ライフサイエンスコーパス: hindrance

1 ses isomerization as a benefit rather than a hindrance.

2 raminidase enzymatic activity through steric hindrance.

3 -APOA2 antibody (Ab) due to its lower steric hindrance.

4 ion of their composition, charge, and steric hindrance.

5 ated congeners, which we attribute to steric hindrance.

6 initial antibody shape that prevents steric hindrance.

7 ty of situations where clogging represents a hindrance.

8 f pi delocalization, cage strain, and steric hindrance.

9 n the polbeta active site without any steric hindrance.

10 helix (Phe-1 site), even if it causes steric hindrance.

11 nevertheless, most likely because of steric hindrance.

12 up to C5) providing no additional benefit or hindrance.

13 (i.e., imidazole and its analogs) via steric hindrance.

14 he vinculin tail domain with actin by steric hindrance.

15 dynamics method to account for hydrodynamic hindrance.

16 10 surface loop sites, presumably by steric hindrance.

17 LA class II-peptide complexes through steric hindrance.

18 tadienyl radical at the site of least steric hindrance.

19 de ejection from the pocket by simple steric hindrance.

20 adsorption, protein denaturation, and steric hindrance.

21 mplification steps effectively avoids steric hindrance.

22 ly interfere with JAM-A engagement by steric hindrance.

23 high-energy state is not occluded by steric hindrance.

24 f kinase substrates and regulators by steric hindrance.

25 ction rules driven by ring strain and steric hindrance.

26 dissociates from the cap to overcome steric hindrance.

27 Deltalambdamax 13nm), possibly due to steric hindrances.

28 t effective phosphines feature remote steric hindrance, a concept that could guide future ligand desi

29 ly attenuated through introduction of steric hindrance adjacent to the ketone carbonyl.

30 rbenoids, which are less sensitive to steric hindrance, allows sterically encumbered carbon-carbon bo

31 However, increased steric and hydrodynamic hindrances, also associated with smaller pores, make it

32 the tryptophan binding site points to steric hindrance and an inability to retain the interactions us

33 this endeavor, owing to MUC1-imposed steric hindrance and antigenic heterogeneity.

34 tapled Trp peptide exhibited signs of steric hindrance and difficulty translocating.

35 t-lived interactions that derive from steric hindrance and diminished avidity with Nsp1p.

36 mino acid exchange G757D causes local steric hindrance and disruption of the channel complex.

37 (QBTs) with controlled variations in steric hindrance and electron activity of the substituents has

38 CeH-BTC displays low steric hindrance and electron density compared to homogeneous o

39 Here, we probe the effect of steric hindrance and electrostatics within the ion conduction p

40 network and diffuse through the cap without hindrance and fully displace/release the retained small

41 have demonstrated the crucial role of steric hindrance and hydrogen-bond interactions in thermal stab

42 the hydrogel interfaces with minimal steric hindrance and hydrophobic collapse.

43 act that the hydrolysis is impeded by steric hindrance and improved by sufficient polarity, in this s

44 eave the disulfide bond to weaken the steric hindrance and increase the polarity, promoting the hydro

45 and organotypic tissues, with reduced steric hindrance and no crosslinking compared with multivalent

46 ic solvents as a result of the strong steric hindrance and propensity for hydrolysis of APTES, which

47 dye uptake saturation by removing the steric hindrance and same-charge repulsion phenomena via multil

48 result cannot be explained by simple steric hindrance and suggests that Tm may have additional effec

49 th boric acid and NDMA is governed by steric hindrance and that they have similar molecular dimension

50 etic factors arising from the greater steric hindrance and the directional nature of the sp(n) hybrid

51 They also experienced the least space hindrance and the fastest rate when binding to target mo

52 ich blocks HCO3(-) activation through steric hindrance and trapping of the Arg176 side chain.

53 the parent compound due to a reduced steric hindrance and/or insertion of electron-donating hydroxyl

54 metal ion radius, likely a result of steric hindrance and/or weaker binding to the larger metal ion.

55 enting protein crowding, myofilament lattice hindrance, and binding to the cytomatrix.

56 twisted linker conformation, intramolecular hindrance, and framework rigidity.

57 ns such as electrostatic interaction, steric hindrance, and hydrogen bonding as well as HA molecular

58 arising from slow membrane diffusion, steric hindrances, and multiple sites, and therefore may be wid

59 has relied on decelerative asymmetric steric hindrance approaches.

60 -based dimer- and trimer-bridged high steric hindrance aromatic groups during photoluminescence (PL)

61 Steric hindrance around the icosahedral 3-fold axes prevents bi

62 rated Lewis pair systems, the lack of steric hindrance around the Lewis basic fragment allows activat

63 Although found in prokaryotes, steric hindrance as a mechanism for negatively regulating trans

64 ing when in the presence of pervasive steric hindrance as is the case with the N-alkoxy-2,2,6,6-tetra

65 These findings strongly implicate steric hindrance as the mechanism of repression of rob by MarA.

66 i) a cumulative effect resulting from steric hindrance associated with the brush block.

67 , with tertiary amines, on increasing steric hindrance at nitrogen, pointing toward the important rol

68 ject to negative cooperativity due to steric hindrance at the dimer interface.

69 Stick or twist: By introducing steric hindrance at the nitrogen atom, stable linear amides bea

70 tivity is primarily controlled by the steric hindrance at the region of the ligand close to the alkyn

71 that substrate inhibition arises from steric hindrance between Sites 1 and 2 of adjacent subunits.

72 tween DNA strands on the surface, (2) steric hindrance between tethered DNA probes, and (3) nonspecif

73 This kink, resulting from steric hindrance between the 5'-flanking guanine amino group an

74 )-hydroxy-2-oxoacids by relieving the steric hindrance between the 5-methyl group of these compounds

75 teins induces their stretching due to steric hindrance between the proteins.

76 The difference in steric hindrance between Tyr/Trp(604) and the trifluoromethoxy

77 activation results from a removal of steric hindrance blocking the actin-binding sites, we simulate

78 The reaction is sensitive to steric hindrance by 4- and 6'-substituents.

79 lysis and modeling of EhACK indicated steric hindrance by active site residues constricts entry to th

80 bition is not solely mediated by active site hindrance by its antitoxin.

81 ocally slowed-down Brownian motion and local hindrance by obstacles both improve it.

82 These differences may be due to steric hindrance by the 11-keto group in CF3DODA-Me, which prev

83 ain interaction with ADAMTS13 through steric hindrance by the bulky carbohydrate structure.

84 ract with downstream effectors due to steric hindrance by the covalently linked AMP moiety.

85 ling of the substrate groove, and the steric hindrance by the cysteine-rich domain.

86 lost when it is N-glycosylated due to steric hindrance by the glycan.

87 phosphorylated state, suggesting that steric hindrance by the His-36 side chain prevents constitutive

88 The detection is based on diffusional hindrance by the insulating objects which alters the flu

89 ligible Si-Ge intermixing owing to geometric hindrance by the Si nano-tip approach.

90 This selectivity comes from steric hindrance by the spectator ligands, a strategy that has

91 grees of branching, likely due to the steric hindrance by these bulky residues.

92 Steric hindrance can result in reaction at quinone oxygen inste

93 this substrate-dependent behavior to steric hindrance caused by substrate-induced rumpling of the Fe

94 Thus, the unfavorable hindrance caused with crowding a large alkyl side chain

95 onpolar interactions, contributing to steric hindrance, characterize the environment of tryptophans t

96 No longer a hindrance: copper-catalyzed electrophilic amination of a

97 Steric hindrance does not affect this process.

98 onding due to T338M mutation and from steric hindrance due to the presence of an inflexible phenyl ri

99 out questionnaire regarding the symptoms and hindrances due to JCP.

100 There is a different tendency in hindrances due to pediatric JCP between in patients and

101 he studied systems is associated with steric hindrance during the chemiexcitation sequence, rationali

102 5 +/- 2.5 kJ/mol) arising from severe steric hindrance during the transition from an orthogonal birad

103 -15 containing amines having distinct steric hindrances (e.g., primary, secondary) and similar loadin

104 ea of the dye molecule increases, the steric hindrance effect exerted on the neighboring adsorbed mol

105 e reactivity, clearly demonstrating a steric hindrance effect.

106 ectrodes leverages three effects: (1) steric hindrance effects at the nanoscale, (2) a size-dependent

107 Steric hindrance effects of polysaccharide chains on the effici

108 dG-C8-AAF in all sequences stems from steric hindrance effects of the acetyl group which significantl

109 electrochemical sensor that utilizes steric hindrance effects to signal the presence of large macrom

110 d to a signaling DNA strand generates steric hindrance effects, which limits the ability of this DNA

111 the neighboring nanoparticles due to stereo-hindrance effects.

112 nsition state intermediate because of steric hindrance, especially from the methyl group of Ala-12 of

113 of the xanthine plane because of the steric hindrance exerted by the two carbonyls.

114 ees ) in PPP-NN were observed due to smaller hindrance for a five vs a six membered ring.

115 drug activity, presumably by reducing steric hindrance for drug binding.

116 entral hydrophobic region provides the major hindrance for ion diffusion along the permeation pathway

117 ode and input/output modes has been the main hindrance for many applications.

118 Steric hindrance for naphthalene increases exponentially from 9

119 obstruct vision at times and are a potential hindrance for patients' functioning or when obtaining vi

120 rotein activities, but also creates a steric hindrance for protecting the glycoproteins from degradat

121 vator molecule asymmetrically without steric hindrance for the binding of a second cofactor.

122 lation at Asn-163 of CD16 removes the steric hindrance for the CD16-hIgG1 Fc binding and thus increas

123 in the constriction zone that suffers steric hindrance for the reorientation needed for its onward tr

124 s PSII supercomplexes from plants has been a hindrance for their deep structural and functional chara

125 indered its deposition mainly through steric hindrance forces.

126 is is the first time that deleterious steric hindrance from long single-stranded regions adjacent to

127 e beta-phosphate is absent because of steric hindrance from the Asn17 side chain.

128 e thiol-Ag chemistry and the specific steric hindrance from the organic layer of fluorescent Ag nanoc

129 drated saccharide residues as well as steric hindrance from the polymer backbone.

130 angevin motion (fLm) due to the viscoelastic hindrance from the surrounding network of proteins and c

131 Due to steric hindrance from the two relatively large labels, attachme

132 thus avoiding limiting artifacts from steric hindrances from the microscope coverslip and other surfa

133 The increased steric hindrance generated by the substitution reduced the exci

134 lood-Brain Barrier (BBB), known as the major hindrance, greatly limits therapeutics penetration into

135 One possible hindrance has been the lack of immunogens that properly

136 This hindrance has motivated us to develop comparative modeli

137 ing new approach, the electrochemical steric hindrance hybridization assay (eSHHA) has been introduce

138 Using this steric hindrance hybridization assay in an electrochemical form

139 de perovskite solar cells has become a major hindrance impairing the ultimate performance and stabili

140 the 40S subunit, suggesting that mere steric hindrance impedes Listerin recruitment.

141 est that in addition to relieving the steric hindrance imposed upon the catalytic lobe by the regulat

142 A major hindrance in engineering tissues containing highly metab

143 modifications (PTMs) is a widely recognized hindrance in epigenetics research.

144 city of examples has served as a significant hindrance in furthering our understanding of this proces

145 ook prototype for the introduction of steric hindrance in organic chemistry, the elucidation of the b

146 te for another, potentially explains a major hindrance in reconstituting enzymatic activity in vitro.

147 A major hindrance in studying human meiosis has been the inabili

148 urrent cultivation limitations have proved a hindrance in studying these organisms.

149 half, resulting in a reduction of the steric hindrance in the "fjord" region of the molecule, which c

150 Bub3-Bub1 molecules: low Bub1 abundance and hindrance in the binding of more than one Bub3-Bub1 mole

151 model that relates these data to the steric hindrance in the matrix, and we briefly discuss the impl

152 covalently, probably due to the less steric hindrance in the Michael addition.

153 dest effect on reaction rate, whereas steric hindrance in the transition state can significantly reta

154 dination of the reagent but increased steric hindrance in the vicinity of the nitrogen (8c,e) results

155 This behavior has been attributed in part to hindrances in the mass transport of gases through the po

156 ith the more crowded C2 and C3, where steric hindrance increases the interplanar separation at contac

157 The steric hindrance induced by the antibody leads to a current dec

158 fic interfacial interactions owing to steric hindrance induced by the covalent tether.

159 structure but the microscopic basis of this hindrance is not fully understood.

160 driven anti-viral immunity; however, a major hindrance is STING's cytosolic localization which requir

161 rements and simulations indicate that steric hindrance is the dominant factor responsible for motion

162 igestion was aimed at removing the molecular hindrance, made up by the heavily glycosylated egg prote

163 One hindrance may come from the adoption of the organic chem

164 ients to date but also raise possible steric hindrance mechanisms by which this antibody blocks HIV-1

165 ents of a standard immunoassay due to steric hindrance-mediated release of prebound fluorescent repor

166 ze the properties attributable to the steric hindrance-mediated release of the fluorescent reporter m

167 Ring size and adjacent steric hindrance modulate this hidden hydrophilicity, thus maki

168 tography-derived indices of tract volume and hindrance-modulated orientational anisotropy (HMOA).

169 Structurally, the dorsal cingulum volume and hindrance-modulated orientational anisotropy was signifi

170 The reason is that steric hindrance must be overcome to nucleate the binding compl

171 Insertion of a steric hindrance mutation in the center of TM7 (G286F in positi

172 affinity and base-CP affinity through steric hindrance; Nas6 clashes with the lid in the ATP-hydrolys

173 Steric hindrance near the oxime functional group played a key r

174 e starting unprotected oses, (ii) the steric hindrance of both targeted furanoses and silylating agen

175 chain conformation due to the strong steric hindrance of bulky ethylhexyl side chains.

176 Our work suggests that steric hindrance of ethereal ligands plays an important role in

177 with a few lysines inserted to overcome the hindrance of extreme insolubility and two D-lysines to l

178 f the molecule, probably resulting in steric hindrance of ficolin-1 interaction with PTX3.

179 ld serve as a simple means to prevent steric hindrance of flagellar motility or to ensure that phage-

180 observations can be explained by the steric hindrance of molecules occupying the highly constrained

181 We further showed that the steric hindrance of Mucin-4, a membrane protein, was responsibl

182 s multimodal delivery strategy minimizes the hindrance of NP diffusion imposed by the brain extracell

183 The steric hindrance of Py and FA largely dictates the HDF reaction

184 We report that steric hindrance of R1 and R2 groups of the chiral lithium amid

185 Further increase in the steric hindrance of R1 and R2 groups results in the formation o

186 operator CIRCE, causing repression by steric hindrance of RNA polymerase.

187 3-57.4% in adult medaka breeding pairs, with hindrance of SSC development resulting in the largest di

188 est that inhibition of AMPK occurs by steric hindrance of the active site pocket and by inhibition of

189 free N2O or MesCNO despite increased steric hindrance of the adducts.

190 Owing to the steric hindrance of the axle phenyl group, the threading of the

191 The steric hindrance of the core unit exerted upon the rotors prove

192 h surface sites and play a marginal sterical hindrance of the crystal growth.

193 are markedly decreased by the severe steric hindrance of the flanking phenyl rings in the polyhetero

194 d to vastly diverse environments despite the hindrance of the geographic axis of the Americas and the

195 The diffusional hindrance of the glycocalyx along the cell surface on ex

196 aride GPI analogue 4, suggesting that steric hindrance of the GPI analogues does not affect their pep

197 litated by MS-FRAP distinguish the diffusive hindrance of the interstitial versus cellular constituen

198 Li.S)2 was observed by increasing the steric hindrance of the ligand.

199 show that the ability to overcome the steric hindrance of the matrix cannot be attributed to a single

200 ich was previously "protected" by the steric hindrance of the MB stem-loop structure, accessible.

201 reaction that was unsuccessful due to steric hindrance of the oxygen at the C33 position, we were abl

202 he N-terminal segment of Par17 causes steric hindrance of the Par17 active site, thus interfering wit

203 Structural and steric hindrance of the polymer backbone forces acene polymeriz

204 tic acid was observed possibly due to steric hindrance of the polymer chains in the cross-linked hydr

205 ed bulkier (NbOF5)(2-) caused the looked-for hindrance of the previously free-rotating pyrazine moiet

206 ning both the proton affinity and the steric hindrance of the probe to fully understand and map the c

207 Increase of steric hindrance of the R1 and R2 groups suppresses the formati

208 tion singles calculations suggested that the hindrance of the rotational relaxation of the S(1) state

209 The role of vhs in pathogenesis and the hindrance of the type I IFN response have classically be

210 These differences result from steric hindrance of the W domain with intersubunit contacts in

211 However, the limited tolerance to steric hindrance of these couplings restricts the synthetic ava

212 i ions has a strong influence through steric hindrance of transverse fluoride ion vibrations, which d

213 Wip1 is a negative regulator of p53 and hindrance of Wip1 activity by novel inhibitor GSK2830371

214 re and the physical properties (e.g., steric hindrance) of the organic shell were fully utilized for

215 uctural characteristics (amine order, steric hindrance, -OH group substitution and alkyl chain length

216 For DPAC and FlPAC with higher steric hindrance on the N,N'-substituents, normal Stokes-shifte

217 ons as an antiviral clamp, conferring steric hindrance on the RNA-dependent RNA polymerases of divers

218 een related not only to the effect of steric hindrance on the thermodynamic stability but also to the

219 ones, probably due to the effects of steric hindrance or electron donors at the ortho position to su

220 es can be restricted in reactivity by steric hindrance or enhanced by binding interactions with nearb

221 ransient anomalous diffusion due to obstacle hindrance or power-law-distributed residence times (cont

222 Whether autoantibody steric hindrance or signaling through pathways such as p38 MAPK

223 fuse inside the body of plants due to steric hindrance or very slow diffusion.

224 ment controls this motion - either by steric hindrances or by modulating the electronic structure of

225 One hypothesis proposes that the hindrance originates in large part from the presence of

226 ten controlled by directing groups or steric hindrance ortho to a potential reaction site.

227 Due to steric hindrance, pcPNAs are unable to form pcPNA-pcPNA duplexe

228 c probes, thereby minimizing possible steric hindrance/perturbation at the binding interface.

229 nnective tissue and must overcome the steric hindrance posed by pores that are smaller than the cells

230 hate) binding, and a second where the steric hindrance predicted between gammaLeu83 and beta(DP) resi

231 These data suggest that the hindrance presented by the location of a DNA lesion is d

232 of keratins, neighboring residues and steric hindrance preventing deamidation of N.

233 the unfolded region may alleviate the steric hindrance produced by the cargo protein, by functioning

234 immuno-magnetic aggregates providing steric hindrance protecting the interior binding sites from int

235 epulsion, high hydrophilicity and the steric hindrance provided by the coating that blocks bacterium-

236 which allows us to conclude that the steric hindrance provided by the glutamate residue is responsib

237 anarization, DPAC and FlPAC encounter steric hindrance raised by the N,N'-disubstitutes, resulting in

238 I) diazoalkane complex showcases that steric hindrance represents an inherent limitation of the chose

239 by parasitic plants is a major agricultural hindrance resulting in substantial crop losses worldwide

240 oxybenzene units present considerable steric hindrance, resulting in the formation of isomers and inh

241 However, this hindrance should not act as a barrier to delay intervent

242 e of its high ring strain and reduced steric hindrance, Sph exhibited fast reaction kinetics (k2 up t

243 rbed quantity at saturation (N asat), steric hindrance (tau), concentration at half saturation (c1/2)

244 alizumab light chain, perhaps causing steric hindrance that disrupts viral entry.

245 that KIR binding to HLA-C must override the hindrance that His-36 puts on KIR2DL1 self-association.

246 ow that the intersection poses a significant hindrance that leads to long pauses in transport only wh

247 ndau, Verwey and Overbeek (XDLVO) and steric hindrance theories to interpret the experimental results

248 e binding pocket that imposes a clear steric hindrance thereby excluding bulkier lignin precursors.

249 between collagen and hyaluronan on diffusive hindrance through the interstitium.

250 assembly of nascent desmosomes due to steric hindrance, thus rendering acantholysis irreversible.

251 ly excludes larger substrates through steric hindrance, thus serving as a molecular gatekeeper for su

252 by a combination of glycol coverage, steric hindrance, TiO2(110) order, and the amount of subsurface

253 larges nanopores, which helps relieve steric hindrance to adsorption.

254 y with the C5 atom of xylose, causing steric hindrance to any additional group at C5.

255 brane itself appears not to be a significant hindrance to diffusion of Fa.

256 g dead-space microdomains, contribute to the hindrance to diffusion.

257 h sides of the cell membranes form the major hindrance to Fa transfer.

258 of plant species richness and N inputs is a hindrance to forecasting the state of the soil N cycle a

259 une evasion by sequence variation is a major hindrance to HIV-1 vaccine design.

260 creases stem primarily from increased steric hindrance to hydration of the nucleophilic oxygen atom w

261 The major hindrance to imaging the intact marrow is the surroundin

262 , suggesting that the latter is the greatest hindrance to increased precision.

263 tants conferred resistance by causing steric hindrance to inhibitor binding.

264 ongoing gene exchange is considered a major hindrance to population divergence and, ultimately, to t

265 s positioned close to strand breaks impose a hindrance to RAD52 catalytic activities.

266 has been at best misleading and at worst, a hindrance to selecting the appropriate treatment plan fo

267 crystals, which is, in many cases, a serious hindrance to structure solution.

268 Graft-versus-host disease remains a primary hindrance to successful allogeneic hematopoietic cell tr

269 One hindrance to the development of cardioprotectants is the

270 e network, as opposed to repulsion or steric hindrance to the diffusion of molecules through narrow p

271 tism has long been conjectured to be a major hindrance to the discovery of genetic risk factors, lead

272 rom known alloy parameters remains the major hindrance to the discovery of new systems.

273 , relapse and chemoresistance remain a major hindrance to the fight to minimize the burden of the dis

274 ent drug release rates resulting from steric hindrance to the formation of enzyme-substrate complex a

275 tiators ("handcuffing"), which causes steric hindrance to the origin.

276 This hindrance to the study of alternative mechanisms of G pr

277 A major hindrance to the study of honey bee pathogens or the eff

278 e(-) transfer process, which poses a severe hindrance to their practical use.

279 ency in the timing of such assessments, is a hindrance to understanding its true prevalence, severity

280 othesized to be due to alterations in steric hindrance to water and urea, and/or changes in protein f

281 O, making foulant adsorption not create much hindrance to water flux.

282 reatment are burdensome to the patient and a hindrance to widespread use of PDT as standard field the

283 gion 1 (HVR1) of E2 are believed to be major hindrances to developing universally protective HCV vacc

284 re cited by only 26% of respondents as major hindrances to implementation of surveyed programs.

285 Given the substantial economic and logistic hindrances to providing ART for all people with HIV in r

286 oteomic changes also demonstrate significant hindrances to vaccine development.

287 ood and drinking water is a major threat and hindrance towards ensuring food and water safety.

288 may block membrane fusion by induced steric hindrance upon primary receptor binding, thereby abrogat

289 Removal of distal pocket steric hindrance via a Leu-->Ala mutation yields favorable O(2)

290 ne metathesis of substrates with propargylic hindrance was investigated, revealing the successful com

291 onditions was initially attributed to steric hindrance, we found out that cyclization via the amide o

292 roxyl groups, hydrophobic bonding and steric hindrance were characterised.

293 l or hydroxyl group and have moderate steric hindrance were enzymatically transformed, likely by phos

294 ng linkers differing in the degree of steric hindrance were used in antibody conjugates to test the e

295 cal modification were reductions from steric hindrance when the bacteriocin bound to the receptor pro

296 rnary complex is prevented, simply by steric hindrance, when the A-site is occupied by peptidyl-tRNA.

297 xpected that van der Waals forces and steric hindrance will render the motion of the larger triptycen

298 alkyl side chains in order to prevent steric hindrance with neighboring hydrogens attached to core th

299 t norepinephrine, and originates from steric hindrance with the aromatic residues on helix6.

300 ompeting effects of base polarity and steric hindrance, without changing the average structure.