ライフサイエンスコーパス: high-throughput screening

1 e linkage between phenotype and genotype for high throughput screening.

2 icity assay in a 1,536-well plate format for high throughput screening.

3 of RAD51 inhibitors that were identified by high throughput screening.

4 RET based assay for OTR, readily amenable to high throughput screening.

5 ctivation inhibitors have been discovered by high throughput screening.

6 n of a Wnt secretion inhibitor from cellular high throughput screening.

7 aminothiazole inhibitors were discovered by high throughput screening.

8 er sensitivity, simplicity and capability of high throughput screening.

9 al nervous system disease while facilitating high-throughput screening.

10 of ion channels, in a format compatible with high-throughput screening.

11 d have broad applications in diagnostics and high-throughput screening.

12 lenges that are currently encountered during high-throughput screening.

13 rs of MIF in a manner that can be scaled for high-throughput screening.

14 been mostly serendipitous, achieved through high-throughput screening.

15 lecular and functional endpoints amenable to high-throughput screening.

16 nce-based assay of DNA bridging suitable for high-throughput screening.

17 nsformation in vitro, but it is unsuited for high-throughput screening.

18 uorescence-based activity assay suitable for high-throughput screening.

19 AP) is an efficient method for Ras inhibitor high-throughput screening.

20 a scintillation proximity assay suitable for high-throughput screening.

21 ombinant RSV virus and applied the strain to high-throughput screening.

22 arget engagement, receptor pharmacology, and high-throughput screening.

23 ome-wide mRNA profiling method to complement high-throughput screening.

24 ntify stable reference miRNAs in CRC through high-throughput screening.

25 eloped hnuSABR (Light-Induced and -Graduated High-Throughput Screening After Bead Release), a microfl

26 We previously identified, by high-throughput screening, aminophenyl-1,3,5-triazine CF

27 ased functional genomics method to perform a high throughput screening and identified TMEM43/LUMA as

28 ic (HPLC-MS/MS) method was developed for the high throughput screening and quantitative analysis of f

29 engineering such as efficiency, specificity, high-throughput screening and delivery for in vivo and t

30 A prevalent observation in high-throughput screening and drug discovery programs is

31 orted method constitutes a blueprint for the high-throughput screening and future discovery of new po

32 which we posit embodies the benefits of both high-throughput screening and high-resolution microscopy

33 utility of antagonistic interactions both in high-throughput screening and in compound mode of action

34 High-throughput screening and lab-scale optimization wer

35 vel small-molecule compounds identified from high-throughput screening and medicinal chemistry optimi

36 haperone of glucocerebrosidase identified by high-throughput screening and medicinal chemistry struct

37 High-throughput screening and structure-activity analysi

38 logical assays and can impact the new way of high-throughput screening and understanding cell activit

39 straightforward enzymatic assay suitable for high-throughput screening and we identified inhibitors w

40 elopments allowing for in vivo examinations, high-throughput screening and whole-brain analyses in la

41 has been an essential tool for diagnostics, high-throughput screening, and biological assays.

42 steric inhibitor of Akt through a FRET-based high-throughput screening, and characterization of its i

43 ombination of experimental high-pressure and high-throughput screening, and computational mechanism d

44 which hold great potential in drug testing, high-throughput screening, and disease modeling.

45 Microfluidic devices offer automation and high-throughput screening, and operate at low volumes of

46 This strategy is compatible with high-throughput screening, and should be adaptable to th

47 zoisoquinolinedione series was identified by high-throughput screening, and subsequent structure-acti

48 s shown great potential for various types of high-throughput screening applications.

49 es (e.g., water quality, urine analysis), or high-throughput screening applications.

50 Using a high throughput screening approach, we identified three

51 We recently devised a chemogenetic high-throughput screening approach ("HiTES") to discover

52 Here we report a rapid and sensitive high-throughput screening approach to identify compounds

53 Here we use a high-throughput screening approach to identify novel mut

54 Here, we describe a novel high-throughput screening approach to identify small mol

55 We used a directed high-throughput screening approach, followed by subseque

56 As SHG offers a powerful, high-throughput screening approach, our results here als

57 Using a high-throughput screening approach, we identified miR-33

58 A complexes have been identified by applying high-throughput screening approaches.

59 Fragment screening and high throughput screening are complementary approaches t

60 Active variants identified by high-throughput screening are thus inherently likely to

61 A bis-phenol pyrazole was identified from high-throughput screening as an inhibitor of the N-termi

62 , the development of a cell-based, medium to high throughput screening assay that is capable of monit

63 H binding site using an ADP-TAMRA probe in a high-throughput screening assay.

64 ntifying these mechanisms will help optimize high-throughput screening assays for molecules and mutat

65 However, cell-based high-throughput screening assays for the rational develo

66 sults from 18 estrogen receptor (ER) ToxCast high-throughput screening assays were integrated into a

67 with standard ELISA and multiplex DVD-array high-throughput screening assays, corroborating the viab

68 ficial riboswitch activators by establishing high-throughput screening assays, fragment-based screeni

69 which impedes their use as tissue models for high-throughput screening assays.

70 of quantitative proteomics, particularly in high-throughput screening assays.

71 hodology specifically designed to complement high-throughput screening assays.

72 tion, and has immense potential for fast and high-throughput screening bacterial chemotaxis.

73 tion, we prioritized candidate compounds via high-throughput screening based on reversal of green flu

74 High throughput screening by fluorescence activated cell

75 fonamides have recently been identified by a high throughput screening campaign as a novel class of i

76 e RAD52 cellular functions, we carried out a high throughput screening campaign to identify compounds

77 In a high throughput screening campaign, we identified an ace

78 of CDK8 inhibitors that was identified in a high-throughput screening campaign and further progresse

79 Starting from hits identified in a high-throughput screening campaign and through structure

80 ying novel tools to study GPR139 function, a high-throughput screening campaign led to the identifica

81 We report on a high-throughput screening campaign performed on KDM1A/Co

82 viously required access to large and complex high-throughput screening centers ..." Read more in the

83 Using high throughput screening-compatible assays for superoxi

84 Utilizing high-throughput screening, compound 1 was identified as

85 of false positives and false negatives under high-throughput screening conditions is particularly dif

86 g predictive computational models trained on high-throughput screening data to evaluate thousands of

87 itro assay data (including Tox21(TM)/ToxCast high-throughput screening data), and in silico model pre

88 diabetes- or obesity-related outcomes using high-throughput screening data.

89 High throughput screening determines the effects of many

90 A chemical inhibitor discovered by high-throughput screening displayed inhibition of ferrop

91 rrently available imaging approaches used in high-throughput screening drug discovery platforms, for

92 High-throughput screening efforts to discover inhibitors

93 istinct cell populations, enabling design of high-throughput screening experiments to identify novel

94 Here, we took a combined approach of high-throughput screening, flow-based cell sorting and i

95 High throughput screening followed by a lead generation

96 this effect have considerable potential for high throughput screening for drug discovery.

97 ethoxybenzyl) amine (ABMA) from a cell-based high throughput screening for its capacity to protect hu

98 We established high-throughput screening for assembly inhibitors based

99 mutagenesis of influenza virus with a rapid high-throughput screening for attenuation to generate W7

100 rter cell line is a sensitive tool for rapid high-throughput screening for bioactives with anti-infla

101 These results demonstrate the utility of high-throughput screening for functional characterizatio

102 High-throughput screening for functional targets reveals

103 icrotiter plates and should prove useful for high-throughput screening for inhibitors of PSD enzymes

104 1 enzymes, and the fluorogenic probe permits high-throughput screening for inhibitors that may hold p

105 holds promise for the future development of high-throughput screening for plant phenotyping and the

106 mechanisms, inhibition by warfarin, and the high-throughput screening for potential anticoagulants.

107 High-throughput screening for SRC small molecule inhibit

108 the BiFC signals allows effective cell-based high-throughput screenings for protein binding partners

109 bility to high-content microscopy in 96-well high-throughput screening format and validate its applic

110 c tissues and adapted them to a quantitative high-throughput screening format to facilitate mechanist

111 Using high-throughput screening, here we identify and characte

112 From a micromolar high throughput screening hit 7, the successful compleme

113 king studies we converted a mutant-selective high-throughput screening hit (7) into a number of targe

114 from the micromolar 8-quinoline carboxamide high-throughput screening hit 1a, a systematic explorati

115 Increasing the sp(3) character of high-throughput screening hit 40 afforded a novel morpho

116 ct NS5B palm site allosteric inhibitors, the high-throughput screening hit anthranilic acid 4, the kn

117 and selective DLK inhibitors starting from a high-throughput screening hit.

118 design effort to improve the ITK potency of high-throughput screening hits, ultimately delivering li

119 Here, we employed host cell-based high throughput screening (HTS) assay to screen and char

120 However, most high throughput screening (HTS) assays for drug discover

121 By performing a cell-based high throughput screening (HTS) campaign, we identified

122 Using a cell-based High Throughput Screening (HTS) campaign, we identified

123 Identification of a sulfoquinoline hit via high throughput screening (HTS) followed by optimization

124 ies of MCL-1 inhibitors that emanated from a high throughput screening (HTS) hit and progressed via i

125 Identification of an indazole amide high throughput screening (HTS) hit followed by truncati

126 Quality control (QC) metrics are critical in high throughput screening (HTS) platforms to ensure reli

127 g an understanding of the pharmacophore of a high throughput screening (HTS)-derived series of compou

128 Demonstrating the high-throughput screening (HTS) adaptability, the gamma9

129 ctive within kinase families and amenable to high-throughput screening (HTS) applications.

130 igand screening and separately by a chemical high-throughput screening (HTS) assay.

131 rug discovery platform that can achieve true high-throughput screening (HTS) capacities.

132 o extrapolation (IVIVE) analyses translating high-throughput screening (HTS) data to human relevance

133 New sources of high-throughput screening (HTS) data, such as the ToxCas

134 -cell phenotypic assays, the GlaxoSmithKline high-throughput screening (HTS) diversity set of 1.8 mil

135 Large high-throughput screening (HTS) efforts are widely used

136 High-throughput screening (HTS) has enabled millions of

137 Initial optimization of high-throughput screening (HTS) hit 1 led to the identif

138 ed through bioisosteric lead change from the high-throughput screening (HTS) hit is described.

139 rtual screening and re-mining of biochemical high-throughput screening (HTS) hits led to the discover

140 In this study, we utilized high-throughput screening (HTS) in vitro data of PAHs to

141 We present a risk-based high-throughput screening (HTS) method to identify chemi

142 Using high-throughput screening (HTS) methodology, DMF and NaH

143 Developing effective high-throughput screening (HTS) methods is of paramount

144 rgently required, however current cell-based high-throughput screening (HTS) models to identify molec

145 RNA fluorescence polarization (FP) assay for high-throughput screening (HTS) of chemical libraries.

146 Utilizing high-throughput screening (HTS) of the T cell receptor (

147 nvironmental Protection Agency (EPA) ToxCast high-throughput screening (HTS) program.

148 e in vitro methods, in particular cell-based high-throughput screening (HTS) studies, have provided t

149 In parallel, high-throughput screening (HTS) was conducted using the

150 High-throughput screening (HTS) was employed to discover

151 e 3 (NHE3) are described based on a hit from high-throughput screening (HTS).

152 ve agent of Argentine hemorrhagic fever, for high-throughput screening (HTS).

153 ) and two larger compound libraries used for high-throughput screening (HTS).

154 es of ATX inhibitors was identified out of a high-throughput screening (HTS).

155 novel compounds isolated by whole-cell-based high-throughput screening (HTS).

156 e assessment is predictive of the success of high-throughput screening (HTS).

157 High throughput screening identified chymostatins, bacte

158 High-throughput screening identified 4, which possessed

159 High-throughput screening identified anthracyclines incl

160 High-throughput screening identified Antimycin A as a sm

161 Here, the authors, through a high-throughput screening, identify HSP90 inhibitors as

162 the smartphone offers a route toward in situ high-throughput screening immunoassays for viruses, path

163 optical sensing platform on a smartphone for high-throughput screening immunoassays.

164 bran (RB), NIRS can be an effective tool for high throughput screening in rice breeding programme.

165 treatments for drug addiction will depend on high-throughput screening in animal models.

166 The model was developed by utilizing high-throughput screening in combination with cheminform

167 d and parallelized, it can be considered for high-throughput screening in metabolic engineering.

168 g tissue-like properties of primary cells in high-throughput screening is a promising avenue for inno

169 l scheme of immunization in conjunction with high throughput screening may represent an effective str

170 39 in serological tests amenable to rapid or high-throughput screening may enable simple and accurate

171 reproducible system that could be used as a high throughput screening method for finding new alpha-s

172 Here we developed a high throughput screening method to identify mutants of

173 escence spectroscopy could offer a rapid and high-throughput screening method for identification of L

174 We report a high-throughput screening method that allows diverse gen

175 s being considered for large-scale use, this high-throughput screening method will facilitate rapid s

176 ting additional medical significance to this high-throughput screening method.

177 -based diagnostic assay as a new approach in high-throughput screening method.

178 ials with high entropy can be designed via a high-throughput screening method.

179 Modern high-throughput screening methods allow researchers to g

180 al research programs, yet the lack of robust high-throughput screening methods for large libraries of

181 evious efforts to discover such molecules by high-throughput screening methods have utilized, as a re

182 erologous hosts; and mass spectrometry-based high-throughput screening methods.

183 curacy mass spectrometers and the desire for high throughput screening, minimal or no chromatographic

184 In this study, using a cell-based high-throughput screening model representing Runt-relate

185 Here, high throughput screening of 177 protein modules of unkn

186 thiazolidine-2,4-dione, was obtained from a high throughput screening of 40000 compounds against KGA

187 This is the first published parallel high throughput screening of a pharma compound collectio

188 , this model is not readily amenable to semi-high throughput screening of candidate clinical reagents

189 The high throughput screening of chemicals for interaction w

190 ctural biology, biotherapeutic analysis, and high throughput screening of kinase inhibitors.

191 This study provides a unique platform for high throughput screening of natural products for specif

192 iques of both bacterial and host factors and high throughput screening of novel therapeutics becoming

193 pathologies in vitro facilitates the future high throughput screening of potential therapeutic agent

194 ection with droplet microfluidics to achieve high throughput screening of yeast strains engineered fo

195 his system provides a unique opportunity for high throughput screenings of behavioral changes in 3D o

196 for detection, and (iii) its suitability for high-throughput screening of (RGD-)peptide libraries.

197 The assay was then used for high-throughput screening of 1,032 C. glabrata surveilla

198 High-throughput screening of a library of small polar mo

199 uantitative sensing technology allowed for a high-throughput screening of a panel of polymer carriers

200 ate multiple TLRs, we performed a cell-based high-throughput screening of a small-molecule library ba

201 ial screening with biomolecular printing for high-throughput screening of anticancer drug combination

202 arts from heterologous filoviruses, allowing high-throughput screening of B cell lines to isolate MAb

203 etabolites into fluorescent readouts enables high-throughput screening of biological catalysts and al

204 nteraction at the level of their DRBDs using high-throughput screening of chemical libraries by homog

205 ral dynamics, and it holds great promise for high-throughput screening of chemical libraries for unkn

206 s that have proven difficult to target using high-throughput screening of complex compound libraries.

207 resent an effective assay that is suited for high-throughput screening of compound libraries for off-

208 d with gel analysis and are not suitable for high-throughput screening of compound libraries.

209 d-shifted fluorophores that are suitable for high-throughput screening of compound libraries.

210 Therefore, we designed a robust protocol for high-throughput screening of compounds that target prima

211 characterization of transporters as well as high-throughput screening of drugs for transporters of p

212 High-throughput screening of extracts from plants, marin

213 ys developed can be used as tools for rapid, high-throughput screening of families of polyphenols tow

214 cient genetic diversification, which enabled high-throughput screening of functional variants.

215 omplexes opens up the possibility to perform high-throughput screening of G-quadruplex ligands for th

216 Libraries of ATFs enable the high-throughput screening of gene networks that trigger

217 he CRISPR/Ca9s system is also being used for high-throughput screening of genes, gene regulatory regi

218 ties (e.g., RNA-seq, ChIP-seq, metabolomics, high-throughput screening of genetic variants), so has o

219 High-throughput screening of IgG B cell repertoires from

220 investigation on microbial pathogenesis and high-throughput screening of immunomodulators of phagocy

221 robust quantitative technologies that allow high-throughput screening of inhibitors.

222 scribe the state-of-the-art methods used for high-throughput screening of large datasets to identify

223 iochemically characterized and optimized for high-throughput screening of molecules that could disrup

224 hanges in GTP levels in living cells and for high-throughput screening of molecules that modulate GTP

225 This robust method is also suitable for the high-throughput screening of NAAAR mutant gene libraries

226 dopted to analyze coding-gene functions, but high-throughput screening of non-coding elements using t

227 The former method is convenient for high-throughput screening of potential GLUT5 inhibitors

228 trates the utility of this technique for the high-throughput screening of potential inhibitors of amy

229 lly, this rapid technique opens the door for high-throughput screening of potential inhibitors of amy

230 ssembly of structurally sorted nanotubes and high-throughput screening of properties that are control

231 atory element screening (CERES) for improved high-throughput screening of regulatory element activity

232 udies of the biochemistry of RBR E3s and for high-throughput screening of small-molecule activators o

233 layer method may be generally applicable for high-throughput screening of the efficacy of cell-penetr

234 High-throughput screening of the host transcriptional re

235 rganization for fundamental studies, and for high-throughput screening of various biomolecules for st

236 e miniaturized assay is extremely suited for high-throughput screening of very large libraries of sma

237 itability of the zebrafish larvae to in vivo high-throughput screenings of small molecule libraries m

238 hibitor (ADDA 5) that was identified using a high throughput screening paradigm.

239 Utilization of a quantitative high-throughput screening paradigm facilitated hit ident

240 We used a genetically encoded high throughput screening platform to screen a SICLOPPS

241 product libraries will require the use of a high throughput screening platform.

242 We previously applied a phenotypic high-throughput screening platform based on an infectiou

243 n, we present the proof of principe of a new high-throughput screening platform for bioanalysis based

244 Furthermore, we have established a high-throughput screening platform for discovering GR-mo

245 Therefore, our robust high-throughput screening platform offers novel opportun

246 human myelin diseases and the development of high-throughput screening platforms for drug discovery.

247 arget information, and predicts a compound's high throughput screening promiscuity, to a higher degre

248 We recently established a dual myxovirus high-throughput screening protocol that combines a fully

249 We employed a virtual high-throughput screening protocol to identify molecules

250 earch efforts that led to the development of high-throughput screening protocols and small-molecule m

251 stness and practicality of this strategy for high-throughput screening purposes is demonstrated.

252 ine triphosphate (ATP) content] quantitative high throughput screening (qHTS) approach combined with

253 ation of hits identified from a quantitative high throughput screening (qHTS) campaign led to analogs

254 We conclude that the newly developed high throughput screening/reactive oxygen species assays

255 f electrochemical methods for the purpose of high-throughput screening remains very limited.

256 High-throughput screening revealed that DSPE-PEG, in com

257 ation of several alleles also scalable for a high throughput screening setting.

258 h could be used in point-of-care devices and high-throughput screening, should be reliable, cost effe

259 include the following: (i) introduction of a high-throughput screening step before evaluation of more

260 cusing on binding specificity in the initial high-throughput screening steps.

261 ystem, makes this model readily adaptable to high-throughput screening strategies and may be used to

262 We have developed a high-throughput screening strategy to identify potent an

263 s new model can be developed into a test for high-throughput screening studies of intracellular targe

264 as rigid, an approximation typically made in high-throughput screening studies.

265 gs and identification of novel inhibitors in high-throughput screening studies.

266 d to CuO engineered nanoparticles (ENP) in a high-throughput screening system and places this model i

267 4, an inhibitor of ROCK1 identified through high-throughput screening, systematic exploration of SAR

268 Using high-throughput screening technique, we identified a spe

269 High-throughput screening techniques enable efficient id

270 st networks of protein interactions, various high-throughput screening technologies have been develop

271 Using a high-throughput screening technology (shotgun mutagenesi

272 reatment targets, we performed a metabolomic high-throughput screening to analyze the effect of Stx2a

273 combination with experimental approaches as high-throughput screening to efficiently improve both pa

274 icrofluidic chip, which opens the way toward high-throughput screening to find suitable nucleation an

275 report the development and application of a high-throughput screening to identify compounds that eit

276 c tools such as haploid cell lines, allowing high-throughput screening to identify critical contact p

277 AR turnover by PARG is an excellent tool for high-throughput screening to identify pharmacological mo

278 We employ a combination of high-throughput screening to identify small-molecule bin

279 developed a cell-based functional assay for high-throughput screening to identify SMIs for steroid r

280 Here we report the use of virtual high-throughput screening to obtain small molecules pred

281 s9 system, from efficient genome editing, to high-throughput screening, to recruitment of a range of

282 -up of our 3D muFCA system may offer a novel high throughput screening tool.

283 sis provides the possibility of a relatively high-throughput screening tool for compounds with putati

284 rapeutic effect of cisplatin, we conducted a high throughput screening using a kinase library contain

285 We performed high-throughput screening using AlphaScreen and ELISA te

286 s of EBOV entry, we carried out a cell-based high-throughput screening using human immunodeficiency v

287 ependent Dictyostelium aggregation assay for high-throughput screening using rapid, laser-scanning cy

288 Here, by high-throughput screening using the UCP1 promoter, we id

289 A luminescence assay adapted for high-throughput screening was used to measure inhibitory

290 Here, through cell-based high throughput screening we identified benzamide deriva

291 Using high-throughput screening, we have identified 2-phenyl b

292 By performing a high-throughput screening, we identified a myriad of miR

293 By high-throughput screening, we identified a sulfonamide s

294 By high-throughput screening, we previously identified 114

295 Using high-throughput screening, we previously identified 114

296 Through high-throughput screening, we previously identified seve

297 vators of human wild-type CFTR identified by high-throughput screening were evaluated in cell culture

298 ibitors and a chemical series identified via high-throughput screening were exploited.

299 The combination of fragment-based and high-throughput screening with structure-guided compound

300 GCase quinazoline inhibitors, obtained in a high throughput screening, with moderate potency against