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1 ostly electrostatic-driven but, nonetheless, highly selective.
4 structural novelty, these hollow cages show highly selective adsorptions for CO2 over CH4 or N2 at a
5 ted molecules known as photosensitizers, are highly selective against many malignancies and can bypas
6 gical concept of biased agonism asserts that highly selective agonists can preferentially direct rece
7 the protein kinase field, only a handful of highly selective allosteric modulators have been found.
8 fast response time (<15s), simple, low cost, highly selective along with abilities towards online mon
9 her prophylactic low-dose dexmedetomidine, a highly selective alpha2 adrenoceptor agonist, could safe
14 methodologies, we report the development of highly selective and bioavailable small molecule IRAK4 i
15 pases that are not targeted by PF04457845, a highly selective and clinically tested FAAH inhibitor.
16 of DABCO with a triarylaminium salt, effects highly selective and contra-thermodynamic C-H abstractio
18 nucleus and the cytoplasm is facilitated by highly selective and efficient biomachines known as nucl
19 T) and nickel catalysis, we have developed a highly selective and general C-H arylation protocol that
20 -3-O-propargyl-thiodigalactoside resulted in highly selective and high affinity galectin-3 inhibitors
21 -folded conformation that is predisposed for highly selective and high affinity recognition of metal
22 ons with Orbitrap mass spectrometry (MS) for highly selective and highly sensitive identification of
24 udy, we investigated the effects of a novel, highly selective and potent BTK inhibitor, BI-BTK-1, in
25 h a rational design approach we discovered a highly selective and potent BTK kinase inhibitor (CHMFL-
29 thetic strategy enabled the discovery of two highly selective and potent SGLT2 inhibitors, thereby pa
30 nsequences of ITK and RLK inhibition using a highly selective and potent small molecule covalent inhi
34 and appKM) showed that the multiplex MBD was highly selective and sensitive (LRS>/=100 nA/mM) for eac
35 d on the fields of economy and science where highly selective and sensitive analysis of odorous subst
36 a unique nanobiosensor HL-FeNPs which showed highly selective and sensitive detection of Al(3+) in 10
37 A label-free fluorescence aptasensor for highly selective and sensitive detection of ATP and thro
43 The results showed that the biosensor is highly selective and sensitive for the detection of prot
46 a dual-responsive optical marker to develop highly selective and sensitive probe as visible (sol-to-
47 sual fluorescence quenching "Test Paper" was highly selective and sensitive recognizing Cu(2+) at mum
48 of novel catalytic systems and new tools for highly selective and sensitive sensing platforms for var
49 ure demonstrates that it is a simple, rapid, highly selective and sensitive, and it gives good enrich
50 e rings, is unique in its ability to undergo highly selective and sequential aminolysis reactions in
52 ed with the imprinted nanocomposite showed a highly selective and ultrasensitive electrochemical resp
54 02 nM; cellular Mps1 EC50 = 6.5 +/- 0.5 nM), highly selective, and orally active small-molecule inhib
56 of alpha-ketoheterocycle LEI105 as a potent, highly selective, and reversible dual DAGL-alpha/DAGL-be
59 ime hybrid synthetic receptors comprising of highly selective aptamer-lined pockets (apta-MIP) with F
60 ion of ATM kinase in HD neuroprogenitors was highly selective, as DNA damage and oxidative injury, ca
61 een established in this study, thus allowing highly selective assembly of various functional units in
62 und in all eukaryotes, MINDY-family DUBs are highly selective at cleaving K48-linked polyUb, a signal
63 o}quinoline-3-carboxamide (74) as potent and highly selective ATM inhibitors with overall ADME proper
64 N-donor chelator led to the development of a highly selective Au(3+) chemosensor that operates via a
65 However, the creation of second-generation, highly selective Aurora kinase inhibitors has increased
66 s enhanced upon binding of Na(+)-ions to the highly selective aza-crown ether receptor due to reducti
67 etonide-protected pyroglutaminol undergoes a highly selective azaaldol addition with (E)-N-phenyl-1-[
71 ucleotide polymorphism (SNP) detection using highly selective BiDz sensors targeting loci associated
72 ally disordered proteins engage in rapid and highly selective binding is a subject of considerable in
75 ent ablation could aid in the development of highly selective broad-acting anti-cancer therapies.
77 ent bonding is found to stem from a chain of highly selective C-H activation and dehydrogenation proc
79 required the development of a late-stage and highly selective C-H oxidation of complex aspidosperma a
82 n, we report that nickel sulfide Ni3 S2 is a highly selective catalyst for the oxygen reduction react
84 hesized and characterized [(3)H]RO6957022, a highly selective CB2R inverse agonist, as a radiolabeled
86 atural systems, which inspires us to develop highly selective chem/(bio)sensors for in vivo analysis
87 propose an NMR analytical procedure based on highly selective chemical shift filters followed by TOCS
88 strated, the development of an efficient and highly selective circularly polarized light photodetecto
89 nt of mouse pancreatic islets with CX4945, a highly selective CK2 inhibitor, greatly reduced agonist-
90 ides and identified JNJ63955918 as a potent, highly selective, closed-state Nav1.7 blocking peptide.
92 ning paradigm, we have identified JNJ0966, a highly selective compound that inhibited activation of M
93 N-aryl tetramic acid which is advanced via a highly selective conjugate addition/intramolecular Fried
94 ention over the last decade as it allows the highly selective construction of poly-substituted cyclop
96 rts the identification of multiple series of highly selective covalent ERK1/2 inhibitors informed by
97 an-FGFR inhibitors, we generated H3B-6527, a highly selective covalent FGFR4 inhibitor, through struc
102 removal of the prodrug moieties to achieve a highly selective delivery of the NDP in CEM cell extract
103 wires and aptamers allowed the sensitive and highly selective detection of acetamiprid with a linear
104 rbitrary waveform generation, we demonstrate highly selective detection of picosecond signals overlap
109 on structures of human Sirt2 in complex with highly selective drug-like inhibitors that show a unique
110 In this study, we report a sensitive and highly selective dual-aptamer-based sandwich immunosenso
115 PDEdelta inhibitor, named Deltazinone 1, is highly selective, exhibits less unspecific cytotoxicity
118 glomerular filtration barrier, a dynamic and highly selective filter that sieves on the basis of mole
120 lso, the addition of ciprofloxacin induced a highly selective fluorescence enhancement of PVD with a
121 rachin I and arachin were found to behave as highly selective fluorescence sensors for periodate amon
124 ty antisense nucleic acid probes, which show highly selective fluorogenic reactivity when annealed to
125 Here, we show that tautomycetin (TTN) is highly selective for a single PPP, protein phosphatase 1
128 The cell death induced by ATR inhibitors is highly selective for cancer cells that rely on ALT, sugg
130 able D3R affinity (Ki = 12-25.6 nM) and were highly selective for D3R vs D3R (ranging from 264- to 90
132 ovel positive allosteric modulators that are highly selective for GluN2A-containing NMDA receptors.
134 ganglion cells in the mouse retina that are highly selective for horizontal and vertical cardinal or
135 ic lexicon based on neuronal representations highly selective for individual written real words (RWs)
136 binding assays confirmed that the protein is highly selective for ligands and that it binds a fatty a
137 bitor 36 (IC50 = 80 nM) was identified to be highly selective for MBLs when compared to other Zn(II)
141 c prolyl oligopeptidase inhibitors that were highly selective for POP over a number of homologous pro
145 subjected to further characterization and is highly selective for the BET family of bromodomains.
147 -fluorine bond functionalization reaction is highly selective for the formation of organoaluminium pr
148 rofiling, we demonstrate that PF-06446846 is highly selective for the inhibition of PCSK9 translation
149 amined novel PI3Kdelta inhibitors, which are highly selective for the p110delta isoform of in CD3/CD2
151 task, disparity-selective neurons in V2 were highly selective for the task, and their activity correl
152 l as inhibition of the mTORC1 pathway and is highly selective for the therapeutic T cells without aff
155 sed in this combination, the alkoxylation is highly selective for tyrosine residues in peptides and p
159 otocol, which can be achieved in one pot, is highly selective, giving rise to a simple mixture of pro
160 hosphoric acids (CPAs) were used to catalyze highly selective glycosylations at the C5 positions of m
161 n diameter, suggesting that high throughput, highly selective graphene electrodialysis membranes can
164 th its protein targets (low in alpha) and is highly selective (high in beta) in forming the probe-pro
167 ynthetic macrocycles for structure-specific, highly selective, host-guest complexation has experience
168 fect transistor (EG-FET) transducer leads to highly selective HSA determination in the femtomolar con
171 the required combination of [Al] and [B], a highly selective hydrosilylative reduction of CO2 system
175 1,2,3-triazol-5-yl)benzene)), is found to be highly selective in the adsorption of CO over a variety
176 y after the onset of a sound and then become highly selective in the following sustained response epo
178 torial review provides critical insights for highly selective in vivo analysis and offers new concept
182 ate that the use of compound ND-336, a novel highly selective inhibitor of gelatinases (MMP-2 and MMP
183 We have identified BMS-986126, a potent, highly selective inhibitor of IRAK4 kinase activity that
184 cell line, suggesting that it may provide a highly selective inhibitor of MEK1/2 for use as a cancer
185 phenoxy)benzyl)morpholine ((11)C-MeNER) is a highly selective inhibitor of noradrenaline transporters
186 ed in the identification of 52, a potent and highly selective inhibitor of PI3Kdelta that demonstrate
187 This work led to the discovery of 35, a highly selective inhibitor of PI3Kdelta which displays a
188 the difference between the responses of our highly selective inhibitors and published tool compounds
189 nge to medicinal chemists seeking to develop highly selective inhibitors as pharmacological probes an
190 re current cancer targets; however, very few highly selective inhibitors for these are available.
193 nyl}acrylonitrile (DG172) was developed as a highly selective inhibitory peroxisome proliferator-acti
195 nidinylated peptide-based ligands that allow highly selective, intermolecular Cu-catalyzed cross-coup
196 dentical withMo(OC(CH3)(CF3)2)3] undergoes a highly selective intramolecular backbiting into the buty
197 tudies unraveling the mechanism of a unique, highly selective intramolecular C(sp(2))-OMe cleavage/C(
198 e mitochondrial calcium uniporter (MCU) is a highly selective ion channel that transports Ca(2+) into
199 during the past 2 decades, identification of highly selective JAK3 inhibitors has eluded the scientif
201 els, despite a significant homology with the highly selective K(+) channels, do not discriminate amon
202 as identified as a potent (Ki = 0.63 nM) and highly selective kappa agonist (EC50 = 1.8 nM) selective
204 3.3.1] nonan-3-amine] is a high-affinity and highly selective ligand at alpha3beta4 nicotinic choline
205 rthermore, chronic administration of a novel highly selective M4 positive allosteric modulator (PAM)
206 (1) a designed, short peptide that displays highly selective, major groove DNA binding, (2) a revers
210 reveal that bacteria have evolved to utilize highly selective metalloregulatory riboswitches, in addi
214 d are expected to provide the foundation for highly selective miR-based therapy to manipulate neutrop
216 e that peripheral nerve injury may result in highly selective mRNA enrichment in the affected axons w
218 g groups with minimal wavelength overlap and highly selective natural and unnatural amino acid recogn
219 Single orientations are better encoded by highly selective neurons, while orientation mixtures are
220 d to the identification of high affinity and highly selective NFT ligands, and recent progress in the
221 eroid-resistant asthma were examined using a highly selective NLRP3 inhibitor, MCC950; the specific c
222 ivity, the results reveal the feasibility of highly selective non-metal chelating, substrate-competit
224 ablishes the molecular basis of binding of a highly selective nonpeptidyl allosteric antagonist of CC
226 e used molecular modeling approach to design highly selective NTS2 ligands by investigating the docki
227 is shown to be susceptible to a subsequent, highly selective nucleophilic displacement reaction.
230 d to the development of MLi-2 (1): a potent, highly selective, orally available, brain-penetrant inhi
232 tent irreversible inhibitor of LOXL2 that is highly selective over LOX and other amine oxidases.
236 he process is not stochastic and mirrors the highly selective patterns of MN degeneration observed in
238 7 (DNS-8254), was identified as a potent and highly selective PDE2a enzyme inhibitor with favorable r
239 he mPTP in failing human myocardium, and the highly selective pharmacological blockade of either iPLA
240 ses in mitochondrial ROS emission, whereas a highly-selective pharmacological inhibitor was exploited
241 f catalytic activation that accomplishes the highly selective photoredox alpha-alkylation/lactonizati
243 (I) mediated aerobic oxidation of betulin, a highly selective PIFA mediated dehydrogenation of an oxi
245 e polymerization resulted in the creation of highly selective polymeric cavities that retained the ab
246 (BQCA) and benzoquinazoline-12 (BQZ-12), two highly selective positive allosteric modulators (PAMs) o
249 luorogenic chemistry to NIR dyes, we believe highly selective proximity-induced fluorogenic tetrazine
250 novel organocatalytic transformations: 1) a highly selective pyranose to furanose ring tautomerizati
251 using oxaziridine-based reagents to achieve highly selective, rapid, and robust methionine labeling
252 nsition-metal-free and temperature-dependent highly selective reaction of arynes with 2H-azirines all
254 rinted polymer (MIP) nanoparticles including highly selective recognition sites for fluoxetine were s
255 we outline the selection and refinement of a highly selective recombinant antibody for specific adduc
256 is contribution reports the first example of highly selective reduction of CO2 into CH4 via tandem hy
258 anced random networks, which already exhibit highly selective responses at eye opening, can develop f
260 ith metformin (Xigduo), is an orally active, highly selective, reversible inhibitor of sodium-glucose
261 Here we describe the discovery of the first highly selective, reversible Rpn13 ligands and show that
264 We identified JNJ-54271074, a potent and highly-selective RORgammat inverse agonist, which dose-d
265 terminus and distinguish the enzyme from the highly selective RppH present in Bacillus subtilis.
267 he synthesis of a metal-free chemosensor for highly selective sensing of pyrophosphate (PPi) anion in
269 al shows permanent porosity and demonstrates highly selective separation of C2H2/CO2 at ambient tempe
270 n, and radiation dosimetry in humans for the highly selective sigma-1 receptor PET agent (18)F-6-(3-f
273 eptide agonist, Melanotan II (MTII), and the highly selective, small-molecule MC4R agonist, Pf-446687
274 oting TIC formation and highlights pdTp as a highly selective SND1 inhibitor as a candidate therapeut
275 ovide a perfect confined environment for the highly selective stabilization of trinuclear copper-oxo
277 ation of covalently modified CFMs to achieve highly selective, subsecond Cu(II) measurements using FS
278 Here, we demonstrate a method to engineer highly selective synthetic antibodies (sABs) against LD2
280 lanine (Cha) derivative of Phe, we generated highly selective tetrapeptide substrates acetyl-Lys-Lys-
283 ed negatively charged modified electrode was highly selective to Amitriptyline and it was shown a wid
284 e site labeling, the capture surface must be highly selective to avoid the influence of nonspecific a
286 In fluorescence channel, 1 was found to be highly selective to H2S in 50% aqueous buffer (pH 7).
289 s spectrometry (MS) is presented as a novel, highly selective tool for the assessment of protein-prot
291 de more active than the Rh(111) surface, but highly selective toward methane, while the Rh(111) surfa
296 To this end, we microinjected BDNF or the highly selective TrkB receptor antagonist [N2-2-2-oxoaze
297 fied a subset of tectal neurons with similar highly selective tuning, which show non-linear mixed sel
298 potentials that span nearly 400 mV, mediate highly selective two-electron reduction of O2 to H2O2 (9
299 5 nM) and A3AR antagonist (Ki = 0.31 nM) and highly selective versus A2A; 11 and 26 were most potent
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