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1 The proposed method is simple, selective and highly sensitive.
2 ly specific, fast, easy, cost effective, and highly sensitive.
3 atbird, a relevant wildlife species, is also highly sensitive.
4  the removal of the Nap protecting groups on highly sensitive 2,6-dideoxy-sugar disaccharides.
5 ification of RNAs has the capability to be a highly sensitive, accurate and discerning method for sin
6  threshold-based spike detection utilizing a highly sensitive algorithm named SWTTEO.
7                                              Highly sensitive ammonia sensors for environmental monit
8 dinary optical transmission (EOT), providing highly sensitive analysis in a label-free configuration.
9 ansduction, enabling chemically specific and highly sensitive analytical signals generation.
10 olabeled NPs could be used as a noninvasive, highly sensitive analytical tool to quantitatively track
11 pecific time points throughout therapy using highly sensitive and accurate HCV RNA assays.
12               Taken together, INTEGRATE is a highly sensitive and accurate tool that is freely availa
13                               We developed a highly sensitive and adaptable donor/acceptor pair that
14      Nearly all motile bacterial cells use a highly sensitive and adaptable sensory system to detect
15 using Sanger, TA cloning and sequencing, and highly sensitive and allele-specific polymerase chain re
16    Thus, the dopamine reward signal is fast, highly sensitive and appropriate for driving and updatin
17                                  CQ probe is highly sensitive and exhibits 100-fold fluorescence enh
18                                              Highly sensitive and fast photodetectors can enable low
19                      Our results showed that highly sensitive and improved LOD is subjected to partic
20                                              Highly sensitive and label free detection of prostate sp
21          In this paper, for the first time a highly sensitive and low-cost electrochemical aptasensor
22               This work aims at developing a highly sensitive and low-cost light emitting diode (LED)
23 pability of nano-biomaterials for developing highly sensitive and more efficient immunosensors was va
24 R and SAF microlens array allows for on-chip highly sensitive and multiplexed pathogen detection with
25 antitative single-cell RNA-seq (MATQ-seq), a highly sensitive and quantitative method for single-cell
26                                         This highly sensitive and reproducible online 2D platform is
27                                         This highly sensitive and robust LC-MS/MS technique was appli
28  Herein, we demonstrate that the strategy is highly sensitive and robust.
29 ity on the downstream response because it is highly sensitive and saturable.
30         Herein, the development of a simple, highly sensitive and selective aggregation-induced emiss
31 gulatory authorities and food analysts adopt highly sensitive and selective analytical methods for mo
32 erials provide a path for the development of highly sensitive and selective biosensors for future gen
33  novel fluorescence sensing platform for the highly sensitive and selective detection of DNA.
34 a block copolymer template was developed for highly sensitive and selective detection of hydrogen per
35 n of a novel ion-selective electrode for the highly sensitive and selective determination of creatini
36 as a potential matrix for the realization of highly sensitive and selective field effect transistor-t
37                            Here we present a highly sensitive and selective glucose sensor based on c
38 here has been an increasing demand for fast, highly sensitive and selective methods of analysis to me
39 S) is an arising new technique for versatile highly sensitive and selective multigas analysis in vari
40                               Development of highly sensitive and selective semiconductor-based metal
41 f CVD graphene were exploited to construct a highly sensitive and selective SPR chip for folate bioma
42                          Here, we describe a highly sensitive and selective surface plasmon resonance
43   The gE-coated immunosensor was shown to be highly sensitive and selective to anti-gE present in com
44                     Au-CBS-LDI MS presents a highly sensitive and specific alternative to MALDI MS fo
45           This SID nanoLC-NSI/MS/MS assay is highly sensitive and specific and it requires only 50 mu
46                       Herein, we developed a highly sensitive and specific assay for the simultaneous
47 e-based material, and instantaneously yields highly sensitive and specific detection of Ebola glycopr
48 ent CHimEra Tracking Engine), which achieves highly sensitive and specific detection of gene fusions
49 ) biosensing strategy has been developed for highly sensitive and specific detection of target DNA by
50                          Here we demonstrate highly sensitive and specific detection of Zika, chikung
51                  There is the urgent need of highly sensitive and specific diagnostic platforms for i
52                                  We report a highly sensitive and specific electrochemical biosensor
53 ing combined with mosaicking has shown to be highly sensitive and specific for non-invasively guiding
54               This biosensor was found to be highly sensitive and specific for SPy, with a limit of d
55 itoring intra- and subcellular redox events, highly sensitive and specific probes are required.
56 In this study, we developed a simple, rapid, highly sensitive and specific sensor based on an aptamer
57  I from non-purified culture samples, having highly sensitive and specific signal responses comparabl
58             INTERPRETATION: Our algorithm is highly sensitive and specific, accurately predicting the
59                The detection of viral RNA is highly sensitive and specific, but periods of viremia an
60 cence In Situ Hybridization (FISH) and while highly sensitive and specific, it is also labour intensi
61 g need to develop biosensor methods that are highly sensitive and that can be combined with low-cost
62 cal strategy of AFP surveillance systems for highly sensitive and timely detection of cases.
63 -health concern prompting an urgent need for highly-sensitive and rapid diagnostic technology.
64          Further, it is simple, inexpensive, highly sensitive, and can be successfully applied to sep
65 gs are very promising for the development of highly sensitive, and potentially portable immunosensors
66                                              Highly sensitive ( approximately 0.6 zeptomole) mass spe
67                          In addition, such a highly sensitive assay allows discrimination of drug-ind
68 increasing the local particle concentration, highly sensitive assays can be performed efficiently and
69 Cardiac troponin detected by new-generation, highly sensitive assays predicts clinical outcomes among
70 y for bone marrow aspiration and the lack of highly sensitive assays to detect residual disease prese
71                           When the PHQ-9 was highly sensitive, authors more often reported results fo
72 ing ProGastrin Releasing Peptide (ProGRP), a highly sensitive biomarker for Small Cell Lung Cancer, a
73 engineering of nanoscale components that are highly sensitive, biorecognition ligands that are capabl
74                                  A novel and highly sensitive biosensor employing graphene oxide nano
75 er through the electrochemical analysis of a highly sensitive biosensor for the detection of tumor ne
76                                 Therefore, a highly sensitive biosensor with a low detection limit th
77 sed here should be applicable for developing highly sensitive biosensors for various protein kinases.
78                     While all platforms were highly sensitive, both the Agena panel and Thermo Fisher
79 us, our approach bridges the gap between the highly sensitive but specific capabilities of digital PC
80       PTSD patients had significantly higher highly sensitive-C-reactive protein levels compared to C
81                                Consequently, highly sensitive cameras, sufficient shielding from back
82                                            A highly sensitive, capacitive biosensor was developed to
83                                            A highly sensitive catheter probe is critical to catheter-
84 ations in DBS samples were assessed by using highly sensitive chromatography-tandem mass spectrometry
85                                We describe a highly sensitive competition ELISA to measure integrin-b
86                      This fast, low cost and highly sensitive CPX specific MIP nanoparticle based nan
87 h can be employed as nanozyme for developing highly sensitive detection methods.
88 itude to 0.1 ng/mL in buffer but also enable highly sensitive detection of as low as 1 and 10 ng/mL o
89                                              Highly sensitive detection of chemokines in various biol
90 rt an electrochemical method for the direct, highly sensitive detection of dsDNA based on the strand
91 embled monolayer (SAM) was the developed for highly sensitive detection of Escherichia coli O157:H7 b
92 nction as a matrix for enzymes as shown by a highly sensitive detection of glucose.
93  with silver signal enhancement strategy for highly sensitive detection of HER2.
94          The EOF transport mechanism enables highly sensitive detection of molecules with low surface
95 which designs are the most rational ones for highly sensitive detection of OTA.
96    In the negative ion mode, DPH permits the highly sensitive detection of small fatty acids (m/z 200
97 d proteins, the glucose sensor is capable of highly sensitive detection over a range of 5-1000micromo
98 modified electrode for a rapid detection and highly sensitive determination of rifampicin (RIF) by sq
99     A quartz crystal microbalance (QCM) is a highly sensitive device to detect such interactions base
100 scade than previously reported, as well as a highly sensitive diagnostic assay for the ultratrace qua
101                    The facile preparation of highly sensitive electrochemical bioprobe based on lutet
102 nt fabrication and successfully testing of a highly sensitive electrochemical biosensor featuring a t
103 tubes (SWCNT) was synthesized to fabricate a highly sensitive electrochemical biosensor for paraoxon
104       In this study, a simple, low-cost, and highly sensitive electrochemical cytosensor was designed
105                       Here, we demonstrate a highly sensitive F. tularensis assay that incorporates s
106 rates nanoprobes in a specific area to yield highly sensitive (femtomolar) and repeatable measurement
107  the activities of bacterial enzymes using a highly sensitive Fluorescence Resonance Energy Transfer
108                              D-dimer (DD) is highly sensitive for AAS but is inadequate as a stand-al
109 ed in microglial (MG) brain cells, which are highly sensitive for neuro-viral infection and were sele
110 f CT findings, two more specimens considered highly sensitive for the CT diagnosis were obtained via
111          Within this work, we will present a highly sensitive gradiometric receive-coil unit combined
112 s spectrometry (MS) for highly selective and highly sensitive identification of these diastereomers.
113   On analysis of secondary outcomes, using a highly sensitive IL-2 assay, the observed plasma concent
114 e physical properties allow them to serve as highly sensitive imaging agents for ultrasound and MRI.
115 d from small-molecule PSMA inhibitors showed highly sensitive imaging of PSMA-positive PC by means of
116                                         This highly sensitive imaging strategy unmasked activated end
117                We have developed a rapid and highly sensitive immunosensing method for visible detect
118 larvae xenotransplants constitute a fast and highly sensitive in vivo model for differential therapy
119              Through the implementation of a highly sensitive inductively coupled plasma mass spectro
120  such viral infections, broadly reactive and highly sensitive influenza rapid diagnostic tests (IRDTs
121       Human genome data contain valuable but highly sensitive information.
122                           The monomer showed highly sensitive interaction with caffeine despite poor
123 ry total alpha-synuclein was assayed using a highly sensitive Luminex assay and oligomeric alpha-synu
124                               In conclusion, highly sensitive mAb-based immunoassays were developed f
125                                            A highly sensitive mass spectrometric (MS) method was deve
126              Using genetic, biochemical, and highly sensitive mass spectrometric approaches, we ident
127               This mechanism can account for highly sensitive mechanical gating in the setting of a n
128           The pH sensing layer is based on a highly sensitive membrane of iridium oxide (IrOx).
129                     A new reliable, fast and highly sensitive method based on ultra-high performance
130 ography-mass spectrometry as a new, fast and highly sensitive method for determining of acrylamide in
131 ction has provided a rapid, noninvasive, and highly sensitive method for diagnosis and is a useful ma
132 NP) in a quantum Hall ferromagnet (QHF) is a highly sensitive method for the discovery of fascinating
133                        (18)F-NaF PET/CT is a highly sensitive method in the evaluation of bone metast
134                                            A highly sensitive method was developed to identify metabo
135                          Here, we reported a highly sensitive method, relying on the use of nanoflow
136                                   Therefore, highly sensitive methods are needed to quantify BPA in v
137       Hence, this rapid, instrument-free and highly sensitive microfluidic approach has great potenti
138 ves way for future development of universal, highly sensitive, miniaturized, and integrated nanoelect
139  the FERS setup has remarkable potential for highly sensitive, miniaturized, easy-to-use, and versati
140 k provides a platform for the development of highly sensitive molecular electrochemical biosensors.
141 cer therapy and, consequently, the described highly sensitive monitoring of Topo II activity may add
142 ture investigations of KLK7, especially when highly sensitive MS-based approaches are employed.
143                      Flow cytometry provides highly sensitive multiparameter analysis of cells and pa
144                                            A highly sensitive nanosensing method for the combined sel
145 rt valve (THV) technologies coupled with the highly sensitive nature of 4-dimensional computed tomogr
146                   Central chemoreceptors are highly sensitive neurons that respond to changes in pH a
147  metabolite, we developed a 25 mum diameter, highly sensitive, nonenzymatic H2O2 sensor with a detect
148                                        While highly sensitive nucleic acid detection methods and test
149 ) such as Chlamydia can be revolutionized by highly sensitive nucleic acid testing that is deployable
150 eratoconus eyes, the ART max is considered a highly sensitive objective parameter.
151 atly enlarged nasal cavity likely reflects a highly sensitive olfactory system.
152 surface water, groundwater, and OSPW using a highly sensitive online solid phase extraction-HPLC-Orbi
153                                          The highly sensitive optical detection of oxygen including d
154                                         This highly sensitive optical molecular imaging approach can
155 particles (NPs) exhibit potential for use in highly sensitive optoelectronic devices through the loca
156                               In assays with highly sensitive outcome measures, Alab49DeltafbaA was c
157                                         This highly sensitive p24 assay can help improve blood safety
158                                   Because of highly sensitive PET imaging even of tissues with low al
159                                         This highly sensitive phenotypic readout of enhancer function
160 s a growing number of applications demanding highly sensitive photodetectors in the mid-infrared.
161                             We then utilized highly sensitive picosecond time-resolved fluorescence d
162 test involving a simple, rapid, specific and highly sensitive procedure based on isothermal amplifica
163 ds rapidly, and allows for the selective and highly sensitive quantification of S. agalactiae cells i
164 OS) optical detection system for a rapid and highly-sensitive quantification of salivary cortisol.
165                Infections were quantified by highly sensitive quantitative polymerase chain reaction
166                              In this work, a highly sensitive quantitative/confirmatory method was de
167 essed by microdialysis in combination with a highly sensitive radioimmunoassay.
168 e, our BL-based immunosensor is suitable for highly sensitive, rapid, and on-site detection of bacter
169  pharmacokinetics using equipment that has a highly sensitive readout.
170 tudy aimed at proposing a novel specific and highly sensitive real-time PCR system for the detection/
171                                      Using a highly sensitive reporter of the global response to DNA
172 monstrates the usefulness of ion channels as highly sensitive reporters of membrane processes.
173       Sensitive responders >/=65 and <65 and highly sensitive responders >/=65 years old required pha
174                                     However, highly sensitive responders <65 years old did not achiev
175 gnals and the developed nanosensor exhibited highly sensitive response, demonstrating improved electr
176                                              Highly sensitive RNA-sequencing technologies were used t
177 cific molecular detection technology that is highly sensitive, robust, and high-throughput has the po
178                                              Highly sensitive, selective, and reliable alcohol detect
179 tection of allergens because they are rapid, highly sensitive, selective, less expensive, environment
180 r platforms based on nanostructures make the highly sensitive sensors which could indicate very low d
181 eavage effects by sequencing (CIRCLE-seq), a highly sensitive, sequencing-efficient in vitro screenin
182     The use of DEN-gas opens new avenues for highly sensitive sheathless CE-ESI-MS approaches in glyc
183 ation and repair genome-wide, we developed a highly sensitive single-nucleotide resolution damage map
184                                 ISEScan is a highly sensitive software pipeline based on profile hidd
185 gests that multimodal nonlinear imaging is a highly sensitive, solid-state (and chemically) specific,
186                                     A rapid, highly sensitive, specific and low-cost capacitive affin
187                                   Using this highly sensitive SPR method, it was possible to sense th
188                                     By using highly sensitive stage-specific molecular methods to det
189 ng metastases), with (18)F-FDG emerging as a highly sensitive staging technique.
190 nomagnetic bead sample preparation method, a highly sensitive strategy to determine the clenbuterol c
191 l cytotoxicity towards HeLa cells, and was a highly sensitive substrate of the multidrug resistance t
192 hthylmethyl (Nap) ether protecting groups on highly sensitive substrates.
193 e a new laser wrapped graphene-Ag array as a highly sensitive Surface-enhanced Raman spectroscopy (SE
194               In this study we constructed a highly sensitive system for in vivo monitoring of the co
195 for NRS and EC-SERS, showing that Raman is a highly sensitive technique that is readily applicable in
196  with minimized fluid evaporation as well as highly sensitive thermoelectric sensing, the approach en
197 tent neutralizing antibody responses against highly sensitive Tier 1A isolates and weaker neutralizin
198                Of note, 1 and 2 proved to be highly sensitive to acid-mediated transformation, with 1
199         This defined subpopulation of GBM is highly sensitive to agents that disrupt this pathway, in
200 hite matter tracts within the brain are also highly sensitive to aging processes.
201 wever, other genes recently identified to be highly sensitive to androgen-regulated AR action, such a
202                  TAX1BP1-deficient cells are highly sensitive to apoptosis in response to infection w
203 her demonstrate that murine SCLC tumors were highly sensitive to ATR- and CHK1 inhibitors, while Kras
204 a much richer variety of assemblies that are highly sensitive to both bulk and local nanoparticle con
205 ntegrity in the brain are also heritable and highly sensitive to both normal and pathological aging p
206 nhibition of ROCK activity, but viscosity is highly sensitive to both.
207                We report a subset of cancers highly sensitive to CDK4/6 inhibition and characterized
208                       Cerebral blood flow is highly sensitive to changes in CO2/H(+) where an increas
209 ficant quantities of methane (CH4 ), and are highly sensitive to climate change.
210 forest-steppe ecotone in southern Siberia is highly sensitive to climate change; global warming is ex
211 largest terrestrial carbon (C) stocks and is highly sensitive to climate warming.
212                   The global carbon cycle is highly sensitive to climate-driven fluctuations of preci
213 ional MRI, and diffusion tensor imaging--are highly sensitive to common artifacts (e.g., head motion
214 evealed 32 T2 genes and 25 T8 genes that are highly sensitive to different FLC perturbations.
215         Intestinal epithelial stem cells are highly sensitive to differentiation induced by endoplasm
216 ifically, optical metabolic imaging (OMI) is highly sensitive to drug response in organoids, and OMI
217 leptin in the LHA-to-VTA neuronal pathway is highly sensitive to energy states: both energy deficienc
218      The (31)P chemical shifts in lipids are highly sensitive to experimental conditions such as pH a
219    The pancreatic beta-cell transcriptome is highly sensitive to external signals such as glucose osc
220 R2-amplified primary breast cancer, which is highly sensitive to HER2-targeted therapy, the clinical
221  very well suited for semi-dry foods, but is highly sensitive to high moisture and liquid foods.
222  murine culture model, we found that GCs are highly sensitive to IFN-gamma with significantly reduced
223 myces cerevisiae However, exomer mutants are highly sensitive to increased concentrations of alkali m
224 , occurs through a saturable process that is highly sensitive to inhibition by the classic nucleoside
225 l screening and observed that NPC cells were highly sensitive to inhibitors of cyclin-dependent kinas
226 c archaea of the order Methanomicrobiales is highly sensitive to its changes.
227  was not sensitive to leaf quantity, but was highly sensitive to leaf quality and its vertical distri
228                             The micelles are highly sensitive to light irradiation: (1)O2 triggering
229 x formation between helix P2b and loop L1 is highly sensitive to magnesium and plays a key role in pr
230  not pathogenic for nonhuman primates and is highly sensitive to mammal type I interferon (IFN) signa
231 d that chemoreceptor cluster localization is highly sensitive to membrane curvature.
232 chondrial calcium buffering capacity and are highly sensitive to mitochondrial permeability transitio
233                       An mntR null mutant is highly sensitive to Mn(II) intoxication, which is attrib
234      Terrestrial biosphere models (TBMs) are highly sensitive to model representation of photosynthes
235 by a cost-effective and scalable method, are highly sensitive to monitor and quantify various events
236 ms that expose cryptic epitopes and that are highly sensitive to neutralization.
237  results show that sea urchin development is highly sensitive to Ni via a mechanism that involves ion
238 shed projections appear widely divergent and highly sensitive to non-trivial model choices.
239           In contrast, reef fish biomass was highly sensitive to oceanographic conditions, being infl
240 uracy of mRNA translation and rendered cells highly sensitive to oxidative stress.
241 ate intrahepatic immune responses and remain highly sensitive to pegIFNalpha in immunocompromised hum
242                                      FisR is highly sensitive to polysulfide, activating sigma(54) -d
243                                 The brain is highly sensitive to proper fuel availability as evidence
244               We show that the delay time is highly sensitive to qualitative details of the prolifera
245 ciency also renders murine pancreatic tumors highly sensitive to radiation.
246 indicate that polar climate and the AIS were highly sensitive to relatively small changes in atmosphe
247 depletion was found to render wild-type mice highly sensitive to respiratory F. tularensis infection,
248       Rice being an important cereal crop is highly sensitive to salinity stress causing growth retar
249 result, GSNOR-deficient cells and tumors are highly sensitive to SDH inhibition, namely to alpha-toco
250 lamp analysis indicates these EB neurons are highly sensitive to sleep loss, switching from spiking t
251                              This readout is highly sensitive to small RNA levels at the source, allo
252 st, the glossopharyngeal nerve, which is not highly sensitive to sodium taste stimulation, did not un
253 e same time we show that this interaction is highly sensitive to structural perturbations, which has
254 lds for photorelease with this photocage are highly sensitive to substituent effects.
255 fection proliferated on reinfection and were highly sensitive to TCR stimulation without costimulatio
256                   Using a murine CMV that is highly sensitive to the antiviral drug famciclovir to mo
257 ot synthetic media and DeltadacA mutants are highly sensitive to the beta-lactam antibiotic cefuroxim
258 l model shows that de novo dTMP synthesis is highly sensitive to the common MTHFR C677T polymorphism
259                   However, our estimates are highly sensitive to the core assumptions, and considerab
260                   The biosensor platform was highly sensitive to the corresponding cytokines and no i
261 ic cells and that these interactions will be highly sensitive to the dynamics of PD-L1 and PD-L2 expr
262 holinergic sprouting is gender dependent and highly sensitive to the genetic risk factor APOE4 Our fi
263 are in the primary analysis, this effect was highly sensitive to the imputation strategy for peak VO2
264           Here, we report that observers are highly sensitive to the lifelikeness of random objects a
265 ent properties of the imaging antibodies are highly sensitive to the methods of conjugation, degree o
266                             Predictions were highly sensitive to the partition coefficient between or
267                  Predicted cVMS behavior was highly sensitive to the partition coefficient between or
268  moisture supply and ecosystem processes are highly sensitive to the position of cool-season storm tr
269 hat the performance of the biotech sector is highly sensitive to the presence of a few outlier compan
270  to human Fc gamma receptors (hFcgammaRs) is highly sensitive to the presence of a single N-linked gl
271                                  As they are highly sensitive to the presence of Vigilquat and Triton
272 P-TMR complex, the fluorescence of which was highly sensitive to the protein state, showing unprecede
273 roperties of the resulting nanostructure are highly sensitive to the shape and size of the nanostruct
274  demonstrate that the specificity of KMTs is highly sensitive to the side chain length of the residue
275  methods, finding: (1) method performance is highly sensitive to the specific combination of genetic
276          The diffraction pattern of a DOE is highly sensitive to the surrounding environment and the
277 the wetting angle of water on top of MgF2 is highly sensitive to the thickness of the MgF2 layer and
278 osensitive (MS) ion channels, since they are highly sensitive to their lipid environment.
279 compounds and showed that male antennae were highly sensitive to them.
280 f resistance using cell line models that are highly sensitive to this class of drugs.
281 ll lines in this panel, SKBr3 and BT474 were highly sensitive to treatment with HER-family inhibitors
282            Projections of future climate are highly sensitive to uncertainties regarding carbon (C) u
283 hod, called Variable Dose Analysis (VDA), is highly sensitive to viability phenotypes and reproducibl
284                     Embryonic development is highly sensitive to xenobiotic toxicity and in utero exp
285 ture onto a molecular beam, which provides a highly sensitive tool for beam displacement measurements
286       By using a constructed ssRNA knot as a highly sensitive topological probe, we find that Escheri
287 vity (ROA)-a spectroscopic technique that is highly sensitive toward carbohydrates-on native agarose
288 ies of as-fabricated arrays were found to be highly sensitive toward the sulfurization, in the presen
289 cular imaging of aneurysm optimally requires highly sensitive tracers with rapid blood clearance.
290                                              Highly sensitive troponin T was lower at follow up (Base
291          We examined changes in pre-dialysis highly sensitive troponin T.
292 ides, soluble suppressor of tumorgenicity 2, highly sensitive troponin, galectin-3, midregional proad
293 ow, this report is the maiden publication on highly sensitive TU sensor based on the CMO NPs/GCE.
294                                        Using highly sensitive tyramide signal amplification, we deter
295                               We developed a highly sensitive, underwater video system (UVS) for this
296 cer cells resistant to MEK inhibition become highly sensitive upon loss of ATM both in vitro and in v
297                               Here, we use a highly sensitive version of chromosome conformation capt
298                                            A highly sensitive vortex assisted liquid-liquid microextr
299 ecules, which are ionized in a selective and highly sensitive way via resonance-enhanced multiphoton
300 te that electrostatic interaction provides a highly sensitive yardstick to probe the allosteric modul

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