COU

160 d the open capsid conformation, in which the high-affinity binding site is available, best fit the da

161 l five PCB sulfates were able to bind to the high-affinity binding site of TTR with equilibrium disso

162 re we show that four charged residues in the high-affinity binding site on obscurin for sAnk1 (betwee

163 tion is necessary and sufficient to reveal a high-affinity binding site with which PF-05089771 intera

164 ly coordinate zinc and then convey it to the high-affinity binding site.

165 ulted in a 0.3 A-resolution structure of the high-affinity binding site.

166 nteractions with a protein bound to RNA at a high-affinity binding site.

167 main protein that contains the following two high affinity binding sites for LRP1: one is located wit

168 Liver exhibits high affinity binding sites for RBP4, but specific recep

169 ble for use in agriculture), suggesting that high affinity binding sites were already in excess in th

170 We found that not only high affinity binding sites, but also numerous moderate

171 d approximately 0.3 molecules of thrombin at high-affinity binding sites (Kd = 0.15 muM).

172 y of Sox2 and Pax6 demands the relaxation of high-affinity binding sites and is enabled by alternativ

173 ty analogs (medium nanomolar Ki) for the GHB high-affinity binding sites as the most high-affinity an

174 rough alpha4beta2 receptors, the predominant high-affinity binding sites for nicotine in the central

175 redicted that the pnr enhancer would contain high-affinity binding sites for the Dpp effector Smad tr

176 we used these advances to rapidly mutate 10 high-affinity binding sites for the nucleoid occlusion p

177 bly and desensitization, and incorporate the high-affinity binding sites for zinc and ifenprodil.

178 -out signaling that culminate in exposure of high-affinity binding sites on integrin alpha(IIb)beta(3

179 ear antigen 1 (EBNA1) with a tandem array of high-affinity binding sites, referred to as the family o

180 of transient cholesterol clusters around the high-affinity binding sites.

181 ly diminished when we examine only predicted high-affinity binding sites.

182 eceptor 1 (NFR1) bind Nod factor directly at high-affinity binding sites.

183 HB) is a neuroactive substance with specific high-affinity binding sites.

184 eted in terms of a model where there are two high-affinity binding sites: the central, S1, site and a

185 s the MTBD to the conformationally unstable, high affinity binding state.

186 inesins, which are open when doing work, the high-affinity binding state for microtubule-depolymerizi

187 at the fast inactivated state represents the high-affinity binding state.

188 These data indicate sequence specificity for high affinity binding, supporting the view that sulfate

189 intensive and mostly limited to elucidating high-affinity binding target proteins.

190 We found that Tmod achieves high-affinity binding through several discrete low-affin

191 Thus, while high affinity binding to 3' ends requires the La domain

192 ing domains of nucleolin were sufficient for high affinity binding to ARE(bcl-2).

193 cells by facilitating transcription through high affinity binding to CACCC elements within its eryth

194 calorimetry (ITC) measurements demonstrated high affinity binding to caveolin by the T20 variants wi

195 t provides the architectural constraints for high affinity binding to either the 50 S ribosomal subun

196 Ultra-high affinity binding to FcRn at both acidic and neutral

197 we show that each of these domains mediates high affinity binding to ferric heme (hemin) and that it

198 PCBP1 and -2 exhibited high affinity binding to ferritin in vitro.

199 ype lectins, oligomerization is required for high affinity binding to glycan ligands and is also like

200 Alboserpin displays high affinity binding to heparin (K(D) ~ 20 nM), but no

201 forms functional homo-oligomers that mediate high affinity binding to its corresponding cellular liga

202 The DXMS data support the view that high affinity binding to mispair-containing DNA and low

203 antigen receptor for chemokines (DARC) shows high affinity binding to multiple inflammatory CC and CX

204 our mutational data conceivably depended on high affinity binding to Na1.

205 ido-NAADP ([(32)P-5N(3)]NAADP) that exhibits high affinity binding to NAADP receptors.

206 Annexin A5 is a 35-kDa protein with high affinity binding to negatively charged phospholipid

207 and R pockets were shown to be necessary for high affinity binding to neuronal and non-neuronal cells

208 Here we report that TeNT high affinity binding to neurons is mediated solely by g

209 mboplastin time clotting assays but retained high affinity binding to PF4 and effectively reversed PF

210 ives were tested for their ability to retain high affinity binding to PF4 despite having greatly dimi

211 ists compete directly with retinoic acid for high affinity binding to purified receptors.

212 ing the APP IRE stem loop exhibited the same high affinity binding to rhIRP1 as occurs for the H-ferr

213 al integrity was further demonstrated by its high affinity binding to soluble CD4, CD4 binding site a

214 The current work revealed that CAPS exhibits high affinity binding to syntaxin-1 and SNAP-25 and mode

215 The Phl p 2-ScFv showed high affinity binding to the allergen and blocked the bi

216 Zinc inhibition through high affinity binding to the ATD has been examined throu

217 These glycoconjugates showed high affinity binding to the human transmembrane lectin

218 procapsid (PC-portal) that is competent for high affinity binding to the large terminase packaging p

219 trating the structural features required for high affinity binding to the receptor.

220 at position 14, 32, 49, or 85 did not affect high affinity binding to the RyR1.

221 osition 52a in HCDR2 is sufficient to confer high affinity binding to the selecting H1 antigen, consi

222 ividual p27 subdomains contribute to equally high affinity binding to these two Cdk/cyclin complexes

223 e DNA binding interface that is required for high affinity binding to ureA but not nixA.

224 with WDR5 provide structural basis for their high affinity binding to WDR5.

225 at the C terminus of PPXY1, is important for high affinity binding to WW3.

226 en implicated in endocrine disruption due to high affinity-binding to the thyroxine-carrying protein,

227 hort beta2 phospho-peptide is sufficient for high-affinity binding to 14-3-3-zeta.

228 recognition motif (RRM1) are sufficient for high-affinity binding to 3' oligoU, recognition of HCV d

229 ing of RRM3 and RRM4, could be essential for high-affinity binding to a flexible polypyrimidine tract

230 ith a binding constant of 18 nM and displays high-affinity binding to a range of SSRIs, SNRIs and a T

231 How proteins achieve high-affinity binding to a specific protein partner whil

232 vel class of proteins selected for specific, high-affinity binding to a target protein.

233 ffold and preorganizes CPSF-30 and WDR33 for high-affinity binding to AAUAAA.

234 te-lisinopril complexes possesses a range of high-affinity binding to ACE, introduces the advantage o

235 modularity with particular domains, lack of high-affinity binding to all DNA triplets, and difficult

236 or the chaperone/GEF Ric-8A], while favoring high-affinity binding to all known GBA motifs.

237 rved W25/D30 pair appears to be critical for high-affinity binding to ApoE(130-149).

238 allergy whereby HLA-DRB1 alleles that confer high-affinity binding to asparaginase epitopes lead to a

239 (18)F-Tr-Sgc8 was found to possess high-affinity binding to both cell lines, with binding a

240 hed the molecular basis of its selective and high-affinity binding to C11/C12-chain fatty acids.

241 how that while the CCD of SA11 NSP4 exhibits high-affinity binding to Ca(2+) at neutral pH and forms

242 ar enzymes, composed of discrete domains for high-affinity binding to cell wall carbohydrates and cle

243 tide and DNA wrapped in MNs is essential for high-affinity binding to chromatin.

244 ture of the polynuclear compounds results in high-affinity binding to DNA and very efficient nuclear

245 n of a small transcription factor capable of high-affinity binding to DNA as a monomer, and this unus

246 -secretase activity is not required and that high-affinity binding to DR6 requires a more C-terminal

247 anomolar) to both BtuB and FhuA; however, no high-affinity binding to FecA was observed.

248 ation of TM4, eliminates G protein-dependent high-affinity binding to GLP-1(7-36)NH(2) but has select

249 3D6 and 3G9 mAbs were selected for high-affinity binding to hDEC205.

250 35)), and WWAV (GPC(428-436)) that displayed high-affinity binding to HLA-A*0201 and were recognized

251 Six of these epitopes exhibited high-affinity binding to HLA-A*02:01 molecules.

252 modified by the enzyme TG2, leading to their high-affinity binding to HLA-DQ2 or HLA-DQ8 molecules, p

253 ange of gram-negative pathogens to establish high-affinity binding to host cells during the early sta

254 , and eight of the nine candidates exhibited high-affinity binding to human chemokines.

255 s conformational changes in gp120 that allow high-affinity binding to its coreceptors.

256 However, high-affinity binding to known potent and specific nonpe

257 s on alpha-dystroglycan that is required for high-affinity binding to laminin.

258 In addition to the expected high-affinity binding to methylated cytosine in the CG c

259 e-gated channels by two separate mechanisms: high-affinity binding to N-terminal domains of GluN2A su

260 ecessary but not sufficient to maintain this high-affinity binding to N.

261 of 5 to 6 nucleotides (nt) is sufficient for high-affinity binding to NS5A.

262 These MAbs show high-affinity binding to NSP2 and differentially recogni

263 hSSB1 exhibits high-affinity binding to PAR and recognizes iso-ADP ribo

264 resonance experiments they showed comparable high-affinity binding to Phl p 1 as a complete human IgE

265 signal on ER precursors, which also display high-affinity binding to PI(3)P.

266 is position, as in importin alpha1, disrupts high-affinity binding to pSTAT1, suggesting that pSTAT1

267 alpha5 Armadillo (ARM) repeat 10 accompanies high-affinity binding to pSTAT1.

268 the oligomannose context is sufficient for a high-affinity binding to receptor CI-MPR, while the pres

269 ed against multiple S. aureus antigens, only high-affinity binding to SpA was observed.

270 These compounds showed high-affinity binding to Stat3's SH2 domain, inhibited i

271 , slows down SNARE complex formation through high-affinity binding to syntaxin.

272 bispecific antibodies in vivo, we found that high-affinity binding to TfR caused a dose-dependent red

273 R652 is important for high-affinity binding to the adhesin whereas F21 is impo

274 the growth of prostate cancer cells through high-affinity binding to the AR and inhibition of AR nuc

275 ition, we could demonstrate that the loss of high-affinity binding to the catalytic site(s) that had

276 my virus long terminal repeat (LTR) that has high-affinity binding to the CCCTC-binding factor.

277 gnizes a receptor on the host cell, enabling high-affinity binding to the cell surface, after which t

278 Furthermore, we found that the NTD exhibits high-affinity binding to the chaperone-adhesin (PapDG) c

279 guanosines essential for both packaging and high-affinity binding to the cognate Gag protein are exp

280 o group by SimC7 was shown to be crucial for high-affinity binding to the enzyme.

281 etworks and basement membranes (BMs) through high-affinity binding to the laminin gamma1 chain.

282 We confirm the hypothesis that methoctramine high-affinity binding to the M(2) receptors involves sim

283 ciation and binding element to contribute to high-affinity binding to the neuronal membrane.

284 hate 4-phosphatase domain of P-REX2 provides high-affinity binding to the postsynaptic density-95/Dis

285 ctivities of these metal complexes and their high-affinity binding to the targeted RRE mRNA following

286 s occupancy of both subsites is required for high-affinity binding to TRIP13.

287 WDR5 establishes their structural basis for high-affinity binding to WDR5.

288 essential elements in MLL1 required for its high-affinity binding to WDR5.

289 The resulting antibody, Ab513, exhibits high-affinity binding to, and broadly neutralizes, multi

290 st, LacY mutants that exhibit pH-independent high-affinity binding up to pH 11.0 (e.g., Glu325 --> Gl

291 liI homologs from diverse bacterial species, high affinity binding was also observed for the type III

292 As well as being required for high affinity binding, we also demonstrate that the Arg-

293 lex that drive heterodimeric specificity and high affinity binding, we carried out biophysical analys

294 o explore the criteria for ligand economical high affinity binding, we systematically probed distance

295 identify molecular targets for specific GHB high-affinity binding, we undertook photolinking studies

296 correlation between the energies of low- and high-affinity binding, which implies that gating commenc

297 While GIC elements responsible for its high affinity binding with Ac-AChBP and alpha3beta2 nACh

298 , we predict and then experimentally confirm high-affinity binding with multiple other HLA-A*02 subty

299 oligosaccharide context are all critical for high-affinity binding with the major M6P receptor.

300 identified molecular features important for high-affinity binding, with high predictive validity.