ライフサイエンスコーパス: highly specific

1 mation about the cancer and is sensitive and highly specific.

2 ed to predict miRNA-disease associations are highly specific.

3 antigen-specific TCR repertoires can remain highly specific.

4 ransgenic plants confirmed that amiRNAs were highly specific.

5 tests on 92 controls identified 12assays as highly specific (0-1 false-positive results).

6 Contrast agent leak was highly specific (96%-98%), but insensitive (42%-46%).

7 These reactions with rLb6H were highly specific (98.5%) when compared against those for

8 By using a highly specific Ab against a cleavage neoepitope in C4d,

9 vation by the targeted acetyltransferase was highly specific across the genome.

10 entire group of proteins, including several highly specific ACTN4 interactors, was globally decrease

11 We discuss how organization of highly specific adaptors into functional hierarchies dri

12 mophilic variant of protein G (HTB1), into a highly specific aggregation inhibitor (designated HTB1M)

13 mechanisms remain unclear, the existence of highly specific alloreactive TCRs has led to their use a

14 Here, we report the identification of a highly specific allosteric inhibitor of Akt through a FR

15 lt in a -1 frameshift, indicating that these highly specific alterations might be a common cause of d

16 ER2 over-expression and therefore it needs a highly specific and accurate detection method for diagno

17 PCR-based methods are highly specific and are amenable to high-throughput and

18 They are also highly specific and do not respond to Pt(II) drugs such

19 ctural similarities to adenosine, the Fab is highly specific and does not bind to adenosine, adenosin

20 s of 137 and 634 proteins, respectively, are highly specific and highlight 94 potentially novel mitoc

21 ew method of bacteria detection that is both highly specific and highly sensitive by combining the sp

22 The binding is highly specific and irreversible.

23 PCR is highly specific and of potential value when used with ot

24 Here we developed a highly specific and robust bimolecular luminescence comp

25 sitive tool for the design of biosensors for highly specific and selective identification of hematolo

26 findings demonstrate that PBPs can serve as highly specific and sensitive affinity recognition eleme

27 ailability of fluorescent fusion proteins or highly specific and sensitive antibodies.

28 INTERPRETATION: This new highly specific and sensitive assay showed asymptomatic

29 Diagnostic systems that can deliver highly specific and sensitive detection of hepatitis A v

30 ers, which were used to generate two unique, highly specific and sensitive DNAm signatures.

31 nant prion protein (rPrPSen), is known to be highly specific and sensitive for the detection of multi

32 These devices are not only highly specific and sensitive for the parameters being a

33 The highly specific and sensitive HCV-Ags EIA developed in t

34 The antibodies are highly specific and sensitive in immunostaining of mesot

35 minimally invasive sample collection with a highly specific and sensitive mass spectrometry (MS) tec

36 This highly specific and sensitive NSD1(+/-) signature encomp

37 The proposed device is able to display a highly specific and sensitive performance with a limit o

38 To address this need, a rapid, highly specific and sensitive point-of-care method for m

39 say based on latent redox probe approach for highly specific and sensitive quantification in living c

40 Thus, the aim of this study was to develop a highly specific and sensitive sandwich enzyme-linked imm

41 These could be accomplished by using highly specific and sensitive substrates, as well as dir

42 to tandem mass spectrometry (LC-MS/MS) is a highly specific and sensitive technique for measuring me

43 The method designed was highly specific and sensitive, with a detection limit of

44 The sensor is highly specific and shows negligible response to non-spe

45 To test this hypothesis, the novel, highly specific, and long-acting PDE5 inhibitor, PF-0048

46 Herein, we developed a rapid, highly specific, and sensitive surface-enhanced Raman sc

47 Acyclovir (ACV), a highly specific anti-herpetic drug, acts as a DNA chain

48 f a panel of anti-lipid A antibodies reveals highly specific antibodies produced through distinct ger

49 ly reduce the resources required to generate highly specific antibodies.

50 While the Fab domains mediate highly specific antigenic recognition to block virus ent

51 Custirsen (OGX011) is a second generation highly specific antisense oligonucleotide that inhibits

52 with the Auger emitter (125)I-DCIBzL yielded highly specific antitumor efficacy in vivo, suggesting p

53 ssed toward the rational design of novel and highly specific antiviral drugs and will aid in the deta

54 Two highly specific aptamers, crn-1 and crn-2, were develope

55 d PCR assay designed in the present study is highly specific as confirmed by competition experiments

56 [(18)F]BF4(-)-PET was also highly specific as in all detected tissues cancer cell p

57 This blockade of PKR function is highly specific, as LCMV is unable to similarly inhibit

58 neration and verification of a compendium of highly specific assays that enable quantification of 99.

59 a combination of clinical phenotype and the highly specific assays, 66 AQP4-Ab seropositive samples

60 sera were positive on at least two of the 12 highly specific assays, leaving 35 patients with seroneg

61 However, the mechanisms that underlie the highly specific assembly of ascarosides are not understo

62 meter space in which packaging sites lead to highly specific assembly via different mechanisms and ot

63 ib, and abemaciclib represent a new class of highly specific ATP-competitive CDK4/6 inhibitors that i

64 M) proteins act as specialized receptors for highly specific autophagy (precision autophagy) of key c

65 ve than IDH1/2 wild-type cells to ABT-199, a highly specific BCL-2 inhibitor that is currently in cli

66 Candida albicans as a model, we identified a highly specific bifunctional molecule able to mediate th

67 icial symbiont Vibrio fischeri, which form a highly specific binary mutualism.

68 ng site is a prerequisite for the subsequent highly specific binding of a second RR dimer to the low-

69 Underlying mechanisms that explain the highly specific binding of TFs to their genomic target s

70 Aptamers comprise a novel class of highly specific bio-recognition elements which are produ

71 res of proteins are a prerequisite for their highly specific biological functions.

72 are tailored with a monoclonal antibody for highly specific biological recognition (BSW biochip).

73 insights and has potential as a noninvasive, highly specific biomarker for rejection and tolerance.

74 A highly specific biotinylated DNA/LNA molecular beacon (M

75 ns in the brain of young mice, by the novel, highly specific, brain-permeable inhibitor I-BET858 lead

76 These highly specific but brief interactions with the rotating

77 Other models were either highly specific but lacked sensitivity or had low to ver

78 Conclusion US is highly specific but nonsensitive for perforated pediatri

79 At 4 hr after reperfusion, anuria was highly specific, but of low sensitivity for detection of

80 ftening assessed by using SWE appeared to be highly specific, but sensitivity was relatively low.

81 oated with a multilayer assembly that allows highly specific capture of EpCAM (epithelial cell adhesi

82 The highly specific CDK7 kinase inhibitors, BS-181 and THZ1,

83 Highly specific cell shape recognition can also be achie

84 nostic kit, which offers the potential for a highly specific clinically-relevant detection system.

85 ting that osseous nasal crests may require a highly specific combination of ontogeny, evolution, and

86 Successful development of highly specific companion diagnostics targeting aberrant

87 The model proved highly specific: COMT-Met mice had reductions in COMT ab

88 f proteins is an attractive option to create highly specific conjugates for therapeutics, diagnostics

89 This provides a highly specific contrast mechanism that can be used to r

90 sensitization between iGluR subtypes and the highly specific contribution of the GluN2 subunit to thi

91 Here, we report a highly specific, convenient and robust biocatalyst based

92 ptors, adaptive immunity activation requires highly specific cooperation between antigen-presenting c

93 Highly specific CPX imprinted nanoparticles were synthes

94 Our results show that fungi use highly specific cytochrome P450 enzymes for regio- and s

95 majority of available methodologies require highly specific data inputs that preclude the use of man

96 of an electrochemical ion (E-ION) sensor for highly specific detection of hexavalent chromium (Cr(VI)

97 ction agents, respectively, giving rise to a highly specific detection of Zika NS1 with a detection l

98 ondition, the CDs-Fe(3+) mixture served as a highly specific detection probe for ascorbic acid (AA).

99 ass measured for the intact lipid as well as highly specific diagnostic product ions that reveal both

100 Immunofluorescence is a highly specific diagnostic test for PCD, and it improves

101 to concentrations of 1-nitropyrene (1-NP), a highly specific diesel exhaust marker, at the neighborho

102 ormational changes and learn that there is a highly specific direction for applied forces to drive th

103 G homing endonucleases ("meganucleases") are highly specific DNA cleaving enzymes that are used for g

104 to Coc ingestion and therapeutic effects of highly specific drugs are measurable on the basis of cel

105 vidence that ctDNA has the potential to be a highly specific early molecular response marker in HGSOC

106 GluN2A or GluN2B subunit had a dramatic and highly specific effect on NMDAR desensitization, making

107 ribe a novel PPARbeta/delta-independent, yet highly specific, effect of DG172 on the differentiation

108 e lysosomal enzyme-targeting pathway produce highly specific effects in mouse pup vocalizations and e

109 hecal application of endomorphin 2 [EM2; the highly specific endogenous mu-opioid receptor (MOR) liga

110 as then further enhanced with the use of the highly specific endonuclease dsDNase for an enzymatic am

111 Ig)A proteases of Haemophilus influenzae are highly specific endopeptidases that cleave the hinge reg

112 The glyoxalase system is a highly specific enzyme system existing in all mammalian

113 of these cells, extracellular cues determine highly specific epigenetic landscapes and transcriptiona

114 that genomic signatures of adaptation can be highly specific, even with respect to subtle environment

115 The three inhibitors are highly specific; even at 1 mum, the phosphorylation of o

116 emical study we demonstrate a pronounced and highly specific expression of the GPR151 protein in the

117 However, we show that MPC1L has a highly specific expression pattern and is localized almo

118 rimental conditions while ideally also being highly specific, extremely sensitive, and spatially conf

119 overcomes these disadvantages, as these are highly specific, fast, easy, cost effective, and highly

120 ditional information encoded into memory for highly specific features of sounds associated with rewar

121 H5.3 is highly specific for a subset of H5 strains, and this spe

122 eby an intracellular "trafficking chaperone" highly specific for a trace element cofactor functions v

123 Ag10c is highly specific for Ag(+) among all the tested metals.

124 ION: GFAPalpha-IgG, when detected in CSF, is highly specific for an immunotherapy-responsive autoimmu

125 se findings demonstrate that CD8 T cells are highly specific for autologous epitopes during acute HIV

126 a novel downregulation of beta2AR signaling highly specific for Cav1.2.

127 al a unique endocytic control switch that is highly specific for DAT.

128 This connectivity pattern was highly specific for delusional misidentifications compar

129 r G4R1, is a DEAH-box ATP-dependent helicase highly specific for DNA and RNA G-quadruplexes (G4s).

130 f receptors are reagents that are robust and highly specific for each receptor.

131 Thus, mAb 26.4 is highly specific for HPA-1a and could potentially be expl

132 and T-2 toxins, the immune complex assay is highly specific for HT-2 alone.

133 luoronicotinamide ((18)F-FNDP), which proved highly specific for imaging of sEH in the mouse and nonh

134 This effect of PD-1H is highly specific for iTreg because both naturally generat

135 The effects were highly specific for L406E relative to six other mutation

136 At 7 days, IgM and macrophages were highly specific for NPIs (alpha1,3-galactosyltransferase

137 The sensor was highly specific for PMPs and did not identify microparti

138 ata suggest that hSMVT-mediated transport is highly specific for R-LA at our tested concentration ran

139 of 8 genes that, when mutated, appear to be highly specific for secondary acute myeloid leukemia (AM

140 Each of these prenyltransferases was highly specific for stilbenoid substrates, and we confir

141 cing technology, we show that these ZFNs are highly specific for the CCR5 locus in primary cells.

142 Results showed that the method was highly specific for the detection of PEDV, and had the s

143 The two nanobodies (CA4910 and CA5183) were highly specific for the human receptor and bind ChemR23

144 Moreover, spine plasticity is highly specific for the principal barrel column receivin

145 the Nem1-Spo7 protein phosphatase, which is highly specific for the sites phosphorylated by Pho85-Ph

146 le of hydrazine oxidation as well, KsHDH was highly specific for this activity.

147 The light-induced response is highly specific for water, immediate and strictly locked

148 allowed upon immunization the generation of highly specific fully human mAbs for therapeutic applica

149 lls to be targeted and killed by F49A-FTP, a highly specific fusion toxin protein that binds this vir

150 ly assumed fluctuations either occur between highly specific genotypes (matching allele: MA) or from

151 three-dimensional microconstructs, evincing highly specific geometry that includes control over posi

152 these genes caused cell wall thickening in a highly specific grain "disarticulation zone," converting

153 o individual vertebrate neurons, engaging in highly specific homophilic interactions to mediate impor

154 a protocol for a large-scale production and highly specific immobilization of Im7 to a solid support

155 nabled biosensor to detect Zika virus with a highly specific immobilized monoclonal antibody.

156 genic mutations, which has been proven to be highly specific in assigning the correct genotype withou

157 ts show that these transcription factors are highly specific in both DNA binding and gene regulation

158 r results suggest that AsCpf1 and LbCpf1 are highly specific in human cells.

159 ed healthy tissues revealed vascular MCAM as highly specific in RCC, where it was induced strongly by

160 al nerve stiffness measurements appear to be highly specific in the diagnosis of established DPN.

161 Furthermore, highly specific in-house generated scFv fragments as rec

162 The Degron-KI system allows for highly specific, inducible, and allele-targeted inhibiti

163 ssion of multiple globin genes, and observed highly specific induction of H3K9 trimethylation (H3K9me

164 e identification of BRD-7880 as a potent and highly specific inhibitor of aurora kinases B and C.

165 set administration of the drug trametinib, a highly specific inhibitor of Ras-Erk-ETS signaling, can

166 targeted many SCF ligases, or conversely, a highly specific inhibitor that discriminated between eve

167 Ceapins are highly specific inhibitors of ATF6alpha signaling, not a

168 Both MPA and mycophenolate mofetil are highly specific inhibitors of guanine nucleotide synthes

169 a yeast surface display technique to obtain highly specific inhibitors of MMP-14 by modifying the na

170 and reagent volumes and lack of complex and highly specific instrumentation, as well as positive con

171 indings by the ability of calcium to block a highly specific interaction between PLC delta1-PH and PI

172 SI involves highly specific interactions during pollination, resulti

173 Many cellular functions depend on highly specific intermolecular interactions, for example

174 of C2 or the closely related C3 neurons with highly specific intersectional driver lines consistently

175 e efficiency of tDCS in sv-PPA by generating highly specific intrasemantic effects.

176 t remodeling arising from Kcne3 deletion was highly specific, involving just 3 of 69 alpha subunit ge

177 PrnB, a highly specific l-proline transporter, only weakly recog

178 at these two EGF-CFC homologs have distinct, highly specific ligand binding activities.

179 LIMK1 expression blocks HIV-1 infection, no highly specific LIMK inhibitor is available.

180 hment of antigens from the serum followed by highly specific MALDI detection.

181 roteases to control protein destruction in a highly specific manner.

182 pinpoint the nanoscale dynamics changes in a highly specific manner.

183 ng a portion of its structure (epitope) in a highly specific manner.

184 Our data suggest M30 as highly specific marker of liver apoptosis both in ALD an

185 the glucose moiety of GMM, GEM TCRs create a highly specific mechanism for recognizing this mycobacte

186 This indirect but highly specific mechanism, by which a chromatin regulato

187 The tool developed by Cho et al. (2005) was highly specific (men, 0.92; women, 0.99) but considerabl

188 The sensitivity of this highly specific method can reach ~0.923 pg/mL and ~0.424

189 onization of body epithelial surfaces with a highly specific microbial community is a fundamental fea

190 The developed highly specific microcantilever sensor has a response ti

191 scheme for entirely on-chip, sensitive, and highly specific miRNA detection without the risk of sequ

192 Here, we investigate the use of CCS as a highly specific molecular descriptor for identifying lip

193 mponents of human upper limb nerves based on highly specific molecular features from spinal cord leve

194 ng for the rational use of long circulating, highly specific monoclonal antibodies (mAbs) for both no

195 in vivo short-term systemic treatment with a highly specific monoclonal antibody against GRP78 suppre

196 CA2-deficient tumors exhibited a complex and highly specific mutation signature, featuring a 2.88-fol

197 HLA ligand data set delineated a panel of 58 highly specific myeloma-associated antigens (including m

198 ovides a starting point from which to design highly specific myosin modulators to treat several human

199 Thus, highly specific nascent chain targeting by Listerin is i

200 rity of reported synthesis techniques, their highly specific nature, and lack of mechanistic understa

201 Photoimmunotherapy induces rapid and highly specific necrosis in targeted cancer cells after

202 Highly specific neural uptake of (18)F-LMI1195 has previ

203 Given the low toxicity and highly specific neuron-targeting properties of BoNT/C1 a

204 We used a highly specific neutralizing anti-S1P antibody (mAb) and

205 defined numbers of dendritic cells (DCs) in highly specific niches where different intrinsic and env

206 f SULT1A1 and mefenamic acid (MEF)-a potent, highly specific NSAID inhibitor of 1A1.

207 Clusters of hyperreflective objects are highly specific of AK.

208 The pairing of these two components is highly specific, often requiring costly and time-consumi

209 This avoidance is mediated via a highly specific olfactory sensory neuron (OSN) type.

210 Here, we developed highly specific oligonucleotides that distribute to the

211 A recent report, describing a highly specific, orally bioavailable inhibitor of the PT

212 The highly specific organization of the olfactory bulb (OB)

213 irming previous results and characterizing a highly specific pattern at IS186 target-sites, 5'-GGGG(N

214 porting imitation in ASD, characterized by a highly specific pattern.

215 e tested here whether a newly identified and highly specific PDK1 inhibitor, 2-O-benzyl-myo-inositol

216 , the main coat protein of caveolae, using a highly specific peptide, CavNOxin.

217 ntixafor PET/CT is suitable for noninvasive, highly specific PET imaging of CXCR4 expression in the a

218 However, introducing low densities of a highly specific piscivorous fish into the community to p

219 Sortase mediated ligation is a highly specific platform for conjugation that relies on

220 In principle, maintaining a large set of highly specific priors may be inefficient and restrict t

221 ermal systems and the importance of coupling highly specific process indicators to elucidate the comp

222 s involved in general proteolysis as well as highly specific processing proteases.

223 We used ADAPT as a highly specific profiling tool that distinguishes women

224 ial expression of ALK1 as an independent and highly specific prognostic factor for metastatic manifes

225 eIF3 binds to a highly specific program of messenger RNAs involved in ce

226 assembly, allowing these cells to maintain a highly specific proinflammatory program.

227 be derived from distinct progenitors, their highly specific properties are shaped by the local envir

228 LF is a highly specific protease, exclusively cleaving mitogen-a

229 Proprotein convertases (PCs) are highly specific proteases required for the proteolytic m

230 Low-affinity but highly specific protein-protein interactions abound with

231 We recommend that physicians include a highly specific question about adherence to medication a

232 in direct coupling led to a design fueled by highly specific reaction conditions for several steps an

233 distinct role throughout the body, obtaining highly specific receptor agonists is essential.

234 Highly specific recognition cavities can be made into po

235 lly weak docking interactions facilitate the highly specific recognition of ERK2 by Ets-1, and enable

236 ve the advantage of signal amplification and highly specific recognition.

237 A) based sensor has been confirmed using the highly specific reference method based on lactate oxidas

238 ication and functional characterization of a highly specific, regulated solute channel in the outer e

239 of the plant innate immunity system provides highly specific resistance, there is emerging evidence t

240 s are voltage-activated to give enhanced and highly specific responses.

241 Overall, our findings demonstrate highly specific roles of AI for affective empathy and TP

242 The highly specific S1 serine protease factor D (FD) plays a

243 ss spectrometry, in electron ionisation with highly specific selected reaction monitoring, quantifica

244 Herein, we report the highly specific self-assembly upon crystallization of a

245 The LAMP-ECL sensor is shown to be highly specific, sensitive (>/=0.1pg/muL) and rapid ( ap

246 ution for each binding site and delineated a highly specific sequence and structure motif for Vts1 bi

247 s of the PNA probes, P-Ca726 was found to be highly specific, showing 2.5- to 5.5-fold-higher discrim

248 We used a highly specific small molecule targeting the prostate-sp

249 e packaged as cargo into eHAV vesicles via a highly specific sorting process.

250 iption factor, and that it is expressed in a highly specific spatiotemporal pattern starting during l

251 Here we demonstrate photocontrol over the highly specific Staudinger-Bertozzi ligation in vitro an

252 ent of a number of critical tools, including highly specific stem cell marker genes along with more r

253 NR2A-containing receptors might constitute a highly specific strategy treating CSD associated migrain

254 nd their functions are determined in part by highly specific structural features.

255 ture numerous stereoisomers, which exhibit a highly specific structure-activity relationship.

256 es have shown that many proteins localize to highly specific subregions within bacterial cells.

257 tical for HPV16 carcinogenesis, presenting a highly specific target for etiologic and therapeutic res

258 d their corresponding pre-miR target through highly specific tertiary interactions rather than Watson

259 Intraoperative SSEP is a highly specific test in predicting neurological outcome

260 the association of genetic variants appeared highly specific, the possibility of pleiotropic associat

261 as a template for the development of future highly specific therapeutic inhibitors targeting FXIII i

262 ted in fatty acid oxidation (FAO), a feature highly specific to adipocyte exosomes.

263 how that the local connectome fingerprint is highly specific to an individual, allowing for an accura

264 r example, decreased native T1 values appear highly specific to detect and quantify disease severity

265 e--often perturb regulatory modules that are highly specific to disease-relevant cell types or tissue

266 in many tissues, including the brain, and is highly specific to EAA deficiency.

267 The enzyme, glutathione reductase, is highly specific to glutathione.

268 multiple recent reports, PLZF expression is highly specific to innate T cells and cannot be induced

269 with VPS52, and show that the association is highly specific to Mpersicae-host interactions.

270 Importantly, sialylation was highly specific to pathogenic IgG at the site of inflamm

271 The method was confirmed to be highly specific to S. typhimurium without interference f

272 by using a novel antibody named 3EG that is highly specific to the -EEEG C-terminal sequence, we dem

273 cular weight = 20,395 Da) RNA-based aptamer, highly specific to the human IL-23 cytokine, with picomo

274 report a near-infrared optical imaging probe highly specific to the hypoxic tumour microenvironment t

275 RNA-guided Cas9 binding was highly specific to the target site while off-target bind

276 sitizing effect of the antisense oligomer is highly specific to the targeted gene's sequence, which i

277 confirming that the fluorescence signals are highly specific to tumor cells.

278 arrying the C-terminal motif -FWxxRamide are highly specific to VdTRP-R.

279 ted removal of mitochondrial labile iron via highly specific tools from these organelles may be an ef

280 e that the HRF approach is both feasible and highly specific toward correct identifications.

281 The prepared MIP sensor was highly specific towards mel and the recognition was anal

282 The biosensor is highly specific towards triacylglycerides and is unaffec

283 ical identity of every cell is maintained by highly specific transcriptional networks that establish

284 dotoxemia to establish the method, we reveal highly specific transcriptional responses and altered RN

285 ste information to the brain; and expose the highly specific transfer of taste information between ta

286 We generated a highly specific transgenic reporter of HSPCs in zebrafis

287 2 hours after ACTH administration, involved highly specific, transient (lasting <24 hours) induction

288 y ultrasound exposure has been shown to be a highly specific treatment modality, making the potential

289 mologous targeting capabilities are used for highly specific tumor imaging.

290 nd equilibrium transition profiles suggest a highly specific two-state transition in which the foldin

291 ecific tRNA (tRNASec) drives the recoding of highly specific UGA codons from stop signals to Sec.

292 rgeting and dendritic arborization, and in a highly specific walking defect in adult flies.

293 This association was highly specific when compared to other non-compulsive as

294 binding of FMN to MtrC is reversible and not highly specific, which may be consistent with a role as

295 Glycans attached to glycoproteins interact highly specific with lectins, natural carbohydrate-bindi

296 The optimised system was demonstrated to be highly specific with negligible cross-reactivity allowin

297 tection of HPV type-specific plasmid DNA was highly specific, with high signal-to-noise ratios for al

298 ons between naturally occurring proteins are highly specific, with protein-network imbalances associa

299 e TST and IGRAs are moderately sensitive and highly specific within countries with low TB burden.

300 se negatives on 50 hERG-sensitive drugs) and highly specific (zero false positives on 50 hERG-insensi