ライフサイエンスコーパス: highly divergent

1 Y formed a unique clade, suggesting that are highly divergent.

2 M-7 homologs are found only in fungi and are highly divergent.

3 gous to ENaC, but a key functional domain is highly divergent.

4 Hence cell wall regulatory pathways may be highly divergent.

5 olyether antibiotics, which are structurally highly divergent.

6 ini, often called the cytoplasmic tails, are highly divergent.

7 ng mechanisms that mediate taste in each are highly divergent.

8 nsists of genetic loci with alleles that are highly divergent (15.1 megabases of the total genome siz

9 S. invicta contains a highly divergent 17-member OBP gene family, that include

10 e Helkesimastix in a strongly supported, but highly divergent 18S sister clade.

11 first genome wide integration profile of the highly divergent AAV-5 serotype.

12 , because coevolutionary interactions can be highly divergent across time and space, it is important

13 Two ancient and highly divergent actin-based cytoskeletal systems have e

14 ly occurring enzyme homologues often display highly divergent activity with non-natural substrates.

15 We report the cloning of six highly divergent alleles of ATR1NdWsB from eight downy m

16 d from a different germ-line gene encoding a highly divergent amino acid sequence.

17 idating these principles because it has many highly divergent amino acid sequences that are <20% iden

18 among eukaryotes, but surprisingly, ISG15 is highly divergent among animals.

19 The mechanism for TER 3'-end processing is highly divergent among different organisms.

20 the intergenic regions of the Q/q locus are highly divergent among homoeologous genomes.

21 The regions with R1 homologues are highly divergent among the three haplotypes, in contrast

22 protein is well-conserved across taxa, TR is highly divergent amongst distinct groups of species.

23 The CaPIMT2 gene is found to be highly divergent and encodes two possible isoforms (CaPI

24 ssociated with the heterochromatic knobs are highly divergent and heavily methylated compared with th

25 uncinata lineages are able to maintain both highly divergent and highly conserved genes within a rap

26 Unfortunately, many protein families are highly divergent and not suitable for sequence-based rec

27 ell conserved between most organisms, TER is highly divergent and thus difficult to identify.

28 mong eukaryotic eIF4G proteins in that it is highly divergent and unusually small in size, raising th

29 eIFiso4G, one of two isoforms in plants, is highly divergent and unusually small in size.

30 One strain was highly divergent and was designated as the HTLV-4 subtyp

31 Telomerase RNA subunits are phylogenetically highly divergent, and different strategies have evolved

32 However, the Fip1 sequence is highly divergent, and residues on both Pap1 and Fip1 at

33 This strategy yielded highly divergent antigenic footprints that do not exist

34 A highly divergent approach for the synthesis of metal-bin

35 to show that alternate supergene alleles are highly divergent at over 1,000 genes and that these alle

36 Despite being highly divergent at the amino acid level, IFITM3 protein

37 Although highly divergent at the primary sequence level, an atomi

38 Although these domains are highly divergent at the primary sequence level, the stru

39 snRNA-specific TUTase enzyme in humans, are highly divergent at the protein sequence level.

40 Through their highly divergent axons, inhibitory neurons indiscriminat

41 immune responses that are protective against highly divergent B. bronchiseptica strains, preventing c

42 catabolic genes and even intact operons from highly divergent bacteria.

43 , but the U and G forms predominantly harbor highly divergent bacterial lineages belonging to two dif

44 odern human Y chromosomes-including A00, the highly divergent basal haplogroup.

45 rches for the BBI inhibitory loop discovered highly divergent BBI-like sequences in the seedless, vas

46 epeat- and transposon-associated siRNAs were highly divergent between A. thaliana and A. arenosa.

47 hibition are encoded by a small exon that is highly divergent between ankyrin family members but cons

48 g B lineage specification and commitment was highly divergent between B-1 and B-2 progenitors.

49 Stl proteins are highly divergent between different SaPIs and respond to

50 we identified 57 protein sequences that are highly divergent between East Asian and non-Asian strain

51 larly, melanism of the central primaries was highly divergent between L. argentatus and L. cachinnans

52 tween 100 and 300 amino acids in length, are highly divergent between organisms, and are resistant to

53 hese results suggest that DNA methylation is highly divergent between populations, and that this dive

54 more meagerly expressed in females, and more highly divergent between species.

55 One route to specificity was found--a highly divergent binding site that facilitates ETS1 and

56 king in Saccharomyces cerevisiae, identified highly divergent box C'/D' motifs that are bound by snoR

57 his represents the first identification of a highly divergent branch of the Psi family and confirms t

58 rference are shared between S. pombe and the highly divergent budding yeast Saccharomyces cerevisiae

59 l bunyavirid group suggests that ancient and highly divergent bunyavirid lineages remain undetected i

60 Most P450 families are highly divergent, but in contrast the cytochrome P450 14

61 Recent studies have identified the highly divergent C-terminal domain in ankyrin-B as the k

62 in the interaction with the ECF module and a highly divergent C-terminal domain that binds the substr

63 ion from the S. cerevisiae (Sc) Sup35 to the highly divergent C. albicans (Ca) Sup35 both in vivo and

64 laminin-332 beta3 chain provide distinct and highly divergent cell adhesion and tumor-promoting funct

65 ising ability for simultaneous adaptation to highly divergent cell types by combinations of mutations

66 We found a highly divergent circovirus in serum samples from severa

67 We found that B. suis is a highly divergent clade with extensive intraspecific gene

68 We show that X-cells group in two highly divergent clades, robustly sister to the bivalve

69 The cytochrome P450s (CYPs) represent a highly divergent class of enzymes involved in the oxidat

70 s present and other regions either absent or highly divergent compared to strain RM1221.

71 ifferences relative to strain R, including a highly divergent complement of vlhA surface lipoprotein

72 to a broad spectrum of complex inhibitors of highly divergent composition including humic acid, bone

73 Overall, the highly divergent contents of FP and EFP indicate that th

74 A highly divergent coronavirus, tentatively named coronavi

75 we found that trigenic interactions in this highly divergent cross were substantially more frequent

76 Cyclophilin38 (CYP38) is one of the highly divergent cyclophilins from Arabidopsis thaliana.

77 12, and have now investigated three further highly divergent, cystoviral P4 NTPases (from 6, 8 and 1

78 h ancestral neurogenesis mode prefigures the highly divergent cytoarchitectures that are seen in exta

79 ilies listed in the SCOPPI database and from highly divergent cytokine families.

80 During chemotaxis, highly divergent cytoskeletal programs are executed at t

81 A highly divergent de novo asymmetric synthesis of benzyl

82 but we propose that TPRX1, DPRX and DUXA are highly divergent derivatives of the CRX gene, itself a m

83 study focuses on the dorsal ectoderm in two highly divergent dipterans, the fruitfly Drosophila mela

84 r discovery and de novo assembly of a novel, highly divergent DNA virus at the interface between the

85 for cell size control in this important and highly divergent domain of life.

86 gue (C domain), we also identified a second, highly divergent E1 superfamily member, annotated as an

87 he predictable migratory patterns and use of highly divergent ecosystems shown by male tiger sharks a

88 data show that dietary n-3 DPA and EPA have highly divergent effects on human lipid mediator profile

89 irically designed shRNA constructs exhibited highly divergent efficiencies in mediating EGFR knockdow

90 tibility is remarkable given the extreme and highly divergent environments to which these species hav

91 r, these studies provide insights into how a highly divergent eukaryote has re-wired protein N-glycos

92 inucleate pathogen Giardia intestinalis is a highly divergent eukaryote with a semiopen mitosis, lack

93 A polymerase II-dependent gene promoter in a highly divergent eukaryote.

94 me of the trypanosome NPC, a representative, highly divergent eukaryote.

95 As evolutionarily highly divergent eukaryotes, the organisation and conser

96 ch longevity genes are conserved between two highly divergent eukaryotic species, the yeast Saccharom

97 rfectly conserved among eukaryotes, ISG15 is highly divergent, even among mammals.

98 chanisms of plants and animals despite their highly divergent evolutionary paths.

99 fy the hypothetical Mtb protein Rv2179c as a highly divergent exoribonuclease.

100 w other proteins were exceptional in showing highly divergent expression patterns in spite of very lo

101 ylogenetic search and uncovered more than 35 highly divergent families of actin-like proteins (Alps)

102 ifying radical SAM enzymes associated with a highly divergent family of peptides in which the only cl

103 lts from our computational case study of the highly divergent family of retroelements accord with pre

104 alization and in vivo protection against two highly divergent filovirus species, i.e., Ebola virus an

105 P. deltoides Bart (ILL-129) and known to be highly divergent for a vast range of phenotypic traits.

106 Detecting genetic variants that are highly divergent from a reference sequence remains a maj

107 A) gene encodes a protein that appears to be highly divergent from all known influenza NAs and was as

108 The neuraminidase (NA) gene is highly divergent from all known influenza NAs, and the i

109 Human mitochondrial ribosomes are highly divergent from all other known ribosomes and are

110 s virus, named astrovirus VA1 (AstV-VA1), is highly divergent from all previously described astroviru

111 Many of the identified genes are highly divergent from all previously known RNase genes,

112 nd rice, a protein-poor agronomic crop, both highly divergent from Arabidopsis.

113 clearly related to the asfarvirus family but highly divergent from ASFV.

114 oviruses and of two related TTV-like viruses highly divergent from both the TTV and TTV-like miniviru

115 of 122 RNA bacteriophage phylotypes that are highly divergent from each other and from previously des

116 Members of the rare biosphere are highly divergent from each other and, at different times

117 strovirus, HAstV-VA1/HMO-C-UK1(a), which was highly divergent from human astrovirus (HAstV 1-8) genot

118 results suggest that Drosophila myosin-18 is highly divergent from most other myosins in the superfam

119 imation may result in FST estimates that are highly divergent from one another.

120 ave numts of the COI gene, many of which are highly divergent from orthologous mtDNA sequences, and D

121 The N-terminal tail of CENP-A is highly divergent from other H3 variants.

122 teristic of the family Polyomaviridae but is highly divergent from other members of this family.

123 The sequence of J3 is highly divergent from previous anti-HIV-1 VHH and its ow

124 in hyperthermophilic archaeal hosts and are highly divergent from RNA viruses that infect eukaryotes

125 The sequences of all of these enzymes are highly divergent from sequences found in other organisms

126 echnical challenge when the novel species is highly divergent from the closest known species.

127 ed SERT phosphorylation site, Thr-276, being highly divergent from the consensus PKG phosphorylation

128 Because C. parvum IMPDH is highly divergent from the host counterpart, selective in

129 Both variants are highly divergent from the prototype virus and variants i

130 The Boodlea chloroplast genes are highly divergent from their corresponding orthologs, and

131 izing human monoclonal antibodies (MAbs) are highly divergent from their germ line counterparts.

132 The ability of highly divergent FtsZs to function for division in E. co

133 le that is related at the sequence level but highly divergent functionally.

134 series of distinct corepressor variants with highly divergent functions.

135 on resulted in diverse and - in some cases - highly divergent future potential occupancy patterns for

136 T2Rs are a family of approximately 30 highly divergent G-protein-coupled receptors (GPCRs) tha

137 Single channel analysis showed highly divergent gating behavior with Hom and WT favorin

138 l other primate hepaciviruses, including the highly divergent GBV-A and GBV-C viruses, are functional

139 Here, we report the discovery of a novel and highly divergent GBV-B-like virus in an Old World monkey

140 proposed to accommodate two newly discovered highly divergent geminiviruses that presently have no kn

141 al genomes, which are compact with fewer and highly divergent genes [8].

142 enome consisting of a family of 4-10 tandem, highly divergent genes encoding pseudokinases that are i

143 rther indicate that about one third of these highly divergent genes, including cagA and vacA, are und

144 her not targeted by the RVP or missed due to highly divergent genome sequences.

145 Phylogenetic analysis placed these highly divergent genomes near the root of the picorna-li

146 ments, and thus is particularly suitable for highly divergent genomes.

147 We show that these two states acquire highly divergent genomic distributions with substantial

148 that some soluble gp120s and gp140s exhibit highly divergent glycosylation profiles compared to trim

149 he immunogen elicited bnAbs that neutralized highly divergent group 1 (H1 and H5 subtypes) and 2 (H3

150 r of the amidohydrolase superfamily (AHS), a highly divergent group of enzymes that catalyze primaril

151 dbx belongs to the highly divergent H2.0 family of homeobox genes.

152 TH2B-175) located at Xq22.2, which encodes a highly divergent H2B variant.

153 isolation and partial characterization of a highly divergent hantavirus, named Nova virus (NVAV), fr

154 lignification, showed dimorphism (i.e., two highly divergent haplotype lineages at equal frequency),

155 covered that the genome was characterized by highly divergent haplotypes and showed 10- to 30-fold va

156 Population-genetic analyses identified two highly divergent haplotypes at the glc-1 locus that have

157 were attributable to the segregation of two highly divergent haplotypes, Hbbs (which carries two ide

158 haeal biochemistries of NH(3) oxidation is a highly divergent homolog of the ammonia monooxygenase (A

159 onuclease P-can sometimes be replaced with a highly divergent homolog, the cellular response to such

160 e, with improvement being most prominent for highly divergent homologs.

161 Such recognition of highly divergent homologues can be improved by reference

162 If this is true, one might expect highly divergent Hsp70-JDP pairs to be unable to functio

163 The highly divergent HST branch is indicative of greater mtD

164 Surprisingly, the highly divergent human SE domain functions in yeast.

165 These 2 genes were highly divergent in cultured isolates obtained from 23 n

166 ymbionts, despite their common function, are highly divergent in different hosts.

167 Genes that are highly divergent in East Asian H. pylori strains compare

168 nt in the conserved set which were absent or highly divergent in K-12 had close homologues in pathoge

169 is sp PCC6803, although the two proteins are highly divergent in primary sequence.

170 The protoflgCK gene organization was highly divergent in relation to other CK genes but share

171 Type II REases are highly divergent in sequence as well as in topology, i.e

172 ants, referred to as eIF4G and eIFiso4G, are highly divergent in size, sequence, and domain organizat

173 a group of closely related species that are highly divergent in the larval period and body shape and

174 ssion of gene neighbors in either species is highly divergent in the other, in particular when the ne

175 me was found to contain a second, redundant, highly divergent infC gene which, when deleted, had no e

176 The recent identification of highly divergent influenza A viruses in bats revealed a

177 the breadth of binding and neutralization to highly divergent influenza virus strains and subtypes.

178 owever, it is unknown what, if any, role the highly divergent intracellular N and C termini contribut

179 of cytoplasmic actins from humans and even a highly divergent invertebrate Ciona intestinalis qualita

180 Two highly divergent isoforms of eIF4G, known as eIF4G and e

181 to fully elucidate the mechanisms underlying highly divergent LD patterns found in commercial chicken

182 na benthamiana plants were associated with a highly divergent left intergenic region and C4 gene.

183 ents-vimentin intermediate filament (IF) and highly divergent, lens-specific beaded filament (BF)-seq

184 A second, highly divergent lentiviral clade, PLVA, infects mountai

185 are the sole surviving representatives of a highly divergent lineage that arose near the dawn of ant

186 for transmissible strains the coexistence of highly divergent lineages acquired by patient-to-patient

187 es to reveal that their causative agents are highly divergent lineages related to M. mackini (Paramik

188 Four highly divergent lineages were observed, all with signal

189 ncestor was unusual in having maintained two highly divergent long-term L1 lineages with different le

190 l positions, providing an explanation of how highly divergent Ly49s that retain the ability to bind c

191 HTCC5015 is a novel, highly divergent marine member of the Gammaproteobacteri

192 enes or proteins, suggesting that TuSp1 is a highly divergent member of the spider silk gene family.

193 1 is a 'housekeeping' gene, and GmPpcK4 is a highly divergent member, distantly removed from the legu

194 perfamily is vertebrate-specific, with 13-20 highly divergent members in primates and rodents, but on

195 genomes encoding replicase proteins plus two highly divergent members of the Picornavirales order wer

196 f sequence homology-based identification for highly divergent microorganisms is the short length of r

197 hin the angiosperm genus Silene that exhibit highly divergent mitochondrial mutation rates.

198 Two new studies show how highly divergent modes of male reproduction in a wading

199 Our work illustrates how highly divergent morphologies can be derived from modifi

200 Combined, these data suggest that this highly divergent motor may function as an actin tetherin

201 ernal domains forming a catalytic core but a highly divergent N terminus.

202 egulation of CSB/ERCC6 despite the otherwise highly divergent nature of the N- and C-terminal regions

203 We identify highly-divergent New World SNPs that coincide with high-

204 Here, we describe two highly divergent nonclassical MHC class I genes found in

205 nvestigation using a metagenomic approach, a highly divergent novel Human papillomavirus type was ide

206 shown that SM gene clusters are often either highly divergent or uniquely present in one or a handful

207 While the conventional odorant receptors are highly divergent, Or83b is remarkably conserved between

208 The trypanosomatids are highly divergent organisms and possess well-documented b

209 The highly divergent organization and sequence of the C24 an

210 AME potently inhibited the replication of a highly divergent panel of HIV-1 isolates in various T-ce

211 ependent plasmid incompatibility between the highly divergent Par operons of plasmids pB171 and pCP30

212 cluded from the study due to the presence of highly divergent paralogs or xenologs.

213 Two highly divergent parasite lipoate ligase A homologues (L

214 Sequences from a highly divergent parvovirus, provisionally called bufavi

215 onserved, numerous peripheral structures are highly divergent, perhaps reflecting requirements to int

216 enetic influence, which may be the basis for highly divergent phenotypes in complex diseases such as

217 nking sequences of known genomic loci of two highly divergent photosynthetic organisms, Rhodobacter c

218 This clade is characterized by highly divergent physiological strategies, with deciduou

219 The highly divergent PmrD protein is responsible for this ph

220 sequencing approach, we identified a novel, highly divergent polyomavirus, provisionally named MX po

221 ficity, the functional NKT cell subsets were highly divergent populations with many gene-expression a

222 with related individuals and admixture from highly divergent populations, we demonstrate that REAP g

223 or admixture mapping in hybrid zones between highly divergent populations.

224 nous retrovirus (ERV) germline integrants in highly divergent, previously unsequenced mouse lineages,

225 conserved laboratory strains, let alone the highly divergent primary HIV-1 isolates of different sub

226 transcription and cell viability, but has a highly divergent primary sequence in comparison to TFIIB

227 Initial studies found that despite the highly divergent primary structure of different amyloid-

228 sful fusion between a PKS and NRPS that make highly divergent products, and four previously reported

229 tructurally conserved regions (SCRs) even in highly divergent protein families.

230 Inferring evolutionary relationships among highly divergent protein sequences is a daunting task.

231 First, what evidence supports these highly divergent proteins being true homologues to the p

232 g, ab initio, phylogenetic relationships for highly divergent proteins in a quantifiable and robust m

233 ions increases with genetic distance so that highly divergent proteins may have evolved codependencie

234 dings that suggest the presence of unique or highly divergent proteins that may offer therapeutic opp

235 ntrast to their eukaryotic counterparts, are highly divergent proteins whose wide-ranging functions a

236 process versus outcomes metrics and lead to highly divergent provider rankings.

237 og revealed an NA-like structure, but with a highly divergent putative active site exhibiting little

238 ory CD4 T cells comprise subpopulations with highly divergent rates of turnover, and show that inflow

239 use this same switch locus to generate their highly divergent red and brown color pattern elements.

240 Our results show that the highly divergent REF-1 proteins are nonetheless HES-like

241 tion across intermediate-sized and sometimes highly divergent repeats.

242 ic-based classification for HCC have yielded highly divergent results, indicating difficulty in ident

243 The highly divergent ribosomes of human mitochondria (mitori

244 (Leptomonas pyrrhocoris ostravirus 1) with a highly divergent RNA-dependent RNA polymerase missed by

245 unction, revealing that these receptors have highly divergent roles in vascular and metabolic homeost

246 A highly divergent route to lipophilic iminosugars that ut

247 In summary, porcine NoVs and highly divergent SaVs were present in North Carolina fin

248 fh), binds the signal peptides, which have a highly divergent sequence divisible into a positively ch

249 formed by structurally similar proteins with highly divergent sequences ("superfamily heterodimers").

250 around the O-antigen gene cluster contained highly divergent sequences and also appears to be duplic

251 at positions 38, 39, and/or 40 of tRNAs with highly divergent sequences and structures through a poor

252 Template switches between highly divergent sequences appear to be mechanistically

253 tail was substituted with the equivalent but highly divergent sequences from Francisella tularensis.

254 und signature of purifying selection only in highly divergent sequences, suggesting that the method y

255 may detect evolutionary relationships among highly divergent sequences.

256 NA, suggests that trypanosomatids assemble a highly divergent set of these factors at the SLRNA promo

257 e we report the identification of two novel, highly divergent simian arteriviruses related to SHFV, M

258 f population substructure, we identified 114 highly divergent SNPs as candidates for environmental se

259 This transfer of novel S determinants into a highly divergent species (>140 million years apart) with

260 Comparative genomic studies among highly divergent species have been problematic because r

261 of temperate and tropical forest plots with highly divergent species pools (46 vs. 607 species).

262 Therefore, particularly when comparing highly divergent species, functional sequences that are

263 the conservation of protein function between highly divergent species.

264 en parallel evolution will be observed among highly divergent species.

265 nction relationship of these residues across highly divergent species.

266 These results demonstrate that multiple and highly divergent stimuli can trigger the senescent check

267 ring neutralizing antibody responses between highly divergent strains suggested that the MNV genogrou

268 ured when genetic mapping is performed using highly divergent strains, and closely similar strains ar

269 bination with xylem vulnerability to produce highly divergent strategies of water management.

270 ory elements mecI/mecR that also have novel, highly divergent structures.

271 ides a straightforward approach for modeling highly divergent subclasses of patients, which may be ad

272 ns, ACT2, ACT7, and ACT8, in two ancient and highly divergent subclasses.

273 t least two xanthotoxin-inducible P450s from highly divergent subfamilies (CYP6B and CYP321A) contrib

274 A concise and highly divergent synthetic use of 1 was developed, there

275 Previously, we identified a highly divergent T. brucei N-acetylglucosaminyltransfera

276 ra/Tcrd locus is unique because it undergoes highly divergent Tcrd and Tcra recombination programs in

277 and RT genes from treated persons may become highly divergent, these changes usually are the result o

278 Although these viruses are highly divergent, they share a similar genomic plan and

279 divergence and is depleted in patients with highly divergent TIL repertoires.

280 ng RNA (siRNA) biogenesis at the 3' cleaved, highly divergent transcript regions, generating over 100

281 eing showed similar affective correlates but highly divergent transcriptome profiles.

282 he Holliday junction intermediate of several highly divergent tyrosine recombinases.

283 Trichomonas vaginalis is a highly divergent, unicellular eukaryote of the phylum Me

284 on under selection or by the appearance of a highly divergent variant.

285 environments and organisms continue to yield highly divergent viral genomes NCA provides a rapid and

286 We found that ticks are hosts to highly divergent viruses across several taxa, including

287 frican monkeys and discovered several novel, highly divergent viruses belonging to the family Arteriv

288 longed to the SIVsm-HIV-2 lineage, they were highly divergent viruses, in spite of the fact that most

289 ice against lethal influenza challenges with highly divergent viruses.

290 The N termini of adenylyl cyclases are highly divergent, which hints at isoform-specific intera

291 Notch ligand expression are observed in two highly divergent wild C. elegans isolates.

292 ngly, giardial TATA-binding protein (TBP) is highly divergent with respect to archaeal and higher euk

293 n virulence determinants (CagA and VacA) are highly divergent, with 77% and 87% mean amino acid seque

294 The three transcriptomes are highly divergent, with about three-quarters of those gen

295 nterestingly, several other protists possess highly divergent XPB paralogues suggesting that XPBs spe

296 inetoplastid organisms, however, possess two highly divergent XPB paralogues with only the larger bei

297 Finally, another highly divergent yeast RCAN, termed Rcn2 (YOR220w), was

298 es with a copurifying partner termed NupA, a highly divergent yet essential NPC protein.

299 s of cadherins from invertebrates, which are highly divergent yet function in similar roles, remain u

300 ively across the glomerular layer to provide highly divergent yet selective output onto interneurons