ライフサイエンスコーパス: highly pathogenic

1 se in alpha2,6 binding affinity, and was not highly pathogenic.

2 T cells escaped negative selection and were highly pathogenic.

3 he window for treating lethal infection with highly pathogenic A(H5N1) influenza virus in mice.

4 mmunity and improve outcomes associated with highly pathogenic A(H5N1).

5 ks and ones that were infected with either a highly pathogenic (A/duck/Hubei/49/05) or a weakly patho

6 tudes and a single host, while ranavirus was highly pathogenic across multiple hosts, life-stages and

7 antibodies can infer some protection against highly pathogenic AIV (HPAI H5N1), our results imply tha

8 No highly pathogenic AIV (HPAIV) H5 or H7 viruses were dete

9 ous clone, which contains the VNDT motif, is highly pathogenic and causes lethality in a mouse model.

10 The emergent Nipah virus (NiV) is a highly pathogenic and deadly zoonotic paramyxovirus.

11 ed lung lesions and weight loss, but was not highly pathogenic and did not cause mortality.

12 ses substantial morbidity and mortality, and highly pathogenic and drug-resistant strains are likely

13 iew the current status of disease models for highly pathogenic and emerging viral pathogens.

14 an viruses (EBOV and SUDV, respectively) are highly pathogenic and have both caused recurring, large

15 ying novel strategies to effectively address highly pathogenic and lethal infections stemming from ba

16 nerated under high-salt conditions display a highly pathogenic and stable phenotype characterized by

17 duced protection against infection by HIV or highly pathogenic and virulent SIV strains has been limi

18 artland virus in the United States, that are highly pathogenic, and UUKV will now serve as a comparat

19 genic NW arenaviruses, in contrast to the OW highly pathogenic arenavirus LASV, readily elicited an I

20 ilable to combat infection by Lassa virus, a highly pathogenic arenavirus, is toxic and prone to trea

21 nterplays between the host immune system and highly pathogenic arenaviruses as well as distinct mecha

22 In conclusion, strain M23ND has become highly pathogenic as the result of a combination of mult

23 me-series structure of outbreak severity for highly pathogenic avain influenza (H5N1) in Egypt.

24 We previously showed that only a subset of highly pathogenic avian (HPAI) H5N1 influenza virus stra

25 o contribute to severe disease caused by the highly pathogenic avian (HPAI) H5N1 influenza viruses.

26 ection compared them to infections caused by highly pathogenic avian (HPAI) H5N1 viruses.

27 ch transgenic mice were largely resistant to highly pathogenic avian H5 and H7 influenza A viruses, b

28 use annual epidemics of respiratory disease; highly pathogenic avian H5N1 and the recently emerged H7

29 Highly pathogenic avian H5N1 influenza A viruses occasio

30 Although the epidemiology differs from human highly pathogenic avian H5N1 influenza virus infections,

31 Highly pathogenic avian H5N1 influenza viruses have spor

32 Highly pathogenic avian H5N1 influenza viruses remain a

33 Highly pathogenic avian H5N1 influenza viruses sometimes

34 Occasional transmission of highly pathogenic avian H5N1 influenza viruses to humans

35 cells and replicated efficiently, whereas a highly pathogenic avian H5N1 virus (A/Vietnam/1203/2004)

36 Infections with highly pathogenic avian H5N1 virus and, more recently, a

37 e, we report that the PA proteins of several highly pathogenic avian H5N1 viruses have attenuating pr

38 Highly pathogenic avian H5N1 viruses that are a threat t

39 Our results demonstrate that a highly pathogenic avian H7 virus can become capable of a

40 glutinin cleavage and viral propagation of a highly pathogenic avian H7N1 influenza virus strain.

41 ies models to incidence data of outbreaks of highly pathogenic avian influenza (H5N1) in Egypt, avail

42 from a pandemic influenza (pdmH1N1) virus or highly pathogenic avian influenza (H5N1) virus elicits r

43 of alternative clade 2.3.4.4 CVVs.IMPORTANCE Highly pathogenic avian influenza (HPAI) A(H5) viruses h

44 Emerging outbreaks of newly found, highly pathogenic avian influenza (HPAI) A(H5N8) viruses

45 ith seasonal influenza, swine influenza, and highly pathogenic avian influenza (HPAI) from 16 differe

46 In 2015, highly pathogenic avian influenza (HPAI) H5 viruses have

47 birds are suspected to have played a role in highly pathogenic avian influenza (HPAI) H5N1 outbreaks

48 susceptibilities to initial infection with a highly pathogenic avian influenza (HPAI) H5N1 virus (A/t

49 The highly pathogenic avian influenza (HPAI) H5N1 viruses co

50 nicity of H5N1 viruses in mammals.IMPORTANCE Highly pathogenic avian influenza (HPAI) H5N1 viruses co

51 Highly pathogenic avian influenza (HPAI) H5N1 viruses co

52 to mammalian transmission of the majority of highly pathogenic avian influenza (HPAI) H5N1 viruses ma

53 kbones of the 2009 pandemic H1N1 (pH1N1) and highly pathogenic avian influenza (HPAI) H5N1 viruses.

54 Emergence of a highly pathogenic avian influenza (HPAI) H5N8 virus in A

55 A novel highly pathogenic avian influenza (HPAI) H5N8 virus, fir

56 and a backyard farm infected during the 2013 highly pathogenic avian influenza (HPAI) H7N7 epidemic i

57 With the emergence of highly pathogenic avian influenza (HPAI) H7N9 and H5N1 s

58 Highly Pathogenic Avian Influenza (HPAI) has recently (2

59 and between-host evolutionary dynamics of a highly pathogenic avian influenza (HPAI) strain during a

60 e 2009 pandemic influenza virus A/H1N1/2009, highly pathogenic avian influenza (HPAI) virus A/H5N1, a

61 An H7N8 highly pathogenic avian influenza (HPAI) virus and an H7

62 PIV5 expressing the hemagglutinin (HA) from highly pathogenic avian influenza (HPAI) virus H5N1 (PIV

63 Highly pathogenic avian influenza (HPAI) virus H5N1 has

64 Recurrence of highly pathogenic avian influenza (HPAI) virus subtype H

65 .IMPORTANCE The outbreak of clade 2.3.4.4 H5 highly pathogenic avian influenza (HPAI) virus that occu

66 In June of 2012, an H7N3 highly pathogenic avian influenza (HPAI) virus was ident

67 aining NP from H5N1 (A/Vietnam/1203/2004), a highly pathogenic avian influenza (HPAI) virus, between

68 Emerging viruses, such as the H5N1 highly pathogenic avian influenza (HPAI) virus, pose not

69 dented outbreak of Eurasian clade 2.3.4.4 H5 highly pathogenic avian influenza (HPAI) virus.

70 cause morbidity and mortality annually, and highly pathogenic avian influenza (HPAI) viruses along w

71 In early 2016, the presence of H7N8 highly pathogenic avian influenza (HPAI) viruses and clo

72 Highly pathogenic avian influenza (HPAI) viruses of the

73 Highly pathogenic avian influenza (HPAI) viruses of the

74 Highly pathogenic avian influenza (HPAI) viruses of the

75 th the intercontinental spread of H5 subtype highly pathogenic avian influenza (HPAI) viruses of the

76 The spread of H5 subtype highly pathogenic avian influenza (HPAI) viruses of the

77 Infections with H7 highly pathogenic avian influenza (HPAI) viruses remain

78 m wild birds have the potential to mutate to highly pathogenic avian influenza (HPAI) viruses, but su

79 Human infections with highly pathogenic avian influenza A (H5N1) virus are fre

80 9 pandemic H1N1 influenza A (H1N1) virus and highly pathogenic avian influenza A (H5N1) virus induce

81 of efforts to control the global movement of highly pathogenic avian influenza A (H5N1) virus.

82 Highly pathogenic avian influenza A (HPAI), subtype H5N1

83 n, tropism, and cytokine induction of human, highly pathogenic avian influenza A virus subtype H5N1 a

84 The unabated circulation of the highly pathogenic avian influenza A virus/H5N1 continues

85 Whole-genome sequences of representative highly pathogenic avian influenza A(H5) viruses from Vie

86 Highly pathogenic avian influenza A(H5N1) causes severe

87 ciplinary team investigated 2 human cases of highly pathogenic avian influenza A(H5N1) virus infectio

88 Mutation and reassortment of highly pathogenic avian influenza A(H5N1) viruses at the

89 , and it is also emerging, as illustrated by highly pathogenic avian influenza and others.

90 The tropism and pathogenesis of highly pathogenic avian influenza H5N1 virus can partly

91 Highly pathogenic avian influenza H5N1 virus causes a se

92 , by virus and lectin histochemistry, during highly pathogenic avian influenza H5N1 virus infection i

93 The emergence of highly pathogenic avian influenza H5N1 viruses has raise

94 Clade 2.2.2.1 highly pathogenic avian influenza H5N1 viruses were isol

95 A-X deficient 2009 pandemic H1N1 (pH1N1) and highly pathogenic avian influenza H5N1 viruses.

96 ckbone of the 2009 H1N1 pandemic (pH1N1) and highly pathogenic avian influenza H5N1 viruses.

97 Since May 2014, highly pathogenic avian influenza H5N6 virus has been re

98 Recently, novel highly pathogenic avian influenza H5Nx viruses (clade 2.

99 The emergence of a highly pathogenic avian influenza H7N3 virus in poultry

100 An outbreak of highly pathogenic avian influenza H7N7 virus in Italy du

101 Outbreaks of highly pathogenic avian influenza in poultry can cause s

102 economic factors on the seasonality of H5N1 Highly Pathogenic Avian Influenza in the domestic poultr

103 ght to light by the 2009 swine flu pandemic, highly pathogenic avian influenza infections, and the mo

104 s in Washington yielded 10 (6.7%) additional highly pathogenic avian influenza isolates (H5N8 = 3 and

105 With recent concern over the highly pathogenic avian influenza outbreaks around the w

106 date there is no rapid method to screen for highly pathogenic avian influenza strains that may be in

107 The highly pathogenic avian influenza subtype H5N1 (HPAI H5N

108 an intensive study was initiated to conduct highly pathogenic avian influenza surveillance in wild b

109 viral spread after intranasal infection with highly pathogenic avian influenza virus (H5N1 [A/Viet Na

110 ccine is the best way to prevent large-scale highly pathogenic avian influenza virus (HPAI) H5N1 outb

111 ing site that has experienced several recent highly pathogenic avian influenza virus (HPAIV) epizooti

112 Highly pathogenic avian influenza virus (HPAIV) H5N1 can

113 The expression of the H5 HA of an H5N1 highly pathogenic avian influenza virus (HPAIV), A/Vietn

114 A novel highly pathogenic avian influenza virus belonging to the

115 ants of recombinant HA (short and long) from highly pathogenic avian influenza virus H5N1 and the ant

116 Finally, highly pathogenic avian influenza virus H5N1 polymerase

117 Highly pathogenic avian influenza virus infection is cha

118 d others obtained experimental evidence that highly pathogenic avian influenza virus subtype H5 can a

119 ird markets (LBMs) to sustain circulation of highly pathogenic avian influenza virus subtype H5N1 (HP

120 Highly pathogenic avian influenza virus subtype H5N1 is

121 In November 2014, a Eurasian strain H5N8 highly pathogenic avian influenza virus was detected in

122 hunter-harvested wild birds were sampled and highly pathogenic avian influenza virus was detected in

123 rium on gain-of-function (GOF) research with highly pathogenic avian influenza virus, severe acute re

124 elate with the severity of both seasonal and highly pathogenic avian influenza virus.

125 HA) can be activated by furin, a hallmark of highly pathogenic avian influenza virus.

126 otential role for DCs in the pathogenesis of highly pathogenic avian influenza virus.

127 Highly pathogenic avian influenza viruses (HPAIV) induce

128 Clade 2.2 Eurasian-lineage H5N1 highly pathogenic avian influenza viruses (HPAIVs) were

129 are the precursors of numerous outbreaks of highly pathogenic avian influenza viruses in commercial

130 Highly pathogenic avian influenza viruses of the H5N1 su

131 Since 1997, highly pathogenic avian influenza viruses of the H5N1 su

132 Highly pathogenic avian influenza viruses pose a continu

133 The pH of HA activation of highly pathogenic avian influenza viruses was greater th

134 to prevent and treat human disease caused by highly pathogenic avian influenza viruses.

135 upon infection with most strains, including highly pathogenic avian influenza.

136 ized as low pathogenicity avian influenza or highly pathogenic avian influenza.

137 governing human-to-human transmission of the highly pathogenic avian-adapted H5N1 virus, the most cri

138 Burkholderia pseudomallei, a highly pathogenic bacterium that causes melioidosis, is

139 Although MojV is genetically related to highly pathogenic bat-borne henipaviruses, the absence o

140 One of highly pathogenic breast cancer cell types are the tripl

141 rus family includes several members that are highly pathogenic, causing acute viral hemorrhagic fever

142 y spreading from zoonotic sources and can be highly pathogenic, causing serious morbidity and mortali

143 and has been implicated in the emergence of highly pathogenic CDV and host switching.

144 accinated animals control replication of the highly pathogenic clonal simian immunodeficiency virus (

145 lines may have facilitated selection of this highly pathogenic clone.

146 n V. cholerae evolution and the emergence of highly pathogenic clones, such as the variant strains as

147 t 1 decade after the appearance of the first highly pathogenic coronavirus, severe acute respiratory

148 Highly pathogenic coronaviruses are rare and appear to e

149 ere is currently no approved therapeutic for highly pathogenic coronaviruses, even as MERS-CoV is spr

150 te evaluation of inhibitors directed against highly pathogenic coronaviruses.

151 Understanding the pathogenesis of this highly pathogenic CoV is crucial for developing successf

152 cs, or therapeutics to prevent or treat this highly pathogenic disease (case-fatality 35-40%).

153 African swine fever virus (ASFV) is a highly pathogenic, double-stranded DNA virus with a mark

154 HIV) entry were challenged with SHIV89.6P, a highly pathogenic dual-tropic chimeric SIV-HIV viral str

155 The highly pathogenic Ebola virus (EBOV) has a nonsegmented

156 iviral therapeutics and vaccines against the highly pathogenic Ebola virus (EBOV), the cellular mecha

157 lts do not support the previous concept that highly pathogenic EEHV1A crossed from African to Asian e

158 The protease is further hijacked by highly pathogenic emerging viruses for the processing of

159 therapies and safer vaccines to combat these highly pathogenic emerging viruses.

160 yadenylated mRNA (HTTexon1) that encodes the highly pathogenic exon 1 HTT protein.

161 Ebola virus is a highly pathogenic filovirus causing severe hemorrhagic f

162 Marburg virus (MARV) is a highly pathogenic filovirus that is classified in a genu

163 resistant influenza viruses and in view of a highly pathogenic flu pandemic, it is important to devel

164 ntly discovered emerging herpesvirus that is highly pathogenic for koi and common carp.

165 at B. salamandrivorans is restricted to, but highly pathogenic for, salamanders and newts (Urodela).

166 ansition from the low pathogenic form to the highly pathogenic form occurred within the first infecte

167 genic ASFV isolate, OUR T88/3 (OURT), or the highly pathogenic Georgia 2007/1 (GRG).

168 1pdm09, H3N2, and type B viruses, as well as highly pathogenic H5 and H7 viruses.

169 ment for influenza, including that caused by highly pathogenic H5N1 and oseltamivir-resistant H1N1 vi

170 n monocyte-derived macrophages infected with highly pathogenic H5N1 and seasonal H1N1 influenza virus

171 penia is a hallmark of severe infection with highly pathogenic H5N1 and the newly emerged H7N9 influe

172 ng a pandemic H1N1 influenza virus strain, a highly pathogenic H5N1 avian influenza virus strain, and

173 ins in vitro, including pandemic H1N1 virus, highly pathogenic H5N1 avian influenza virus, and the re

174 Highly pathogenic H5N1 avian influenza viruses are assoc

175 Highly pathogenic H5N1 avian influenza viruses are assoc

176 Highly pathogenic H5N1 avian influenza viruses continue

177 Many amino acid substitutions in highly pathogenic H5N1 avian influenza viruses have been

178 Highly pathogenic H5N1 avian influenza viruses have caus

179 96 (H5N1) in farmed geese in southern China, highly pathogenic H5N1 avian influenza viruses have pose

180 Highly pathogenic H5N1 avian influenza viruses must acqu

181 ruses are harmless for humans, some (such as highly pathogenic H5N1 avian influenza viruses) are capa

182 agent or prophylactic with activity against highly pathogenic H5N1 avian influenza viruses.

183 as well as in the pandemic 2009 H1N1 and the highly pathogenic H5N1 flu strains.

184 Highly pathogenic H5N1 influenza A viruses continue to c

185 sonal H1N1 and H3N2, pandemic 2009 H1N1, and highly pathogenic H5N1 influenza A viruses: identificati

186 acid stability) influences the properties of highly pathogenic H5N1 influenza virus in mammalian host

187 Although the number of human infections with highly pathogenic H5N1 influenza viruses continues to ri

188 rast to other avian IAVs, recent isolates of highly pathogenic H5N1 influenza viruses had a high prop

189 ns known to increase the transmissibility of highly pathogenic H5N1 influenza viruses.

190 in thus plays a role in the pathogenicity of highly pathogenic H5N1 influenza viruses.

191 ylactically before intranasal inoculation of highly pathogenic H5N1 virus (A/Indonesia/05/2005) and w

192 protective efficacy of an H5N1 LAIV against highly pathogenic H5N1 virus challenge in the absence of

193 ickens from challenge with the novel H7N9 or highly pathogenic H5N1 viruses, respectively.

194 ficant contributors to progeny production of highly pathogenic H5N1 viruses.

195 s frequently truncated in recent isolates of highly pathogenic H5N1 viruses.

196 and morbidity of homologous and heterologous highly pathogenic H5N1.

197 Similar to other highly pathogenic H7 viruses, MX/7218 replicated to high

198 However, unlike highly pathogenic H7 viruses, the disease-causing potent

199 Adaptation of low-pathogenic H7N7 to highly pathogenic H7N7 in Europe in 2015 raised further

200 H7N9, seasonal H3N2, pandemic-2009 H1N1, and highly pathogenic H7N7 influenza A viruses.

201 These results suggest that the highly pathogenic H7N9 virus has pandemic potential and

202 The highly pathogenic H7N9 viruses replicated efficiently in

203 We report here that the highly pathogenic HIV R3A efficiently activated pDCs to

204 nons, as well as that from recently isolated highly pathogenic HIV-1 group N, do not discriminate bet

205 Risk factors for human infection with highly pathogenic (HP) and low-pathogenic (LP) avian inf

206 exemplified by the apparent disappearance of highly pathogenic (HP) H5N1, H5N2, and H5N8 (H5Nx) virus

207 protein, which were previously found in the highly pathogenic (HP) human influenza A (H7N9) [IAV(H7N

208 iratory syndrome coronavirus (MERS-CoV) is a highly pathogenic human CoV that emerged in Saudi Arabia

209 espiratory syndrome CoV (SARS-CoV) represent highly pathogenic human CoVs that share a property to in

210 Highly pathogenic human respiratory coronaviruses cause

211 Bats are the reservoir host for many highly pathogenic human viruses, including henipaviruses

212 of these genes in lung tissue in response to highly pathogenic IAV infection by 400-fold, 30-fold, 30

213 proteins have consistently been shown to be highly pathogenic in HD mouse models, the aberrant splic

214 enia syndrome virus and Heartland virus, are highly pathogenic in humans.

215 H5N1 viruses possessing these mutations are highly pathogenic in mice).

216 r to that of A/Anhui/1/2013 (H7N9), which is highly pathogenic in mice.

217 and reemerging viruses, several of which are highly pathogenic in other mammals but cause no clinical

218 induce hepatitis in wild-type mice, but was highly pathogenic in RNase L deficient mice.

219 receptors CCR6 and CXCR3, are proposed to be highly pathogenic in several autoimmune disorders due in

220 nteract with cartilage in vivo and are often highly pathogenic in the mouse.

221 genic CD103(-) DCs that overexpress Opn were highly pathogenic in vivo.

222 White-nose syndrome is a highly pathogenic infectious disease of bats currently s

223 e, that were challenged with lethal doses of highly pathogenic influenza A H5N1 or H1N1 viruses.

224 Thus, we sought to determine if a highly pathogenic influenza A H7N1 (A/H7N1) virus with n

225 Highly pathogenic influenza A viruses, including avian H

226 llenged with homologous or heterologous H5N1 highly pathogenic influenza strains.

227 ule in inflammation, was evaluated following highly pathogenic influenza virus challenge in mice.

228 ated in vitro can promote survival against a highly pathogenic influenza virus via an antibody-indepe

229 Highly pathogenic influenza viruses of the H5N1 subtype

230 clones with divergent disease potentials: a highly pathogenic isolate that replicates rapidly in vit

231 compared a low pathogenic H7N9 virus with a highly pathogenic isolate, and two of its variants that

232 s obtained from macaques infected with three highly pathogenic lines of Lassa virus (LASV), the causa

233 l activity of Ceftriaxone/Cefotaxime against highly pathogenic MRSA infection.

234 However, the host innate immune responses to highly pathogenic New World (NW) arenaviruses are not we

235 The G attachment protein stalk domain of the highly pathogenic Nipah virus (NiV) contains a distinct

236 en that replication and dissemination of the highly pathogenic Nipah virus (NiV) include exposure to

237 In contrast, infections with the highly pathogenic NW arenavirus JUNV are associated with

238 MACV, another highly pathogenic NW arenavirus, also activated IFN resp

239 we report that Machupo virus (MACV), another highly pathogenic NW arenavirus, also induces an IFN res

240 We have previously shown that the highly pathogenic NW arenavirus, Junin virus (JUNV), ind

241 The highly pathogenic Old World (OW) arenavirus Lassa fever

242 , were evaluated for their ability to render highly pathogenic organisms nonviable and safe for handl

243 y, enables commensal bacteria to function as highly pathogenic organisms, causing rapid host death.

244 (VACV) stimulates long-term immunity against highly pathogenic orthopoxvirus infection of humans (sma

245 pment of next-generation, safer vaccines for highly pathogenic orthopoxviruses.

246 Infections of humans with the highly pathogenic OW LASV are accompanied by potent supp

247 via aerosol may lead to the development of a highly pathogenic pandemic H5 virus.

248 diagnostic indicators of virulence linked to highly pathogenic pandemic influenza viruses without amp

249 otein associated with increased virulence in highly pathogenic pandemic influenza viruses.

250 Hendra virus is a highly pathogenic paramyxovirus classified as a biosafet

251 HA cleavage site, non-H5/H7 HA can support a highly pathogenic phenotype in the appropriate viral bac

252 eplication of EEEV and may contribute to its highly pathogenic phenotype.IMPORTANCE Eastern equine en

253 In this study, we demonstrated that highly pathogenic PRRSV (HP-PRRSV) infection specificall

254 The highly pathogenic R3A efficiently activated pDCs to indu

255 enza viruses have recently evolved to become highly pathogenic, raising concerns of a pandemic, parti

256 iratory syndrome coronavirus (SARS-CoV) is a highly pathogenic respiratory virus that causes morbidit

257 iratory syndrome coronavirus (MERS-CoV) is a highly pathogenic respiratory virus that emerged from zo

258 iratory syndrome coronavirus (MERS-CoV) is a highly pathogenic respiratory virus that emerged from zo

259 onavirus (MERS-CoV) emerged in 2012 and is a highly pathogenic respiratory virus.

260 implicated in lung disease induced by other highly pathogenic respiratory viruses.IMPORTANCE PF has

261 e for ERGIC-53 in the propagation of several highly pathogenic RNA virus families.

262 ear import antagonists, expressed by several highly pathogenic RNA viruses, likely mediate pleiotropi

263 matory cytokine response, and the outcome of highly pathogenic S. suis infection in a mouse model.

264 ly was serotype specific and associated with highly pathogenic serotypes (O157 and top non-O157 Shiga

265 Highly pathogenic severe acute respiratory syndrome coro

266 The highly pathogenic severe acute respiratory syndrome coro

267 After seven rectal challenges with highly pathogenic SIVmac251, the hazard ratio was 0.27,

268 ted low-dose intravaginal challenge with the highly pathogenic SIVmac251, we show that although these

269 milar to that of GP from Zaire ebolavirus, a highly pathogenic species, in terms of both the activati

270 mechanistic insights into the activity of a highly pathogenic splice variant of HER2.

271 minants for growth in vitro and in vivo of a highly pathogenic strain of C. jejuni.

272 Upon challenge with a highly pathogenic strain of ChikV, the mutant blocked vi

273 The major findings of this report are that a highly pathogenic strain of H7N1 avian influenza virus c

274 ve immunity against enteric challenge with a highly pathogenic strain of Salmonella.

275 ble, aviraemic control of infection with the highly pathogenic strain SIVmac239.

276 hesus macaques from mucosal infection by the highly pathogenic strain SIVmac251.

277 Outbreaks of highly pathogenic strains of avian influenza viruses (AI

278 Infection with highly pathogenic Streptococcus suis can cause septic sh

279 In highly pathogenic systemic influenza infections, the win

280 ese findings demonstrate that AEA suppresses highly pathogenic T cell subsets through CB1-mediated ma

281 licated in such infections, but since 2003 a highly pathogenic, tetracycline-resistant C. jejuni clon

282 ycete clade, adapted to vertebrate hosts and highly pathogenic to amphibians.

283 Although these viruses are highly pathogenic to humans, our study highlights distin

284 that although all viruses studied herein are highly pathogenic to humans, the host IFN responses towa

285 viruses, including several viruses that are highly pathogenic to other mammals.

286 ses are insect-specific DNA viruses that are highly pathogenic to their insect hosts.

287 Although highly pathogenic to their spillover hosts, bats harbor

288 A novel and a highly pathogenic TPMT variant not detectable through st

289 V), a member of the Filoviridae family, is a highly pathogenic virus that causes severe hemorrhagic f

290 or high-containment conditions to study this highly pathogenic virus.

291 ction.IMPORTANCE EBOV belongs to a family of highly pathogenic viruses that cause severe hemorrhagic

292 Many of the NW arenaviruses are highly pathogenic viruses that cause systemic human infe

293 ability to develop vaccine platforms against highly pathogenic viruses, but rather the lack of will/i

294 The arenavirus family consists of several highly pathogenic viruses, including the Old World (OW)

295 ch was to modify the hemagglutinin gene of a highly pathogenic wild-type (wt) clade 2.2.1.1 virus, A/

296 sulted in significant protection against the highly pathogenic wild-type H5N1 virus.

297 Ebola virus (EBOV) is highly pathogenic, with a predisposition to cause outbre

298 from a rapid-progressor PTM was consistently highly pathogenic, with high acute and chronic viral rep

299 The highly pathogenic Yersinia enterocolitica strains have a

300 us with a 5'-monophosphorylated genome, is a highly pathogenic zoonotic agent with significant public