ライフサイエンスコーパス: high-resolution structure

1 o the lack of homology to other proteins and high-resolution structure.

2 myoglobin was the only protein with a known high-resolution structure.

3 f PDE6, and each domain was readily fit with high resolution structures.

4 ive KOW domains in Spt5, and a lack of their high-resolution structures.

5 roscopy (cryo-EM) as a technique to generate high-resolution structures.

6 ine receptors has been hindered by a lack of high-resolution structures.

7 d structures are in very good agreement with high-resolution structures.

8 h experimental data and previously published high-resolution structures.

9 and are a matter of debate in the absence of high-resolution structures.

10 ny years was characterized by the paucity of high-resolution structures.

11 is and other biological processes, many lack high-resolution structures.

12 fall within the footprints identified by our high-resolution structures.

13 We present here a high resolution structure (1.55 A) of ZIKV NS5 methyltra

14 Here we report high resolution structures (1.9-2.25 A) of AcrB/designed

15 Here, we report the first high-resolution structure (1.92A) of UP1 bound to a 5'-A

16 The high-resolution structure allowed us to identify 57 orde

17 High resolution structures and computational methods hav

18 density, superior fits between experimental high resolution structures and SAXS data are obtained.

19 This high-resolution structure and accompanying functional an

20 Ultra-high-resolution structure and composition analysis via s

21 Though the importance of high-resolution structure and dynamics of membrane prote

22 Here, we describe the high-resolution structure and dynamics of the C domain,

23 ther facilitate its use by the community for high-resolution structure and function prediction.

24 ))(2) LysRS tetramer crystallized to yield a high-resolution structure and raised the question of how

25 mportant HRD motif deviates from ideality in high-resolution structures and the strained geometry res

26 Outcomes reconcile low- and high-resolution structures and yield a partial sequentia

27 High resolution structures are available for individual

28 DEBS, as well as a set of domains for which high-resolution structures are available.

29 se are the only circadian proteins for which high-resolution structures are available.

30 st of the prokaryotic transporters for which high-resolution structures are available.

31 High-resolution structures are essential for rational dr

32 All available high-resolution structures are of homopentameric recepto

33 Their flexibility limits both the number of high-resolution structures available, leaving only a sma

34 ected by yeast surface display combined with high-resolution structure-based predictions, and validat

35 ing the smallest protein crystals to yield a high-resolution structure by X-ray crystallography to da

36 Complete data sets and resulting high-resolution structures can be obtained from a single

37 aled that with this supramolecular approach, high-resolution structures can be written that show unpr

38 these fusion protein TMDs have so far eluded high-resolution structure characterization because of th

39 The very high resolution structures combined with the extensive s

40 Using high-resolution structures coupled with biochemical and

41 exemplified in homomeric structures, but no high-resolution structure currently exists of heteromeri

42 Thereby, the comparison of their high-resolution structures defines the mechanistic and s

43 Our high-resolution structures delineated the altered PAM re

44 sting technical difficulties associated with high resolution structure determination of transmembrane

45 spectroscopy and outline a strategy for the high-resolution structure determination and positioning

46 High-resolution structure determination and thermodynami

47 evelopments that led to this breakthrough in high-resolution structure determination by cryo-EM and p

48 r nanocrystals can provide a simple path for high-resolution structure determination by the cryoEM me

49 High-resolution structure determination crucially depend

50 "developing cryoelectron microscopy for the high-resolution structure determination of biomolecules

51 P) crystallization has proven successful for high-resolution structure determination of challenging m

52 the NMR resonance assignment as well as the high-resolution structure determination of polytopic mem

53 ains for other functions, paving the way for high-resolution structure determination of TRs.

54 thologies that render them inappropriate for high-resolution structure determination.

55 tly celebrate the maturation of cryo-EM as a high-resolution structure-determination tool, I believe

56 plicity of biological sample preparation for high-resolution structure elucidation by cryo-EM.

57 High-resolution structure elucidation has been challengi

58 graphy to medicine was evident, as the first high-resolution structures emerged in the 50s and 60s.

59 ational rearrangements during translocation, high-resolution structures exist for essentially only on

60 No structural homologs or high-resolution structure exists for the TP domain.

61 espite its importance, there is currently no high resolution structure for subunit a of the V-ATPase.

62 This first high-resolution structure for a kobuvirus is intermediat

63 y, the solid state NMR data lead to a unique high-resolution structure for the dimerization interface

64 delling with Autobuild chain tracing yielded high-resolution structures for 8 of 13 X-ray diffraction

65 There are no high-resolution structures for any of the ToxB homologs,

66 Despite having high-resolution structures for eukaryotic large ribosoma

67 In an extensive study, we present high-resolution structures for native AnCE and in comple

68 ion reaction, which altogether have provided high-resolution structures for the reactants, the interm

69 nsitive to these modulators, and for which a high resolution structure has been solved.

70 ionality and plasticity, but for decades its high-resolution structure has remained elusive.

71 their isolation from infected tissue and no high resolution structures have yet been reported.

72 nome that are responsible for packaging, and high-resolution structures have been determined for a fe

73 High-resolution structures have been solved for an allos

74 These high-resolution structures have greatly increased our un

75 resented a number of challenges, but several high-resolution structures have now become available.

76 X-ray crystallography can reveal high resolution structures; however, one perceived limit

77 High-resolution structured illumination microscopy (SIM)

78 High-resolution structured illumination microscopy sugge

79 a CaM-IQ motif complex and to determine its high-resolution structure in absence of calcium using mu

80 Docking of high-resolution structures into the 3D map provides a mo

81 sequence-dependent features of DNA found in high-resolution structures introduce irregularities in t

82 A set of 33 ultra-high resolution structures is used to characterize the a

83 cades of effort in fiber diffraction, and no high-resolution structure is available for any member of

84 structure of cpSRP43 has been determined, no high-resolution structure is yet available for cpSRP54.

85 ance (NMR) spectroscopy, the availability of high-resolution structures is limited owing to the frequ

86 The high-resolution structures made possible the identificat

87 Regardless, high-resolution structures obtained from XFEL data mostl

88 dely investigated as potential therapeutics, high-resolution structures obtained under biologically r

89 In the absence of a high resolution structure of a gp120-coreceptor complex,

90 crystal X-ray diffraction methods provided a high resolution structure of a trapped covalent glycosyl

91 Unfortunately, efforts toward a high resolution structure of full-length apoA-I have not

92 There is no high resolution structure of human P-gp, but homology mo

93 Interestingly, a new high resolution structure of ligand-free P450 2B4 was ob

94 so used cryo-electron microscopy to obtain a high resolution structure of MamK filaments.

95 A high resolution structure of PdxK in complex with ATP re

96 utations was analyzed by comparison with the high resolution structure of Sphingomonas sp. A1-III alg

97 High resolution structure of synthetic alpha-pheromone f

98 reement with the position it occupies in the high resolution structure of the active site of Sin.

99 The high resolution structure of the ankyrin-B ZZUD tandem d

100 We report the high resolution structure of the C-terminal domain of eu

101 A recent high resolution structure of the catalytic domain of Sin

102 We recently reported the high resolution structure of the N-terminal domain of Tb

103 A high resolution structure of the NTD of TbBILBO1 showed

104 The high resolution structure of this domain has not been de

105 High resolution structures of all the individual BAM sub

106 The high resolution structures of each step in the catalytic

107 f experimental data on the system, including high resolution structures of individual domains and ext

108 ndent enzyme, we have determined a series of high resolution structures of QueG from Bacillus subtili

109 Very often this aim can be pursued using high resolution structures of the complex in combination

110 cs, site-specific histidine protonation, and high resolution structures of the intermolecular interfa

111 Here, we report the high resolution structures of the major pilin subunit, P

112 ogy modeling of human SERT (hSERT), based on high resolution structures of the microbial SLC6 family

113 These x-ray structures are also the first high resolution structures of the Pierisin subgroup of t

114 CRBP1 in a ligand-free form as well as ultra-high resolution structures of this protein bound to eith

115 Based on high resolution structures of TRPV1, we discuss T406 bei

116 Despite efforts, a high-resolution structure of a channel for this family o

117 tR DBD free in solution and to determine the high-resolution structure of a CytR DBD monomer bound sp

118 We report a high-resolution structure of a designed MPER trimer asse

119 In the present work, we determined the first high-resolution structure of a glycomimetic/DC-SIGN comp

120 f Molecular Cell, He and colleagues unveil a high-resolution structure of a key regulatory interface

121 A high-resolution structure of a Kir3.1 chimera revealed t

122 After the emergence of the first high-resolution structure of a Na(+)-channel, an anionic

123 these structural models by comparing with a high-resolution structure of a NaChBac homolog and showi

124 The metallonuclease domain is a unique high-resolution structure of a Nedd4-BP1, YacP Nucleases

125 Here we report the high-resolution structure of a novel C-3'-methyltransfer

126 We solved the first high-resolution structure of a peptide docking motif (PI

127 al information; currently, there is only one high-resolution structure of a plant sHsp published, tha

128 Here, we present a high-resolution structure of a proteorhodopsin from a pe

129 Our study reveals the high-resolution structure of a small molecule bound to F

130 Here we report a high-resolution structure of a TRIM5alpha PRYSPRY domain

131 -tube crystal structure represents the first high-resolution structure of a virally encoded DNA-trans

132 nding sites is confirmed by a just-published high-resolution structure of A(2A) cocrystallized with a

133 We sought to obtain a high-resolution structure of Alt a 1 using x-ray crystal

134 FliD from Pseudomonas aeruginosa, the first high-resolution structure of any FliD protein from any b

135 Determination of a high-resolution structure of APETx2 combined with scanni

136 Homology models based upon the high-resolution structure of bacterial NaV channels pred

137 However, by solving the high-resolution structure of both the wild-type and muta

138 Here we solved the high-resolution structure of DISC1 C-terminal tail in co

139 Although the high-resolution structure of EF-G bound to the posttrans

140 r monomeric actin (G-actin) are available, a high-resolution structure of F-actin is still missing, h

141 The high-resolution structure of holo-PS1 is in sub-A agreem

142 '-end using computational screening with the high-resolution structure of human Ago2, the key nucleas

143 While the high-resolution structure of human PHPT1 (hPHPT1) is ava

144 Here, we determined the high-resolution structure of huntingtin 1-17 in dodecyl

145 To date, however, there is no high-resolution structure of iC3b, and some aspects of i

146 cked a library of 600,000 fragments into the high-resolution structure of KDM4A.

147 Here we show the high-resolution structure of melon (Cucumis melo) eIF4E

148 Here, we present the high-resolution structure of netrin-4, which shows uniqu

149 A recently determined 1.35 A high-resolution structure of P51G-m4-CVN provided detail

150 We report a complete high-resolution structure of the 200 kDa alpha-actinin-2

151 Also reported here is the first high-resolution structure of the A. baumannii class B en

152 However, a high-resolution structure of the array has been lacking,

153 We have determined the high-resolution structure of the BPV capsid assembled fr

154 this issue of Blood, Zhou et al reported the high-resolution structure of the collagen-activated oste

155 Here we present the first high-resolution structure of the complex between an intr

156 Now, Fernandez-Martinez et al. present a high-resolution structure of the cytoplasmic nuclear por

157 We report here a high-resolution structure of the Est3 telomerase subunit

158 The high-resolution structure of the eukaryotic ribosome fro

159 Since the high-resolution structure of the gp16 motor is not avail

160 identified a sodium ion binding pocket in a high-resolution structure of the human adenosine A2A rec

161 The high-resolution structure of the mammalian ribosome-Sec6

162 Although a high-resolution structure of the protein is still lackin

163 crystal scanning approach, we determine the high-resolution structure of the radiation sensitive mol

164 Here, we report the high-resolution structure of the tail adaptor protein gp

165 domain-swapped GB1 dimer were modeled into a high-resolution structure of the wild type monomeric GB1

166 Understanding the high-resolution structure of the Z-band will help us und

167 cture of the IL-1alpha/aptamer, we provide a high-resolution structure of this critical cytokine and

168 allow for further efforts toward obtaining a high-resolution structure of this important signaling co

169 We reconstructed a high-resolution structure of WHAMM's MT-binding motif (M

170 We present high-resolution structures of a cytosolic fragment of Pe

171 made possible the determination of the first high-resolution structures of a peptide and a protein in

172 High-resolution structures of a wild-type/variant pair r

173 utiny of the myosin superfamily, the lack of high-resolution structures of actin-bound states has pre

174 Despite representative high-resolution structures of all of the individual modu

175 the first time among characterized ADHs, the high-resolution structures of all reaction steps were ob

176 While high-resolution structures of all three proteins have be

177 tic views of such interactions, by providing high-resolution structures of annular lipids surrounding

178 By fitting high-resolution structures of assembly components into t

179 -EM) has emerged as a method for determining high-resolution structures of biological macromolecules

180 Recently, high-resolution structures of both open- and closed-pore

181 High-resolution structures of C8 subunits have provided

182 Despite the large repository of high-resolution structures of CaM bound to peptide fragm

183 Altogether, our database consists of 37 high-resolution structures of caspase-3 variants, and we

184 Here, we present high-resolution structures of catalytic domain 2 from Da

185 Here, we report a series of high-resolution structures of CDO soaked with Cys at pH

186 Therefore, we used the available high-resolution structures of DEBS domains to model the

187 ated for the explicit water molecules in the high-resolution structures of glucose isomerase and lyso

188 Here, high-resolution structures of hCT at concentrations of 0

189 Here, we present two high-resolution structures of Helicobacter pylori XerH w

190 High-resolution structures of hIAPP determined from NMR

191 are not known, due, in part, to the lack of high-resolution structures of highly tension-sensitive m

192 program, CATM, predicts ab initio the known high-resolution structures of homodimeric GASright motif

193 Here we present high-resolution structures of human Sirt2 in complex wit

194 Although high-resolution structures of individual CBD1 and CBD2 a

195 With the advent of high-resolution structures of individual domains, many o

196 Although several high-resolution structures of individual NOS domains hav

197 By combining high-resolution structures of individual proteins and ma

198 Making use of high-resolution structures of individual VSG domains, we

199 ns that may improve the chances of obtaining high-resolution structures of intrinsically unstable mem

200 nisms is limited, partially due to a lack of high-resolution structures of IRES RNAs bound to their c

201 By determining high-resolution structures of key components of this mot

202 However, the lack of high-resolution structures of Lmod nucleators in action

203 he direct effect of crowding on the level of high-resolution structures of macromolecules has not bee

204 Here, we report high-resolution structures of Magnetospirillum gryphiswa

205 on microscopy is currently poised to produce high-resolution structures of many biological assemblies

206 escribed in budding yeast, and there are now high-resolution structures of many components of the yea

207 Examination of B-factors from available high-resolution structures of membrane-embedded beta bar

208 High-resolution structures of metalloamyloids are needed

209 Here we report the high-resolution structures of MvINS, an Insig homolog fr

210 Here, we determine high-resolution structures of Myo7a and Myo7b C-terminal

211 The absence of high-resolution structures of oligomers formed by alpha-

212 High-resolution structures of oligomers formed by the be

213 Although the high-resolution structures of only the BamA POTRA domain

214 hts into receptor-ligand interactions, while high-resolution structures of other members of the penta

215 ivity, is poorly understood, largely because high-resolution structures of PfAct1 filaments were miss

216 We have determined high-resolution structures of PhnZ bound to its substrat

217 Despite the existence of several high-resolution structures of pLGICs, their dynamical pr

218 Our high-resolution structures of pro-activin A share featur

219 tal during the past two decades in providing high-resolution structures of protein complexes.

220 the ethyl caffeates, we have determined the high-resolution structures of representative inhibitors

221 The absence of high-resolution structures of RyR1 has limited our under

222 d groups of clan CD peptidases, there are no high-resolution structures of separases and the details

223 s in a protein beta-sheet context as well as high-resolution structures of several mixed-backbone alp

224 Despite the important achievement of the high-resolution structures of several prokaryotic channe

225 One of the next challenges is to merge these high-resolution structures of soluble parts of fusion ef

226 High-resolution structures of T. curvata PARG in complex

227 No high-resolution structures of tau filaments are availabl

228 We report the first high-resolution structures of TDG in an enzyme-substrate

229 We generated high-resolution structures of the 1E6 TCR bound to 7 alt

230 A number of high-resolution structures of the 20S proteasome with an

231 in information on ANK folding, we solved two high-resolution structures of the ANK repeat-containing

232 Complementary high-resolution structures of the apo- and Cx-SAM bound

233 Here, I review the extensive ensemble of high-resolution structures of the building blocks of the

234 Here we determine the high-resolution structures of the catalytic domain compr

235 Here, we present high-resolution structures of the catalytic domain of hP

236 Here we present high-resolution structures of the complete EphA2 ectodom

237 Here we present high-resolution structures of the complete EphA4 ectodom

238 Several high-resolution structures of the CTD-CTD dimerization i

239 High-resolution structures of the designed proteins CA01

240 Here we report high-resolution structures of the DH and PH domains and

241 mechanism of F(1)-ATPase is based mainly on high-resolution structures of the enzyme from mitochondr

242 In this study, high-resolution structures of the full-length enzyme fro

243 Here, the high-resolution structures of the homologous 22-residue

244 Because high-resolution structures of the human LRRK2 kinase dom

245 The high-resolution structures of the human PYK2 kinase doma

246 There are no high-resolution structures of the human transporters ava

247 Here, we report high-resolution structures of the ligand-binding region

248 change remains unresolved and in most cases high-resolution structures of the non-specific complexes

249 High-resolution structures of the protein from Gloeobact

250 ng their predicted folding pathways based on high-resolution structures of the proteins in their nati

251 High-resolution structures of the ribosome and its ligan

252 Although high-resolution structures of the ribosome have been sol

253 We also determined high-resolution structures of the trimeric MERS-CoV S ec

254 In this paper, we describe the high-resolution structures of the two main astrovirus ca

255 es, NMR has recently provided the first-ever high-resolution structures of their complexes with unfol

256 actions with membrane proteins and determine high-resolution structures of their complexes.

257 -crystallin (ABC) and HSP27; here we present high-resolution structures of their core domains (cABC,

258 With high-resolution structures of these engineered NaK chann

259 This study obtained the first high-resolution structures of three human bocaparvovirus

260 In this issue, Alushin et al. report high-resolution structures of three states of the microt

261 Here we present high-resolution structures of toluene 4-monooxygenase hy

262 High-resolution structures of trifluoromagnesate (MgF(3)

263 In recent years, high-resolution structures of triple-layered rotavirus v

264 emic crystallization has been used to obtain high-resolution structures of two variants of the villin

265 High-resolution structures of viruses have made importan

266 Here we report high-resolution structures of yeast Rev1 with three BP-N

267 Because high-resolution structures of zfV2 and mammalian V1 have

268 This new high-resolution structure permits us to correct an error

269 ometer spatial resolution cell that opens up high resolution structure-(photo)activity measurements.

270 ructurally largely uncharacterized and their high-resolution structure prediction is currently hinder

271 The high-resolution structures presented here do not resolve

272 High-resolution structures provide new insights into how

273 The high-resolution structure provides a substantial advance

274 The high-resolution structure provides detailed insight into

275 well as structural predictions based on the high-resolution structure recently determined for the C

276 is agonist-bound receptor was built based on high resolution structures reported for amino-terminal d

277 Enabled by the growing database of high-resolution structures, required deposition of diffr

278 These high resolution structures reveal a conserved positively

279 Their high-resolution structures reveal a hitherto unseen sele

280 High-resolution structures reveal large-scale motions of

281 High-resolution structures reveal that yeast ribosomal p

282 These high resolution structures revealed a hydrophobic groove

283 A high-resolution structure reveals how the ribonucleoprot

284 The high-resolution structure reveals unambiguously the heli

285 Fitting with high-resolution structures reveals the organization of T

286 The data, together with a survey of high resolution structures, show that the vast majority

287 The high resolution structures showed that removal of the ar

288 On the basis of these high-resolution structures, site-directed mutant protein

289 similar magnitude for backbone atoms in even high-resolution structures, so comparison of wildtype-vs

290 However, unlike high-resolution structures stored in PDB, methods for co

291 We show with high-resolution structures that calcium acetate and eith

292 Furthermore, despite high resolution structures the transported substrate in

293 haracterizing RNA-protein interactions, from high resolution structures to transcriptome-wide profili

294 This work emphasizes the need for a high-resolution structure to guide mutational analysis a

295 isotopic labeling have enabled us to obtain high-resolution structures using fusion proteins, unifor

296 er technique offers the possibility to solve high-resolution structures using submicron crystals.

297 A high-resolution structure was solved for a (full-length

298 In addition, based on the high resolution structures, we propose a molecular mecha

299 Prior to achieving a high-resolution structure, we are investigating whether

300 New high-resolution structures were determined for the H257Y