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4 ts of nitrogen-regulated gene expression and highlight the need for a quantitative approach to study
6 omic status among African-American women and highlight the need for additional evidence to more thoro
7 s that store or use hazardous chemicals, and highlight the need for additional regulations to prevent
8 cognition of L. monocytogenes in the gut and highlight the need for additional studies on the interac
9 ul for future planning of manpower needs and highlight the need for aggressive prevention of complica
10 quality and health cobenefits of biochar use highlight the need for an improved understanding of bioc
11 ings are particularly important because they highlight the need for an in vivo approach that accurate
15 can be readily translated into practice, but highlight the need for appropriate patient, drug and dos
20 ediating myostatin and activin signaling and highlight the need for blocking both receptors to achiev
24 The frequency and severity of Blau uveitis highlight the need for close ophthalmologic surveillance
28 een synapsis and recombination in barley and highlight the need for detailed studies of meiosis in no
34 ing GPP under current and future climate; we highlight the need for experimental studies to identify
37 d the continuing diagnosis of new MERS cases highlight the need for finding therapeutics for these di
41 fferentiation over the last 80,000 years, we highlight the need for further evaluation of the effects
42 in patients with acute coronary syndrome and highlight the need for further investigation in this are
44 utline several economic arguments we believe highlight the need for further investment in alternative
45 ese findings have important implications and highlight the need for further research on factors affec
46 er N addition over a range of ecosystems and highlight the need for further studies on the response o
49 es when the molecular clock is violated, and highlight the need for improving the computational effic
50 e-associated outbreaks via medical equipment highlight the need for infectious disease professionals
52 ding of Bcc infection in non-CF patients and highlight the need for interventions to improve their ou
55 e poised for drastic changes in function and highlight the need for long-term, factorial experiments.
56 acquired drug resistance are concerning and highlight the need for longer-term follow-up studies.
57 itating effects on the developing child, and highlight the need for molecularly targeted treatments w
59 s variation in the context of adaptation and highlight the need for more empirical studies focused on
61 f future interventional clinical trials, and highlight the need for more sensitive diagnostic tests a
62 as well as high rates of angina readmission, highlight the need for more targeted interventions to re
64 ing the diagnosis of CanL are underscored to highlight the need for novel diagnostic test development
65 nces in behavioural responses to atomoxetine highlight the need for patient stratification in future
66 for the importance of thrombus stability and highlight the need for physiologically relevant tests to
68 n cases of suspected Parkinson's disease and highlight the need for precision in the neurological exa
69 nts in an unselected patient population, and highlight the need for predictive biomarkers in the trea
74 y-sample approach in cytometric analysis and highlight the need for scalable clustering algorithms to
75 r to those identified in multiple sclerosis, highlight the need for scales to have strong conceptual
76 ts to probe microscopic mechanisms, and they highlight the need for single-molecule measurements.
77 hanges in post-ST-segment-elevation MI edema highlight the need for standardization of CMR timing to
79 t in treatment delay during the study period highlight the need for standardized diagnostic routines
82 uses and consequences of social immunity, we highlight the need for studies that evaluate the effects
85 ation of the individually linked survey also highlighted the need for a comprehensive list of HFs and
86 uring the 2014 Ebola outbreak in West Africa highlighted the need for a global, centralized database
87 te with protection against dengue virus have highlighted the need for a human DENV challenge model to
91 differential for certain bacteria, our study highlighted the need for further evaluation of the most
92 The search for a cure for HIV infection has highlighted the need for increasingly sensitive and prec
93 ed by borders or eliminated by vaccines have highlighted the need for proper training of all resident
94 airports, and recent terrorist attacks have highlighted the need for reliable analytical instrumenta
95 ization of coal ash into the environment has highlighted the need for the assessment of the environme
96 nt infectious disease outbreaks have further highlighted the need for vaccines that can achieve full
97 half of the amnestic amyloid-negative cases, highlighting the need for a clinical framework and termi
98 iple tests, IA can be excluded or confirmed, highlighting the need for a combined diagnostic strategy
99 gas phase is becoming increasingly popular, highlighting the need for a greater understanding of how
100 bstantially in their structure and dynamics, highlighting the need for a simple and flexible framewor
101 between axon growth and behavioral outcome, highlighting the need for additional strategies to optim
102 bit low overlap across the three dimensions, highlighting the need for an integrative approach for bi
103 re likely to be lower than in surface water, highlighting the need for analytical thiol quantificatio
104 ant disparity in delisting practices by sex, highlighting the need for better assessments of sickness
105 es as a possible risk factor for stillbirth, highlighting the need for better skilled care during del
106 able toxicity at clinically effective doses, highlighting the need for better understanding LAM's mol
107 However, almost 40% of athletes die at rest, highlighting the need for complementary preventive strat
108 ing optimum targets continue to be reported, highlighting the need for computational CRISPR targeting
110 ntly associated with higher rates of events, highlighting the need for continuous monitoring of the s
111 sizes than the enzymatic digestion approach, highlighting the need for development of robust plant di
112 to a failure to effectively engage in care, highlighting the need for differentiated care models.
113 children's risk for psychological disorders, highlighting the need for effective interventions, espec
114 ay affect deep well formation sustainability highlighting the need for effective PPW management.
115 ped world associated with an ageing society, highlighting the need for effective treatment options.
117 reveal the paucity of high-quality evidence, highlighting the need for further targeted research.
118 emporal variation within climatic scenarios, highlighting the need for future studies to incorporate
119 genetic complexity has been underestimated, highlighting the need for greater conservation efforts f
120 the overall quality of the evidence was low, highlighting the need for high-quality medical education
121 ubstantially smaller per-area CH4 emissions, highlighting the need for improvements in such models.
122 numerical parity between genders is reached, highlighting the need for increased efforts to combat su
123 jects, treatment significantly increases IR, highlighting the need for metabolic health monitoring wi
124 inevitably become resistant to bevacizumab, highlighting the need for more effective antiangiogenic
125 patients remain unresponsive to anxiolytics highlighting the need for more effective, mechanism-base
126 gest high MRSA pathogenicity in dental wards highlighting the need for more efficient surveillance/in
127 target toxicities in normal, healthy tissue, highlighting the need for more tumor-selective chemother
128 osis, treatment with SOF/RBV was suboptimal, highlighting the need for new therapies for this populat
130 IV and HCV have not been successful, thereby highlighting the need for novel approaches to circumvent
133 T1, demonstrating phenotypic variability and highlighting the need for ophthalmic review of these pat
134 unced in adolescents than in young children, highlighting the need for raising public health awarenes
135 non-viral) pose additional limitations, thus highlighting the need for safer and more deterministic i
136 nly investigated when studying reproduction, highlighting the need for sex parity in future studies.
137 in the spectra of 2D materials such as MoS2, highlighting the need for stable solvents and exfoliatio
138 dentified burden ofT. evansiin local cattle, highlighting the need for surveillance of this infection
139 ferences were found between USAAs and FBAAs, highlighting the need for tailored strategies for preven
140 g cause of diarrhea in developing countries, highlighting the need for the development of new treatme
141 umber of malignancies and cancer stem cells, highlighting the need for the identification and develop
142 EGFR TKIs target the ATP-site of the kinase, highlighting the need for therapeutic agents with altern
143 lapse remain challenging in this population, highlighting the need for validated models to predict al
144 nation of an emerging infectious disease and highlights the need for a coordinated global response to
145 resources among patients and health centres highlights the need for a health-system-wide approach to
148 t to both ice-only and liquid-bearing clouds highlights the need for accurate cloud representations i
150 entification of multidrug-resistant isolates highlights the need for additional measures to respond t
152 ivity of past ice sheets to volcanic ashfall highlights the need for an accurate coupling between atm
153 tter understanding of the WAF components and highlights the need for better experimental and theoreti
156 high prevalence of IDH1 mutations in glioma highlights the need for brain-penetrant IDH1 mutant-sele
157 ns; and its association with cardiac myxoma, highlights the need for cardiac investigations in all pa
159 cation bias in the outcome used in the study highlights the need for caution when a difference-in-dif
166 revalence and disease burden of elevated BMI highlights the need for continued focus on surveillance
167 pearance of H7N8 viruses in domestic poultry highlights the need for continued influenza surveillance
168 rther regional expansion of this novel clone highlights the need for continued strengthening of case-
170 a therapy may not prove to be successful and highlights the need for detailed pharmacogenomic analyse
172 mall rivers can emit significant methane and highlights the need for further studies on the link betw
175 er populations using standard approaches and highlights the need for generalized risk prediction meth
177 esistance to a last resort antimicrobial and highlights the need for improved surveillance to identif
178 ase incursion will affect model accuracy and highlights the need for improvements in these areas.
180 g redistribution of known invasive pests and highlights the need for international cooperation to slo
182 tates in determining the legality of KPD and highlights the need for legal clarity and flexibility as
183 equelae limits its utility in the clinic and highlights the need for limiting Treg cell activity with
186 owever, the narrow reach of this action also highlights the need for more comprehensive, precautionar
189 gal keratitis recorded in the present study, highlights the need for nationwide study on fungal kerat
191 ruses with resistance to approved antivirals highlights the need for new anti-influenza therapeutics.
194 rrelation with disease duration and severity highlights the need for rapid diagnosis and adequate imm
197 istribution, and number of nations affected, highlights the need for safe, effective, and readily ava
199 culty in generating accurate gene models and highlights the need for the establishment of stable cult
201 nt with redundancy in chemokine pathways and highlights the need for therapies blocking multiple path
205 ation in the early phase of adipogenesis and highlight the need of studying adipogenesis in vivo.
206 uestionnaire-based epidemiologic studies and highlights the need of better definitions for this patie
207 ble explanation for the observed pattern and highlights the need of better understanding human mobili
208 s of reef rugosity in a warming climate, and highlights the need of combining local (protecting and r
212 sophisticated nutrient cycles, these results highlight the need to adequately understand plant physio
213 viduals of African descent, and our findings highlight the need to assess the contribution of this va
214 may facilitate ecosystem sustainability and highlight the need to assess the effects of climate extr
220 ation by different EGF receptor agonists and highlight the need to characterize network interactions
221 ence higher exposures than their mothers and highlight the need to characterize potential health risk
222 AgRP to POMC neurons is state dependent and highlight the need to consider different types of transm
224 D24(-) cells can remain aggressive, and they highlight the need to consider nucCD24 in both fundament
227 n and diagnosis of multifocal desmoid tumors highlight the need to develop effective systemic treatme
229 icular, the dynamics of enacted PADDD events highlight the need to explicitly consider PA robustness
234 olicy makers across Amazonian countries, and highlight the need to include local stakeholders in cons
239 turn quality in the Intensive Care Unit and highlight the need to reinforce optimal turning practice
240 ge contribution from uncorrected presbyopia, highlight the need to scale up vision impairment allevia
241 tified an emerging public health concern and highlight the need to strengthen surveillance to detect
243 ed understanding of their disease mechanisms highlight the need to study these pathogens on a molecul
245 ells dominate the tumor microenvironment and highlight the need to target extrinsic as well as intrin
246 edicted from single-species experiments, and highlight the need to understand future marine global ch
250 ilings placement (DSTP) in coastal zones has highlighted the need to better understand the fate and e
252 migration across the Mediterranean Sea, have highlighted the need to better understand the possible e
253 ed the available compounds that inhibit Hv1, highlighted the need to develop better drugs suitable fo
254 nic obstructive pulmonary disease (COPD) has highlighted the need to develop more specific treatments
255 e transmission of T. solium infection, which highlighted the need to intensify the subsequent strateg
256 disrupt PD-L1-mediated tumour tolerance has highlighted the need to understand the molecular regulat
257 late immune responses in adults and infants, highlighting the need to conduct vaccine trials in pedia
258 syndrome at a clinically relevant frequency, highlighting the need to determine the best methods for
259 s, with 264 sites expected by the year 2044, highlighting the need to develop and standardize metrics
260 training rates in the United States are low, highlighting the need to develop CPR educational approac
261 rden of sepsis in resource-limited settings, highlighting the need to establish programmes aiming for
262 onmental impacts for four impact categories, highlighting the need to explicitly consider local impac
263 iversity protection are possible, while also highlighting the need to explicitly link desired conserv
264 ized genes, are generally of low occurrence, highlighting the need to functionally annotate the long
265 rease in morbidity and economic burden, thus highlighting the need to identify methods to limit FVIII
266 y to conventional chemotherapy or radiation, highlighting the need to identify new therapeutic target
267 ts with ALK-mutant neuroblastoma is limited, highlighting the need to improve their effectiveness in
268 has the potential to impact fish demography, highlighting the need to include anthropogenic noise in
269 ession reverses RTT-like phenotypes in mice, highlighting the need to search for therapeutic approach
270 eutic strategy for treating these disorders, highlighting the need to study angiogenesis in more deta
271 is exposed to high pressure and temperature, highlighting the need to study catalysts in realistic en
272 f predictive uncertainty in modeled biomass, highlighting the need to target these processes in futur
273 n part a result of antimicrobial resistance, highlighting the need to uncover novel antibiotic target
274 nd PARP inhibition were cell line-dependent, highlighting the need to understand how these treatments
275 icacy in an orthotopic model of glioblastoma highlights the need to balance significant uptake withou
276 link between protein misfolding and disease highlights the need to better understand the elaborate m
278 tion during Ostreopsis blooms and in seafood highlights the need to characterize its toxic effects an
279 rrent state of pharmacology research for CUD highlights the need to consider particular characteristi
283 break, spread by the Aedes aegypti mosquito, highlights the need to create high-quality assemblies of
286 sorders underscores their critical roles and highlights the need to develop targeted therapies for tr
287 dest efficacy (31.2%) achieved in this trial highlights the need to examine approaches and factors th
288 ns associated with recent ZIKV outbreaks and highlights the need to exert great caution when designin
289 r JNCL that slows disease progression, which highlights the need to explore novel strategies to exten
296 ization and warming-induced respiration, and highlights the need to protect both existing carbon stoc
298 ota-directed therapeutics for undernutrition highlights the need to simultaneously consider a variety
300 The growing elderly population worldwide highlights the need to understand how aging promotes CVD
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