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1 trates that the large majority of sgRNAs are highly active.
2 inant in proliferating cells where mTORC1 is highly active.
3 minoDMAP/Squaramides, which are proved to be highly active (1 mol % cat. loading) promoters in conjug
6 d biological evaluation iteration led to the highly active 5-cyclopropyl-2-(4-(2,6-difluorophenoxy)-3
9 ary, preclinical studies show SGN-CD19B is a highly active ADC, which releases a DNA cross-linking ag
16 thoxybenzene, and a sulfonamide isostere, is highly active against laboratory and primary clinical HI
17 s from Streptomyces-derived griselimycin are highly active against M. tuberculosis, both in vitro and
19 mutant-selective irreversible inhibitors are highly active against the T790M mutant, but their effica
20 bacterium tuberculosis, while 9b and 9c were highly active also against multidrug-resistant clinical
21 CSDS or caloric restriction, while the more highly active analog P7C3-A20 also exerted an antidepres
22 vide a novel platform for the development of highly active and affordable base metal catalysts for th
23 Matrix metallopeptidase-13 (MMP-13) is a highly active and an abundantly expressed protease in OA
24 ccessible bench-stable Ni(II) precatalyst is highly active and can couple synthetically important het
26 atalytic hydrosilylation of ketones with the highly active and enantioselective iron(II) boxmi comple
28 hetic metalation with Rh complexes to afford highly active and enantioselective single-site solid cat
29 of AlMe3/B(C6F5)3/[Ph3C][B(C6F5)4] yields a highly active and productive catalyst system for the con
30 eing coordinated with iron centers to afford highly active and reusable single-site solid catalysts f
31 ts (SBUs) with cobalt and iron salts affords highly active and reusable single-site solid catalysts f
32 lding units of a Zr-MOF with Me2Mg affords a highly active and reusable solid catalyst for hydroborat
33 followed by treatment with NaBEt3H, afforded highly active and reusable solid Zr-MTBC-CoH catalysts f
34 ollowed by treatment with NaBEt3H afforded a highly active and reusable solid Zr12-TPDC-Co catalyst f
36 d shows the enormous potential of developing highly active and robust single-site solid catalysts bas
38 ates a balanced Lewis acid-base pair for the highly active and selective cascade ethanol-to-isobutene
39 saturated M(III)H centers in M(III)H-BTC are highly active and selective for 1,4-dearomative hydrobor
40 ter, these bis(diazaphospholane) ligands are highly active and selective in asymmetric hydroformylati
41 etone-d6 and D2O unambiguously showed that a highly active and selective nature of balanced Lewis aci
42 sed approaches have been developed to design highly active and selective protease substrates and prob
43 ch that make it a useful tool for developing highly active and selective reagents for a wide variety
49 ructure design and sequential synthesis of a highly active and stable hydrogen evolution electrocatal
50 portantly, as-made coordination polymers are highly active and stable in the aerobic oxidation of all
51 developed a novel purification protocol for highly active and stable mitochondrial complex I using t
52 findings suggest that a small subnetwork of highly active and stable neurons supports group stabilit
53 ridged-ansa-zirconocenium ester enolate 1 is highly active and stereospecific in the polymerization o
55 per week with trastuzumab and pertuzumab is highly active and well tolerated and seems to be an effe
56 terization of electron-transfer processes at highly active and well-defined catalytic sites on a ligh
57 This work opens doors for the preparation of highly active and well-structured nano-mesoporous alumin
58 N4 sites are structurally reminiscent of the highly active and widely studied non-platinum group meta
59 modelling, we show that the dislocations are highly active, and we delineate the specific atomic-scal
63 ant end point for accelerated development of highly active anticancer therapies, yet its relationship
64 pression-based virtual screening to identify highly active antileukemic drugs that synergize with NOT
65 tors (NRTIs) are the essential components of highly active antiretroviral (HAART) therapy targeting H
66 is study was to determine whether initiating highly active antiretroviral therapy (ART) before concep
67 ether people living with HIV (PLHIV) ever on highly active antiretroviral therapy (ART) follow a patt
68 os of outcomes for time after HIV diagnosis, highly active antiretroviral therapy (ART) initiation, a
69 (3)) before and up to 3 years after starting highly active antiretroviral therapy (HAART) and compare
70 iciency virus-positive (HIV+) patients under highly active antiretroviral therapy (HAART) and their a
73 udy was to determine if patients with HIV on highly active antiretroviral therapy (HAART) had any dif
75 ple have decreased since the introduction of highly active antiretroviral therapy (HAART) in 1996.
77 e of brain biopsy in HIV patients in the pre-highly active antiretroviral therapy (HAART) versus post
78 xis and growth factor support were required; highly active antiretroviral therapy (HAART) was discret
80 iption, RT is a key target of currently used highly active antiretroviral therapy (HAART), though RT
81 it was not found differentially modulated in highly active antiretroviral therapy (HAART)-treated HIV
84 lity risk and improves the odds of accessing highly active antiretroviral therapy (HAART); however, t
86 There were 434 HIV-infected men receiving highly active antiretroviral therapy and 200 HIV-uninfec
88 sults in a chronic illness because long-term highly active antiretroviral therapy can lower viral tit
89 se birth outcomes associated with the use of highly active antiretroviral therapy during pregnancy.
90 HIV-1 protease inhibitors are part of the highly active antiretroviral therapy effectively used in
91 IV-infected patients with sepsis in the post-highly active antiretroviral therapy era are conflicting
97 two percent of HIV-infected patients were on highly active antiretroviral therapy prior to admission,
99 ed anal intercourse, older age, and being on highly active antiretroviral therapy were independently
101 (CD4 cell counts, HIV viral load, and use of highly active antiretroviral therapy), sexual orientatio
102 antiretroviral therapy (ART), also known as highly active antiretroviral therapy, provides clinical
103 may negatively affect patients' adherence to highly active antiretroviral therapy, psychological heal
107 viral inhibition and CD4 T cell recovery by highly active antiretroviral treatment (HAART), HIV-1 is
109 female patients of white race/ethnicity with highly active AQP4-ab-seropositive NMO (n = 6) and NMO s
110 ported the association of combination ART or highly active ART use with the following outcomes: high-
113 tionally, CelA is extremely thermostable and highly active at elevated temperatures, unlike commercia
114 inant Burkholderia thailandensis DNase II is highly active at low pH in the absence of divalent metal
115 tudies demonstrated that the Mgp promoter is highly active at the cranial sutures, cranial base synch
121 ler density of active sites if compared with highly active bulk MoB2 (which contains only the more ac
122 s of epitope-deleting mutations and produced highly active but aggressively deimmunized constructs in
125 lf-sandwich ruthenium complex 12, which is a highly active catalyst for the anti-Markovnikov reductiv
126 t, a variety of experiments suggest that the highly active catalyst generated from the 1:1 combinatio
127 lorination reaction conditions and show that highly active catalysts comprise single-site cationic Au
128 terphenoxide) recently have been found to be highly active catalysts for cross-metathesis reactions b
129 -Ir, mBPV-MOF-Ir, and mPT-MOF-Ir), which are highly active catalysts for tandem hydrosilylation of ar
130 addition, the utility of copper(II) salts as highly active catalysts for the Michael reactions of tra
132 activated with alkyl aluminum reagents, form highly active catalysts for the polymerization of ethyle
133 se of Pt nanoparticle-decorated nanotubes as highly active catalysts for the reduction of 2,4,6-trini
135 ng of immediate early genes (IEGs) indicates highly active cells within the entire brain, albeit with
137 ir extracellular gates to ATP occupancy, and highly active CFTR channels that bypass defects in ATP b
138 iflimide (Tf2NH) in CH2Cl2 solution leads to highly active chiral Lewis acids that are very effective
140 signment of these newly observed features to highly active Co(4+) centers under catalytic conditions.
141 en evolution catalysts and, here, we study a highly active Co3O4/Co(OH)2 biphasic electrocatalyst on
142 mers with high precision by using simple but highly active combinations of phosphorus-containing Lewi
143 t cancer cells in culture and, for selected, highly active compounds, inhibition of tubulin polymeriz
144 panel of cancer cell lines and, for selected highly active compounds, interaction with tubulin, cell
148 ted Cmr-alpha binary complex functioned as a highly active DNase to destroy a large excess DNA substr
155 The brain's default mode network (DMN) is highly active during wakeful rest when people are not ov
157 lectrochemical studies confirm that NiP is a highly active electrocatalyst in aqueous electrolyte sol
158 ve, chemically stable coatings that also are highly active electrocatalysts for the oxidation of wate
160 ng off-target DNA breaks at loci that harbor highly active enhancers and display convergent transcrip
161 binant human COT kinase that yields pure and highly active enzyme in sufficient yields for biochemica
162 phocytic leukemia, where it has proven to be highly active, even in patients with high-risk del(17p)
163 strains for CFPS applications, make possible highly active extracts from non-model organisms, and pro
165 rane preparations of A. fermentans contain a highly active ferredoxin/flavodoxin-NAD(+) reductase (Rn
166 ial protonation of (PCP)Ir(CO) to generate a highly active five-coordinate cationic intermediate, whi
168 p a catalyst made of earth-abundant elements highly active for a complete oxidation of methane at a r
170 njugated rhenium (GCC-Re) catalysts that are highly active for CO2 reduction to CO in acetonitrile el
171 Notably, longer oligomers are found to be highly active for nonlinear absorption and emission prop
173 lysts containing dative nitrogen ligands are highly active for the borylation and silylation of C-H b
174 emistry from a mesityl complex [Cu5Mes5] are highly active for the hydrogenation of a broad range of
175 re we show metal/oxide interfacial sites are highly active for the oxidation of benzyl alcohol and ot
177 soporous Mn0.5Ce0.5Ox solid solution that is highly active for the selective oxidation of hydrocarbon
178 dppb = 1,4-bis(diphenylphosphino)butane) are highly active for the transfer hydrogenation of ketones
179 Here we show that Tfh cells expressed a highly active form of leukocyte function-associated anti
180 Finally, we describe a method to purify a highly active form of the Bam complex that should facili
181 This includes reduced expression of the highly active glycine-n-methyltransferase and the biliar
183 ing a np(+) structure and by incorporating a highly active heterogeneous Ni-Fe oxygen evolution catal
184 nzyme from Bacillus megaterium (P450-BM3), a highly active His-ligated variant of P450-BM3 that can b
185 neurons, the existence of donor L1s that are highly active ('hot') in specific spatiotemporal niches,
187 of LRH-1 with the Wnt/beta-catenin pathway, highly active in a critical subpopulation of CRC cells,
188 es (MHC) molecules on their surfaces and are highly active in antigen presentation in the autoimmune
190 s, containing a B26-B29 triazole bridge, was highly active in binding to both IR isoforms, with a sig
191 nd 2 studies, ceritinib has been shown to be highly active in both ALK inhibitor-naive and ALK inhibi
192 regulation of brain function and behaviour, highly active in early development and continuing throug
194 romoter region upstream of the distal TSS is highly active in naive pluripotent cells, autonomously r
196 SO2CF3)(CO)(SIMes)(CBA) was also found to be highly active in olefin selective hydrogenation in the p
197 ate that GRP78 and alpha-2-macroglobulin are highly active in osteoblastic, androgen-independent pros
199 amethasone) was generally well tolerated and highly active in patients with relapsed and/or refractor
200 The combination of CPD is well-tolerated and highly active in patients with relapsed/refractory multi
201 5 (Cdk5), a serine-threonine kinase that is highly active in postmitotic neurons and in many cancers
202 zing the anti-apoptotic function of Bcl-2 is highly active in preclinical models of refractory acute
203 particularly important for cells, which are highly active in protein secretion, and that breakdown o
204 simple and effective approach for producing highly active in situ catalysts on a carbon support for
208 ndeed, an inhibitor of Bcl2, venetoclcax, is highly active in the treatment of patients with CLL.
211 lpha, HK2 and glycolytic metabolism was also highly active in vivo as demonstrated by fluorodeoxygluc
213 e reaction entrance and the formation of the highly active intermediate BH3 are responsible for the u
217 inishing the l-glutaminase activity of these highly active l-asparaginases, our engineered ErA varian
221 Adipose tissue has been recognized as a highly active metabolic and endocrine organ, secreting a
222 master transcription factor for establishing highly active metabolic states in proliferating cells.
224 As a result, the cathode, despite being a highly active metal that will self-corrode in acid, last
225 eorgeite, which we find to be a precursor to highly active methanol-synthesis and superior LTS cataly
226 ifies unpaired guanosines in Y-form DNA as a highly active, minimal cGAS recognition motif that enabl
227 s, decreased glutathione redox capacity, and highly active mitochondria with increased vulnerability
229 s were related to moderate activity; and (3) highly active mutations included exon 3 deletions and am
231 f simple, almost instantaneous production of highly active nanostructures for reinvigorating SOCs dur
233 ss of treatment and the introduction of some highly active new agents such as antibody-drug conjugate
236 The piggyBac (PB) transposon system is a highly active non-viral gene delivery system capable of
238 ge of physiological functions in a cohort of highly active older individuals (cyclists) aged 55-79 ye
240 that were active in C deamination were also highly active on methylated C (mC), with hap II displayi
242 However, progress in the development of highly active oxide nanostructures is hampered by a lack
247 using 3 kDa centrifugal filters resulted in highly active permeate fractions, the most potent being
250 just recently experienced a renaissance as a highly active photocatalyst, and the metal-free polymer
251 ed thin films and nanoparticles of Ni3S2 are highly active, poison- and corrosion-resistant catalysts
253 hemical catalysis and biocatalysis to create highly active, productive, and selective metalloenzymes
254 ind that Chlorobi-affiliated bacteria may be highly active protein degraders, catabolizing extracellu
255 was as effective in killing cancer cells as highly active recombinant isoleucine-zipper-tagged TRAIL
258 erating ISCs, suggesting a trade-off between highly active repair mechanisms and late-life pathology
259 combination of idelalisib and rituximab was highly active, resulting in durable disease control in t
261 abilisation in the majority of patients with highly active RRMS over an average seven-year follow-up.
262 g on nucleoside analogs to capitalize on the highly active salvage pathways of Leishmania, which are
263 conferring an extended elongation stage and highly active secondary wall deposition during extra-lon
265 Dmt = 2',6'-dimethyltyrosine) resulted in a highly active, selective MOR antagonist, c[-d-Arg-Phe-Ly
266 oparticles embedded in the capsule walls are highly active, selective, and recyclable catalysts for t
267 ly prepared Sn and Bi catalysts proved to be highly active, selective, and robust platforms for CO ev
271 e mutation plus a cytosolic GOF mutation was highly active (single-channel open probability >0.3) in
272 In summary, helenalin acetate is the first highly active small-molecule C/EBPbeta inhibitor that in
273 uel cells also requires a WGS catalyst to be highly active, stable, and energy-efficient and to match
275 eus undergoes programmed transformation from highly active status, associated with execution of the g
276 (SL) in root exudates from 5-deoxystrigol, a highly active Striga germination stimulant, to orobancho
278 theory calculations suggest the formation of highly active surface layers during strontium leaching w
279 s relies on the design of architectures with highly active surfaces and optimized utilization of the
280 NMDAR function was more severely impaired at highly active synapses and synapses with bound Abeta, bu
281 NMDAR function was more severely impaired at highly active synapses and synapses with bound Abeta.
282 d the nucleoplasm, sandwiched in between two highly active systems inside the cell: cytoskeleton and
283 ome a useful and flexible tool for designing highly active TALENs for genome-editing applications.
287 lfanyl, and 6-methyl derivatives, which were highly active to cancer cells and less toxic or nontoxic
291 ith antibodies such as AMG655 to introduce a highly active TRAIL-R2-agonistic therapy into the cancer
292 high-valent states is a key factor in making highly active transition-metal-based catalysts of the ox
293 are disease free, suggesting that this is a highly active treatment program even in patients with su
294 t of UBCH5B, RAD6B can be transformed into a highly active UBCH5B-like E2 that polyubiquitinates SUMO
296 ant lung tumors, rociletinib and AZD9291 are highly active when T790M is present and modestly active
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