ライフサイエンスコーパス: hinder

1 es formed in the acidic vesicles is strongly hindered.

2 he Cas9/single-guide RNA (sgRNA) interior is hindered.

3 was ejected in favor of the less sterically hindered 2-formylpyridine, with concomitant high- to low

4 This lack of information has hindered a mechanistic understanding of these diseases.

5 nd stage and defined remaining research gaps hindering a personalized medical approach for diabetes t

6 erically significant steric role by directly hindering access to the enolate double bond.

7 This electrostatic effect often hinders accurate measurements.

8 ngestion might not influence outcome but may hinder adherence.

9 ulosis, the causative agent of tuberculosis, hinders advancement in all areas of research toward prev

10 hieve similar performances with a sterically hindered alpha-chiral aliphatic side chain.

11 n-Bu2BOTf.i-Bu3N bearing a hindered amine shifts the rate-limiting step to proton t

12 ce of VZV nucleic acids in human neurons has hindered an understanding of the mechanisms that regulat

13 ge uncertainty of HONO sources and chemistry hinders an accurate prediction of the OH budget.

14 proficiency in the Negishi cross-coupling of hindered and electronically deactivated coupling partner

15 en limited to about 0.05 square micrometres, hindering applications that demand a larger layout and i

16 n buffering pH; (3) high salinity in general hinders As release from minerals; and (4) the magnitude

17 cal causes of past changes in growth, but is hindered at many High Arctic sites by short and fragment

18 A lack of homology with known proteins has hindered attempts to define its domain composition.

19 the room-temperature coupling of deactivated/hindered biaryl partners.

20 al growth (from 1.4 x 10(7) to 0 CFU/mL) and hindered biodegradation.

21 une cells to the transplanted cells but also hinders blood vessel ingrowth.

22 eutralizing antibodies (non-nAbs), which may hinder bnAb induction.

23 cantly increased bone formation and slightly hindered bone resorption.

24 ent of the domain IV voltage sensor (VSDIV), hindering both fast and slow inactivation and leading to

25 which patients are most at risk of SUDEP is hindered by a complex genetic etiology, incomplete under

26 river ecosystems respond to warming has been hindered by a dearth of information about how otherwise

27 her DNA to gold surfaces, but this method is hindered by a lack of control over monolayer density and

28 nthesis of complex oligosaccharides is often hindered by a lack of knowledge on the reactivity and se

29 l understanding of RNA localization has been hindered by a lack of simple, high-throughput methods fo

30 rowave irradiation has in chemistry is still hindered by a lack of understanding of the physical prin

31 f this approach in neuroscience is, however, hindered by a limited variety of suitable ion channels,

32 nsequences for nitrogen processing, is still hindered by a paucity of adequate measurement techniques

33 pathogenesis of leprosy granulomas has been hindered by a paucity of tractable experimental animal m

34 wering device voltage to avoid this issue is hindered by an inadequate understanding of the electrica

35 elivery and therapeutic efficacy are greatly hindered by barriers presented by the vascular endotheli

36 large-scale materials screening efforts are hindered by computationally expensive transition state b

37 ddition, their use in clinical trials may be hindered by differences in the time interval between pat

38 ng screening tools in plant biology has been hindered by difficulty of delivering high quantities of

39 Unfortunately, protein measurement in DBS is hindered by high abundance proteins and matrix interfere

40 validation of small RNA biomarkers has been hindered by high quantitative variability and biased seq

41 udes longer than competing processes, though hindered by impurities and intrinsic/extrinsic defects.

42 Animal models of FSHD are hindered by incomplete knowledge regarding the conservat

43 f metabolic regulation in these datasets are hindered by inherent limits of pathway enrichment statis

44 s, systematic experimental studies have been hindered by inhomogeneous broadening in ensemble measure

45 To date, much of this has been hindered by issues of sample preparation and assay signa

46 l deployment of LLL12 in cancer treatment is hindered by its low bioavailability and hypoxia-induced

47 n of the role of PP2A B' in meiosis has been hindered by its myriad of other essential roles.

48 tems remains challenging and is particularly hindered by lack of compatible methods to quantify filop

49 However, evidence for microrefugia is hindered by lack of understanding of how rates of warmin

50 However, drug development has been hindered by limited structural information.

51 Studies of EV function have been hindered by limited understanding of their biogenesis.

52 riven oncogenic process; a mechanism that is hindered by miRNA-142-3p.TRPA1 has been reported to cont

53 ast, proton passage through the D-channel is hindered by N139's preference for a closed conformation

54 ent of solar-energy technologies is severely hindered by poor energy-conversion efficiencies due to l

55 Development of wound therapies is hindered by poor understanding of combinatorial integrin

56 ivity and its associated health benefits are hindered by poor urban infrastructure.

57 tion and confirmation of these findings were hindered by potential heterogeneity and by the rarity of

58 The release of this peptide during GID was hindered by protein glycation.

59 microscale soft noble metal objects has been hindered by sample preparation.

60 However, interpretation of the results is hindered by several confounders.

61 equencing to large cell populations has been hindered by technical challenges in isolating single cel

62 groundwater contaminant 1,4-dioxane is often hindered by the absence of dissolved oxygen and the co-o

63 However, progress in this field has been hindered by the challenge to probe optical and transport

64 the capacity for such a shift is potentially hindered by the compatibility of different host-symbiont

65 ication and quantification of species can be hindered by the complexity of the solutions if bands ove

66 peutic development for spinal cord injury is hindered by the difficulty in conducting clinical trials

67 tegies for promoting neural regeneration are hindered by the difficulty of manipulating desired neura

68 l properties of blue phases, which have been hindered by the existence of grain boundaries.

69 The analysis of RNA tertiary structure is hindered by the fact that not too many structural data a

70 n of results between primates and rodents is hindered by the fact that the organization of descending

71 biomolecular structural data sets have been hindered by the geometric and biological complexity.

72 n structure of protonated glycoconjugates is hindered by the inability to differentiate linkage and s

73 wever, progress in coupling these methods is hindered by the inability to interpret the complex excha

74 ioselective control that PT domains exert is hindered by the inaccessibility of intrinsically unstabl

75 to explain dopamine neuron vulnerability are hindered by the lack of dopaminergic cell death in alpha

76 erties and connectivity of these neurons are hindered by the lack of markers to define their molecula

77 neurological manifestations of MPS has been hindered by the lack of objective measures of central ne

78 scading failures in complex systems has been hindered by the lack of realistic large-scale modeling a

79 e phenomenon of cellular senescence has been hindered by the lack of senescence-specific markers.

80 their applicability for on-line diagnosis is hindered by the lack of sensitive and portable on-chip o

81 ed on the activity of individual neurons, is hindered by the lack of suitable meaningful and reproduc

82 ccessful translation to clinical practice is hindered by the lack of thorough preclinical testing usi

83 intellectual impairment in Down syndrome is hindered by the large number of genes duplicated in Tris

84 rapeutics whose discovery has otherwise been hindered by the limitations of existing cell based appro

85 se interactions and their dynamics have been hindered by the low throughput and resolution of current

86 Experimental discovery of such solitons is hindered by the need for spatial imaging of the 3D field

87 ABTRACT: Establishing a cure for HIV is hindered by the persistence of latently infected cells w

88 r, quantitative analysis of IT data has been hindered by the piecemeal development of relevant statis

89 Ideal bandgap PVSCs are currently hindered by the poor optoelectronic quality of perovskit

90 understanding of cAMP signaling pathways is hindered by the presence of at least 15 distinct adenyly

91 on of point-of-care systems for diagnosis is hindered by the prohibitive costs of existing chloride s

92 xidized di- and triterpenes, for example, is hindered by the superposition of similar absorption band

93 of technologies to accomplish this has been hindered by the susceptibility of synthetic genetic circ

94 instem to attention has, in particular, been hindered by the tiny amplitude of the brainstem response

95 ates for exo-glycosidases, however, has been hindered by their constrained pocket-shaped active sites

96 of antimicrobial peptides (AMPs) is largely hindered by their non-specific toxicity against mammalia

97 e transcriptase (RT) inhibitors (NNRTIs) are hindered by their unsatisfactory pharmacokinetic (PK) pr

98 ankton communities under field-conditions is hindered by traditional labor-intensive approaches that

99 The development of new treatments is hindered by uncertainty about the nature of the aggregat

100 nce, and quality improvement initiatives are hindered by variations in case definitions.

101 l favoring the attack on the most sterically hindered carbon of the cyclic aziridinium intermediate.

102 easier bond formation between two sterically hindered carbons.

103 us, we discuss how the long channel does not hinder catalysis under physiological conditions and the

104 Depletion of HDAC5 by shRNA hindered cellular proliferation, induced G1 cell cycle a

105 Subsequent edema can hinder cerebrospinal fluid efflux and can lead to locall

106 ility of peptide-receptive MHC molecules has hindered characterization of such conformational plastic

107 of the byproduct of spray-coated SWCNTs that hinders charge transfer and stable CD4(+) T cell sensing

108 ies in targeted nuclear gene editing broadly hinder Chlamydomonas research.

109 An exceptionally hindered class of enantiopure NHC ligands has been devel

110 iNKT cells indeed hinder CLL survival in vitro by restraining CD1d-express

111 xametaphosphate corrosion/scaling inhibitors hinder clogging but natural organic matter (NOM) has rel

112 ible in unstructured free-text format, which hinders computational analysis.

113 mutations that decrease hepcidin binding or hinder conformational changes required for ubiquitinatio

114 either before or after a target stimulus can hinder conscious perceptual processing of the target via

115 of spatial data on biodiversity threats has hindered conservation strategies.

116 ularly in North America, is lacking, thereby hindering conservation and management programs.

117 The lack of a vaccine hinders control.

118 genetic variants in the folate pathway that hinder conversion to its active form.

119 s are preferred in reactions with sterically hindered coupling partners with relatively low bond diss

120 assembly, (iii) may enhance (CCL2, CCL5) or hinder (CXCL10) early parasite control, (iv) may promote

121 tablishing PCP in the vestibule are unclear, hindering data interpretation and employment of the vest

122 s of rural-urban environmental gradients and hinders development of effective strategies for mitigati

123 mulate very high SHM levels, a property that hinders development of vaccine strategies to elicit them

124 adequate for simple SECM measurements under hindered diffusion conditions.

125 cial role of the actin cortex in maintaining hindered diffusion modes of many but not all of the memb

126 Hindered diffusion of phospholipids and sphingolipids is

127 hile ATR-FTIR experiments indicated strongly hindered diffusion with diffusion coefficients in the me

128 tical model is developed to account for this hindered diffusion.

129 is directly proportional to the timescale of hindered dihedral rotations within the polypeptide chain

130 nd the first example of this coupling with a hindered diortho substituted hydrazone substrate.

131 ave been crystallographically characterized, hindering direct experimental validation of the offline

132 m of the parasite is poorly understood which hinders drug discovery.

133 w-abundance class of phospholipids, has been hindered due to its difficulties to be resolved from its

134 Ubiquitination hinders Dvl binding to phosphatidic acid, an interaction

135 l changes in chromatin structure that likely hindered effective distal V-DJ recombination.

136 rbon and nutrients enter river networks, has hindered effective modelling and management.

137 manifesting an excessive indecisiveness that hinders efficient decision making.

138 This has hindered efforts to analyze fine-root trait variation an

139 LE: Heterogeneity in the septic response has hindered efforts to understand pathophysiology and devel

140 rmation on the unique ABC ion channel, CFTR, hinders elucidation of its functional mechanism and corr

141 ged nucleic acids and hydrophobic drugs have hindered entrapment of both components within a single c

142 host material and usually in low densities, hindering experiments aiming to investigate this new cla

143 quality control and analysis procedures have hindered extensive reuse of these data.

144 of the axial ligand would occur on the less hindered face of the porphyrin, away from the strap.

145 race amounts in India bauxite, significantly hindered fluoride removal by increasing solution pH.

146 On the other hand, downregulating PCK2 hindered fumarate carbon flows in TCA cycle, leading to

147 ionary trajectory are unclear, which greatly hinders functional studies.

148 rehensive information about 6mA distribution hinders further investigations into its function and reg

149 d is capable of addressing challenges of the hindered gene target in drug repositioning approaches to

150 While neutralizing TNFalpha hindered GVT effects by the combined T-cell infusion, a

151 kylation of aliphatic amines by unactivated, hindered halides persists as a largely unsolved challeng

152 ing covalently linked to Cys-319 and thereby hindering homodimerization.

153 from DSBs in cells expressing HPV E6 and E7 hinders HR through a distinct mechanism.

154 emonstrated in the oxidation of a sterically hindered hydroxymethylpyrimidine precursor to the blockb

155 Inducing and controlling electric dipoles is hindered in the ultrathin limit by the finite screening

156 ons, and lack of standardization metrics has hindered independent experimental comparison and validat

157 that the Glu-221 side chain could sterically hinder insertion of the N terminus into the HABP2 protea

158 in the structures of fluorophores to impart hindered intramolecular rotations, leading to desirable

159 in tumor extracellular matrix contributes to hindered intratumoral distribution of nanocarriers and t

160 Because the heterogeneous nature of ASD hinders investigations in human subjects, we explored br

161 nd what genetic or environmental factors may hinder it.

162 an a lengthy device fabrication process that hinders it.

163 l-established large-area synthesis protocols hinder its applications.

164 ding and assembly requirements of Te-Rubisco hinder its heterologous expression in leaf chloroplasts.

165 fficiency and formation of lithium dendrites hinder its practical application.

166 ion by Arbidol has remained obscure, thereby hindering its further development as a specific and opti

167 V/C103V retards initial fusion-pore opening, hinders its expansion and leads to premature closure in

168 e full-length 5 UTR of the zorO type I toxin hinders its own translation independent of the sRNA wher

169 s errors are two individual-level mechanisms hindering judgment propagation at the scale of the chain

170 s in behavior, but circuit complexities have hindered linking specific cellular mechanisms with their

171 y, the formation of a dense paddy plough pan hindered long-term Po accumulation in the paddy subsoil.

172 enged group because donor site morbidity can hinder manual labour and vigorous sexual activity might

173 vivo mouse models, we showed that COUP-TFII hinders myogenic development by repressing myoblast fusi

174 nols, possibly because their less sterically hindered nitro groups can be released more easily as nit

175 The Mo layer likely hinders O2 gas permeation, impeding contact with active

176 DBAN does not hinder ongoing DNA replication, but specifically blocks

177 f standardized health outcomes measurements, hindering optimal monitoring and comparison of the quali

178 low abundance of some constituents in cells hinder our understanding of cellular heterogeneity.

179 uctures of CSB or the Pol II-CSB complex has hindered our ability to address these questions.

180 on in the Mg cation environment has severely hindered our understanding and prevents effective measur

181 ecapitulate tissue-specific architecture has hindered our understanding of FTE transformation and ini

182 d substantially lag behind climatic changes, hindering our ability to make temporally realistic proje

183 However, a lack of virus genome information hinders our ability to answer fundamental, biological qu

184 This knowledge gap hinders our ability to anticipate and mitigate the impac

185 This lack of data hinders our ability to inform policy and apply sustainab

186 This limitation especially hinders our understanding of how the gut microbiota inte

187 tion trade-off-it facilitates peak shift and hinders patterning discrimination-and that PN-to-KC conn

188 on effective post-reactivation interference, hindered performance may rapidly recover, raising the po

189 myosin VI to various organelles in vivo and hinders peroxisome motion in a light-controllable manner

190 It has been shown to hinder phagocytosis, is retained in tumors, and aids in

191 binds to histone deacetylase type 4 (HDAC4), hindering phosphorylation of HDAC4 at Ser(246) and preve

192 eats to study validity have the potential to hinder progress in cardiovascular medicine as preclinica

193 te fraction for characterization analyses is hindering progress in assessing the fate and toxicity of

194 r, several key methodological flaws that are hindering progress in the study of insect social behavio

195 available that lack significant attenuation, hindering progress toward understanding determinants of

196 at temozolomide, which induces apoptosis and hinders proliferation, also normalizes intratumoral pHe.

197 Glycation strongly hindered protein breakdown, whereas cross-linking result

198 orrelation are the reactions with sterically hindered pyridines, which apparently hinder the close ap

199 ynes, and rapid access to diverse sterically hindered quaternary centers.

200 phous structures of many surface oxides have hindered realistic theoretical studies.

201 ic redox species and the nanoconfinement and hindered redox diffusion inside 3-nm-diameter silica nan

202 have not been systematically characterized, hindering refinements of future epidemic predictions and

203 ) administration just after injury similarly hinders regeneration and compromises muscle strength.

204 age of alveolar-capillary barrier cells that hinders regeneration of respiratory function.

205 s altered following a burn injury and likely hinders regrowth of muscle.

206 and required chaperone complementarity that hinder Rubisco biogenesis in alternative hosts.

207 cell stream spacing of 375 microm and larger hinders SCS advancement, thus providing abilities to eng

208 Ocean flows are found to both facilitate and hinder shifts depending on their directional agreement w

209 e approach of the electrophile from the more hindered side.

210 l for compounds with up to four rotationally hindered sigma bonds, for which a single stereoisomer ou

211 Cs proved efficacious in the fluorination of hindered silicon substrates, with fluorination yields de

212 the strongest positive effect on yield, but hindered simultaneous harnessing of below- and above-gro

213 ucible, high-throughput wounding methods has hindered single-cell wound repair studies.

214 s probably due to their high rigidity, which hinders some of the peptide catalysts to adopt the prope

215 ce of side reactions involving only the less hindered starting alkene, resulting in homo-metathesis b

216 n the metastable pre-fusion conformation has hindered structural and immunological studies.

217 The lack of cell culture has hindered studies of OvHV-2 biology, including its entry

218 Only in the case of particularly sterically hindered substrates, such as those bearing tertiary alky

219 nyl side chain pointing toward the metal may hinder such a ferryl flip and promote ethylene formation

220 hput limitations of existing approaches have hindered systematic forward genetic screening for NMD fa

221 oil bacteria do not propagate coliphages and hindered T4 diffusion through the biofilm.

222 When starting from sterically hindered terpenes, allenylphosphonates were also easily

223 Sterically hindered tertiary and neopentyl substrates are reduced e

224 the electrode surface to be slowed down and hindered that resulted in low luminol intensity.

225 on and other unique characteristics that may hinder the ability of conventional approaches to consist

226 nd adducts and collision-induced adduct loss hinder the acquisition of quality MS2 spectra.

227 Notably, complexation with HSA did not hinder the activity of silencing oligonucleotides inside

228 its protonated dimers at Bronsted acid sites hinder the adsorption of cyclohexene and the formation o

229 fy and resolve those uncertainties that most hinder the choice of an optimal intervention.

230 rically hindered pyridines, which apparently hinder the close approach of proton donor and acceptor t

231 nue, as the current population structure may hinder the efficacy of refuge plants in delaying insect

232 n in particular wavelength range is known to hinder the efficiency of c-Si cell.

233 learning identifies protein properties that hinder the HPA high-throughput antibody production pipel

234 Ependymal cilia dysfunction can hinder the movement of CSF leading to an abnormal accumu

235 th a many-body system, the size of which can hinder the preparation of controlled states.

236 obust analytical techniques that continue to hinder the purification and characterization of DNA-base

237 and thermal effect near room temperature can hinder the rich physics.

238 lized by hydrogen bonds and salt bridges can hinder the separation of fragments even with preactivati

239 n the core of the transporter and sterically hinder the transit of uric acid through the substrate ch

240 This hindered the access of the iron redox probe to the condu

241 lity of biomarkers in 24-h urine samples has hindered the collection and use of the samples in epidem

242 This hydrophobicity has hindered the determination of the molecular mechanisms o

243 mpromised the benefits of Mg/S chemistry and hindered the development of Mg/S batteries.

244 -damping, magnetostrictive ferrite films has hindered the development of power-efficient magnetoelect

245 luorescence from photosynthesis pigments has hindered the investigation.

246 animal model of dengue infection has greatly hindered the study of dengue pathogenesis and the develo

247 This property of capsule hindered the therapeutic utility of anti-OmpA MAbs, and

248 r conductivity obtained through this process hindered the widespread use of the technique.

249 eters are probably some of the factors still hindering the application of graphene in commercial batt

250 A critical barrier hindering the application of transplantation strategies

251 -related morbidity is difficult to quantify, hindering the attribution of direct effects of exposure

252 lls results in cell death by excitotoxicity, hindering the development of cell-based assays for NMDAR

253 y significant during the AGN phase, possibly hindering the development of complex life within a few k

254 hemorrhagic stroke (NHS) remains undefined, hindering the development of strategies to improve outco

255 uces the enzymatic activity of EPT1, thereby hindering the final step in phosphatidylethanolamine syn

256 ion, however, are still not well understood, hindering the forecast and mitigation of haze pollution.

257 ies such as large defective grain boundaries hindering the further improvement of the detector perfor

258 structures tend to grow in a random fashion, hindering the future integration in nanoscale devices.

259 -poor regions tend to be inherited together, hindering the generation of novel allelic combinations t

260 pecifically, whether one agent is helping or hindering the other.

261 f PI(3,4)P2 and PI(4,5)P2, a technical issue hindering the phosphoinositide signaling field.

262 tion and multi-photon emission are currently hindering the use of defects in layered hBN as reliable

263 tion under typical storage conditions, often hinders the ability of a candidate antibody to be develo

264 Here we show that species diversity hinders the adaptation to toxicants.

265 own, and whether this disruption enhances or hinders the alloimmune responses is unclear.

266 e a mosaic pattern of gene disruption, which hinders the application of the technology to study gene

267 f light, photosensitizer, and oxygen greatly hinders the broad application of PDT as a first-line can

268 ntive treatments, the lack of PIE biomarkers hinders the clinical implementation of such treatments.

269 s rely on linear signal amplification, which hinders the detection of small amounts of genetic materi

270 structure of insect odorant receptors (ORs) hinders the development of more effective repellants to

271 table third-order nonlinear material greatly hinders the development of this technology.

272 e during disease state since it dramatically hinders the drug delivery.

273 As force hinders the folding transition, chaperones must play a r

274 onents that participate in chemotaxis, which hinders the identification of the conceptual framework o

275 er in the central channel of the hexamer and hinders the interaction of Mpa with the proteasome core

276 highly microdiverse and that microdiversity hinders the metagenomic assembly, which could explain wh

277 e diamond-like film, in a multilayer film it hinders the phase transformation.

278 putative proteins of unknown function, which hinders the understanding of their biology.

279 This hinders the widespread application of ionic liquids in t

280 d synthesis methods for asymmetric particles hinder their application because these methods have a li

281 d toxicity still remain that may potentially hinder their commercialization.

282 ional group(s) on chemical shifts combine to hinder their effectiveness.

283 he rarity of autoimmune T cells in the blood hinder their study.

284 ple dilution are still common drawbacks that hinder their use in routine diagnosis.

285 d assess this potential for lung repair have hindered their applicability.

286 lines and scalable manufacturing methods has hindered their applications.

287 utputs of conventional textiles have largely hindered their development.

288 rties of ecological communities, potentially hindering their ability to provide ecosystem services fo

289 ocks are in intronic and intergenic regions, hindering their functional evaluation.

290 chemical fuels (e.g., H2 O2 ), which greatly hinders their applications in biologically relevant medi

291 mely enlarged LDs in seeds and pollen, which hinders their subsequent mobilization during germination

292 l wall recalcitrance to deconstruction still hinders their widespread use as bioenergy and biomateria

293 ly show that Li-ion conductivity is severely hindered through the grain boundaries.

294 m, subject to given lattice constraints, are hindered to simultaneously minimize their local interact

295 ckel catalysis and proceeds using sterically hindered tri- and tetrasubstituted olefins to give produ

296 developed to provide facile access to highly hindered trisubstituted alpha-branched olefins, which wh

297 zes of AIPs and labile thiolactone bond have hindered vaccine development.

298 This process hinders VZV and is regulated by a viral glycoprotein, gB

299 conduct numerical evaluations is critically hindered when dealing with large models.

300 In contrast, chronic ACh deprivation hindered whisker-evoked CBF responses and the amplitude