ライフサイエンスコーパス: high-risk

1 genetic testing for screening individuals at high risk.

2 ore and classify contacts as low, medium, or high risk.

3 e return on investment is the highest in the high-risk 0-19 years subpopulation in the catastrophic,

4 y (LEAP) study, early peanut introduction in high-risk 4- to 11-month-olds was associated with a sign

5 mic indicators, and diabetes incidence among high-risk adults.

6 ement discussion, with stronger consensus in high-risk/advanced and metastatic setting.

7 Other causes of the high-risk age window for post-HTx mortality should be de

8 This study sought to test whether a high-risk age window in HTx recipients persisted in the

9 R-182 and identify this miRNA as a marker of high-risk AML.

10 tion was distributed among high-risk and non-high risk among 0-19, 20-64 and 65+ years subpopulations

11 the allergic reactions, placing patients at high risk and demanding prompt recognition and immediate

12 risk factors identified are at particularly high risk and must be carefully managed.

13 Population was distributed among high-risk and non-high risk among 0-19, 20-64 and 65+ ye

14 was improved with IRd vs placebo-Rd in both high-risk and standard-risk cytogenetics subgroups: in h

15 l systems for women medically or socially at high risk, and financial subsidies for antenatal and del

16 also showed a shift toward increased use of high-risk antibiotics was 1.30 (95% CI, 1.03-1.64; P < .

17 Given that only 17.9% of these high-risk areas are formally protected and only 8.9% hav

18 High-risk areas for PRRS were best-predicted by pig dens

19 y for interrupting polio transmission in the high-risk areas.

20 arterial occlusion localized at the site of high-risk atherosclerotic plaques, of which early detect

21 Conclusion Children with high-risk B-lineage ALL who were age < 10 years at diagn

22 hronic stress, in which aberrant choices and high-risk behaviors occur.

23 In a high-risk birth cohort, the persistence of asthma at age

24 develop a machine learning model that allows high-risk breast lesions (HRLs) diagnosed with image-gui

25 ith renal impairment as low risk and more as high risk, but with lower specificity for type 1 myocard

26 ieve a plasma fibrinogen level of 2.5 g/L in high-risk cardiac surgery patients with intraoperative b

27 Similarly, high-risk cases of myelodysplastic syndrome (MDS) showed

28 In high-risk cases, temporary mechanical hemodynamic suppor

29 w-risk, 70% in intermediate-risk, and 29% in high-risk categories, corresponding to median OS of 27.7

30 ve measures, it is also important to monitor high-risk children at 1 year of age with hepatitis B sur

31 serum specific IgE levels at age 3 years in high-risk children.

32 Youths at clinical high risk (CHR) for psychosis exhibit similar, subtle sy

33 for liver cancer screening in patients with high-risk cirrhosis generates positive and negative pred

34 A specialized High Risk Clinic in Sydney, Australia was found to be ef

35 Results Specialized surveillance through the High Risk Clinic was both less expensive and more effect

36 virulence, and the concerning international high-risk clones (such as ST111, ST175, and ST235) still

37 using a generalized linear Poisson model, in high-risk cluster the prevalence of nervous system malfo

38 education, and location of households within high-risk clusters, as well as factors linked to a local

39 ss ports, were common but acceptable in this high-risk cohort.

40 ected increased PD-1 and PD-L2 expression in high-risk cSCC.

41 , 552 had cytogenetic results; 137 (25%) had high-risk cytogenetic abnormalities and 172 (32%) had 1q

42 High-risk cytogenetic abnormalities were defined as del(

43 r age (p = 0.0018), male gender (p = 0.019), high risk cytogenetics (p = 0.002), higher IDO-1 mRNA (p

44 es of therapy was two (2-5), 38 patients had high-risk cytogenetics, 17 were unresponsive to all prev

45 staging system score, increased incidence of high-risk cytogenetics, and higher revised international

46 an autologous transplant, and (30 [62%]) had high-risk cytogenetics.

47 d, venue-based vaccine delivery that targets high-risk demographic groups may improve both vaccine fe

48 mplicated as antecedents to schizophrenia in high-risk, developmental studies, might represent early

49 -risk disease (11.1%; range, 4.8%-31.5%) and high-risk disease (5.8%; range, 3.2%-16.5%).

50 with WDTC should be limited to patients with high-risk disease features, and patients with WDTC treat

51 ned for primary staging of intermediate- and high-risk disease in 25% of patients and for restaging/b

52 imated rates of observation for low-risk and high-risk disease was assessed.

53 -containing vaccine (DTP3) coverage in polio high-risk districts of 10 polio focus countries.

54 caution should be taken with rechallenge of high-risk drugs.

55 the detection of abdominal LN metastasis in high-risk endometrial cancer.

56 fy patients with low likelihood of harboring high-risk esophageal varices (EVs) or having clinically

57 TOP2A-normal breast cancer and at least one high-risk factor were randomly assigned to receive six c

58 AD patients had more acute presentations and high-risk features than women with NP-SCAD did.

59 os with unstable angina and intermediate- or high-risk features were deemed appropriate.

60 lusion In two genetically related cohorts at high risk for ASD, reciprocal neuroanatomic abnormalitie

61 t and Childhood Asthma) is a birth cohort at high risk for asthma (n = 560) in four inner cities.

62 s with essential thrombocythemia (ET) are at high risk for both thrombosis and hemorrhage.

63 tools that can identify patients with BE at high risk for cancer, detect dysplastic lesions more rel

64 of patients with native valve MR who were at high risk for cardiac surgery.

65 d as a subcutaneous injection in patients at high risk for cardiovascular disease who had elevated LD

66 Among patients with type 2 diabetes at high risk for cardiovascular events, degludec was noninf

67 e individuals with ADHD may be at especially high risk for certain comorbid developmental conditions

68 these individuals were regarded as being at high risk for COPD (defined as individuals aged 40 years

69 inical settings: to rescue patients from the high risk for death associated with severe hypoxemia, hy

70 ial preventive interventions for patients at high risk for delirium and tailored transitional care pl

71 the early conceptus of an infected mother at high risk for destruction.

72 women 65 years of age or older who are at a high risk for fracture based on a discussion of patient

73 nopausal women with osteoporosis who were at high risk for fracture, romosozumab treatment for 12 mon

74 d patients with BE at low, intermediate, and high risk for HGD or EAC.

75 However, even among US black women at high risk for HIV infection, sample size requirements fo

76 t BV, which may place them at a particularly high risk for HIV infection.

77 ations: Participants were not necessarily at high risk for HIV infection.

78 n the USA, men who have sex men (MSM) are at high risk for HIV, and black MSM have a substantially hi

79 nts with heart failure are associated with a high risk for hospitalization and mortality.

80 on model may be able to identify patients at high risk for late adverse events after an initially unc

81 -Is and 0-IIa+Is non-granular lesions have a high risk for malignancy, whereas proximally located 0-I

82 nform early identification of individuals at high risk for mental illness.

83 The perinatal period is a time of high risk for onset of depressive disorders and is assoc

84 ) continued, the targeting of settlements at high risk for polio transmission with routine immunizati

85 ould be strongly considered among infants at high risk for postoperative acute kidney injury and flui

86 women with singleton pregnancies who were at high risk for preterm preeclampsia to receive aspirin, a

87 dinally assessed 200 individuals at clinical high risk for psychosis for violent ideation and violent

88 omen with node-positive breast cancer are at high risk for recurrence.

89 esign, we randomly assigned 5177 patients at high risk for renal complications who were scheduled for

90 (5) Children at high risk for retinoblastoma require more frequent scree

91 amin K oral anticoagulants among patients at high risk for stroke with a previously placed implantabl

92 ormalities, affected individuals are also at high risk for the development of schizophrenia symptoms,

93 Best Practice Advice 5: Patients at high risk for ulcer-related bleeding from NSAIDs should

94 However, it may be associated with a high risk for viral infections due to combined T cell an

95 identify men prior to PSA failure who are at high-risk for death.

96 of Tp53- and Atm-defective CLL mimicking the high-risk form of human disease and show that Atm-defici

97 postoperative adjuvant radiochemotherapy for high risk gastric and gastroesophageal junction adenocar

98 or deficient in p53, resembling standard or high-risk genetic constellations, respectively.

99 Persistent high-risk genus human Alphapapillomavirus (HPV) infectio

100 For the high-risk group and its subcategories, the ICER was very

101 orn LGA may be identified early in life as a high-risk group for asthma.

102 Children <3-months old were a high-risk group for severe pneumonia, independently of R

103 ear kidney allograft survival rates of 6.0% (high-risk group, n=40), 44.9% (intermediate-risk group,

104 ta applicable to this frequently encountered high-risk group.

105 uberculosis transmission must be targeted to high-risk groups and settings.

106 (SAMS) to classify patients into low-risk or high-risk groups based on the 52-gene signature.

107 NSCLC patients identified as high-risk groups exhibited >5 CTCs/15 mL in PPB and >50

108 implemented as a pretesting tool to identify high-risk groups for broad monitoring of HPV-associated

109 n (0-19 years) and seniors (65+ years) after high-risk groups for influenza vaccination during times

110 tion tree analysis was performed to identify high-risk groups for LN positivity.

111 vaccination for healthcare workers and other high-risk groups is the mainstay of the public health st

112 d on risk of death and return on investment, high-risk groups of the three age group subpopulations c

113 e target for preventing colorectal cancer in high-risk groups such as those with familial adenomatosi

114 berculosis in the low-risk, medium-risk, and high-risk groups were, respectively, 2.8% (95% CI 1.7-4.

115 dults, although the uptake was suboptimal in high-risk groups.

116 Eligible patients were aged 18-55 years, had high-risk haematological malignancies.

117 with >1 sibling with AS had an exceptionally high risk (hazard ratio, 32.84) but were uncommon (34 si

118 xicity and disease control in the setting of high risk, heavily pretreated patients.

119 nd transfer of these cells is often used for high-risk hematological malignancies, including acute my

120 The incidence of IA in high-risk hematology populations is relatively low (<10%

121 according to this study, 13% of eyes harbor high-risk histopathologic features at presentation, with

122 All patients with high-risk histopathologic features were treated with adj

123 Cohort Study, 3 separate clinical studies of high-risk, HIV-negative persons conducted in Botswana an

124 tiple autoantibody positivity, sex, selected high-risk HLA-DR-DQ genotypes, relationship to a family

125 cells, epigenetic downregulation of HLA-E by high-risk HPV E7 may contribute to virus-induced immune

126 By contrast, the prevalence of high-risk HPV genotypes other than 16 and 18 remained th

127 ame-sex oral sex partners, the prevalence of high-risk HPV infection was 22.2% (CI, 9.6% to 34.8%).

128 ed margins on excisional treatment; however, high-risk HPV post-treatment predicts treatment failure

129 A negative high-risk HPV test post treatment was associated with a

130 ving with HIV on ART had lower prevalence of high-risk HPV than did those not on ART (adjusted odds r

131 onfidence interval [CI], 38.3%-46.1%) and of high-risk (HR) HPV was 23.4% (95% CI, 21.3%-25.6%).

132 Subsequently, all cases of high-risk (hr) HPV-associated high-grade lesions and car

133 53 mutations (HR, 6.9; P < .0001) and MIPI-c high-risk (HR, 2.6; P = .003) had independent prognostic

134 axAC regimens improved IDFS in patients with high-risk human epidermal growth factor receptor 2-negat

135 Five discarded high-risk human livers were perfused with HBOC-based per

136 (CIN2+) and compared it with post-treatment high-risk human papillomavirus (HPV) testing.

137 The risk of anal cancer due to high-risk human papillomavirus (HR-HPV) is higher in wom

138 High-risk human papillomavirus (hrHPV) testing to triage

139 ce risk behaviors and increase monitoring in high-risk IDU and MSM if HCV elimination targets are to

140 date a PDA risk prediction model to identify high-risk individuals among those with new-onset diabete

141 erscore the importance of early detection in high-risk individuals.

142 ants requiring examinations by 34.3% if only high-risk infants received examinations.

143 uction of whole-egg powder into the diets of high-risk infants reduced sensitization to EW and induce

144 owth observed between 12 and 24 months in 15 high-risk infants who were diagnosed with autism at 24 m

145 biotics and probiotics, to the management of high-risk infants.

146 performance status of 0-2, and did not have high-risk lesions for tumour flare (eg, >5 sites of visc

147 scular tortuosity increased significantly in high-risk lesions, whereas diameter decreased significan

148 It recruits men with high-risk, locally advanced or metastatic prostate cance

149 tality and faster time to discharge alive in high-risk, longer stay patients but not significantly so

150 MBGrp3 and MBGrp4 were each split into high-risk (MBGrp3-HR [n=65] and MBGrp4-HR [n=85]) and lo

151 ages encompassing preleukemia, low-risk MDS, high-risk MDS, and secondary AML.

152 fectiveness Data and Information Set (HEDIS) high-risk medication in older adults (PUM-HEDIS), any da

153 ), and 95% had acute myelogenous leukemia or high-risk myelodysplastic syndrome.

154 sed before and after haploidentical HSCT for high-risk myeloid malignancies.

155 High-risk NBL is characterized by N-Myc amplification an

156 High-risk neuroblastoma patients receive myeloablative c

157 mproved event-free survival in children with high-risk neuroblastoma with an adequate response to ind

158 bility gene that functions as an oncogene in high-risk neuroblastoma.

159 ll continue to aim to optimise treatment for high-risk neuroblastoma.

160 mproves event-free survival in patients with high-risk neuroblastoma; however, which regimen has the

161 response to induction therapy, nearly 50% of high-risk neuroblastomas recur because of chemoresistanc

162 sk of developing eczema is possible and such high-risk newborns may benefit from early stratification

163 patients and screening in all individuals at high risk of acquiring and transmitting sexually transmi

164 VGs) has historically been associated with a high risk of adverse ischemic events, but there is a pau

165 with a history of posttransplant SCC have a high risk of aggressive SCC.

166 Studies had medium and high risk of bias, and overall evidence was judged insuf

167 The randomized trial, assessed as having high risk of bias, suggested that a predischarge decreas

168 he Gazelle Bare Metal Stent in Patients With High Risk of Bleeding [LEADERS FREE]; NCT01623180).

169 stain aspect defined a new HCA subgroup at a high risk of bleeding.

170 abetes mellitus and prediabetes, patients at high risk of cardiovascular disease, and those with prev

171 etes mellitus and prediabetes and those with high risk of cardiovascular disease, stroke, heart failu

172 Despite the high risk of compromised nutrition, evidence of the effe

173 re developed as a screening tool to identify high risk of death within three months.

174 ence of JAK2 mutations (P=0.001), owing to a high risk of death without relapse.

175 s identifies patients with very severe AS at high risk of death.

176 specially those younger than 5 years, are at high risk of death.

177 cysteine are assumed to be associated with a high risk of developing atherosclerosis.We estimated the

178 ent and ulcer characteristics that predict a high risk of developing corneal perforation and/or the n

179 ter tools are needed to identify patients at high risk of developing HF in the setting of right ventr

180 model is helpful in screening children with high risk of developing obesity.

181 with a simple tool to screen for patients at high risk of developing persistent pain after breast can

182 s that identify and rapidly offer kidneys at high risk of discard may contribute to minimizing the un

183 hy mass spectrometry to identify patients at high risk of early death, to identify patients who respo

184 with shorter telomeres in populations facing high risk of extinction when compared to non-threatened

185 tients with T or TC, albeit with a potential high risk of fatal pneumonitis.

186 on; or whether the plaque (or patient) is at high risk of future adverse events.

187 duals were screened and 32 518 (34%) were at high risk of having COPD.

188 Data were collected from local youth at high risk of HIV infection and, specifically, sexual min

189 h confirmed or suspected A(H1N1)pdm09 and at high risk of hospitalization, outpatient or community-ba

190 ty successfully discriminated districts with high risk of invasion from others with a lower risk (are

191 or all CDH1 mutation carriers because of the high risk of invasive diffuse-type gastric cancer and la

192 nd human immunodeficiency virus (HIV) are at high risk of liver disease progression.

193 trategy for the management of individuals at high risk of melanoma.

194 with pulmonary arterial hypertension with a high risk of mortality, independent of existing clinical

195 atory breathing at rest is associated with a high risk of mortality.

196 Overweight and obese older people face a high risk of muscle loss and impaired physical function,

197 CA-based screening is an option for women at high risk of OC/FTC who defer or decline RRSO, given its

198 tudy sites in three districts of Pakistan at high risk of polio.

199 We conclude that older KT recipients have a high risk of post-KT dementia and AD, and these sequelae

200 class III or higher (indicating moderate to high risk of postoperative kidney injury) undergoing maj

201 ex was used to identify SMD individuals with high risk of progression to mild cognitive impairment (M

202 rietal (FPS) subnetworks in rMDD patients at high risk of recurrence (rrMDD).

203 s who had undergone surgery for GISTs with a high risk of recurrence were randomized to receive adjuv

204 ns to benefit patients with breast cancer at high risk of recurrence.

205 or persistently elevated values and were at high risk of recurrent events.

206 Because of the high risk of reinfection, vaccinating boys who have not

207 RAS pathway mutations (P=0.004), owing to a high risk of relapse, and the presence of JAK2 mutations

208 interventions, and for identifying those at high risk of relapse.

209 was likely to be cost-effective in those at high risk of repeated systemic sting reactions and/or im

210 This induces a high risk of sample loss of the collected rare cells.

211 The identification of patients at high risk of secondary CNS relapse is therefore paramoun

212 is restricted to prophylaxis in neonates at high risk of severe RSV disease.

213 -BRCA germline mutations in individuals with high risks of breast cancer, which in turn aids in the i

214 y slums are unhealthy places with especially high risks of infection and injury.

215 in magnitude and direction to estimates from high-risk-of-bias studies.

216 rogression of cancer from low to moderate or high risk or death during 24 months' follow-up) and abse

217 The predicted probability of high-risk oral HPV infection was greatest among black pa

218 ), respectively, but the studies oversampled high-risk participants and those with OSA and OSA syndro

219 tients, relapses do occur, especially in the high-risk patient population.

220 on postoperative day 1 (POD 1) for moderate/high risk patients.

221 ge pharmacoprophylaxis can be considered for high-risk patients (ie, VTE risk >0.4%).

222 y warning system to help clinicians identify high-risk patients for further screening.

223 ts, and practices that served more medically high-risk patients had lower quality and higher costs.

224 hysician practices that served more socially high-risk patients had lower quality and lower costs, an

225 Although we found evidence that high-risk patients had more to gain from treatment, we w

226 High-risk patients have an increased screening failure r

227 There is a major unmet need to identify high-risk patients in myocarditis.

228 Select high-risk patients may benefit from consideration of del

229 associated with an improved outcome in these high-risk patients needs further study.

230 How these recommendations are implemented in high-risk patients or according to setting of drug initi

231 In very high-risk patients receiving combination haploidentical

232 Cost savings was more prominent amongst high-risk patients where the difference of total episode

233 ical circulatory support, may be required in high-risk patients who are reasonable candidates for the

234 s in US and Canadian cooperative groups with high-risk patients who had ccRCC histology and pT3, pT4,

235 ion (PCI), can influence physicians to avoid high-risk patients who may benefit from treatment.

236 ICD therapy is an effective therapy in high-risk patients with BrS.

237 ion CD19 CAR-T cells are highly effective in high-risk patients with CLL after they experience treatm

238 VR procedure provided acceptable outcomes in high-risk patients with degenerated bioprostheses or fai

239 of immunomodulatory drugs as maintenance in high-risk patients with DLBCL.

240 atin was enhanced in patients with DM and in high-risk patients without DM.

241 le is not necessarily the optimal target for high-risk patients, although it is not possible to rule

242 ological, and imaging biomarkers to identify high-risk patients, and clinical trials evaluating novel

243 In high-risk patients, discussions regarding extended stays

244 warfarin treatment after PVI is not safe in high-risk patients, especially those who have previously

245 Among these high-risk patients, molecular adsorbent recirculating sy

246 e may be useful to allocate resources toward high-risk patients, particularly in resource-poor settin

247 In high-risk patients, TAVR for bioprosthetic aortic valve

248 and standard-risk cytogenetics subgroups: in high-risk patients, the hazard ratio (HR) was 0.543 (95%

249 stigations and lacks CMR imaging to identify high-risk patients.

250 or duration of AKI after cardiac surgery in high-risk patients.

251 and to prioritize alternative approaches in high-risk patients.

252 subgroups, including among intermediate- and high-risk patients.

253 y practices that serve socially or medically high-risk patients.

254 a cardioverter-defibrillator in appropriate high-risk patients.

255 Reduced EFhd2 function induces high-risk personality traits of sensation-seeking/low an

256 (18)F-Fluoride uptake correlated with high-risk plaque features (remodeling index [r=0.53, P=0

257 support the hypothesis that patients have a high-risk plaque phenotype.

258 Presence and characteristics (high-risk plaque, including spotty calcification and low

259 claims for secondary AMI identifies a unique high-risk population and has important clinical, economi

260 laxis should be strongly considered for this high-risk population.

261 reening modalities to aid early diagnosis of high-risk populations and assist the clinical management

262 may eventually prevent cataract formation in high-risk populations and may prevent progression of ear

263 population trends in EOL care and identifies high-risk populations for future interventions.

264 eye disease detection and follow-up care in high-risk populations in the United States.

265 is suggested to detect incident diabetes in high-risk populations.

266 ed with fewer bonuses and more penalties for high-risk practices.

267 iated at 20 ppm on postnatal days 5 to 14 to high-risk preterm infants and continued for 24 days, app

268 ntixafor signal is higher in patients with a high-risk profile and may hold promise for identificatio

269 PARP is required for effective treatment of high risk prostate cancer.

270 For patients with high-risk prostate cancer receiving EBRT and androgen-de

271 tes of observation for men with low-risk and high-risk prostate cancer.

272 t to taking the active drug in patients with high-risk (pT3, pT4, node-positive) clear cell renal can

273 ity CFR >/=2.3 to CFR <2.0, thereby implying high-risk quantitative severity potentially appropriate

274 ow), intermediate (RDW-high or NLR-high) and high risk (RDW-high and NLR-high) groups, especially in

275 r antagonists, and antithymocyte globulin in high-risk recipients.

276 il through November 2015, five patients with high-risk, refractory ventricular tachycardia underwent

277 nged from 11% (low risk score 0-2) to 43.1% (high risk score >4; P<0.0001).

278 nificantly increased bleeding in patients at high risk (score >/=25), but not in those with lower ris

279 considerable light on transmission patterns, high-risk settings and subpopulations, and the effective

280 approaches, participants tended to comprise high-risk social networks.

281 High-risk SPECT tests significantly decreased, and the p

282 e as well as within low-, intermediate-, and high-risk SSIGN groups.

283 Although frailty represents a high-risk state for this population, the correlates of f

284 The DI assigned high-risk status to 759 of 767 patients with significant

285 0 mm or greater, which is characterized as a high-risk stigma.

286 nting post-ERC infectious complications in a high-risk study population.

287 arly high (78% at 6 months) in the screening high-risk subgroup.

288 her value for patients in several recognized high-risk subgroups.

289 ive risks were greater in three prespecified high-risk subgroups: patients with diabetes, those 70 ye

290 also referred to as BCR-ABL1-like ALL, is a high-risk subset with a gene expression profile that sha

291 ike) acute lymphoblastic leukemia (ALL) is a high-risk subtype characterized by genomic alterations t

292 heir conversations with patients considering high-risk surgery.

293 58 (12%) of participants were classified as high-risk; the probability of having non-dysplastic endo

294 underlying pathogenesis, and often requires high-risk therapeutic intervention.

295 hould) this be the laborious, uncertain, and high-risk trajectory of disruptive medical innovation?

296 ential novel prognostic biomarker to predict high-risk tumors before they metastasize.

297 s 16 and 18, HPV types 31, 33, and 45, other high-risk types, and any HPV were calculated using logis

298 Although high-risk vaccination remains cost-effective, substantia

299 pecificity, and better power to discriminate high-risk versus low-risk coronary lesions than [(18)F]F

300 However, areas of high risk were also found in drought-prone regions for b