ライフサイエンスコーパス: hindpaw

1 noxious stimulation of the face than of the hindpaw.

2 ardise the mechanical stimulation of a rat's hindpaw.

3 a persistent, mechanical hyperalgesia of the hindpaw.

4 ermined by von Frey filaments applied to the hindpaw.

5 to have two distinct receptive fields on the hindpaw.

6 noreactivity in the glabrous skin of the rat hindpaw.

7 of complete Freund's adjuvant (CFA) into the hindpaw.

8 al, hypersensitivity only in the ipsilateral hindpaw.

9 that receive sensory inputs from an inflamed hindpaw.

10 hyperalgesia in the contralateral, uninjured hindpaw.

11 1% formalin into the plantar surface of the hindpaw.

12 n of complete Freund's adjuvant (CFA) in one hindpaw.

13 e responses of the contralateral, uninflamed hindpaw.

14 was produced by capsaicin injected into the hindpaw.

15 when administered intrathecally or into the hindpaw.

16 n of complete Freund's adjuvant (CFA) in one hindpaw.

17 om the forepaw was larger than that from the hindpaw.

18 ues following injection of formalin into the hindpaw.

19 % and 28%, respectively, in the non-inflamed hindpaw.

20 ss formalin-induced pain derived from either hindpaw.

21 e non-inflamed or had a carrageenan-inflamed hindpaw.

22 in those with inflammation induced in their hindpaw.

23 o mechanical stimuli in glabrous skin of the hindpaw.

24 subcutaneous injection of formalin into one hindpaw.

25 ng stimuli (acetone) applied to the lesioned hindpaw.

26 to the skin of the dorsal surface of the rat hindpaw.

27 olet irradiation-induced inflammation of one hindpaw.

28 in following chronic inflammation of the rat hindpaw.

29 d during zymosan-induced inflammation of the hindpaw.

30 neously into the plantar surface of the left hindpaw.

31 the hyperalgesia induced by IL-1beta in the hindpaw.

32 st cutaneous blood flow increases in the rat hindpaw.

33 graded pressure stimuli to the contralateral hindpaw.

34 before injection of formalin into the right hindpaw.

35 inated axons in the glabrous skin of the rat hindpaw.

36 the hyperalgesia induced by IL-1beta in the hindpaw.

37 cal and heat hyperalgesia in the ipsilateral hindpaw.

38 ciceptive testing on the dorsum of the rat's hindpaw.

39 and after carrageenan administration to one hindpaw.

40 subcutaneous formalin injection to the left hindpaw.

41 .4 mN) applied to the plantar surface of the hindpaw.

42 withdrawal frequencies in the tumor-bearing hindpaw.

43 and mechanical hyperalgesia in the injected hindpaw.

44 ting complete Freund's adjuvant (CFA) in the hindpaw.

45 m granulosum throughout the epidermis of the hindpaw.

46 G, sciatic nerve, or transcutaneously across hindpaws.

47 served in both ipsilateral and contralateral hindpaws.

48 defect due to an inability to dorsi-flex the hindpaws.

49 a C-fiber irritant, mustard oil (MO), to the hindpaw].

50 ripheral activity by QX-314 at the amputated hindpaw 120 min after amputation did not significantly a

51 ut not after chronic inflammation of the rat hindpaw 2 d after injection of complete Freund's adjuvan

52 a unilateral injection of formalin into the hindpaw, a strong and bilateral phosphorylation of CREB

53 ne derivative (QX-314, 5%) into the injected hindpaw abolished both mechanical and thermal facilitati

54 ected with complete Freund's adjuvant in one hindpaw and from uninflamed control rats.

55 te Freund's adjuvant (CFA) injections in the hindpaw and hindleg are reported.

56 the dorsal horn ipsilateral to the inflamed hindpaw and in contralateral deep dorsal horn in both DL

57 the hyperalgesia present in the ipsilateral hindpaw and induced hyperalgesia in the contralateral, u

58 ed gelatin/plasmid DNA polyplex into the rat hindpaw and its subsequent retrograde transport via scia

59 ministered in the L5-peripheral field of rat hindpaw and mechanical hyperalgesia was evaluated after

60 tion injury of the sciatic nerve of the left hindpaw and observed a striking loss of connections betw

61 ory cortex to electrical stimulation of both hindpaws and the right forepaw were recorded under ureth

62 s of morphine, especially in the neuropathic hindpaw, and did not display opioid-dependent stress ana

63 ersistent pain behavior, inflammation of the hindpaw, and ipsilateral dorsal horn Fos immunoreactivit

64 sing radiant heat applied to the ipsilateral hindpaw, and we found that agonist potency was significa

65 lved pigmentary disturbances of the abdomen, hindpaws, and tail, with additional neurological related

66 d by a severity index, hindpaw swelling, and hindpaw ankylosis.

67 Dilute formalin injected into the rat hindpaw as a nociceptive stimulus increases neurokinin-1

68 te Freund's adjuvant (CFA; 3 d) into the rat hindpaw as well as adjuvant-induced polyarthritis (21 d)

69 lication of a cold stimulus by immersing the hindpaw at 10 degrees C for 10 s resulted in decreases i

70 PI3K or MEK (ERK kinase) inhibitors into the hindpaw attenuated capsaicin- and NGF-evoked heat hypera

71 Male rats of 3-4 weeks old were exposed to a hindpaw burn injury.

72 neous fentanyl on thermal nociception of the hindpaw but not the forepaw.

73 ntensities produced vasodilation in the left hindpaw, but not in the right.

74 us morphine on the withdrawal latency of the hindpaw, but not the forepaw, measured with a radiant he

75 ked responses of spinal neurones in control, hindpaw carrageenan inflamed, spinal nerve ligated and s

76 rs, using the Dlx5/6-Cre transgene, led to a hindpaw-clasping phenotype and a 50% loss of MSNs withou

77 In vivo, hindpaw compression induced NK1R internalization in ipsi

78 Mechanical stimulation of the hindpaw consisted of repeated 10 s clamps with a hemosta

79 ith formalin into the plantar surface of the hindpaw, counted the number of flinches for 2 h and then

80 utting the DLF ipsilateral to the stimulated hindpaw, depression of BK-induced PE was already markedl

81 chanical and thermal hypersensitivity of the hindpaw developed and was associated with spinal sensiti

82 55,212-2 (10 microg) into the contralateral hindpaw did not decrease paw withdrawal frequencies in t

83 Amputation of a third hindpaw digit in an adult rat induced rapid expression o

84 ess cutaneous blood flow changes in both rat hindpaws during DCS with a unipolar ball electrode.

85 le allodynia and thermal hyperalgesia of the hindpaws (during the DAMGO infusion) and a decrease in a

86 ocorticoids, we now demonstrate that chronic hindpaw edema in the sciatic transection CRPS model is r

87 ibuted to the development and maintenance of hindpaw edema, and that chronic MP administration dose-

88 Localized inflammation of a rat's hindpaw elicits an accumulation of beta-endorphin-(END)

89 We measured forepaw- and hindpaw-evoked sensory responses in rat, before and afte

90 en injected with capsaicin (1% or 3%) in the hindpaw fail to learn, even when tested on the leg contr

91 r activating ET(B) receptors on ET-1-induced hindpaw flinching and excitation of nociceptors in rats.

92 Hindpaw flinching developed within minutes after ET-1 (8

93 ant BP increase in the right (contralateral) hindpaw following formalin injection with or without lid

94 Only OEG-injected rats plantar placed their hindpaws for more than two steps by the 7-month endpoint

95 Following either mouse hindpaw formalin injection or sciatic nerve ligation, pY

96 ic tibiotarsal joints of the uninjected left hindpaws from AIA rats demonstrated 2 distinct phases of

97 Rats were tested for the latency to withdraw hindpaws from thermal stimuli (Hargreaves test).

98 s after the stimulation of the contralateral hindpaw (from 64 to 91%), and the proportion exhibiting

99 ocuous mechanical stimulation of an inflamed hindpaw gives rise to further facilitation of neuronal a

100 vokes chronic limb edema, pain behavior, and hindpaw hyperalgesia, a syndrome resembling the complex

101 We find that secondary hindpaw hypersensitivity in arthritic rats results from

102 n by either capsaicin (>/=100 micrograms) or hindpaw immersion in hot water (>/=45 degrees C for 4 mi

103 Cs were triggered either by immersion of the hindpaw in 49 degrees C water or application of 300 g of

104 enuated SCS-induced vasodilation in the left hindpaw in a dose dependent manner (linear regression, P

105 s generated by immersing the metatarsus of a hindpaw in a water-bath at 52 degrees C for 5 s (n=10).

106 ction of complete Freund's adjuvant into one hindpaw in rats, and neurons in the gracile nucleus were

107 Capsaicin injected into the hindpaw in these spinalized animals produced a small dep

108 Thermal stimulation consisted of immersing a hindpaw in water at 52 degrees C for 2 min.

109 images were collected simultaneously in both hindpaws in anesthetized rats to determine the level of

110 examining the blood perfusion (BP) change in hindpaws in response to formalin injection (an acute inf

111 Blood flow changes in the hindpaw induced by SCS were measured in the footpad with

112 -noxious (brush) stimulation of the inflamed hindpaw induced internalization in large numbers of supe

113 ls of staphylococcal s.c. abscess formation, hindpaw infection, and surgical wound infection, S. aure

114 Hindpaw inflammation and hyperalgesia were induced by in

115 on of bilirubin also was found to ameliorate hindpaw inflammation induced by the injection of lambda-

116 Hindpaw inflammation induces tyrosine phosphorylation (t

117 ed expression of spinal CD11b and GFAP after hindpaw inflammation was also attenuated by molecular de

118 or without complete Freund's adjuvant (CFA) hindpaw inflammation, in response to electrical stimulus

119 nd lumbar regions ipsilateral to forepaw and hindpaw inflammation, respectively.

120 ral funiculus-lesioned (DLFX) rats following hindpaw inflammation.

121 lete spinal transection following persistent hindpaw inflammation.

122 n in normal rats and in rats with persistent hindpaw inflammation.

123 or without complete Freund's adjuvant (CFA) hindpaw inflammation.

124 VGF was also upregulated 24 h after hindpaw inflammation.

125 lectively induced by CCI but not CFA-induced hindpaw inflammation; and (5) the number of nuclear prof

126 Effects of hindpaw inflammatory injury were similarly decreased in

127 Finally, hindpaw injection of artemin, neurturin, GDNF, or NGF pr

128 Hindpaw injection of beta-endorphin was sufficient to pr

129 egshocks after (Experiment 2) a subcutaneous hindpaw injection of capsaicin.

130 lated in response to inflammation induced by hindpaw injection of complete Freund's adjuvant (CFA): a

131 Hindpaw injection of SLIGRL-NH(2) produced Fos staining

132 were investigated after subcutaneous plantar hindpaw injections in adult male Sprague Dawley rats.

133 Subcutaneous hindpaw injections of horseradish peroxidase conjugated

134 ifted the V1/2 of the inactivation curve, of hindpaw innervating DRG neurons, which is retrogradely l

135 BS was colocalized with NaV1.7 and NaV1.8 in hindpaw-innervating DRG neurons.

136 Hindpaw intraplantar injection of complete Freund's adju

137 emic (subcutaneous), spinal (intrathecal) or hindpaw (intraplantar) injections of test compounds, we

138 The animals, however, dragged the hindpaw ipsilateral to the lesion along the treadmill be

139 onse appeared to be limited primarily to the hindpaw ipsilateral to the site of DCS.

140 nged, formalin-induced pain derived from the hindpaw ipsilateral, but not contralateral, to the inact

141 von Frey filaments (4-100 g) applied to the hindpaws ipsilateral and contralateral to the injury, an

142 aneous receptive fields was observed only in hindpaws ipsilateral to the lesion, acutely.

143 ectrical shocks were delivered to the normal hindpaw, it is likely that plastic changes occur central

144 was somatotopically oriented (e.g. to either hindpaw); its function may be to ensure that when a sens

145 Furthermore, CNP injection into mouse hindpaw led to the development of thermal hyperalgesia t

146 spinal neurons in SNL rats but did not alter hindpaw levels of endocannabinoids.

147 eurons in spinal nerve ligated (SNL) rats or hindpaw levels of endocannabinoids.

148 Heat stimulus was generated by immersing a hindpaw metatarsus in a water-bath at 52 degrees C for 1

149 Following inflammation of the hindpaw, myelinated, CGRP-positive neurons projecting to

150 ensory neurons damaged by burn injury to the hindpaw, Na(v)1.7 currents contribute to the hyperexcita

151 cold (20 degrees C) stimuli, applied to the hindpaw of anesthetized rats induce SPR internalization

152 apsaicin (CAP) into the glabrous skin of one hindpaw of anesthetized rats.

153 (CFA) into the plantar surface of the right hindpaw of female Sprague-Dawley rats.

154 re applied to the abraded skin of the dorsal hindpaw of mice.

155 nse to pressure stimuli to the contralateral hindpaw of rats under urethane anesthesia.

156 red prior to injection of capsaicin into the hindpaw of rats, which produces mechanical and heat hype

157 , and oleoyl ethanolamide in the ipsilateral hindpaw of sham-operated rats.

158 5.0% formalin in the plantar surface of one hindpaw of the rat produced a concentration-dependent in

159 5 min of an acute mechanical stimulus to the hindpaw of the rat, there is a significant increase of 5

160 PGE2)-induced mechanical hyperalgesia in the hindpaw of the rat.

161 ater mechanical hyperalgesia in the affected hindpaw only during the first 60 days after toxin.

162 ter at 50 degrees C either on their forepaw, hindpaw, or on both the hindpaw plus forepaw concurrentl

163 vasodilation at all intensities in the left hindpaw (P<0.05, n=7) compared with responses before RTX

164 letely abolished both prolonged allodynia to hindpaw PGE(2) and enhanced nocifensive behaviors evoked

165 chanical stimulus was applied by a bilateral hindpaw pinch for 5 s that increased mean arterial press

166 chanical stimulus was applied by a 10-second hindpaw pinch that increased mean arterial pressure (MAP

167 rongly activated by noxious stimuli, such as hindpaw pinches or electrical footshocks.

168 The effects of tactile stimulation on hindpaw plantar skin was measured weekly using the Von F

169 er on their forepaw, hindpaw, or on both the hindpaw plus forepaw concurrently.

170 jected subcutaneously into the tumor-bearing hindpaw produced a dose-dependent decrease in paw withdr

171 n of complete Freund's adjuvant (CFA) into a hindpaw produced a persistent inflammation and a sustain

172 concentration of capsaicin injected into the hindpaw produced significant swelling of the injected pa

173 Direct administration of C5a into the mouse hindpaw produced strong thermal hyperalgesia, an effect

174 n of QX-314 together with capsaicin into rat hindpaws produced a long-lasting (more than 2 h) increas

175 produced by carrageenan injection in the rat hindpaw, produced mechanical hyperalgesia that resolved

176 tor endothelin-1 (ET-1) into the rat plantar hindpaw produces pain behavior and selective excitation

177 us administration of ET-1 to the rat plantar hindpaw produces pain-like behavior and selective excita

178 els predominated by neurones innervating the hindpaw) rather than L3.

179 gether with BQ-123 (3.2 m), into the plantar hindpaw receptive fields of these units.

180 chrome oxidase barrel pattern in forepaw and hindpaw regions of S1.

181 n responses of somatosensory neurones in the hindpaw representation area to muscarinic cholinoceptor

182 trol group and two groups in which the right hindpaw representational area had been ablated 3-4 weeks

183 Responses of single units in the hindpaw representational area of the left primary somato

184 resent in the regions of the forepaw and the hindpaw representations were absent, whereas the lateral

185 Intradermal injection of GsMTx-4 in the rat hindpaw reversed the mechanical hyperalgesia induced by

186 iculus (DLF) contralateral to the stimulated hindpaw (segmental level C5/C6 and T8/T9), depression of

187 r dermorphin-saporin did not change baseline hindpaw sensitivity to non-noxious or noxious stimuli.

188 nd to be significantly enhanced in the hairy hindpaw skin and its receptor GDNF family receptor alpha

189 ern blot and real-time PCR analysis of hairy hindpaw skin and L2/L3 DRGs after saphenous nerve regene

190 al-time PCR analysis of L2/L3 DRGs and hairy hindpaw skin at various times after saphenous nerve axot

191 calcitonin gene-related peptide release from hindpaw skin biopsies, and increased capsaicin-evoked in

192 ced spontaneous protein extravasation in the hindpaw skin by 80%.

193 l threshold to mechanical stimulation of the hindpaw skin in rats by a peripheral mechanism.

194 gene-related peptide (CGRP) release from rat hindpaw skin in vitro; 2) the effects of a peripherally

195 cally-evoked neurogenic extravasation in the hindpaw skin of normal rats.

196 in spontaneous protein extravasation in the hindpaw skin of rats after sciatic transection, similar

197 tra-epidermal nerve fibre density in plantar hindpaw skin, and produced spinal cord dorsal and ventra

198 imately 40%) MO-evoked CGRP release from rat hindpaw skin, and this effect was not antagonized by the

199 ng targets outside of the knee joint such as hindpaw skin.

200 Two pulses of hindpaw stimulation caused paired-pulse depression in th

201 so caused depression of sensory responses to hindpaw stimulation, suggesting that the population of s

202 ay overlap with that activated by peripheral hindpaw stimulation.

203 Total hindpaw sweat secretion was measured by proton nuclear m

204 fect of MTX as measured by a severity index, hindpaw swelling, and hindpaw ankylosis.

205 demonstrate that wire grates rapidly induce hindpaw tactile hyperesthesia and plantar neuropathy in

206 hanical pain-related hypersensitivity of the hindpaw that was significantly greater than the 1 mg tre

207 .06, 0.12 or 0.6 mg/100 microl into the left hindpaw to block CGRP responses; N-omega-nitro-l-arginin

208 d at 0.02 or 0.1 mg/100 microl into the left hindpaw to block neuronal nitric oxide synthesis.

209 d at 0.02 or 0.2 mg/100 microl into the left hindpaw to block nitric oxide synthesis; (4S)-N-(4-Amino

210 apsaicin, was injected locally into the left hindpaw to functionally inactivate TRPV-1 containing sen

211 felone treatment reduced hypersensitivity of hindpaws to mechanical, but not thermal, stimulation, in

212 thology were correlated with changes in left hindpaw volumes, circulating leukocytes, acute-phase rea

213 he flexor reflex ipsilateral to the inflamed hindpaw was enhanced approximately two-fold compared to

214 g sympathetic sprouting in the local DRGs or hindpaw was the sole mechanism.

215 , inflamed and the contralateral, uninflamed hindpaws was determined by the radiant-heat paw withdraw

216 Cutaneous blood flow from left and right hindpaws was recorded with laser Doppler flow perfusion

217 determined for the contralateral, uninflamed hindpaw, was also progressively enhanced 4 hr, 4 d, and

218 ephalin (DAMGO), determined for the inflamed hindpaw, was enhanced 4 d and 2 weeks after injury.

219 ving an injection of formalin into the right hindpaw were assayed for NK-1R mRNA with the use of solu

220 ists, ATP, BzATP or alpha,beta-meATP, into a hindpaw were measured in rats that were injected intrath

221 urons to mechanical noxious stimulation of a hindpaw were strongly inhibited by intravenous dipyrone

222 e fields (RFs) on the plantar surface of the hindpaw were studied.

223 Mechanical and thermal sensitivity of the hindpaws were assessed after injections of acidic saline

224 iserum to beta-endorphin was injected in the hindpaw where the noxious thermal stimulus was applied,

225 Consequently, affected animals drag their hindpaws while walking and support themselves on the hin

226 ollowing subcutaneous injection in the right hindpaw with 0.5 mg of heat-killed Mycobacterium butyric

227 g a small number of electrical pulses to the hindpaw with varied stimulus intensity, number, and inte

228 to injection of capsaicin exhibited a lower hindpaw withdrawal frequency (18+/-4%) and a longer with

229 jection of capsaicin produced an increase in hindpaw withdrawal frequency to mechanical stimuli (from

230 For this, hindpaw withdrawal from either a thermal or mechanical s

231 Fore- and hindpaw withdrawal latencies from a 30 degrees or 48 deg

232 raoral sucrose and suckling did not increase hindpaw withdrawal latencies in either control or CFA-in

233 After just 1 week on grates, hindpaw withdrawal thresholds were already markedly decr

234 ermal capsaicin also elevated the mechanical hindpaw-withdrawal threshold in the awake rat.