ライフサイエンスコーパス: high-affinity ligand

1 mammalian cells depends on the presence of a high affinity ligand.

2 mall protein scaffold in order to identify a high affinity ligand.

3 ormational change in the protein, leading to high affinity ligands.

4 transforms consensus sequence peptides into high affinity ligands.

5 by deriving a plausible binding pose for the high affinity ligands.

6 iciently high to enable in vivo imaging with high affinity ligands.

7 al its functional interaction interface with high-affinity ligands.

8 er a successful strategy for the creation of high-affinity ligands.

9 e when tuning selection pressures to isolate high-affinity ligands.

10 sed screening approach for rapidly modifying high-affinity ligands.

11 ligands, and with Hg(Cys)2, which has bulky, high-affinity ligands.

12 idly combinatorial mixtures of compounds for high-affinity ligands.

13 d, optimized, and linked together to produce high-affinity ligands.

14 e in the generation of memory in response to high-affinity ligands.

15 s model, we found that AHR activation by the high-affinity ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin

16 s factor receptor superfamily and binds to a high-affinity ligand (4-1BBL) expressed on several antig

17 ively express AhR, and its activation by the high-affinity ligand 6-formylindolo[3,2-b]carbazole (FIC

18 The binding of a high affinity ligand, Ac-Asp-Ala-Asp-Glu-F(2)Pmp-Leu-NH(

19 yl azelaoyl phosphatidylcholine (azPC), as a high affinity ligand and agonist for PPARgamma.

20 se, but foreign peptides can incidentally be high affinity ligands and can therefore stimulate T cell

21 3beta-Adiol is a high-affinity ligand and agonist of ERbeta and is derive

22 is well established that the monomer is the high-affinity ligand and that the interactions between t

23 hesis and time required for the discovery of high-affinity ligands and appears particularly useful in

24 16 structures of PDZ domains in complex with high-affinity ligands and have elucidated four additiona

25 labeling, is suited to the slow kinetics of high-affinity ligands, and has agonist binding, which ha

26 CCCC and CCAA with Hg(CN)2, which has small, high-affinity ligands, and with Hg(Cys)2, which has bulk

27 Cs might determine local availability of its high-affinity ligand APRIL, because sBCMA has been shown

28 nnel are poorly understood because selective high affinity ligands are not available, and the thresho

29 monstrated that, when high concentrations of high affinity ligands are used in this RC system, double

30 se receptors, more selective small-molecule, high-affinity ligands are needed for a better understand

31 Similar high-affinity ligands are rarely available for most rece

32 olding state can be reversibly tuned using a high affinity ligand, as model substrates to interrogate

33 JMV-180 ( 1) and CCK-8(s) are high affinity ligands at the CCK 1 receptor that have si

34 s model will be useful for the prediction of high-affinity ligands at radiolabeled H(1) receptors in

35 e anticipated to be useful for the design of high affinity ligand based probes of siglec function.

36 supporting, in principle, the development of high-affinity ligands based on molecular modeling analys

37 steines play a critical role in removing the high-affinity ligands before Hg(II) reaches the redox-ac

38 for which lysophosphatidylcholine (LPC) is a high affinity ligand, belongs to a newly defined lysopho

39 ntegrin beta cytoplasmic tails (CTs) induces high affinity ligand binding (integrin activation), wher

40 of the receptor was critically important for high affinity ligand binding activity.

41 a and delta subunits into a heterodimer with high affinity ligand binding activity.

42 ntegrin extracellular domain is required for high affinity ligand binding and is also involved in pos

43 s require different sets of interactions for high affinity ligand binding and receptor activation.

44 ly(6.55)) as a critical residue required for high affinity ligand binding and receptor function.

45 c), a subunit of the IL-2R, is essential for high affinity ligand binding and signal transduction due

46 e charge at the C1 position is essential for high affinity ligand binding and that the charge at this

47 ses, we show that the motif is necessary for high affinity ligand binding as well as function.

48 activation process by maintaining apoAR in a high affinity ligand binding conformation which is impor

49 While high affinity ligand binding has been attributed to the

50 e presence of the appropriate LIBS antibody, high affinity ligand binding of the constrained receptor

51 complexes in the extended conformation, the high affinity ligand binding pocket between domains I an

52 this aspartate ring also contributes to the high affinity ligand binding site.

53 r reveal the mechanism by which TACI engages high affinity ligand binding through a single CRD, and w

54 High affinity ligand binding to alphaIIb/beta3 triggers

55 ated protein (RAP), a universal inhibitor of high affinity ligand binding to LRP, to evaluate the par

56 When Asp(374) was substituted by alanine, high affinity ligand binding was abolished and inhibitio

57 nist-mediated receptor activation but not in high affinity ligand binding.

58 y large extracellular domain responsible for high affinity ligand binding.

59 arge extracellular (EC) sequence forming the high-affinity ligand binding domain.

60 These results suggest that high-affinity ligand binding is an intrinsic property of

61 This high-affinity ligand binding process is unique among the

62 he case of the glucocorticoid receptor (GR), high-affinity ligand binding requires the interaction of

63 High-affinity ligand binding was demonstrated with both

64 These studies showed that high-affinity ligand binding was sufficient for DT388-GM

65 ed Bpa-substituted Ste2p receptors exhibited high-affinity ligand binding, and incorporation of Bpa i

66 gen atoms provides a significant barrier for high-affinity ligand binding.

67 nd R7.67 produced mutant receptors that lost high-affinity ligand binding.

68 s a 15 nucleotide motif that is required for high-affinity ligand binding.

69 chicken transferrin receptor without loss of high-affinity ligand binding.

70 6-alpha7 loop and alpha7-helix, required for high-affinity ligand binding.

71 inhibitors, suggesting that they target the high affinity ligand-binding pocket of EphA4 and inhibit

72 he beta subunit to form a heterodimer with a high affinity ligand-binding site.

73 phaXbetagamma complex was able to induce the high affinity ligand-binding state in the N-formyl pepti

74 ipated in Hsp-ER-alpha complex, enhanced the high-affinity ligand-binding capacity of ER-alpha, and s

75 chemokine activation of CXCR3 involves both high-affinity ligand-binding interactions with negativel

76 This substitution disrupted the high-affinity ligand-binding interface of the prolactin

77 arization, whereas activation of Alk1 by its high-affinity ligand BMP9 rescues hypersprouting induced

78 Its high-affinity ligand, bone morphogenetic protein 9 (BMP9

79 four major effects: first, the definition of high affinity ligands both for T cells and antibodies; s

80 etric dimer of Drosophila EGFR with a single high-affinity ligand bound and provides a model for sing

81 secutive steps: (i) a gel-shift selection of high-affinity ligands bound to the AChR in the electropl

82 Nicotinic acid is a high affinity ligand, but the endogenous ligand is still

83 or family members, HER-2/neu does not bind a high-affinity ligand, but rather functions as the prefer

84 established that the monomer functions as a high-affinity ligand, but the binding affinity of the di

85 G8 with weak affinity, was converted into a high-affinity ligand by a single point mutation.

86 nt development of in vitro methods to select high-affinity ligands by combinatorial chemistry methodo

87 The development of high-affinity ligands capable of selectively recognizing

88 In addition, its high-affinity ligand CD155 was upregulated in mediastina

89 nds at overlapping epitopes, we hypothesized high affinity ligands compete with low affinity ligands

90 ue virus NS2B-NS3 protease in complex with a high-affinity ligand containing a tert-butyl group.

91 by alpha5beta1 integrin interaction with its high-affinity ligand CRRETAWAC in murine and human MSCs

92 VACV-138 also abrogated D8 binding to the high-affinity ligand CS-E, but we observed residual CS-E

93 ded the bile acid pool enriched with the FXR high affinity ligand, DCA.

94 We show activin A and other high affinity ligands directly inhibited signaling by th

95 Activation of AHR by a high-affinity ligand during T(H)17 cell development mark

96 of the binding thermodynamics of hydrophobic high-affinity ligands employing a new calorimetric compe

97 ty of BGC 945 for the alpha-FR is 70% of the high-affinity ligand folic acid.

98 by Scarborough et al. has been employed as a high affinity ligand for alphaIIbbeta3 to examine the sp

99 Here we show that RA is a high affinity ligand for another nuclear receptor, namel

100 ich binds only retinoic acid receptors, is a high affinity ligand for both retinoic acid receptors an

101 the CD2 subset of the Ig superfamily, is the high affinity ligand for CD48.

102 and patterning in the developing head, is a high affinity ligand for Cubn.

103 VEGF-A, expressed in the epithelium, is a high affinity ligand for Flk-1.

104 Overexpression of apolipoprotein E (apoE), a high affinity ligand for LRP, results in dramatically re

105 Instead, the high affinity ligand for mouse CD22 has N-glycolylneuram

106 of compounds has been developed based on the high affinity ligand for nAChRs, 2-chloro-5-((1-methyl-2

107 resulted in strong down-regulation of H60, a high affinity ligand for NKG2D, from the surface of viru

108 The major high affinity ligand for P-selectin on human leukocytes

109 Recently, 9-cis retinoic acid, a high affinity ligand for retinoic acid receptors and ret

110 plasmon resonance (SPR) confirmed it to be a high affinity ligand for Robo1.

111 reconstituted HDL particles, functions as a high affinity ligand for SR-BI.

112 omain of laminin alpha4 chain is a specific, high affinity ligand for the alphavbeta3 and alpha3beta1

113 bitory factor (LIF), a previously identified high affinity ligand for the cation-independent mannose

114 The peptide growth factor apelin is the high affinity ligand for the G-protein-coupled receptor

115 ng protein from rabbit and rat brain using a high affinity ligand for the I(2) subtype, 2-BFI, to gen

116 he discovery of H-Phe-Phe-NH2 as a small and high affinity ligand for the substance P 1-7 (SP(1-7), H

117 Our findings suggest that, in the absence of high affinity ligand for the TCR, the CD28-B7.2 system p

118 we show that human R-spondin1 (hRspo1) is a high affinity ligand for the Wnt co-receptor LRP6 (K(d)

119 osttranslational modification by itself is a high affinity ligand for XRCC1, requiring a minimum chai

120 tizing thiazolidinedione (TZD) compounds are high affinity ligands for a member of the nuclear recept

121 strate that 7-oxygenated sterols function as high affinity ligands for both RORalpha and RORgamma by

122 lass of oxidized phospholipids that serve as high affinity ligands for CD36 and mediate recognition o

123 ospholipids (oxPC(CD36)) that serve as novel high affinity ligands for cells stably transfected with

124 is approach with the discovery of selective, high affinity ligands for CLL BCRs of the aggressive, st

125 to these cells was not competed by the other high affinity ligands for CXCR3, monokine induced by IFN

126 D45 requires expression of core 2 O-glycans (high affinity ligands for galectin-1), galectin-1 signal

127 In order to find novel high affinity ligands for hdm2 which would interfere wit

128 ession pattern correlates with expression of high affinity ligands for L-selectin.

129 n mouse skin, it is now clear that different high affinity ligands for PKC have distinct biological e

130 d to the identification of a number of novel high affinity ligands for RXRalpha.

131 vo at sites of oxidative stress and serve as high affinity ligands for scavenger receptors class B (C

132 ethylpyrrolidinyl analogues were found to be high affinity ligands for the CB1 and CB2 cannabinoid re

133 Hence, the generation of rhGAA containing high affinity ligands for the CI-MPR represents a strate

134 These compounds were shown to be high affinity ligands for the ER with nanomolar IC50 bin

135 ioactive cyclic N-methylated hexapeptides as high affinity ligands for the integrin alphavbeta3 is ba

136 oxPC(CD36) serve as high affinity ligands for the scavenger receptor CD36, m

137 ine ANV indicated that low concentrations of high affinity ligands for the TCR were efficient inducer

138 Donepezil is a high-affinity ligand for acetylcholinesterase-the enzyme

139 erotype of foot-and-mouth disease virus is a high-affinity ligand for alpha v beta 6, and we recently

140 vascular cell adhesion molecule-1 (VCAM-1) a high-affinity ligand for apha4beta1, and that VCAM-1 med

141 ration-inducing ligand" (APRIL) is a natural high-affinity ligand for BCMA and transmembrane activato

142 anisotropy approach, PEA-15 is shown to be a high-affinity ligand for both ERK1 and 2, exhibiting a d

143 novel fibrate, designated GW2331, that is a high-affinity ligand for both PPARalpha and PPARgamma.

144 sults demonstrate that only the monomer is a high-affinity ligand for both receptors, and also provid

145 ncentrations of CCL2 (also known as MCP1), a high-affinity ligand for CCR2, are elevated in obesity,

146 , Pachymedusa dacnicolor, and validated as a high-affinity ligand for CRF receptor studies.

147 Reports of a high-affinity ligand for E-selectin, sialyl di-Lewis(x)

148 though a lipid metabolite, lipoxin A4, was a high-affinity ligand for FPRL1, it was not reported to i

149 We show that LPC is a high-affinity ligand for G2A, a lymphocyte-expressed G p

150 , the major elicitor-releasing isozyme, is a high-affinity ligand for GIP1, which completely inhibits

151 bean endoglucanases: EGaseA, which acts as a high-affinity ligand for GIP1; and EGaseB, with which GI

152 a novel nonthiazolidinedione identified as a high-affinity ligand for human PPAR-gamma.

153 ora-3a,4a-diaza-s-indacene (BODIPY FL), as a high-affinity ligand for human PXR with a Kd value of 67

154 s, compound 5a (GSK8470) was identified as a high-affinity ligand for LRH-1 and SF-1.

155 We report that Dkk-1 is a high-affinity ligand for LRP6 and inhibits Wnt signaling

156 This compound was found to be a high-affinity ligand for MCHr1 and a potent inhibitor of

157 demonstrated that soluble NE is a specific, high-affinity ligand for NRP1 with a calculated Kd of 38

158 We characterized a high-affinity ligand for P450 2D6, also devoid of a basi

159 ProNGF is a high-affinity ligand for p75(NTR) with high affinity and

160 ifferent plasma lipoproteins and serves as a high-affinity ligand for several receptors.

161 le, we report the development of a selective high-affinity ligand for Siglec-G and its application as

162 ine-glycine-aspartic acid) peptide that is a high-affinity ligand for the alphavbeta3 integrin.

163 fructose 2,6-bisphosphate and cyclic AMP, a high-affinity ligand for the AMP/ADP binding site.

164 ddition of the HIV-1 Nef protein, which is a high-affinity ligand for the Hck SH3 domain, to either t

165 ry N-acetyl galactosamine (GalNAc, GN3: ), a high-affinity ligand for the hepatocyte-specific asialog

166 d supertypic epitope C2, which constitutes a high-affinity ligand for the inhibitory natural killer (

167 dinated to 3,5,3'-triiodothyronine (T(3)), a high-affinity ligand for the nuclear TH receptors TR alp

168 ing from the phosphorylated dipeptide (2), a high-affinity ligand for the p56lck SH2 domain, we have

169 Hybrid peptides consisting of a high-affinity ligand for the peptide-binding site of hsp

170 15d-PGJ(2) is a high-affinity ligand for the peroxisome proliferator-act

171 f fluoro furanyl norprogesterone (FFNP) 1, a high-affinity ligand for the progesterone receptor (PgR)

172 on of a distinct drug clearance program by a high-affinity ligand for the related nuclear receptor, t

173 Recently, we reported that LGD1069, a high-affinity ligand for the retinoid X receptors (RXRs)

174 Targretin (LGD1069; a high-affinity ligand for the retinoid X receptors) is an

175 macological studies showed that Ucn III is a high-affinity ligand for the type 2 CRF receptor (CRF-R2

176 using 125I-linear-AVP, which is a selective high-affinity ligand for the V1a receptor, we found earl

177 represents a powerful method of identifying high-affinity ligands for a broad range of molecular tar

178 g solubilized membranes show oligomers to be high-affinity ligands for a small number of nonabundant

179 structural biology is the identification of high-affinity ligands for arbitrary receptors.

180 has emerged as a successful method to design high-affinity ligands for biomacromolecules of therapeut

181 d choline glycerophospholipids that serve as high-affinity ligands for CD36 were at markedly increase

182 ty of using N6-modified ATP/ADP analogues as high-affinity ligands for CFTR gating, since these analo

183 imal models, ADM and PanINs are initiated by high-affinity ligands for EGF-R or activating Kras mutat

184 fen (TAM), and 4-hydroxytamoxifen (4-OHT) as high-affinity ligands for ERR gamma.

185 Our findings show that PCB sulfates are high-affinity ligands for human TTR and therefore indica

186 oforms of the neurotrophins are preferential high-affinity ligands for p75NTR and potent inducers of

187 acylglycerol (DAG) lactones, which behave as high-affinity ligands for protein kinase C (PK-C), have

188 tro selection methods to identify drug-like, high-affinity ligands for protein targets of interest.

189 pected to have increased chances of yielding high-affinity ligands for proteins, and they suggest tha

190 sation is integral to the rational design of high-affinity ligands for proteins.

191 nding proteins, led to the identification of high-affinity ligands for siglec-9 and siglec-10.

192 d synthetic HDL-like nanoparticles (HDL NP), high-affinity ligands for SR-B1, to carry a fluorescentl

193 The search for high-affinity ligands for studying such interactions inv

194 These peptides are the first high-affinity ligands for tetrodotoxin-resistant periphe

195 In our effort to develop high-affinity ligands for the dopamine transporter which

196 These results demonstrate the existence of high-affinity ligands for the ERR family of orphan recep

197 that certain tetrasubstituted pyrazoles are high-affinity ligands for the estrogen receptor (ER) and

198 dized phospholipids that serve as endogenous high-affinity ligands for the macrophage scavenger recep

199 ed hydroxylated PCB metabolites (OH-PCBs) as high-affinity ligands for TTR, but the binding potential

200 TA and OA are high-affinity ligands for TYRA-3 and F14D12.6, respectiv

201 d the outnumbered clusters engendered by the high-affinity ligands from launching the more complete c

202 No high affinity ligand has yet been reported for this rece

203 kinase C (PKC) binding to several classes of high-affinity ligands has been investigated through comp

204 ominant due the presence of large amounts of high-affinity liganded hemoglobin dimers.

205 ELC, SLC, and TECK comprised high affinity ligands (IC50 <15 nM); lower affinity liga

206 There are more high-affinity ligands (IC50 < 1 micromol/L) derived from

207 dless of ligand density, like a low density, high affinity ligand in all these parameters.

208 al over time allows T cell activation with a high-affinity ligand in the absence of CD8 engagement.

209 amily kinase Hck, SH3 was unable to engage a high-affinity ligand in trans and that interaction with

210 surprise, we find that even single copies of high-affinity ligands in a pool of billions can strongly

211 nism whereby alpha5beta1 integrin priming by high-affinity ligands integrates Wnt/beta-catenin signal

212 type of the DeltaL8TbpA mutant suggests that high-affinity ligand interaction is required for transfe

213 In both species, the high affinity ligand is based on the sequence Siaalpha2-

214 us secondary structure motif for most of the high-affinity ligands is a three-way helix junction with

215 eged" substructure concept for the design of high-affinity ligands is presented, and an example of th

216 This represented a high affinity ligand (K(i) = 56 +/- 8 nM) that was a pot

217 ively eliminated by itraconazole, which is a high-affinity ligand known to coordinate to the heme iro

218 since direct access of HgX2 substrates with high-affinity ligands leads to formation of an inhibited

219 Circular dichroism demonstrated that high affinity ligands (long chain fatty acyl-CoAs, unsat

220 The chemokine receptor, CCR5, and its three high-affinity ligands, macrophage inflammatory protein-

221 Ala), while the high affinity site binds the high affinity ligand Manalpha(1-2)Manalpha with a K(d) v

222 ryl hydrocarbon receptor (AhR) activation by high-affinity ligands mediates immunosuppression in asso

223 Addition of a high affinity ligand mimetic peptide or Mn(2+) results i

224 Finally, a high affinity ligand-mimetic compound stabilized noncova

225 The high affinity ligand N-acetylmannosamine (ManNAc) binds

226 4-positive cells, suggesting that gp120 is a high affinity ligand of CXCR4.

227 that the endogenous lipid mediator AGP is a high affinity ligand of PPARgamma but that it binds via

228 results indicate that PPT-C encodes another high affinity ligand of the NK1 receptor which may play

229 ow that 20-mer peptide ligands, derived from high affinity ligands of alpha v beta6 (foot-and-mouth-d

230 Neurocan and phosphacan are also high affinity ligands of amphoterin and HB-GAM (Kd = 0.3

231 the thiazolidinediones (TZ), which are also high affinity ligands of peroxisome proliferator-activat

232 Although all are high affinity ligands of the human receptor (K(i) <5 nm)

233 studies resulted in the discovery of several high affinity ligands of which compound 22 showed the hi

234 s activities, p17 mimicked IL-8, the natural high-affinity ligand of CXCR1.

235 ondeamidated precursor, and (iv) a reference high-affinity ligand of HLA-DQ2 that is not recognized b

236 Phosphatidylinositol 3,4,5-trisphosphate, a high-affinity ligand of JFC1 did not affect its ATPase k

237 w that the INS region in HIV-1 gag mRNA is a high-affinity ligand of p54nrb/PSF, a heterodimeric tran

238 ion for binding to the molecule CCdApPuro, a high-affinity ligand of ribosomal peptidyl transferase d

239 above, we have demonstrated that N-CAM is a high-affinity ligand of TAG-1/axonin-1 (Kd approximately

240 nd diabetic rat hearts with rosiglitazone, a high-affinity ligand of the peroxisome proliferator-acti

241 Pase-activating protein (GAP) for Rab7, is a high-affinity ligand of the retromer cargo selective com

242 High-affinity ligands of enzymes are much larger than th

243 protein-tyrosine phosphatase-zeta/beta), are high-affinity ligands of tenascin-C.

244 ple modification of fullerenes can result in high-affinity ligands of the HIV protease, for which the

245 osine phosphatase-zeta/beta were found to be high-affinity ligands of the neural cell adhesion molecu

246 Positive beads that carry high-affinity ligands of the SH2 domains were identified

247 st the SH2 domains, and the beads that carry high-affinity ligands of the SH2 domains were identified

248 phosphatase SHP-1, and the beads that carry high-affinity ligands of the SH2 domains were identified

249 ic acid (Neu5Ac) as the sialic acid, and the high affinity ligand on naive B-cells contains 6-O-sulfa

250 we show in both mice and humans that loss of high affinity ligands on GC B-cells unmasks the binding

251 bules bind proteins in a specific manner via high affinity ligands on the polar head groups of the li

252 proteomics initiatives is the production of high affinity ligands or probes that specifically recogn

253 The functional activity of high-affinity ligands ranged from antagonist to full ago

254 e closely resembles the pyranose ring in the high-affinity ligands rapamycin and FK506.

255 he contribution of Arg(120) and Glu(121) for high-affinity ligand-receptor interactions is essential,

256 High-affinity ligands recognizing biomolecules with high

257 structurally related PBR ligands, including high-affinity ligands Ro5-4864 and PK11195, failed to in

258 (<2 kDa) molecules (referred to as selective high-affinity ligands [SHALs]) to mimic the targeting pr

259 We conclude that the high-affinity ligand SPP specifically induces the revers

260 0, a low-affinity ligand, but still binds to high-affinity ligands, such as Mad1 and MBP1, forming li

261 Previous studies suggested that high affinity ligands targeting M cells may be used to d

262 Herein, we describe the design of high affinity ligands that bind expanded rCUG and rCAG r

263 strategy to inhibit amyloidosis is to design high affinity ligands that specifically increase the sta

264 al features relevant to the design of novel, high-affinity ligands that are family and subtype specif

265 Thus far, there are no high-affinity ligands that directly target any inward-re

266 ep toward this goal is the identification of high-affinity ligands that stabilize an sGC conformation

267 nd at pH 6.5 (i.e. trans Golgi network) to a high affinity ligand (the terminally phosphorylated tris

268 ility, we examined whether the addition of a high affinity ligand to rhGAA would improve its delivery

269 r, REDOR NMR requires strategically labeled, high affinity ligands to determine interlabel distances

270 High affinity ligands to human IFN-gamma from each modif

271 ed displacement assay, however, requires the high-affinity ligand to be soluble at high concentration

272 change labeling-quench strategy, employing a high-affinity ligand to displace Cdc42 from WASP, was us

273 ration of distinct modes of docking the same high-affinity ligand to highly homologous receptors.

274 The ratio of each high-affinity ligand to its individual target within a p

275 This method is based on the coupling of a high-affinity ligand to the binding of the low-affinity

276 We tested these ideas by isolating high-affinity ligands to human keratinocyte growth facto

277 chnology as a method for producing specific, high-affinity ligands to proteins.

278 A method for the rapid identification of high-affinity ligands to Src homology-2 (SH2) domains is

279 gives a greatly reduced rate of selection of high-affinity ligands to that target.

280 g the groundwork for discovery and design of high-affinity ligands to this class of cofactor-independ

281 Antisense oligonucleotides may be coupled to high-affinity ligands (triantennary N-acetyl galactosami

282 id structural basis for the design of novel, high-affinity ligands useful in modulating the activity

283 zation of ActRIIB binding to several low and high affinity ligands using a soluble activin receptor t

284 A strategy is described for designing high-affinity ligands using information derived from the

285 High affinity ligands were able to reverse a reduction i

286 The AR agonist and antagonist activities of high-affinity ligands were determined by the ability of

287 High-affinity ligands were discovered for recombinant hu

288 High-affinity ligands were identified by replacing the 6

289 Thus, high affinity ligands, when presented to DP thymocytes b

290 e and phenyl-2-aminoimidazoline compounds as high affinity ligands with conflicting functional activi

291 forms of the insulin hexamer, the design of high-affinity ligands with a carboxylate donor for coord

292 ies against fresh human colonic adenomas for high-affinity ligands with preferential binding to prema