ライフサイエンスコーパス: high-threshold

1 er threshold or the longer-term benefit of a high threshold.

2 le regime are usually achieved either with a high threshold (10(2)-10(4) MW cm(-2)) or at cryogenic t

3 haemically sensitive C fibre afferents had a high threshold (86 +/- 12 mmHg, n = 10) and a larger pea

4 li that are sufficiently intense to activate high-threshold A(delta) and C sensory fibres, which rela

5 6/S1 DRG, of which approximately 75% exhibit high-threshold action potentials that are mediated by TT

6 ve to capsaicin and exhibited TTX-resistant, high-threshold action potentials, whereas a smaller prop

7 NX-482-sensitive transient Ca(2+) current is high-threshold activated and shows moderate steady-state

8 Lamina I NK1R+ neurons were shown to receive high-threshold (Adelta/C fiber) monosynaptic input, wher

9 the TRPV1+/+ littermates while surprisingly high threshold afferent sensitivity was unchanged.

10 NS (33 +/- 7%) and may require activation of high-threshold afferent fibres.

11 nd that ageing is associated with attenuated high-threshold afferent mechanosensitivity in the murine

12 rons in specific spinal laminae that process high threshold afferents and that harbor neurons with sy

13 chanosensory function was more pronounced in high-threshold afferents compared to low-threshold affer

14 e difference from the average gene exceeds a high threshold and codon usage differences from ribosoma

15 bias relative to the average gene exceeds a high threshold and the codon bias relative to ribosomal

16 the deep dorsal horn and were classified as high threshold and wide dynamic range.

17 eral biceps and quadriceps the responses had high thresholds and delayed onset compared with normal s

18 Sodium and potassium have high thresholds and prefer the CF(3) end of the molecule

19 c chemiluminescent immunoassay (CLIA) with a high threshold, and immunoglobulin G (IgG)-specific CLIA

20 cal stimuli are classified as low threshold, high threshold, and wide dynamic range neurons.

21 h perception will improve when channels with high thresholds are deactivated.

22 s demonstrated that channels with relatively high thresholds, as measured with the tripolar configura

23 t for fremanezumab's selective inhibition of high-threshold, as a result of a predominant A-delta inp

24 noise exposure can cause a selective loss of high-threshold auditory nerve fibers without affecting a

25 that typifies plague is a consequence of the high threshold bacteremia level that must be attained to

26 izing RTK signaling is to erect and maintain high threshold barriers that prevent inappropriate respo

27 ited by thalamocortical neurons that exhibit high-threshold bursts.

28 al dura, and found a selective inhibition of high-threshold but not wide-dynamic range class of neuro

29 reflect the large population of unmyelinated high-threshold C fibre afferents that innervate the urin

30 ith the incidence of spontaneous activity in high-threshold C-fiber afferents.

31 cate that this oscillation correlates with a high threshold Ca(2+) current in the dendrites.

32 ich is capable of the production of isolated high threshold Ca(2+) spikes in distal branch segments,

33 An aging-related increase was found in high-threshold Ca and barium (Ba) currents, particularly

34 pected because it also reduced the composite high-threshold Ca channel current recorded in these cell

35 It similarly reduced the high-threshold Ca channel current that remains after a b

36 It included N-type Ca channels as well as high-threshold Ca channels that displayed the pharmacolo

37 agonist blocks the potentiation by CXCL12 of high-threshold Ca(2+) channels in rat neurons.

38 reas the apamin-sensitive channels relate to high threshold Ca2+ channels.

39 rences in the proportion of low-threshold to high-threshold Ca2+ channels were observed in small and

40 zation of this current was consistent with a high-threshold Ca2+ current.

41 High-threshold Ca2+ currents were also suppressed by (1S

42 The high-threshold calcium channel (gCa) and C-type potassiu

43 a-CTx-MVIIC blocked approximately 50% of the high-threshold calcium channel current; one component (a

44 critically evaluated for antagonism of three high-threshold calcium channel subtypes in rat neurons t

45 icologically relevant lead concentrations on high-threshold calcium currents in chronically exposed m

46 cologically relevant lead concentrations and high-threshold calcium currents in mammalian cells.

47 or human embryonic kidney 293 cells produced high-threshold calcium currents that were blocked by ome

48 prevent the activation and sensitization of high-threshold (central) trigeminovascular neurons by co

49 macological compound that modulates Kv3.1, a high-threshold channel expressed in fast-spiking neurons

50 To select high-threshold channels for deactivation, subjects' thre

51 ype, L-type, and at least two other types of high-threshold channels.

52 effects of XE991 and camphor are largest in high-threshold cold nociceptors.

53 ynia is linked to a reduction of IKD in both high-threshold cold thermoreceptors and nociceptors expr

54 lation not only enhances cold sensitivity of high-threshold cold thermoreceptors signaling cold disco

55 hange occurred earlier in low-threshold than high-threshold cold thermosensors.

56 Kv3.1 gene in mice results in the loss of a high-threshold component of potassium current and failur

57 o a functional downregulation of IKD in both high-threshold CSNs and in a subpopulation of polymodal

58 IKD density was reduced in high-threshold CSNs from CCI mice compared with sham ani

59 Three components of high-threshold current were distinguished on the basis o

60 onclustered channels are responsible for the high threshold delayed rectifier K(+) current typical of

61 drotoxin (DTX)-sensitive current (ILT) and a high-threshold DTX-insensitive current (IHT).

62 uracy appears to be inadequate in tests with high thresholds (ELISA; IgG-specific CLIA), combination

63 red spatial response is a spatially-limited, high-threshold expression pattern.

64 The cac channels contribute to low- and high-threshold, fast- and slow-inactivating types of Ca2

65 Single-fiber analysis showed that high-threshold fibers were particularly affected by alph

66 ergic neurons also had convergent input from high-threshold fibers, suggesting that this novel subcla

67 individual afferents into low-threshold and high-threshold fibres.

68 fibres (2) wide dynamic range fibres and (3) high-threshold fibres.

69 dicate that Kv3.1 channels have an unusually high threshold for activation.

70 Behavioral screens using a high threshold for detection have generally had limited

71 ty of dopaminergic neurons may explain their high threshold for firing and their low discharge rate.

72 e for the low ligand stability and suggest a high threshold for gammadelta T cell activation.

73 propose that in the L2 stage, lin-14 sets a high threshold for LIN-12 activation to help prevent pre

74 a-DTX)] played a prominent role in setting a high threshold for somatic calcium spikes, thus restrict

75 This raises a high threshold for success in future intervention protoc

76 suggest that DNA-PK is involved in setting a high threshold for the ATR-Chk1-mediated S-phase checkpo

77 erian Shakers and channels with an unusually high threshold for voltage activation.

78 rrow inclusion criteria focused only on MDD, high thresholds for quality, potential publication bias,

79 tunately, inappropriate screening practices, high thresholds for referral, misplaced concerns about c

80 High-threshold GABAergic inputs, in contrast, cause nonm

81 of morbidity amongst the elderly population High-threshold gastrointestinal sensory nerves play a ke

82 R thresholds are used for decision-making: a high threshold (>/=90 ml/min per 1.73 m(2)) to accept an

83 GD, whereas 42/57 (74%) of these neurons had high-threshold (> or =0.4 ml) responses to DD.

84 king it a candidate receptor for transducing high-threshold heat responses in this class of cells.

85 Consistent with CL-II being critical for high-threshold Hh target gene expression, its phosphoryl

86 were made from wide dynamic range (WDR) and high threshold (HT) dorsal horn neurons in mice with tum

87 Single-unit analysis revealed that both high threshold (HT) fibres (> 15 mmHg; known to be assoc

88 Abs) prevent activation and sensitization of high-threshold (HT) but not wide-dynamic range trigemino

89 in both sexes, fremanezumab inhibited naive high-threshold (HT) neurons, but not wide-dynamic range

90 STT cells in the superficial dorsal horn and high-threshold (HT) STT cells in superficial or deep lay

91 ted two different types of action potential: high-threshold humped spikes in small-sized neurones and

92 neurones which were small in size exhibited high-threshold humped spikes mediated by tetrodotoxin (T

93 Selective organic antagonists of high-threshold (HVA) Ca2+ channels, nimodipine, omega-Co

94 When IK(IR) begins to decrease, a high-threshold inactivating Ca2+ current and a slowly ac

95 ion action potentials that are mediated by a high-threshold, inactivating Ca2+ current.

96 and synaptic terminal, contrasting with the high threshold K+ channel subunit Kv3.1 which is located

97 By blocking high-threshold K(+) conductances in motor neurons within

98 ata demonstrate that clusters do not contain high threshold Kv2.1 channels whose voltage sensitivity

99 Many such neurons express "high threshold" Kv3-family channels that are required fo

100 lting temperature and P is pressure, above a high threshold laser fluence; while the slower thermal p

101 Current optical transmitters consisting of high-threshold lasers plus external modulators consume f

102 xhibit a constant probability of attaining a high threshold level of Spo0A P due to fluctuations in t

103 ter bacterial numbers in vivo have reached a high threshold level, commonly called the lethal load.

104 ed with, and preceded by, Spo0A P reaching a high threshold level; (iii) activation of Spo0A takes pl

105 tation, we found that sporulation required a high (threshold) level of Spo0A and that many genes in t

106 control rats were capsaicin sensitive, with high-threshold long-duration action potentials that were

107 aw withdrawal responses to low threshold and high threshold mechanical stimuli compared to pre-operat

108 nd lowered the threshold of response for the high threshold mechanical stimuli in a dose-dependent ma

109 ry neurons that are selectively activated by high-threshold mechanical stimulation (HTMRs).

110 Positive C-fibre high threshold mechanoreceptive (HTM) units had receptiv

111 nd thermal stimuli as nociceptive (including high-threshold mechanoreceptive (HTM) units), and non-no

112 ptor (LTM) units, A-mechanoheat (AMH) units, high threshold mechanoreceptor (HTM) units, and C-mechan

113 in C-fibre nociceptors was apparent both in high threshold mechanoreceptor and polymodal nociceptors

114 rast, none of twenty superficial cutaneous A high threshold mechanoreceptor units or the thirty-five

115 n shown to deplete the population of A-delta high threshold mechanoreceptors and to reduce neurogenic

116 hether the same might be true for myelinated high-threshold mechanoreceptors (HTMRs).

117 few small nociceptor neurons (which include high-threshold mechanoreceptors).

118 In contrast, citric acid activated only 8/17 high threshold mechanosensitive jugular Adelta fibres.

119 In the gut, high-threshold mechanosensitive fibres also express Nav1

120 Sensations of touch, proprioception, and high-threshold mechanosensitive nociception, as well as

121 High-threshold mechanosensory afferent fibres and small-

122 arations, octreotide inhibited both low- and high-threshold mechanosensory responses, whereas in the

123 susceptibility to excitability changes since high-threshold MNs innervating fast fatigable muscle fib

124 In contrast, blockade of high-threshold N-type calcium channels increased the fir

125 The activation of high-threshold (N-type and L-type) voltage-gated Ca(2+)

126 I neurons in control slices were elicited by high-threshold nerve stimulation, whereas the majority o

127 s a result of a predominant A-delta input to high-threshold neurons, but not wide dynamic-range dorsa

128 tors may be restricted to synapses formed by high-threshold nociceptive (pain-sensing) and thermorece

129 These neurons include high-threshold nociceptors that are involved in transduc

130 ection of noxious heat in a subpopulation of high-threshold nociceptors.

131 en expressed heterologously, gives rise to a high-threshold noninactivating potassium current.

132 Kv3.1 mRNA levels and in the amplitude of a high-threshold, noninactivating current before the onset

133 other delayed rectifier channels by its very high threshold of activation and lack of use-dependent i

134 um channel Kv3.1, a delayed rectifier with a high threshold of activation, is expressed in the time c

135 The lung must maintain a high threshold of immune 'ignorance' to innocuous antige

136 rmal tissues of young mice but is induced by high thresholds of aberrant hyperproliferative signals,

137 n and DNA damage that are triggered when the high thresholds of intracellular Ca2+ required for cell

138 threshold, relay cells produce a fast ragged high threshold oscillation in somatic voltage.

139 ible for separating low threshold input from high threshold output neurons of lamina I.

140 (IR) is absent when only a slowly activating high-threshold outward K+ current is present, these acti

141 asers reported to date exhibit impractically high thresholds owing to their unfavourable bandstructur

142 ng rats demonstrated the loss of low but not high threshold penile inputs to medullary reticular form

143 ocess initiated by activation of specialised high-threshold peripheral sensory neurons.

144 The expression patterns for two high-threshold potassium channels, Kv3.1 and Kv3.3, that

145 We propose that, after the decay of high-threshold potassium currents, the tonic cation curr

146 asy-to-fabricate nanolasers, but suffer from high threshold powers.

147 These receptors also contribute to high-threshold primary afferent drive onto NK1R+ neurons

148 derlie inflammation-induced sensitization of high-threshold primary afferent neurons, including the m

149 oral task, children (7- to 11-year-olds) had high thresholds, regardless of language status, but teen

150 This induces a suite of high-threshold response genes in the underlying mesenchy

151 ral neurogenic ectoderm demands a relatively high-threshold response to dl.

152 esponses to DD (<or=0.2 ml) and 26 (22%) had high-threshold responses to DD (>or=0.4 ml).

153 nses preferentially and failed to affect the high-threshold responses.

154 proposed thresholds were more sensitive than high thresholds (sensitivities: distribution volume rati

155 old sensory fibres, while these receptors on high threshold sensory fibres mediate pain.

156 ing neurons received direct projections from high-threshold sensory afferents but transmitted nocicep

157 al spinal cord, where they are innervated by high-threshold sensory afferents.

158 of intense or noxious stimuli by specialized high-threshold sensory neurons (nociceptors), a transfer

159 We also identify a pair of high-threshold sensory neurons that encode variability i

160 classes of primary afferents were found: 70 high-threshold serosal afferents, four low-threshold mus

161 Blockade or ablation of high-threshold, small-diameter unmyelinated group C nerv

162 trated a mixture of inputs from both low and high threshold sources.

163 ble Pittsburgh compound-B signal, as well as high thresholds (standard uptake value ratiohigh = 1.40,

164 The mature action potential is mediated by a high-threshold sustained Ca2+ current.

165 rointestinal system is innervated by low and high threshold sympathetic C fibre afferents, the latter

166 e of the BMP-activity gradient and increased high threshold target gene expression in the early embry

167 wing discs, overexpression of Ihog represses high-threshold targets, while extending the range of low

168 Onset cells have a unique high-threshold tetraethylammonium-sensitive K(+) current

169 neurones which were small in size expressed high-threshold tetrodotoxin (TTX)-resistant Na+ channels

170 includes a model for a specialized class of high-threshold thalamocortical cells (HTC cells), which

171 PTEN), potentially setting Akt activity at a high threshold that is unresponsive to EGFR inhibition a

172 were found to be unrelated, as predicted by high-threshold theories.

173 tential V2 (TRPV2) has been proposed to be a high-threshold thermosensor.

174 Firing threshold decreases among high-threshold TMNs and increases in a subpopulation of

175 This high-threshold transient K+ current was abolished by ext

176 ifting the expression of Na+ channels from a high-threshold TTX-resistant type to a low-threshold TTX

177 Enhancements above the generally high threshold value of 2.5 have important implications

178 45% of individual variances in the low- and high-threshold variants of three psychoacoustic tasks as

179 viously reported that the current density of high threshold voltage-activated (HVA) calcium (Ca(2+))

180 substantial decrease in the amplitude of the high-threshold voltage-activated (HVA) calcium current.

181 K current is activated by Ca2+ entry through high-threshold voltage-activated Ca2+ channels (L- and N

182 d K+ currents and their Ca2+ sources through high-threshold voltage-activated Ca2+ channels were stud

183 ve to that of Kv3.1b subunits, which mediate high-threshold voltage-activated currents.

184 xhibited significantly decreased whole cell, high-threshold voltage-dependent calcium currents, with

185 Ca(2+) influx through the dendritic high-threshold voltage-gated Ca(2+) channels activates C

186 + and was inhibited 65 +/- 3% by blockade of high-threshold voltage-gated Ca2+ channels with omega-gr

187 High-threshold voltage-gated calcium currents were recor

188 three different pathways for calcium influx: high-threshold voltage-sensitive calcium channels, NMDA

189 also shown for five of seven parameters for high-threshold vs. low-threshold MNs, and three of seven

190 quire determining whether the other types of high-threshold VSCCs (e.g., N, P/Q, and R) also exhibit

191 In both spinal segments, an area of high threshold was found in the middle of the dorsolater

192 cellular Wg, producing ectopic activation of high threshold Wg targets but reducing the expression of