ライフサイエンスコーパス: higher affinity @2 than

1 D2E7 has a higher affinity for TNFalpha than 2SD4 and the two antib

2 d new lead compound (11) displaying >20-fold higher affinity for SaHPPK than 8MG.

3 strated that the (dsFv)2 molecule has a much higher affinity for erbB2 than a monovalent dsFv molecul

4 than p145; 7 induced Abs with significantly higher affinity for p145 than Abs induced by p145 itself

5 As ATP has a higher affinity for Mg2+ than ADP, the cytosolic magnesi

6 three base-specific contacts with DNA had a higher affinity for DNA than Adr1 containing three finge

7 Despite NMDARs having a much higher affinity for glutamate than AMPARs, quantal relea

8 The compound possessed 3-fold higher affinity and potency than and efficacy equal to t

9 at human than at rat receptors, because of a higher affinity at human than at rat alpha3beta4 nAChRs.

10 A1 promoter, in which AaCHE interacts with a higher affinity to AtHD1 than AtCHE.

11 AaCHE also showed a higher affinity to TOC1 than AtCHE, consistent with the

12 the absence of S3, Lon exhibits a 10-20-fold higher affinity for ADP than ATP.

13 o bind BAFF, although BCMA has significantly higher affinity for APRIL than BAFF.

14 DeltaCbfa1 has a higher affinity for DNA than Cbfa1 itself, has no transc

15 assical MHC class I molecule that binds with higher affinity to CD8alphaalpha than CD8alphabeta.

16 e PDE-46 thus showed a approximately 60-fold higher affinity for rolipram than cytosolic PDE-46.

17 s and competition assays, pYT demonstrated a higher affinity for p85 than did pY alone.

18 binding competition assays, TSP-1 exhibited higher affinity for SF than did nine other ECM molecules

19 The AA chimera had a much higher affinity for ssDNA than did the other tandem DBDs

20 , between positions -80 and -50, exhibited a higher affinity for UhpA than did the downstream or weak

21 we selected a variant (Ad35K(++)) that had a higher affinity to CD46 than did the natural Ad35 fiber

22 inhibition assays, 70S ribosomes bound with higher affinity, or stability, than did 30S subunits to

23 Uniquely, 1B3 has a higher affinity for digitoxin than digoxin, the immunizi

24 ated Na+ channels usually have a severalfold higher affinity for LAs than do resting channels.

25 omal STRs, upper and middle rank castes show higher affinity to Europeans than do lower rank castes f

26 polymer, oligomeric silica, that has a much higher affinity for aluminum than does monomeric silica

27 e analyses demonstrate that UmuD possesses a higher affinity for beta than does UmuD' because of the

28 The Delta252-259 mutant has 4-fold higher affinity for glucagon than does the wild type rec

29 The major form of the mutant enzyme has a higher affinity for HCN than does native CcP.

30 between scuPA and its receptor have somewhat higher affinity for plasminogen than does tcuPA.

31 (Sema3A), but the NP-1/Plex 1 complex has a higher affinity for Sema3A than does NP-1 alone.

32 First, E-P has a 10(3)-fold higher affinity for substrates than does nonphosphorylat

33 andom-binding model for MCT4; 2), MCT1 has a higher affinity to lactate than does MCT4; 3), the theor

34 Rad59 binds DNA, showing much higher affinity for ssDNA than dsDNA.

35 higher rate of intrinsic GTP hydrolysis and higher affinity for GTP than dynamin-I.

36 22 FAs, including omega-3 fish oil FAs, have higher affinities for Ecat than Eallo subunits of PGHSs.

37 CyaA has 100-fold higher affinity for CaM than EF.

38 (micromolar), whereas PLB3 and PLB4 had much higher affinities, severalfold greater than even thapsig

39 ity pattern similar to that of 2, displaying higher affinities for glucopyranosides than for other mo

40 from the classical GTPases in that it has a higher affinity for ATP than for GTP and is a functional

41 t kinetic parameters from Hcam1, which has a higher affinity for cGMP than for cAMP.

42 ause anthrax toxin has approximately 11-fold higher affinity for CMG2 than for TEM8.

43 It has a much higher affinity for DAT than for the serotonin transport

44 established that (i) the PBCV-1 enzyme has a higher affinity for dCTP than for dCMP, (ii) dCTP serves

45 ity for G7-RP than for DNA while 33.C9 had a higher affinity for DNA than for G7-RP and binds nuclei

46 g from center P and also implies a >2.5-fold higher affinity for QH2 than for Q at center N, which wo

47 e culture supernatants have at least 10-fold higher affinity for quadruplexes than for triplex and du

48 However, PriSL had a significantly higher affinity for ribonucleotides than for deoxyribonu

49 ts, HIV-, AMV- and MuLV-RT showed relatively higher affinity for RNA than for DNA oligonucleotides bo

50 with the C-terminal Thr-NH2 residue (2) has higher affinity for rSSTR5 than for mSSTR2B.

51 The secondary DNA binding site displays a higher affinity for ssDNA than for double-stranded DNA,

52 suggesting that E2 approximately SUMO-1 has higher affinity for TDG than for the SUMO targets RanGAP

53 an LT ELISA revealed that 22 of them have a higher affinity for LT than galactose itself.

54 howed that gD1(Delta290-299t) had a 100-fold-higher affinity for HveAt than gD1(306t) (3.3 x 10(-8) M

55 Deoxyglucose has a higher affinity for transporters than glucose and a lowe

56 cholesterophilic than HDL and that LDL has a higher affinity for phospholipids than HDL whereas HDL h

57 nsduced mutant also had approximately 2-fold higher affinity for antithrombin than heparan sulfate de

58 (45 nucleotides versus 34 nucleotides) and a higher affinity for oligothymidine than hRPA.

59 BSA was found to have a higher affinity for halothane than HSA, and it contained

60 domains (HBDs) with approximately threefold higher affinity in fibrin than in FBG.

61 t IL-8 binds the N-domain with significantly higher affinity in micelles than in solution (approximat

62 IsdC has a higher affinity for hemin than IsdA.

63 igned small-molecule inhibitors that display higher affinity for BCL6 than its endogenous corepressor

64 Kinetic studies showed that GST-WbsJ has a higher affinity for lactose than lactulose with apparent

65 showed that the immobilized cyclic RGD is a higher affinity ligand than linear RGD.

66 b 3P1A6 (K(d) = 0.22 nM) displayed a 50-fold higher affinity for cocaine than mAb MM0240PA (K(d) = 11

67 iments showed that MjCobY(G153D) had 10-fold higher affinity for GTP than MjCobY(WT) but failed to bi

68 he PLC-zeta X-Y linker region also bind with higher affinity to polyvalent than monovalent phosphoino

69 e three cation binding sites in NaDC-1 has a higher affinity for Li+ than Na+.

70 Our studies show a >100-fold higher affinity of NADH than NAD+, consistent with the p

71 Our results demonstrate that SNO-Hb has a higher affinity for oxygen than native Hb.

72 We now report that NBD1 has moderately higher affinity for ATP than NBD2.

73 ides immobilized on biosensor chips showed a higher affinity for fractalkine than non-sulfated peptid

74 NPVF-derived peptides displayed higher affinity for FF1 than NPFF-derived peptides, but

75 pha subunit has an approximately 80,000-fold higher affinity for CO than O2, causing it to rapidly ta

76 sferase (E2)) dimers was enhanced by K+ with higher affinity K+ binding than occurs at the PDHK2 acti

77 7 in squirrel monkey receptor, modulates the higher affinity of neotame than of aspartame.

78 dicated that ICP47 binds to human TAP with a higher affinity (50 nM) than peptides whereas the affini

79 However, rhAT had a fourfold higher affinity for heparin than phAT.

80 ta suggest that PLC-beta3 and PLC-beta1 form higher affinity homodimers than PLC-beta2.

81 rs of magnitude lower concentrations and for higher-affinity systems than previously possible.

82 The canonical CysRS has a higher affinity for cysteine than ProCysRS, a reason why

83 Agonists bound with higher affinity to RG than R, whereas antagonists bound

84 oligomers showed that RPA70A has a 5-10-fold higher affinity for ssDNA than RPA70B.

85 1 (S1A1) has higher catalytic efficiency and higher affinity for actin than S1A2.

86 for a reformatting step, and used to isolate higher-affinity antibodies than scFv libraries.

87 munodeficiency virus (HIV)-1 mAbs bound with higher affinity as scFabs than scFvs.

88 fects and pi-pi interactions, MWCNTs exhibit higher affinity for SRHA than SDS.

89 Interestingly, Bsn bound fibronectin with higher affinity, lower Kd, than several bacterial pathog

90 es which contain an ANSN leaving group had a higher affinity for tPA than substrates with p-nitroanil

91 own evidence that the system I pathway has a higher affinity for haem than system II for cytochrome c

92 d N23 all bound to fibrinogen, but N23 had a higher affinity for fibrinogen than that observed for th

93 - of C1-indole-substituted glycosides afford higher affinities at sst4 than the C4-benzyl group of (+

94 The D3.49(164)H, -Y, -M, and -Q mutants had higher affinities for DAMGO than the wild-type, which we

95 One diastereomer exhibited higher affinity and potency than the unrestricted analog

96 We find that the open structure has a higher affinity for ATP than the closed structure, and t

97 Both rPMCA2a and rPMCA2b had a much higher affinity for calmodulin than the corresponding fo

98 , (2) a truncated form of CNA (CNA35) with a higher affinity for collagen than the wild type, (3) CNA

99 dues have been deleted) showed significantly higher affinity for DNA than the larger proteins, SspC(D

100 en, except for in 9, 13, and 15, resulted in higher affinity for DNA than the parent compound as judg

101 itution of the amidino nitrogens resulted in higher affinity for DNA than the parent compound as judg

102 omparable to the phosphorylated enzyme but a higher affinity for dopamine than the latter.

103 effectors, with the GTP-bound state having a higher affinity for effector than the GDP-bound state.

104 nd serine, the D-isomers showed 6- to 8-fold higher affinity for hPAT1 than the corresponding L-isome

105 bly bind monomeric IgG and appears to have a higher affinity for IgG than the lower affinity Fc gamma

106 The FcgammaRIIIB-NA1 variant, which confers higher affinity for IgG than the NA2 variant, is a deter

107 ual arrestin, p44, demonstrates dramatically higher affinity for microtubules than the full-length pr

108 otif where the A allele is predicted to have higher affinity for Oct1 than the G allele.

109 This enzyme has a higher affinity for oxygen than the cytochrome o oxidase

110 from the same donors exhibited equivalent or higher affinity for PC than the well-characterized murin

111 ed binding site had an approximately 30-fold higher affinity for PfRh4 than the native one in CCP 1.

112 ion of transport by secondary process with a higher affinity for PMX than the other antifolates evalu

113 nstituted pentameric human stalk complex had higher affinity for RTA than the P1-P2 dimer.

114 NP as the label enhanced the signals for the higher affinity ligands than the lower ones.

115 he two (-)-enantiomers showed 10- to 30-fold higher affinities for GR than their respective (+)-enant

116 -linked DNA with a greater specificity and a higher affinity (>2-fold) than to the same undamaged DNA

117 says showed that TIA-1 apparently binds with higher affinity to DNA than to RNA.

118 ta demonstrated that the upper castes have a higher affinity to Europeans than to Asians, and the upp

119 efining Y-chromosome SNPs, Tamil castes show higher affinity to Europeans than to eastern Asians, and

120 However, BRC1-3 bind with higher affinity to RAD51 than to DMC1, whereas BRC6-8 bi

121 bond configuration, pairs with significantly higher affinity to T than to dC.

122 bond conformation, pairs with significantly higher affinity to T than to dC.

123 of the double mutant with 8.4- and 4.4-fold higher affinity, respectively, than to the single mutant

124 analyses revealed that Efb-N exhibits a much higher affinity for Fg than typically observed with Fg-b

125 We also found that VMAT1 has a higher affinity for tryptamine than VMAT2.