ライフサイエンスコーパス: highly

1 ons for the synthesis of dsRNA precursors of highly abundant viral and host siRNAs by the cellular Rd

2 se of chemical kinetics has recently enabled highly accurate quantifications of the effects of small

3 at highly efficient skills (i.e., fluent and highly accurate, "automatic," performance) can be acquir

4 The highly acidic gastric environment creates a physiologica

5 The endothelial binding parameter Kb varied highly across brain regions.

6 nsformation of different cancers, and JNK is highly activated in basal-like triple-negative breast ca

7 udy was to determine if patients with HIV on highly active antiretroviral therapy (HAART) had any dif

8 ple have decreased since the introduction of highly active antiretroviral therapy (HAART) in 1996.

9 Results highlighted that KuQs are highly active toward the analyzed cell lines and almost

10 c transcription to which cancer cells become highly addicted.

11 The results were in highly agreement with LC/MS/MS which verified our method

12 ignment introduced in the RNA-Seq context is highly applicable in the metagenomics setting.

13 The gene module most highly associated for COPD in Weighted Gene Co-Expressio

14 mited to the testes and ovaries, making it a highly attractive cancer target.

15 cted in the homogeneous treatment was also a highly beneficial mutualist, implying that the trade-off

16 44 expression has recently been described as highly beta-cell selective in the human pancreas and con

17 ire of Gag293-specific CD4(+) T cells proved highly biased, with a predominant usage of the TCRbeta v

18 Astrocytes extend highly branched processes that form functionally isolate

19 lso receptor tyrosine kinases, including the highly cancer relevant insulin-like growth factor type 1

20 t component of Critical Zone science, but is highly challenging to investigate across the enormous ph

21 Focusing initially on highly characterized drugs and genes, COSMIC v78 contain

22 ion of the preferential localization of more highly charged cations to the inner shell of the ion atm

23 CaM adopts a highly compact conformation in which its open Ca(2+)-act

24 Results are highly comparable and in very good agreement with HPLC r

25 y suggest that surface water mutagenicity is highly complex and driven by synergistic mechanisms of a

26 The gastrointestinal tract is a highly complex organ in which multiple dynamic physiolog

27 lower (95% CI, -14.0% to -2.3%; P = .008) in highly concentrated markets.

28 A hydrotropic solution of highly concentrated sodium tosylate (NaOTs) can be used

29 atures that make dopamine neurons unique are highly concordant and not a principal source of sexual d

30 ing early cardiomyocyte differentiation were highly concordant between hiPSCs and hESCs, and clusteri

31 r a remarkably simple procedure for printing highly conductive (3 x 10(5) S m(-1) ) features in degra

32 ive disease subtypes comprising subgraphs of highly connected comorbid conditions.

33 mbedded in a basophilic kinase motif that is highly conserved across species.

34 getics and kinetics of NTD self-assembly are highly conserved across spider species despite the diffe

35 and transgenic approaches demonstrate that a highly conserved ERG-bound enhancer located upstream of

36 r the periplasm of bacteria is mediated by a highly conserved heterotrimeric membrane protein complex

37 complex, showing IncE bound to a unique and highly conserved hydrophobic groove on SNX5.

38 We have cloned both; while highly conserved in domain organization they display jus

39 It is highly conserved in many non-vertebrate taxa and may pro

40 The homeotic (Hox) genes are highly conserved in metazoans, where they are required f

41 Since the ten Cys residues are highly conserved in Meteorin and Cometin, it is likely t

42 ategy elicits potent T cell responses toward highly conserved internal Ags while simultaneously induc

43 The amino acid substitutions lie in two highly conserved loop regions of uS12 with known roles i

44 s 70 kDa (Hsp70s), a class of ubiquitous and highly conserved molecular chaperone.

45 ed protein glycosylation is an essential and highly conserved post-translational modification in euka

46 In the course of this analysis, highly conserved protein motifs and domains within each

47 ene in human Chanarin-Dorfman syndrome, is a highly conserved regulator of adipose triglyceride lipas

48 The highly conserved Rho-GTPase Cdc42p promotes yeast fusion

49 ral accessions of this species, indicating a highly conserved role of this protein in controlling org

50 us GAS M-Prts have shown that they contain a highly conserved sortase A-dependent cell wall-anchored

51 activity of sodium channels, and while it is highly conserved, it is not known whether the functional

52 derlying target recognition and cleavage are highly conserved.

53 gh the sequence and function of Domain 2 are highly conserved.

54 n 'all-or-none' fashion, HerA-NurA harbors a highly coordinated pairwise binding mechanism and enable

55 of particle rotation is lowest for the more highly coordinated particles and decreases during sinter

56 nes, among which the expression changes were highly correlated (r >/= 0.7, P </= 0.001).

57 s of corner-sharing tetrahedra gives rise to highly correlated magnetic phases with strong fluctuatio

58 either independent, somewhat correlated, or highly correlated test statistics.

59 ke fluorescing species were determined to be highly correlated with the concentrations of recalcitran

60 formability (a mechanical biomarker) that is highly correlated with the infection status.

61 Volatilities of different features are highly correlated with their divergence in longitudinall

62 In general, marker order was highly correlated, which provides support for strong syn

63 (DALY) averted, PMI-funded interventions are highly cost-effective.

64 Controllable growth of highly crystalline transition metal dichalcogenide (TMD)

65 ion and that Yop1p favours the generation of highly curved membrane structures.

66 Double strand breaks (DSBs) represent highly deleterious DNA damage and need to be accurately

67 Rapid, low-cost and portable solution is in highly demand for point of care test.

68 We show that recorded spectra are highly dependent on the cluster morphology and size of p

69 successful therapeutic intervention will be highly dependent on the specific therapeutic target and

70 the serpentine path provides the basis for a highly desirable combination of ultrahigh sensitivity an

71 (SEI) films with controllable properties are highly desirable for improving battery performance.

72 ons that can be used for in vitro studies is highly desirable.

73 ular morphology and unique edge structure is highly desired and important for fundamental research an

74 and light trapping and field localization is highly desired in enhanced light-matter interaction, esp

75 lopment of a targeted GEM delivery system is highly desired.

76 The mDOS system enables highly detailed insights into oxygen dynamics in various

77 We combined 3 y of highly detailed visual observations of Bornean orangutan

78 prolonged disruptions of normal rhythms are highly detrimental to health, deeper knowledge of how ou

79 2-tosyl-6-oxa-2-azabicyclo[3.2.1]octane in a highly diastereoselective manner through an unexpected i

80 ly critical in neurons, which comprise vast, highly differentiated domains such as the axon and dendr

81 This highly directional attraction between a halogen atom and

82 Our newly developed MLVA-13Bc assay is a highly discriminatory assay for B. canis genotyping, and

83 cgMLST represents a standardized, accurate, highly discriminatory, and reproducible method for diffe

84 Our data suggest a highly disordered CUB, which has acquired a state simila

85 ental results reported in the literature are highly disparate and difficult to structure, a new forma

86 abundant nanopores, large surface area, and highly dispersed ultrafine MgO nanocrystallites (ca. 3 n

87 The sequences of all of these enzymes are highly divergent from sequences found in other organisms

88 character of some phenomena and explain the highly diverse and unpredictable magnitude of the total

89 gnificant body of evidence suggests that the highly dynamic Abeta oligomers are the main causal agent

90 lver nanoparticle collision and oxidation is highly dynamic and likely controlled by a strong electro

91 We find that species occupy highly dynamic network positions through time, causing t

92 The highly dynamic process of nanoparticle collision and oxi

93 BlaC) that mediates resistance to one of the highly effective antibacterials, beta-lactams.

94 l bioactive botanicals from GTPs and BSp are highly effective in inhibiting ERalpha-negative breast c

95 Pneumococcal conjugate vaccines (PCVs) are highly effective in preventing invasive pneumococcal dis

96 ine-preventable childhood death, even though highly effective pneumococcal conjugate vaccines (PCVs)

97 in itself, seems most judicious to achieve a highly effective therapeutic outcome.

98 Doxorubicin is a highly efficacious and well-established anthracycline ch

99 on self-regulation and illuminates how even highly efficacious interventions may be culturally bound

100 re found in all patients, including those on highly efficacious treatments.

101 ork will enable future efforts in developing highly efficient biomimetic assays for interaction analy

102 Highly efficient colored perovskite solar cells that exp

103 imited, and there is an intensive search for highly efficient electrocatalysts by more rational contr

104 Highly efficient energy storage is in high demand for ne

105 Supplied separately, PB permitted highly efficient isolation of Cas9-mediated knockout of

106 We demonstrate a highly efficient optical interface between Si3N4 wavegui

107 lationship may aid in the development of new highly efficient photoreactions.

108 However, we argue that highly efficient skills (i.e., fluent and highly accurat

109 nd to be straightforward, high yielding, and highly efficient, and scalable.

110 In response to this rising threat, a highly efficient, environmentally friendly and biocompat

111 MMP9 highly efficiently cleaved DSP into distinct fragments i

112 were used as a conductive skeleton to anchor highly electrolytic manganese nanoparticles (Mn NPs), wh

113 diminato complexes as an example case, these highly electron-withdrawing substituents allow for polym

114 A highly enantioselective synthetic route to hexahydropyrr

115 via the dry reforming of methane (DRM) is a highly endothermic process conducted under harsh conditi

116 cess; moreover, we find that these genes are highly evolutionarily plastic both at the level of codin

117 Highly exfoliated layers of WS2 mixed with Nafion soluti

118 The calculated activation barrier for the highly exothermic reaction to a classical Lewis structur

119 ed by androgen in prostate cancer cells that highly express AR, emphasizing its potential as a therap

120 while COL2D is repressed in wild cottons but highly expressed due to methylation loss in all domestic

121 thylation was enriched at super-enhancers in highly expressed genes critical for liver function.

122 Conversely, D cells highly expressed genes related to differentiated endothe

123 This isoform is highly expressed in advanced stages of breast and cervic

124 Because HILPDA is highly expressed in atherosclerotic plaques, we examined

125 keda G-protein coupled receptor5 (TGR5) were highly expressed in esophageal adenocarcinoma (EAC) and

126 Here, we report that PIPKIgamma is highly expressed in lung cancer tissues and its expressi

127 HEC1 mRNA and protein are highly expressed in many malignancies as part of a signa

128 eport that IFN regulatory factor 4 (Irf4) is highly expressed in murine thymic epithelium and is requ

129 qPCR analysis indicated that BmAce1 is highly expressed in muscle and BmAce2 is more ubiquitous

130 Here, we report that CAIII is highly expressed in osteocytes, is regulated by parathyr

131 , NFAT3 and phosphorylated NFAT3-Ser259 were highly expressed in skin cancer compared with normal ski

132 ocused on the GluN2B NMDAR subunit, which is highly expressed in the hippocampus and cortex throughou

133 d use in label-free selection of cells for a highly expressed molecular phenotype.

134 We confirm GPC2 to be highly expressed on most neuroblastomas, but not detecta

135 up box transcription factor SOX4 is the most highly expressed SOX family protein in pancreatic islets

136 The biosensors function by recognizing the highly expressed tumor marker CD133, which is located on

137 ng an explicit model of Ca2+, CaM, and seven highly-expressed hippocampal CaM binding proteins, we fi

138 It was significantly more highly-expressed in EAC, SCC and glandular lesions than

139 use of its complex architecture and multiple highly flexible regions.

140 . aureus infection can usher in a new era of highly focused personalized therapy that may be particul

141 ion of diverse bicyclic compounds possessing highly functionalized cyclopentane rings has been develo

142 A highly functionalized variety of N-substituted pyridine-

143 Study of the highly glycosylated glycosyl inositol phosphorylceramide

144 Furthermore, tooth form is considered to be highly heritable and selectively neutral; thus, teeth ar

145 We demonstrate that skin pigmentation is highly heritable, but known pigmentation loci explain on

146 cause of visual impairment and represents a highly heterogeneous group of conditions.

147 nal sample identified many more eccDNAs with highly heterogenous molecular structure.

148 rain regions tend to coordinate by forming a highly hierarchical chain-like structure of homogeneousl

149 ent and covalent binding states, and for two highly homologous proteases, calpain-1 and calpain-2.

150 antitumor immunity, as deletion of PD-L1 on highly immunogenic MC38 tumor cells allows effective ant

151 istent immunomodulatory impact, serving as a highly important epigenetic system.

152 ath to recovery are populated by a series of highly individualised questions.

153 pithelial antigen of prostate 4 (STEAP4) was highly induced in mouse models of colitis and in IBD pat

154 concentrating magnetic flux and producing a highly inductive device.

155 s, altering a trait by random mutagenesis is highly inefficient due to gene redundancy.

156 hing fingerprinting and scripting) providing highly informative chemical signatures for quality asses

157 ith dynamic network analyses likely to prove highly informative.

158 e hedonic value of water-evoked responses is highly internal-state dependent.

159 ic systems exploit self-assembly to generate highly intricate closed supramolecular architectures, ra

160 ate unstable intermediates and are therefore highly irreproducible.

161 Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal and disseminating cancer resistant to ther

162 with these red blood cells are resistant to highly lethal doses of BoNT/A.

163 a new catalytic cyclization reaction using a highly Lewis acidic borane with concomitant C-H or C-C b

164 ide evidence that RIM1alpha and RIM1beta are highly likely absent from mouse photoreceptors and that

165 es where thermal stratification is absent or highly limited.

166 KCC2 is highly localized to excitatory synapses where it regulat

167 related calculations show the presence of a highly mixed (3)MLCT/(3)pipi* excited state as the lowes

168 ns are an important aspect of the ecology of highly mobile animals, allowing populations to exploit s

169 In this highly modulated and oscillating circuit, neuronal struc

170 lti-walled carbon nanotube (MWCNT) supported highly monodisperse nickel nanoparticles modified on gla

171 To address this problem, we developed a highly multiplexed single-cell DNA sequencing approach t

172 Myosin systems are shown to have highly nonlinear behavior across force conditions that m

173 Rice bran, a by-product of milling rice, is highly nutritious but contains very high levels of the n

174 Chenopodium quinoa (quinoa) is a highly nutritious grain identified as an important crop

175 xture of ionic species represented and their highly organized assembly in the crystal lattice.

176 othelial cells (ECs) and Bruch's membrane, a highly organized basement membrane that lies between bot

177 GRPr proteins are highly overexpressed in several human tumors, including

178 ying novel strategies to effectively address highly pathogenic and lethal infections stemming from ba

179 m wild birds have the potential to mutate to highly pathogenic avian influenza (HPAI) viruses, but su

180 9 pandemic H1N1 influenza A (H1N1) virus and highly pathogenic avian influenza A (H5N1) virus induce

181 Whole-genome sequences of representative highly pathogenic avian influenza A(H5) viruses from Vie

182 ciplinary team investigated 2 human cases of highly pathogenic avian influenza A(H5N1) virus infectio

183 Mutation and reassortment of highly pathogenic avian influenza A(H5N1) viruses at the

184 l activity of Ceftriaxone/Cefotaxime against highly pathogenic MRSA infection.

185 iratory syndrome coronavirus (SARS-CoV) is a highly pathogenic respiratory virus that causes morbidit

186 African swine fever virus (ASFV) is a highly pathogenic, double-stranded DNA virus with a mark

187 autistic disorders - whether caused by rare highly penetrant mutations or sporadic forms - and holds

188 ve now been built downtown, next to the most highly performing technological plateau.

189 Here, we show that TFR cells are highly permissive to HIV-1 both ex vivo and in vivo The

190 Marrow-derived macrophages are highly phagocytic, but whether they can also traffic int

191 Using human primary melanocytes and a highly pigmented melanoma cell line, we demonstrate that

192 Five highly polar organic acids in serum were successfully qu

193 tains several gene families characterized by highly polymorphic loci with extensive nucleotide divers

194 results in ten models defined by centers of highly populated clusters of low-energy docked structure

195 We identified and confirmed the highly potent antiandrogen 4-methyl-7-diethylaminocoumar

196 This highly powered study provides strong rationale for a con

197 , using a combination of manual curation and highly precise automated tools, aiming to have the same

198 ons with hepatitis C virus (HCV) and HIV are highly prevalent in the USA and concentrated in people w

199 Pornography consumption is highly prevalent, particularly among young adult males.

200 information channels emerge, each encoding a highly processed feature like edges or the direction of

201 densin's translocation activity is rapid and highly processive, with individual complexes traveling a

202 nonical model of DNA replication describes a highly-processive and largely continuous process by whic

203 n AMD, including intraretinal cells that are highly prognostic for progression, can be followed and q

204 ll acute lymphoblastic leukemia (T-ALL) is a highly proliferative hematologic malignancy that results

205 LTL represents TL in the highly proliferative hematopoietic system, whereas TL in

206 essed by Lgr5(+) cells, as well as adjacent, highly proliferative Lgr5(-) cells that are able to repo

207 ave been most thoroughly investigated in two highly proliferative tissues prone to oncogenic transfor

208 ucose cotransporter 2 (SGLT2) inhibitors are highly promising drug candidates for the treatment of Ty

209 Highly promising photonics-based chemical sensing opened

210 The analysis results show that highly pure, uniform, and monolayer MoS2 QDs can be succ

211 ion in recent years due to the generation of highly reactive and selective sulfate radical (SO4(*-)).

212 We demonstrate that a highly reactive CF3(-) adduct can be synthesized from al

213 tolysis of 2,5-diphenyltetrazoles, affording highly reactive nitrile imines, is probed via a monochro

214 port the simple solution-phase generation of highly reactive phosphaborenes, RP=BR, and demonstrate t

215 OM correlated with the relative abundance of highly reduced sulfur functionality.

216 that the matricellular protein CCN1/CYR61 is highly regulated by stiffness in endothelial cells.

217 ider methylation-based tumour classification highly relevant for the future diagnosis and treatment o

218 in vitro antioxidant capacity which appears highly relevant from an industrial perspective.

219 helix" due to its repeating turns, which are highly reminiscent of peptide beta-turns.

220 We show that L1000 is highly reproducible, comparable to RNA sequencing, and s

221 However, the boundary was highly resilient, and only a 400-kb deletion, including

222 is that platelets collected from donors with highly responsive platelets to agonists in vitro assesse

223 th its protein targets (low in alpha) and is highly selective (high in beta) in forming the probe-pro

224 h a rational design approach we discovered a highly selective and potent BTK kinase inhibitor (CHMFL-

225 ucleotide polymorphism (SNP) detection using highly selective BiDz sensors targeting loci associated

226 ning paradigm, we have identified JNJ0966, a highly selective compound that inhibited activation of M

227 cell line, suggesting that it may provide a highly selective inhibitor of MEK1/2 for use as a cancer

228 This work led to the discovery of a highly selective PI3Kbeta/delta inhibitor displaying exc

229 n, and radiation dosimetry in humans for the highly selective sigma-1 receptor PET agent (18)F-6-(3-f

230 Here, we show that a highly selective TLR7 agonist, GS-9620, activated HIV fr

231 Valbenazine (NBI-98854) is a novel, highly selective vesicular monoamine transporter 2 inhib

232 a block copolymer template was developed for highly sensitive and selective detection of hydrogen per

233 f CVD graphene were exploited to construct a highly sensitive and selective SPR chip for folate bioma

234 This SID nanoLC-NSI/MS/MS assay is highly sensitive and specific and it requires only 50 mu

235 sed here should be applicable for developing highly sensitive biosensors for various protein kinases.

236 Highly sensitive detection of chemokines in various biol

237 rt an electrochemical method for the direct, highly sensitive detection of dsDNA based on the strand

238 Through the implementation of a highly sensitive inductively coupled plasma mass spectro

239 such viral infections, broadly reactive and highly sensitive influenza rapid diagnostic tests (IRDTs

240 This highly sensitive p24 assay can help improve blood safety

241 In this work, a highly sensitive quantitative/confirmatory method was de

242 gnals and the developed nanosensor exhibited highly sensitive response, demonstrating improved electr

243 r platforms based on nanostructures make the highly sensitive sensors which could indicate very low d

244 ISEScan is a highly sensitive software pipeline based on profile hidd

245 wever, other genes recently identified to be highly sensitive to androgen-regulated AR action, such a

246 The brain is highly sensitive to proper fuel availability as evidence

247 are in the primary analysis, this effect was highly sensitive to the imputation strategy for peak VO2

248 cific molecular detection technology that is highly sensitive, robust, and high-throughput has the po

249 model of severe antibody-mediated damage in highly sensitized recipients.

250 lites also revealed that many compounds were highly sequestered among the various seed tissue types.

251 Two highly significant CAD loci were identified on chromosom

252 ATG treatment resulted in highly significant increases of both IgM (for anti-ATG a

253 phenotype PD/AG (Ncombined =1012) obtaining highly significant P-values also for GLRB single-nucleot

254 In this post hoc study, a highly significant reduction in HPV prevalence 4 years a

255 This task requires subjects to discriminate highly similar scenes, faces, or objects from multiple v

256 For complex, highly specialized procedures, hospital market consolida

257 Conclusion US is highly specific but nonsensitive for perforated pediatri

258 Immunofluorescence is a highly specific diagnostic test for PCD, and it improves

259 Each of these prenyltransferases was highly specific for stilbenoid substrates, and we confir

260 ution for each binding site and delineated a highly specific sequence and structure motif for Vts1 bi

261 m and as a result in the development of more highly step-economical syntheses, a synthesis that combi

262 The ring closure of domino protocol was highly stereoselective and resulted in the formation of

263 ve a vinyl cyclohexanol derivative and (2) a highly stereoselective intramolecular Diels-Alder (IMDA)

264 nstrate that subsets of cells discharge in a highly stereotypical sequential pattern during ictal eve

265 ing diagnosed with and treated for cancer is highly stressful and potentially traumatic.

266 -sensing approach to pseudo-randomly acquire highly subsampled, multi-dimensionally-encoded and time-

267 and enamines 1, affording the appealing and highly substituted 1,4-dihydropyridines 4 with very good

268 This reaction furnishes highly substituted and functionalized carbazole derivati

269 ) is a major crop and a member of the large, highly successful Compositae family of flowering plants.

270 Our results present a highly supported phylogeny of the stinging wasps.

271 monstrate experimentally that NN animals are highly susceptible after i.c.

272 that hamsters devoid of functional STAT2 are highly susceptible to as few as 10 PFU of SFTSV, with an

273 The highly thermally stable dimers dissociate on the sub-sec

274 We found that Tfu-FNO is highly thermostable, reaching its highest activity at 65

275 in the beaker", avoiding direct handling of highly toxic fluorine gas.

276 Such autoimmunity has been shown to be highly toxic in several bacteria and is believed to be o

277 rodotoxin (TTX) and saxitoxin (STX) that are highly toxic to humans and other vertebrates, target con

278 on complex contribute to Chd1 recruitment to highly transcribed genes and identified Spt4 as a factor

279 a factor of about 2 on average for the most highly transcribed genes.

280 DNMT3B shapes intragenic CpG-methylation of highly-transcribed genes.

281 Colorless and highly transparent copolymers of poly(monothiocarbonate)

282 and contains a population of self-renewing, highly tumorigenic glioma stem cells (GSCs), which contr

283 The CH(+) absorption lines reveal highly turbulent reservoirs of cool (about 100 kelvin),

284 Our studies identified a highly up-regulated mammalian lncRNA, FOXD3-AS1, known a

285 a spectrum from rural nomadic populations to highly urbanized communities.

286 observed to be healthy and resilient in this highly urbanized environment.

287 This powerful single-molecule assay can be highly useful in diagnostic applications using various s

288 This method has proven highly useful to monitor the Warburg effect in cancer, t

289 Repeatability was highly variable among features.

290 hes, this provides the possibility to reveal highly variable and heterogeneous oxygen dynamics at a h

291 ence of 1:2,000-3,000, is characterized by a highly variable clinical presentation.

292 t to antenatal BS, classic BS manifests with highly variable phenotypes.

293 s, whereas the surface-exposed N terminus is highly variable, a feature used for identification and s

294 Dissolved greenhouse gas concentrations were highly variable, but peak concentrations of N2O accounte

295 While the responses were highly variable, numerous instances of cross-reactive ki

296 ed noise can be continuously adapted even to highly variable, unknown input signals via a feedback lo

297 The galvanic replacement reaction is a highly versatile approach for the creation of a variety

298 into the medial rectus muscle of the cat, a highly visual nonprimate with frontally placed eyes.

299 This study demonstrates the highly volatile nature of the beta cell, indicating that

300 :P ratios for evergreen broadleaf forest and highly weathered Ultisols, and more pronounced temporal