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1                                Our estimates highlight the need for 2 important efforts: planning for
2                               These findings highlight the need for a better understanding of the est
3                                These results highlight the need for a general method to extract the t
4 ts of nitrogen-regulated gene expression and highlight the need for a quantitative approach to study
5 tions emphasize its public health threat and highlight the need for a vaccine.
6 omic status among African-American women and highlight the need for additional evidence to more thoro
7 s that store or use hazardous chemicals, and highlight the need for additional regulations to prevent
8 cognition of L. monocytogenes in the gut and highlight the need for additional studies on the interac
9 ul for future planning of manpower needs and highlight the need for aggressive prevention of complica
10 quality and health cobenefits of biochar use highlight the need for an improved understanding of bioc
11 ings are particularly important because they highlight the need for an in vivo approach that accurate
12                                These results highlight the need for and facilitate the development of
13                                           We highlight the need for applied programs to include hypot
14                                     Here, we highlight the need for approaches that complement RNA-se
15 can be readily translated into practice, but highlight the need for appropriate patient, drug and dos
16                                  The results highlight the need for better coastal planning and manag
17                       Recent clinical trials highlight the need for better models to identify patient
18                               These findings highlight the need for better risk assessment tools amon
19                       Our findings in Brazil highlight the need for better understanding of long-term
20 ediating myostatin and activin signaling and highlight the need for blocking both receptors to achiev
21                                  Our results highlight the need for careful modelling of nonlineariti
22              Margaret McNairy and colleagues highlight the need for clinical decision tools to help i
23                                 Our findings highlight the need for clinicians to actively screen for
24   The frequency and severity of Blau uveitis highlight the need for close ophthalmologic surveillance
25                               These findings highlight the need for considering normative sex-related
26                                 These issues highlight the need for continued synthesis between fossi
27                               These findings highlight the need for detailed entomological data, base
28 een synapsis and recombination in barley and highlight the need for detailed studies of meiosis in no
29                               These findings highlight the need for earlier diagnosis of FH and initi
30                                 Our findings highlight the need for early hypertension treatment to m
31                               These findings highlight the need for early interventions that can impr
32                                     Findings highlight the need for educational campaigns regarding h
33                               These findings highlight the need for epidemiological studies and anima
34 ing GPP under current and future climate; we highlight the need for experimental studies to identify
35                                These results highlight the need for explicit quantitative modeling wh
36                             Our results thus highlight the need for exploring alternative roles for m
37 d the continuing diagnosis of new MERS cases highlight the need for finding therapeutics for these di
38                               These findings highlight the need for focused and pragmatic randomized
39                                 Our findings highlight the need for further analysis of the T cells i
40 IST expression and non-random X inactivation highlight the need for further culture improvement.
41 fferentiation over the last 80,000 years, we highlight the need for further evaluation of the effects
42 in patients with acute coronary syndrome and highlight the need for further investigation in this are
43                               These findings highlight the need for further investigation of the effe
44 utline several economic arguments we believe highlight the need for further investment in alternative
45 ese findings have important implications and highlight the need for further research on factors affec
46 er N addition over a range of ecosystems and highlight the need for further studies on the response o
47                                  The results highlight the need for general vision screenings for all
48                                These results highlight the need for healthcare providers to ensure gu
49 es when the molecular clock is violated, and highlight the need for improving the computational effic
50 e-associated outbreaks via medical equipment highlight the need for infectious disease professionals
51 scent brain and school performance, and thus highlight the need for informed interventions.
52 ding of Bcc infection in non-CF patients and highlight the need for interventions to improve their ou
53                                 Our findings highlight the need for larger studies and prospective co
54                                These results highlight the need for local, community-based investigat
55 e poised for drastic changes in function and highlight the need for long-term, factorial experiments.
56  acquired drug resistance are concerning and highlight the need for longer-term follow-up studies.
57 itating effects on the developing child, and highlight the need for molecularly targeted treatments w
58                                  Our results highlight the need for more detailed studies of tree phy
59 s variation in the context of adaptation and highlight the need for more empirical studies focused on
60                              These anomalies highlight the need for more psychological work.
61 f future interventional clinical trials, and highlight the need for more sensitive diagnostic tests a
62 as well as high rates of angina readmission, highlight the need for more targeted interventions to re
63  optimal glycemic control in type 2 diabetes highlight the need for new therapies.
64 ing the diagnosis of CanL are underscored to highlight the need for novel diagnostic test development
65 nces in behavioural responses to atomoxetine highlight the need for patient stratification in future
66 for the importance of thrombus stability and highlight the need for physiologically relevant tests to
67                  Recent infectious outbreaks highlight the need for platform technologies that can be
68 n cases of suspected Parkinson's disease and highlight the need for precision in the neurological exa
69 nts in an unselected patient population, and highlight the need for predictive biomarkers in the trea
70                 However, conflicting results highlight the need for prospective validation in large,
71                                           We highlight the need for quantitative flux analysis to stu
72                                           We highlight the need for refined diagnostic tools and effe
73                                   These data highlight the need for research into prevention of infla
74 y-sample approach in cytometric analysis and highlight the need for scalable clustering algorithms to
75 r to those identified in multiple sclerosis, highlight the need for scales to have strong conceptual
76 ts to probe microscopic mechanisms, and they highlight the need for single-molecule measurements.
77 hanges in post-ST-segment-elevation MI edema highlight the need for standardization of CMR timing to
78                               These findings highlight the need for standardized approaches as ROP te
79 t in treatment delay during the study period highlight the need for standardized diagnostic routines
80 n the clinical course of burn patients would highlight the need for standardized protocols.
81                                    They also highlight the need for studies that define in vivo effec
82 uses and consequences of social immunity, we highlight the need for studies that evaluate the effects
83                         Our results not only highlight the need for theoretical models of graphene to
84                                These results highlight the need for users of rainfall datasets to qua
85 ation of the individually linked survey also highlighted the need for a comprehensive list of HFs and
86 uring the 2014 Ebola outbreak in West Africa highlighted the need for a global, centralized database
87 te with protection against dengue virus have highlighted the need for a human DENV challenge model to
88          The 2014 Zaire Ebola virus outbreak highlighted the need for a safe, effective vaccine with
89                         This information has highlighted the need for better stent size selection for
90                                This outbreak highlighted the need for careful monitoring of all unexp
91 differential for certain bacteria, our study highlighted the need for further evaluation of the most
92  The search for a cure for HIV infection has highlighted the need for increasingly sensitive and prec
93 ed by borders or eliminated by vaccines have highlighted the need for proper training of all resident
94  airports, and recent terrorist attacks have highlighted the need for reliable analytical instrumenta
95 ization of coal ash into the environment has highlighted the need for the assessment of the environme
96 nt infectious disease outbreaks have further highlighted the need for vaccines that can achieve full
97 half of the amnestic amyloid-negative cases, highlighting the need for a clinical framework and termi
98 iple tests, IA can be excluded or confirmed, highlighting the need for a combined diagnostic strategy
99  gas phase is becoming increasingly popular, highlighting the need for a greater understanding of how
100 bstantially in their structure and dynamics, highlighting the need for a simple and flexible framewor
101  between axon growth and behavioral outcome, highlighting the need for additional strategies to optim
102 bit low overlap across the three dimensions, highlighting the need for an integrative approach for bi
103 re likely to be lower than in surface water, highlighting the need for analytical thiol quantificatio
104 ant disparity in delisting practices by sex, highlighting the need for better assessments of sickness
105 es as a possible risk factor for stillbirth, highlighting the need for better skilled care during del
106 able toxicity at clinically effective doses, highlighting the need for better understanding LAM's mol
107 However, almost 40% of athletes die at rest, highlighting the need for complementary preventive strat
108 ing optimum targets continue to be reported, highlighting the need for computational CRISPR targeting
109 humans or cause human-to-human transmission, highlighting the need for continued vigilance.
110 ntly associated with higher rates of events, highlighting the need for continuous monitoring of the s
111 sizes than the enzymatic digestion approach, highlighting the need for development of robust plant di
112  to a failure to effectively engage in care, highlighting the need for differentiated care models.
113 children's risk for psychological disorders, highlighting the need for effective interventions, espec
114 ay affect deep well formation sustainability highlighting the need for effective PPW management.
115 ped world associated with an ageing society, highlighting the need for effective treatment options.
116 l tumors with a 5-year survival rate of 50%, highlighting the need for further STS research.
117 reveal the paucity of high-quality evidence, highlighting the need for further targeted research.
118 emporal variation within climatic scenarios, highlighting the need for future studies to incorporate
119  genetic complexity has been underestimated, highlighting the need for greater conservation efforts f
120 the overall quality of the evidence was low, highlighting the need for high-quality medical education
121 ubstantially smaller per-area CH4 emissions, highlighting the need for improvements in such models.
122 numerical parity between genders is reached, highlighting the need for increased efforts to combat su
123 jects, treatment significantly increases IR, highlighting the need for metabolic health monitoring wi
124  inevitably become resistant to bevacizumab, highlighting the need for more effective antiangiogenic
125  patients remain unresponsive to anxiolytics highlighting the need for more effective, mechanism-base
126 gest high MRSA pathogenicity in dental wards highlighting the need for more efficient surveillance/in
127 target toxicities in normal, healthy tissue, highlighting the need for more tumor-selective chemother
128 osis, treatment with SOF/RBV was suboptimal, highlighting the need for new therapies for this populat
129 commended for immunocompromised individuals, highlighting the need for new therapies.
130 IV and HCV have not been successful, thereby highlighting the need for novel approaches to circumvent
131  prevent hypoglycemia are often ineffective, highlighting the need for novel therapies.
132 ce and frequency in 60% of areas after 2008, highlighting the need for ongoing surveillance.
133 T1, demonstrating phenotypic variability and highlighting the need for ophthalmic review of these pat
134 unced in adolescents than in young children, highlighting the need for raising public health awarenes
135 non-viral) pose additional limitations, thus highlighting the need for safer and more deterministic i
136 nly investigated when studying reproduction, highlighting the need for sex parity in future studies.
137 in the spectra of 2D materials such as MoS2, highlighting the need for stable solvents and exfoliatio
138 dentified burden ofT. evansiin local cattle, highlighting the need for surveillance of this infection
139 ferences were found between USAAs and FBAAs, highlighting the need for tailored strategies for preven
140 g cause of diarrhea in developing countries, highlighting the need for the development of new treatme
141 umber of malignancies and cancer stem cells, highlighting the need for the identification and develop
142 EGFR TKIs target the ATP-site of the kinase, highlighting the need for therapeutic agents with altern
143 lapse remain challenging in this population, highlighting the need for validated models to predict al
144 nation of an emerging infectious disease and highlights the need for a coordinated global response to
145  resources among patients and health centres highlights the need for a health-system-wide approach to
146                                    Our study highlights the need for a more holistic study of climate
147                                         This highlights the need for a worldwide reassessment of biod
148 t to both ice-only and liquid-bearing clouds highlights the need for accurate cloud representations i
149                            However, it still highlights the need for additional epidemiological studi
150 entification of multidrug-resistant isolates highlights the need for additional measures to respond t
151 ntibody-based isolation and analysis systems highlights the need for alternative methods.
152 ivity of past ice sheets to volcanic ashfall highlights the need for an accurate coupling between atm
153 tter understanding of the WAF components and highlights the need for better experimental and theoreti
154                                   This study highlights the need for better regional coordination, es
155                                         This highlights the need for better understanding of the effe
156  high prevalence of IDH1 mutations in glioma highlights the need for brain-penetrant IDH1 mutant-sele
157 ns; and its association with cardiac myxoma, highlights the need for cardiac investigations in all pa
158                                         This highlights the need for careful patient monitoring in al
159 cation bias in the outcome used in the study highlights the need for caution when a difference-in-dif
160                                 This finding highlights the need for cautious use of APs in patients
161                            This finding also highlights the need for characterizing areas suitable fo
162               We discuss a recent study that highlights the need for clarity about the causal path by
163                                 This article highlights the need for clinical guidance about ACOS, su
164                                         This highlights the need for clinicians to be aware of the in
165                                    This work highlights the need for combined quantitative histologic
166 revalence and disease burden of elevated BMI highlights the need for continued focus on surveillance
167 pearance of H7N8 viruses in domestic poultry highlights the need for continued influenza surveillance
168 rther regional expansion of this novel clone highlights the need for continued strengthening of case-
169                              Thus, our study highlights the need for deeper characterization of very
170 a therapy may not prove to be successful and highlights the need for detailed pharmacogenomic analyse
171                                    Our study highlights the need for experiments with multiple, inclu
172 mall rivers can emit significant methane and highlights the need for further studies on the link betw
173                                    This work highlights the need for future study of how changes in u
174                             This new finding highlights the need for future surveillance of GPV-QH15
175 er populations using standard approaches and highlights the need for generalized risk prediction meth
176                                   This study highlights the need for improved risk stratification on
177 esistance to a last resort antimicrobial and highlights the need for improved surveillance to identif
178 ase incursion will affect model accuracy and highlights the need for improvements in these areas.
179                             This observation highlights the need for improving in silico predictions
180 g redistribution of known invasive pests and highlights the need for international cooperation to slo
181                                         This highlights the need for large-scale collaborative approa
182 tates in determining the legality of KPD and highlights the need for legal clarity and flexibility as
183 equelae limits its utility in the clinic and highlights the need for limiting Treg cell activity with
184               The recent Zika virus outbreak highlights the need for low-cost diagnostics that can be
185                        Altogether, our study highlights the need for mechanism-guided targeting of an
186 owever, the narrow reach of this action also highlights the need for more comprehensive, precautionar
187                  Although this meta-analysis highlights the need for more high-quality placebo-contro
188                     Hence, the present study highlights the need for more research focusing on the im
189 gal keratitis recorded in the present study, highlights the need for nationwide study on fungal kerat
190      The emergence of drug-resistant malaria highlights the need for new agents.
191 ruses with resistance to approved antivirals highlights the need for new anti-influenza therapeutics.
192 rum including artemisinin-tolerant parasites highlights the need for new antimalarials.
193                                           It highlights the need for prophylactic therapy, especially
194 rrelation with disease duration and severity highlights the need for rapid diagnosis and adequate imm
195 nce poses new threats to longer-term use and highlights the need for rational drug development.
196                                 This finding highlights the need for renal preventive measures and in
197 istribution, and number of nations affected, highlights the need for safe, effective, and readily ava
198                                 This finding highlights the need for sex-specific and cycle-specific
199 culty in generating accurate gene models and highlights the need for the establishment of stable cult
200                                   This study highlights the need for the inclusion of particulate nit
201 nt with redundancy in chemokine pathways and highlights the need for therapies blocking multiple path
202                                   This study highlights the needs for better indicators and tools by
203                                  Our results highlight the need of evaluating antiretroviral effects
204 immunotherapy for these elderly patients and highlight the need of prospective clinical trials.
205 ation in the early phase of adipogenesis and highlight the need of studying adipogenesis in vivo.
206 uestionnaire-based epidemiologic studies and highlights the need of better definitions for this patie
207 ble explanation for the observed pattern and highlights the need of better understanding human mobili
208 s of reef rugosity in a warming climate, and highlights the need of combining local (protecting and r
209                                 Our findings highlight the need to address financial burden in this p
210                                  Our results highlight the need to address several ecosystem function
211                  INTERPRETATION: Our results highlight the need to address the issue of higher preval
212 sophisticated nutrient cycles, these results highlight the need to adequately understand plant physio
213 viduals of African descent, and our findings highlight the need to assess the contribution of this va
214  may facilitate ecosystem sustainability and highlight the need to assess the effects of climate extr
215                               These findings highlight the need to better define the value, specific
216                                 Our findings highlight the need to better understand effects of sex o
217                                 Our findings highlight the need to better understand the potential he
218                               These findings highlight the need to better understand the risk factors
219                                   These data highlight the need to block multiple evasion and subvers
220 ation by different EGF receptor agonists and highlight the need to characterize network interactions
221 ence higher exposures than their mothers and highlight the need to characterize potential health risk
222  AgRP to POMC neurons is state dependent and highlight the need to consider different types of transm
223                                  The results highlight the need to consider entropy in transition rat
224 D24(-) cells can remain aggressive, and they highlight the need to consider nucCD24 in both fundament
225                                  Our results highlight the need to consider residential proximity to
226                                      Here we highlight the need to define standardized practices for
227 n and diagnosis of multifocal desmoid tumors highlight the need to develop effective systemic treatme
228                                 The findings highlight the need to establish a universal public healt
229 icular, the dynamics of enacted PADDD events highlight the need to explicitly consider PA robustness
230                                These studies highlight the need to focus on prevention and control st
231                               These findings highlight the need to further investigate the effect of
232       Limitations of current antidepressants highlight the need to identify novel treatments for majo
233                                  Our results highlight the need to include impacts on cloud formation
234 olicy makers across Amazonian countries, and highlight the need to include local stakeholders in cons
235                                  Our results highlight the need to integrate mutualisms into trophic
236                                  Our results highlight the need to more fully incorporate ecosystem s
237                      Overall, these findings highlight the need to parse the heterogeneity of MDD by
238                                   These data highlight the need to protect wetlands to mitigate the r
239  turn quality in the Intensive Care Unit and highlight the need to reinforce optimal turning practice
240 ge contribution from uncorrected presbyopia, highlight the need to scale up vision impairment allevia
241 tified an emerging public health concern and highlight the need to strengthen surveillance to detect
242                            Thus our findings highlight the need to study forces exerted and felt by c
243 ed understanding of their disease mechanisms highlight the need to study these pathogens on a molecul
244               Qualitative systematic reviews highlight the need to tailor interventions to each trans
245 ells dominate the tumor microenvironment and highlight the need to target extrinsic as well as intrin
246 edicted from single-species experiments, and highlight the need to understand future marine global ch
247        Taken together, our findings directly highlight the need to understand the critical role of pa
248                              In addition, we highlight the need to validate animal models for these d
249                             Collectively, we highlight the need to: better document the biodiversity
250 ilings placement (DSTP) in coastal zones has highlighted the need to better understand the fate and e
251                        These techniques have highlighted the need to better understand the interplay
252 migration across the Mediterranean Sea, have highlighted the need to better understand the possible e
253 ed the available compounds that inhibit Hv1, highlighted the need to develop better drugs suitable fo
254 nic obstructive pulmonary disease (COPD) has highlighted the need to develop more specific treatments
255 e transmission of T. solium infection, which highlighted the need to intensify the subsequent strateg
256  disrupt PD-L1-mediated tumour tolerance has highlighted the need to understand the molecular regulat
257 late immune responses in adults and infants, highlighting the need to conduct vaccine trials in pedia
258 syndrome at a clinically relevant frequency, highlighting the need to determine the best methods for
259 s, with 264 sites expected by the year 2044, highlighting the need to develop and standardize metrics
260 training rates in the United States are low, highlighting the need to develop CPR educational approac
261 rden of sepsis in resource-limited settings, highlighting the need to establish programmes aiming for
262 onmental impacts for four impact categories, highlighting the need to explicitly consider local impac
263 iversity protection are possible, while also highlighting the need to explicitly link desired conserv
264 ized genes, are generally of low occurrence, highlighting the need to functionally annotate the long
265 rease in morbidity and economic burden, thus highlighting the need to identify methods to limit FVIII
266 y to conventional chemotherapy or radiation, highlighting the need to identify new therapeutic target
267 ts with ALK-mutant neuroblastoma is limited, highlighting the need to improve their effectiveness in
268 has the potential to impact fish demography, highlighting the need to include anthropogenic noise in
269 ession reverses RTT-like phenotypes in mice, highlighting the need to search for therapeutic approach
270 eutic strategy for treating these disorders, highlighting the need to study angiogenesis in more deta
271 is exposed to high pressure and temperature, highlighting the need to study catalysts in realistic en
272 f predictive uncertainty in modeled biomass, highlighting the need to target these processes in futur
273 n part a result of antimicrobial resistance, highlighting the need to uncover novel antibiotic target
274 nd PARP inhibition were cell line-dependent, highlighting the need to understand how these treatments
275 icacy in an orthotopic model of glioblastoma highlights the need to balance significant uptake withou
276  link between protein misfolding and disease highlights the need to better understand the elaborate m
277                                    Our study highlights the need to carefully evaluate the confoundin
278 tion during Ostreopsis blooms and in seafood highlights the need to characterize its toxic effects an
279 rrent state of pharmacology research for CUD highlights the need to consider particular characteristi
280                                   This study highlights the need to consider sampling devices as pote
281                                    Our study highlights the need to consider the functional significa
282                                         This highlights the need to consider the temporal aspects of
283 break, spread by the Aedes aegypti mosquito, highlights the need to create high-quality assemblies of
284                                  Our article highlights the need to determine standardized reporting
285                      Furthermore, this study highlights the need to develop new treatments not depend
286 sorders underscores their critical roles and highlights the need to develop targeted therapies for tr
287 dest efficacy (31.2%) achieved in this trial highlights the need to examine approaches and factors th
288 ns associated with recent ZIKV outbreaks and highlights the need to exert great caution when designin
289 r JNCL that slows disease progression, which highlights the need to explore novel strategies to exten
290                                   This study highlights the need to identify the molecular mechanisms
291                                 Our analysis highlights the need to incorporate forest age profiles i
292                                     Our work highlights the need to measure demographic responses to
293                                   This study highlights the need to more effectively look for ITD's i
294                            The present study highlights the need to perform detailed analysis of AFFF
295         The Asiana Airlines flight 214 crash highlights the need to plan for high use of advanced ima
296 ization and warming-induced respiration, and highlights the need to protect both existing carbon stoc
297                       Importantly, our study highlights the need to record eye movements when studyin
298 ota-directed therapeutics for undernutrition highlights the need to simultaneously consider a variety
299                                    Our study highlights the need to study the impact of prior exposur
300     The growing elderly population worldwide highlights the need to understand how aging promotes CVD

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