ライフサイエンスコーパス: higher eukaryote

1 ve roles in multiple processes that occur in higher eukaryotes.

2 nticodon 'wobble' position in both yeast and higher eukaryotes.

3 tekeeper role in the proteostasis network of higher eukaryotes.

4 res many conserved biological functions with higher eukaryotes.

5 replication of G-quadruplex DNA (G4 DNA) in higher eukaryotes.

6 by a complex, replication-coupled pathway in higher eukaryotes.

7 basis and regulation of NAD(+) metabolism in higher eukaryotes.

8 ) subunits present in both budding yeast and higher eukaryotes.

9 and non-randomly organized in the nucleus of higher eukaryotes.

10 functional diversification between lower and higher eukaryotes.

11 ng nucleosomes, much like heterochromatin in higher eukaryotes.

12 ination is not well defined, particularly in higher eukaryotes.

13 -tail signaling pathway is poorly defined in higher eukaryotes.

14 e versatile regulators of gene expression in higher eukaryotes.

15 an essential strategy for gene silencing in higher eukaryotes.

16 fects of oxidative stress on mitochondria in higher eukaryotes.

17 d for formation of extracellular matrices in higher eukaryotes.

18 ransposons and other repeat elements in many higher eukaryotes.

19 of lysosomes where it is typically found in higher eukaryotes.

20 s underlying the developmental ontologies of higher eukaryotes.

21 rnal modification of messenger RNA (mRNA) in higher eukaryotes.

22 ll migration and neuronal differentiation in higher eukaryotes.

23 So far, no CaM gene deletion was reported in higher eukaryotes.

24 s, morphogenesis, and the development of all higher eukaryotes.

25 oxidase site is identified in ferritins from higher eukaryotes.

26 s highly conserved from unicellular yeast to higher eukaryotes.

27 tion as a widespread regulatory mechanism in higher eukaryotes.

28 arches in transcriptional gene regulation in higher eukaryotes.

29 echanisms controlling Cdc14B phosphatases in higher eukaryotes.

30 described, process of ribosome biogenesis in higher eukaryotes.

31 dreds of nuclear and cytoplasmic proteins in higher eukaryotes.

32 lamina is a key step during open mitosis in higher eukaryotes.

33 he regulation of transcription initiation in higher eukaryotes.

34 oper selection of DNA replication origins in higher eukaryotes.

35 rs and their target genes are commonplace in higher eukaryotes.

36 lymerase 1 (PARP1), a chromatin regulator in higher eukaryotes.

37 basis and regulation of NAD(+) metabolism in higher eukaryotes.

38 important genes in the genomes of almost all higher eukaryotes.

39 ary development of redundant NLSs in NXF1 of higher eukaryotes.

40 se proteins are used for "genome editing" in higher eukaryotes.

41 ssential roles in the chromatin structure of higher eukaryotes.

42 d is a major source for protein diversity in higher eukaryotes.

43 that are generally common to those found in higher eukaryotes.

44 80CTR and DNA-PKcs only occur in a subset of higher eukaryotes.

45 chaperone, called Scm3 in yeast and HJURP in higher eukaryotes.

46 environments, including during infection of higher eukaryotes.

47 nscriptional repression and silencing in all higher eukaryotes.

48 ations impact the function of H1 variants in higher eukaryotes.

49 ionally analogous to the mucus secretions of higher eukaryotes.

50 or proteome expansion and gene regulation in higher eukaryotes.

51 tical roles in maintaining sterol balance in higher eukaryotes.

52 n clathrin-mediated endocytosis in yeast and higher eukaryotes.

53 T corresponds to the mediator head module of higher eukaryotes.

54 are critical regions for gene regulation in higher eukaryotes.

55 de a mechanism for lethality of Apex loss in higher eukaryotes.

56 protein processing are poorly understood in higher eukaryotes.

57 a C-terminal domain (CTD) that is unique to higher eukaryotes.

58 tes a pre-rRNA processing event specific for higher eukaryotes.

59 er networks, such as functional networks for higher eukaryotes.

60 synthesized acid hydrolases to lysosomes in higher eukaryotes.

61 is a predominant form of gene regulation in higher eukaryotes.

62 lex may also function in RNA surveillance in higher eukaryotes.

63 with the preferred methylation consensus of higher eukaryotes.

64 clear how recovery and fork restart occur in higher eukaryotes.

65 ents (TEs) are major sources of new exons in higher eukaryotes.

66 identify TFs and cis regulatory elements in higher eukaryotes.

67 nderstanding of NE structure and function in higher eukaryotes.

68 either of these types of microorganisms with higher eukaryotes.

69 MN), a multifunctional protein essential for higher eukaryotes.

70 erved organelles present in basal as well as higher eukaryotes.

71 n unicellular organisms, but is mitigated in higher eukaryotes.

72 rototype for understanding related events in higher eukaryotes.

73 logue of the AMP-activated protein kinase in higher eukaryotes.

74 of CCT activity by this PLP have emerged in higher eukaryotes.

75 3, appears to be conserved for 60S export in higher eukaryotes.

76 ver, little is known about MOF regulation in higher eukaryotes.

77 molog of the AMP-activated protein kinase of higher eukaryotes.

78 y pathway, most of which have orthologues in higher eukaryotes.

79 ively occupy the majority of genome space in higher eukaryotes.

80 decapping activities and mRNA metabolism in higher eukaryotes.

81 e believe are present in low copy numbers in higher eukaryotes.

82 understood mechanism for gene regulation in higher eukaryotes.

83 l model for the reduction of histone load in higher eukaryotes.

84 ant role in the complex splicing observed in higher eukaryotes.

85 ficking some secretory proteins in yeast and higher eukaryotes.

86 patterns that more closely resemble those of higher eukaryotes.

87 centromeric cohesion of sister chromatids in higher eukaryotes.

88 presence is well conserved both in lower and higher eukaryotes.

89 is the primary nitric oxide (NO) receptor in higher eukaryotes.

90 ed and general feature of gene expression in higher eukaryotes.

91 re the fidelity of chromosome segregation in higher eukaryotes.

92 ression and chromatin structure/stability in higher eukaryotes.

93 are organized nonrandomly in the nucleus of higher eukaryotes.

94 n certain yeast strains, but barely found in higher eukaryotes.

95 omplexes also encounter replication forks in higher eukaryotes.

96 ses that shape the complex transcriptomes of higher eukaryotes.

97 complexes is largely unknown, especially in higher eukaryotes.

98 ernative MPC subunits have been described in higher eukaryotes.

99 derstood how CDC6 activity is constrained in higher eukaryotes.

100 mechanisms at the inner nuclear membrane of higher eukaryotes.

101 % of all alternative splicing (AS) events in higher eukaryotes.

102 ay critical roles in chromatin compaction in higher eukaryotes.

103 as a cell-specific mRNA labeling reagent in higher eukaryotes.

104 G-protein-based symmetry-breaking systems of higher eukaryotes.

105 restoring small linear chromosome numbers in higher eukaryotes.

106 kely relevant for development and disease in higher eukaryotes.

107 egulatory axis in controlling development in higher eukaryotes.

108 and as the first independent I9 inhibitor in higher eukaryotes.

109 ay play a role in lysosomal acidification in higher eukaryotes.

110 nisms targeting genes and repeat elements in higher eukaryotes.

111 genomic fragments for genetic engineering of higher eukaryotes.

112 r poses a significant information problem in higher eukaryotes.

113 Bub3 activity and chromosome congression in higher eukaryotes.

114 ike the unfolded protein response pathway in higher eukaryotes.

115 omic diversity, which is likely unique among higher eukaryotes.

116 ation of genome stability by nuclear RNAi in higher eukaryotes.

117 reas RNMTL1 appears to have evolved later in higher eukaryotes.

118 are subject to restricted nuclear export in higher eukaryotes.

119 important means of diversifying function in higher eukaryotes.

120 for homologues of Rgf1p in budding yeast and higher eukaryotes.

121 hannel synthesis being controlled by Mg2+ in higher eukaryotes.

122 ted gene families that are commonly found in higher eukaryotes.

123 posons and other repetitive elements in many higher eukaryotes.

124 fication present in the messenger RNA of all higher eukaryotes.

125 of monomeric actin (G-actin) within cells of higher eukaryotes.

126 nserved during evolution from prokaryotes to higher eukaryotes, a detailed evolutionary assessment of

127 In higher eukaryotes, a variety of proteins are post-transl

128 homologues initiate mismatch repair and, in higher eukaryotes, act as DNA damage sensors that can tr

129 to post-replicative DNA repair in yeast and higher eukaryotes and accumulates at sites of laser-indu

130 hat are conserved in homologous complexes in higher eukaryotes and are reported to interact with modi

131 s notion that the enzyme is non-essential in higher eukaryotes and cautions against targeting the enz

132 es applicable to numerous species, including higher eukaryotes and humans.

133 tif found in critical regulatory proteins of higher eukaryotes and in certain species of bacteria.

134 s a modified base present in the mRNA of all higher eukaryotes and in Saccharomyces cerevisiae, where

135 r tryptophan restriction extends lifespan in higher eukaryotes and increased proline or tryptophan le

136 hanges with target loci is unprecedented for higher eukaryotes and indicates that most repair events

137 st-translational modification that occurs in higher eukaryotes and is involved in cell-cell communica

138 Cellular messenger RNA (mRNA) of higher eukaryotes and many viral RNAs are methylated at

139 cies of the dinucleotides CpG (suppressed in higher eukaryotes and most RNA viruses) and UpA (suppres

140 he mechanism of ATG3 recruitment by ATG12 in higher eukaryotes and place ATG12 among the members of s

141 d by catalytic residues in the two conserved Higher Eukaryotes and Prokaryotes Nucleotide-binding (HE

142 cytoplasmic filaments of the NPC specific to higher eukaryotes and provides a multitude of binding si

143 g controls a myriad of cellular processes in higher eukaryotes and similar signaling pathways are evo

144 nservation of NatA biochemical properties in higher eukaryotes and uncover specific and essential fun

145 ional chromatin states between the algae and higher eukaryotes and uncovered regulatory components at

146 nt DNA double-strand break repair pathway in higher eukaryotes) and is stimulated by XLF.

147 PTS2 processing upon import is conserved in higher eukaryotes, and in watermelon the glyoxysomal pro

148 roles in organization of complex genomes of higher eukaryotes, and their coordinated actions appear

149 Centromeres in most higher eukaryotes are composed of long arrays of satelli

150 Centromeres of higher eukaryotes are defined by the epigenetic inherita

151 Centromeres of higher eukaryotes are epigenetically defined by centrome

152 Centromeres of higher eukaryotes are epigenetically maintained; however

153 Centromeres of higher eukaryotes are epigenetically marked by the centr

154 ance systems that respond to such defects in higher eukaryotes are not clear.

155 eukaryotes is well understood, but events in higher eukaryotes are not.

156 that the Trf4p/Air2p complex is conserved in higher eukaryotes as well as in yeast and that the TRAMP

157 dictate asymmetric cell division in diploid, higher eukaryotes as well.

158 e them are also used in antiviral defense in higher eukaryotes, as they are in plants and lower eukar

159 le to assume that this mechanism operates in higher eukaryotes, as well.

160 nly a few centromeres have been sequenced in higher eukaryotes because of their repetitive nature, th

161 ts N terminus, and is highly conserved among higher eukaryotes, being a member of a family of exonucl

162 The strap is conserved in higher eukaryotes but absent from yeast and prokaryotes

163 This protein has homologs not only in higher eukaryotes but also in bacteria, fungi, and plant

164 interactions are physiologically relevant in higher eukaryotes but also indicate that these interacti

165 owth of cells ranging from microorganisms to higher eukaryotes, but its molecular targets are largely

166 ndoplasmic reticulum and nuclear envelope of higher eukaryotes, but what it does and how changes caus

167 thin pericentromeric heterochromatin in most higher eukaryotes, but, interestingly, it can show euchr

168 Such conjecture has been supported in higher eukaryotes by direct studies of several individua

169 sical unfolded protein response, mediated in higher eukaryotes by transcriptional changes.

170 covering the posttranscriptional networks in higher eukaryotes can help our understanding of the link

171 Higher eukaryotes can thus control low rates of near irr

172 esidues on cytosolic and nuclear proteins of higher eukaryotes catalyzed by O-GlcNAc transferase (OGT

173 on or reduction of FIT proteins in yeast and higher eukaryotes causes LDs to remain in the ER membran

174 A occurs and what its potential roles are in higher-eukaryote cells remain unknown.

175 In higher eukaryotes, centromeres are typically composed of

176 R)-plasma membrane (PM) contacts in cells of higher eukaryotes concerns proteins implicated in the re

177 DNA repair by non-homologous end-joining in higher eukaryotes, consists of a catalytic subunit (DNA-

178 spite much progress, it is still unclear why higher eukaryotes contain multiple core histone genes, h

179 Although higher eukaryotes contain multiple TAF variants that spe

180 e find that the C-terminal domain of OS-9 in higher eukaryotes contains "mammalian-specific insets" t

181 udy thus reveals a unique mechanism by which higher eukaryotes deal with the collateral effect of sil

182 ve organism to study cytokinesis as it, like higher eukaryotes, divides using a contractile actomyosi

183 In higher eukaryotes, DNA DSBs are predominantly repaired b

184 ation is relatively limited, particularly in higher eukaryotes, due to technical difficulties stemmin

185 We suggest that "silencing" in higher eukaryotes (e.g., by Polycomb or HP1) follows sim

186 Knockdown of UAP56 [2, 3] and NXF1 [4-7] in higher eukaryotes efficiently blocks mRNA export, wherea

187 yeast harbors only one such factor (Mex67p), higher eukaryotes encode multiple NXFs.

188 Higher eukaryotes encode various Y-family DNA polymerase

189 Higher eukaryotes express repeated copies of three close

190 ies that are conserved from bacteria through higher eukaryotes facilitate assembly of the FeS cofacto

191 uine is a micronutrient that is scavenged by higher eukaryotes from the diet and gut microflora.

192 In higher eukaryotes, growth factors promote anabolic proce

193 5 protons to make each ATP, but until now no higher eukaryote has been examined.

194 ts, but the functional equivalent of Srs2 in higher eukaryotes has been elusive.

195 nd long-term effect of ionizing radiation on higher eukaryotes has been well documented, we do not ha

196 The extensive alternative splicing in higher eukaryotes has initiated a debate whether alterna

197 ces cerevisiae Sae2 and its ortholog CtIP in higher eukaryotes have a conserved role in the initial p

198 Higher eukaryotes have channels, such as gap junctions a

199 Many higher eukaryotes have evolved strategies for the matern

200 Higher eukaryotes have two complexes, condensin I and co

201 in bacterial and viral pathogens as well as higher eukaryotes, have evolved to inhibit and fine-tune

202 In higher eukaryotes, heritable gene silencing is associate

203 signaling extends the life span in yeast and higher eukaryotes; however, the mechanisms are not compl

204 owever, mechanistic insights into the HSR in higher eukaryotes, in particular in mammals, are limited

205 Two isoforms of CCT appear to be present in higher eukaryotes, including Drosophila melanogaster, wh

206 teria to mediating the action of hormones in higher eukaryotes, including human.

207 cies in craniofacial and limb development in higher eukaryotes, including split hand and foot malform

208 evidence suggests that UPRT homologues from higher-eukaryotes, including Drosophila, are incapable o

209 In higher eukaryotes, increasing evidence suggests, gene ex

210 ) plays a central role in DNA replication in higher eukaryotes, initiating synthesis on both leading

211 The best understood PCD pathway in higher eukaryotes is apoptosis although emerging evidenc

212 Protein fate in higher eukaryotes is controlled by three complexes that

213 The existence of a DPC protease in higher eukaryotes is inferred from data in Xenopus laevi

214 1/RAD50/NBS1 (MRN) complex in end joining in higher eukaryotes is less certain.

215 Our findings suggest that UPRT from all higher eukaryotes is likely enzymatically active in vivo

216 Oxygen sensing via the Cys-Arg/N-end rule in higher eukaryotes is linked through a single mechanism t

217 Mitosis in higher eukaryotes is marked by the sequential assembly o

218 trates that regulation of O-mannosylation in higher eukaryotes is more complex than envisioned, and t

219 Ribosomal protein (RP) expression in higher eukaryotes is regulated translationally through t

220 Elongator in higher eukaryotes is required for normal growth and deve

221 anism in genome defense and RNA silencing in higher eukaryotes is suggested.

222 tegy to achieve regulated gene expression in higher eukaryotes is to prevent illegitimate signal-inde

223 Alternative splicing (AS), in higher eukaryotes, is one of the mechanisms of post-tran

224 In higher eukaryotes, loss of cytoplasmic ribosomal protein

225 ound in the mitochondria and chloroplasts of higher eukaryotes, mammalian nuclei, and many other bact

226 strates for the alkyltransferase proteins in higher eukaryotes might, by analogy, signal such lesions

227 In higher eukaryotes, mtRNAP requires two transcription fac

228 Higher eukaryotes must adapt a totipotent genome to spec

229 sports features of heterochromatin found in higher eukaryotes, namely cytosine methylation (5mC), me

230 In higher eukaryotes, nuclear pore assembly begins with the

231 Because postmitotic cells in higher eukaryotes often do not starve, we developed a mo

232 ignaling pathway of bacteria--is found among higher eukaryotes only in plants, where it regulates div

233 binds to specific DNA elements; however, in higher eukaryotes, ORC exhibits little sequence specific

234 In higher eukaryotes, ORC lacks sequence-specific DNA bindi

235 in which to elucidate consequences of GD for higher eukaryotes, owing to their propensity for chromos

236 position CTD kinases have been identified in higher eukaryotes: P-TEFb and CDK12/CyclinK.

237 messenger RNA 3'-end processing machinery in higher eukaryotes, participating in both the polyadenyla

238 Targeting endogenous protein complexes of higher eukaryotes, particularly in large-scale efforts,

239 tissue specification and differentiation in higher eukaryotes, particularly man, remains limited.

240 dentification of i6A37-containing tRNAs in a higher eukaryote, performed using small interfering RNA

241 Compared to higher eukaryotes, Plasmodium parasites have a fundament

242 iscovery of interchromosomal interactions in higher eukaryotes points to a functional interplay betwe

243 In higher eukaryotes, proteins containing DENN-domains comp

244 In higher eukaryotes, reductions of H3K9me3 and DNA methyla

245 that control this PtdIns4P pool in cells of higher eukaryotes remain elusive.

246 nd bacteria, the mechanism of DNA priming in higher eukaryotes remains poorly understood in large par

247 ciently demonstrated, its biological role in higher eukaryotes remains poorly understood.

248 ated reaction; in contrast, its mechanism in higher eukaryotes remains unclear.

249 e possibility that appearance of this PTM in higher eukaryotes represents an evolutionary substitutio

250 polyadenylation) sites from a broad range of higher eukaryotes reveals a conserved core pattern of th

251 In higher eukaryotes, secretory vesicles are transported to

252 verall our data indicate that Neurospora and higher eukaryotes share a common mechanism for the signa

253 sed hypothesis is suggested to apply also to higher eukaryotes, since the key components are conserve

254 e data indicate that NF45 and NF90 are novel higher-eukaryote-specific factors required for the matur

255 r yeast heterohexameric counterparts, but in higher eukaryotes such as Drosophila, MCM-associated DNA

256 Small RNAs are well described in higher eukaryotes such as mammals and plants; however, k

257 The expansion of the ATG8 family in higher eukaryotes suggests that specific interactions wi

258 through much more diversified mechanisms in higher eukaryotes than previously thought.

259 emonstrate a mechanism for RNR regulation in higher eukaryotes that acts by enhancing allosteric RNR

260 mologous type IA TOP3alpha and TOP3beta from higher eukaryotes that also have multiple 4-Cys zinc rib

261 enabling insertional mutagenesis screens in higher eukaryotes that are not amenable to germline tran

262 or the mechanistic pathway in ferritins from higher eukaryotes that drive uptake of bivalent cation a

263 d component of the telomerase RNP complex in higher eukaryotes that is required for maximal enzyme ac

264 During evolution of higher eukaryotes that utilize vitamin B12, the high rea

265 In higher eukaryotes, the APC/C works with the E2 enzyme UB

266 Within the secretory pathway of higher eukaryotes, the core of these glycans is frequent

267 In higher eukaryotes, the endoplasmic reticulum (ER) contai

268 ion of the dynein motor domain from yeast to higher eukaryotes, the extensively studied S. cerevisiae

269 n metabolism differ drastically in fungi and higher eukaryotes, the glutaredoxins are conserved, yet

270 In Saccharomyces cerevisiae and higher eukaryotes, the loading of the replicative helica

271 ng pathways in different hosts.IMPORTANCE In higher eukaryotes, the majority of transcribed RNAs do n

272 Instead, our data show that, like other higher eukaryotes, the MCM complex in plants remains in

273 In higher eukaryotes, the microRNA biogenesis enzyme Dicer

274 In higher eukaryotes, the mitochondrial GTPase Miro binds M

275 ediate are probably identical in insects and higher eukaryotes, the presence or absence of this speci

276 In higher eukaryotes, the related actin depolymerizing fact

277 Thus, in higher eukaryotes, there appears to be redundancy betwee

278 Similar to 'enhancer-blocking insulators' in higher eukaryotes, these factors shield the proximal pro

279 In higher eukaryotes, these processes are important for pre

280 d copper-responsive transcription factors in higher eukaryotes, these studies may yield important ins

281 ive splicing (AS) of pre-mRNA is utilized by higher eukaryotes to achieve increased transcriptome and

282 s a powerful tool but has been restricted in higher eukaryotes to artificial cell lines and reporter

283 ed DNA, mismatch repair enzymes are known in higher eukaryotes to directly signal cell cycle arrest a

284 Alternative splicing enables higher eukaryotes to increase their repertoire of protei

285 In higher eukaryotes, transfer RNAs (tRNAs) with the same a

286 In higher eukaryotes, up to 70% of genes have high levels o

287 It is well established that higher eukaryotes use alternative splicing to increase p

288 Many signaling pathways in higher eukaryotes use Ras-like small GTPases.

289 sults revealed that most prokaryotes and all higher eukaryotes utilize Mo whereas many unicellular eu

290 the structure and function of the genomes of higher eukaryotes was under-appreciated.

291 In higher eukaryotes we find a strong enhancement of Z-form

292 y the physiological significance of Cdc20 in higher eukaryotes, we generated hypomorphic mice that ex

293 s, but little is known about this process in higher eukaryotes, where genomes and chromosomes are muc

294 an integral component of the CSN complex in higher eukaryotes, where it is essential for life.

295 starvation, this pathway is also present in higher eukaryotes, where it is triggered by stress signa

296 This observation contrasts with higher eukaryotes, where RPS23 is monohydroxylated; the

297 is a crucial factor for the survival of most higher eukaryotes which depend on class II photolyases t

298 g greater degrees of chromatin compaction in higher eukaryotes, which have evolved several mechanisms

299 major contribution to proteomic diversity in higher eukaryotes with approximately 70% of genes encodi

300 2A.Z-containing pericentric chromatin, as in higher eukaryotes with regional centromeres, is importan