ライフサイエンスコーパス: hippocampi

1 gions (periventricular white matter and both hippocampi).

2 re hypothalamic specific, with no changes in hippocampi.

3 ronal loss, inflammation, and gliosis in the hippocampi.

4 ary hippocampal neuron cultures and in mouse hippocampi.

5 d methylation of the histone H3 in E17 fetal hippocampi.

6 ion were also increased in astrocytes in NBD hippocampi.

7 e) glycohydrolase mRNA were decreased in NBD hippocampi.

8 es in spared ipsi- and contralateral ventral hippocampi.

9 in synaptic plasticity in eed and Mll mutant hippocampi.

10 lish or depress recurrent seizures in 70% of hippocampi.

11 in brain metabolites characterize epileptic hippocampi.

12 RNA and protein levels were increased in NBD hippocampi.

13 nto SGs and away from polyribosomes, in both hippocampi.

14 uced by 44% in area CA1 of MTLE vs. non-MTLE hippocampi.

15 ficantly down-regulated in the neurons of AD hippocampi.

16 rd deviation in the Sommer sector of the MTS hippocampi.

17 ell as NFT formation, was observed in the AD hippocampi.

18 was associated with systemic hypoxia in both hippocampi.

19 quences predominantly involving the pons and hippocampi.

20 lex families, had significantly smaller left hippocampi.

21 he brain, enhances neuronal survival in both hippocampi.

22 associated with increased activation of the hippocampi.

23 ulate white matter (WM), and the thalami and hippocampi.

24 tionalize the function of the left and right hippocampi.

25 Voxels were tailored to the individual hippocampi.

26 ere differences in T2 between right and left hippocampi.

27 ced by a mean of 42.7% compared with control hippocampi.

28 regions of interest within the head of both hippocampi.

29 fferent spiking trains among eight different hippocampi.

30 onal morphology in human fetal and postnatal hippocampi.

31 ethanol exposure increased the weight of the hippocampi.

32 e selectively reduced in the TFEB-transduced hippocampi.

33 o date comparing epileptic with normal human hippocampi.

34 es as well as in the thalami, amygdalae, and hippocampi.

35 lvement of the brainstem, basal ganglia, and hippocampi.

36 he largest effects seen in the amygdalae and hippocampi.

37 al-like discharges induced in vitro in mouse hippocampi.

38 ers reflect the extent of sclerosis in human hippocampi.

39 oven to depend on the presence of functional hippocampi.

40 57BL/6J mice and increased IL-1beta in their hippocampi.

41 Denervated hippocampi (2,6,15, and 30 days post ERC lesion) were st

42 12 of 15 had abnormally low NAA in sclerotic hippocampi; 3 of these 12 also had abnormally low NAA co

43 iation (LTP) could not be induced in injured hippocampi; (3) GFAP and inducible NO synthase (iNOS) im

44 Hippocampi (5/group/time point) were harvested immediate

45 synchrony of neural oscillations between the hippocampi, a measure of brain function that indexed cog

46 hermore, impaired growth of normal-appearing hippocampi after FSE suggests subtle injury even in the

47 ater than 50% seizure reduction in bilateral hippocampi after treatment.

48 rom this study of monkeys suggest that small hippocampi also reflect an inherited characteristic of t

49 G allele predicted lower volume of bilateral hippocampi among cannabis users relative to controls (bo

50 identified differentially expressed genes in hippocampi and amygdalae of the endogenous depression an

51 n gray matter (GM) volume in their posterior hippocampi and concomitant changes to their memory profi

52 injured but also the contralateral uninjured hippocampi and correlated with the lesion induced atroph

53 (DHA) to arachidonic acid, were lower in the hippocampi and cortices and plasma of injured mice.

54 its cleavage products was also increased in hippocampi and cultured hippocampal neurons lacking Fbxo

55 Risk adjustment correlated with DOC in the hippocampi and deliberation time with DOC in the medial

56 refrontal cortex, retroesplenial cortex, and hippocampi and elevated connectivity between anterior an

57 and a pattern of atrophy including bilateral hippocampi and entorhinal cortex, right inferior parieta

58 n a set of 110 manually segmented atlases of hippocampi and find the manifold learning technique and

59 en and women had significantly smaller right hippocampi and larger cerebrospinal fluid volumes than h

60 ated caspase 3 protein were increased in NBD hippocampi and localized to nuclei, mossy fibers, and de

61 His hippocampi and medial frontal cortex were significantly

62 levels of BDNF were associated with smaller hippocampi and poorer memory, even when controlling for

63 with bumetanide abolished seizures in 70% of hippocampi and significantly reduced the frequency, dura

64 dine 10 mg/kg/day) for 5 days, and cortices, hippocampi and spinal cords were collected for immunoblo

65 RNA miR-124 was increased in demyelinated MS hippocampi and targets mRNAs encoding 26 neuronal protei

66 ps for the analysis of the right versus left hippocampi and the hippocampal head versus body.

67 exhibited greater activity in both posterior hippocampi and the right fusiform gyrus during smooth pu

68 Cs of both human and pilocarpine-treated rat hippocampi and those in the control rat DGCs.

69 Findings suggest that smaller left hippocampi and verbal memory deficits are an expression

70 ility to schizophrenia includes smaller left hippocampi and verbal memory deficits.

71 ysis included both the MTS and contralateral hippocampi, and covariance for changes in brain parenchy

72 response in the posterior cerebellar cortex, hippocampi, and lenticular nuclei bilaterally and the ri

73 ed significantly lower NAA in right and left hippocampi, and significantly higher Glu and Glu/NAA in

74 sensory barrel fields, lacunosum moleculare hippocampi, and specific nuclei of the rostral ventral m

75 ansgene spontaneously develop RIDNs in their hippocampi, and the formation of RIDNs correlates with t

76 lifetime of seizures on both left and right hippocampi, and the presence of any co-existing malforma

77 tionality of remaining tissue in the damaged hippocampi, and to appreciate the neural basis of a dist

78 induces tPA activity and cell death in both hippocampi, and unilateral treatment of rats with neuros

79 plasma, young mouse plasma, and young mouse hippocampi, appears in the brain after systemic administ

80 in triple-transgenic AD mice, CAR levels in hippocampi are low and further reduced after systemic in

81 Consequently, Lis1+/- hippocampi are prone to interictal electrographic seizur

82 ed significant neuronal damage in KA-treated hippocampi at 16 h post-injection in both maternal and v

83 on microscopic analyses confirm that PS-cDKO hippocampi at 2 months postnatal do not yet exhibit syna

84 d with fixed paraffin-embedded sections from hippocampi at various stages of fetal and postnatal deve

85 re used to measure structural differences in hippocampi between genotype groups.

86 or densities significantly decreased in both hippocampi (binding potential: controls 1.62 +/- 0.07; A

87 HS-1 degrees Rel had bilaterally small hippocampi, but no focal white matter atrophy was detect

88 were significantly decreased in demyelinated hippocampi, but not in demyelinated motor cortices from

89 vulnerable regions of the brain, notably the hippocampi, but was not sufficient to result in the more

90 46), temporal cortices (Brodmann's area 22), hippocampi, caudate nuclei, and cerebella of schizophren

91 les, but volume changes in dorsal or ventral hippocampi, caudate-putamen, or thalamus were not detect

92 0 mRNA levels were elevated in tetanized rat hippocampi compared with those of sham controls that rec

93 ipitation assays in NG108-15 cells and mouse hippocampi confirmed specific Egr1 binding to the Ca(V)3

94 vitro slice preparation containing bilateral hippocampi connected by the VHC.

95 /B, was selectively increased in 4E-BP2(-/-) hippocampi, consistent with unaltered I-V relation of EP

96 LTP induced in chronic nicotine-treated hippocampi contained a component that is immune to rever

97 uggests that radiation-induced injury to the hippocampi could play an important role in this cognitiv

98 s, and subcortical regions such as bilateral hippocampi depended predominantly on the perceptual diff

99 Inhibition of the MAPK/ERK cascade in dorsal hippocampi did not impair acquisition, but blocked the f

100 nome miRNA sequencing in surgically resected hippocampi did not reveal obvious differences in express

101 Notably, the two hippocampi diverged in their responses to remoteness.

102 re is no T2 relaxation time abnormality, the hippocampi do not meet the criteria for MTS.

103 zure reduction greater than 98% in bilateral hippocampi during stimulation and greater than 50% seizu

104 e changes were attenuated in parkin-injected hippocampi, even in the presence of Tau pathology, sugge

105 n in an interface chamber were compared with hippocampi fixed by perfusion or by immersion of the who

106 Using surgically acquired hippocampi from 129 TLE patients, we identify a gene-reg

107 s homolog NMNAT1, but not NMNAT3, in rTg4510 hippocampi from 6 weeks of age using recombinant adeno-a

108 62 were observed in cytoplasmic fractions of hippocampi from chronically stressed rats, and immunoflu

109 Hippocampi from control- and KD-fed rats were also compa

110 Hippocampi from hippocampal sclerosis patients (n = 28)

111 Using RNA-sequencing data from 100 hippocampi from mice with epilepsy (pilocarpine-temporal

112 Hippocampi from MMP9 null mice showed higher levels of l

113 interneuronal synapse formation, we studied hippocampi from mutant mice that completely lack the z+

114 Analysis of hippocampi from patients with intractable epilepsy revea

115 this pathway to experimental seizures and in hippocampi from patients with intractable temporal lobe

116 NA profiles from myelinated and demyelinated hippocampi from postmortem MS brains and performed valid

117 cular changes in myelinated and demyelinated hippocampi from postmortem MS brains.

118 gical changes in myelinated and demyelinated hippocampi from postmortem MS brains.

119 Unexpectedly, in hippocampi from subsets of mice, abnormally low levels o

120 We measured changes in individual hippocampi from the mast cell mutant mouse strain, C57BL

121 c human epilepsy were validated by examining hippocampi from the pilocarpine model of chronic TLE.

122 itu hybridization and immunocytochemistry in hippocampi from three groups: TLE with hippocampal scler

123 activities of various apoptotic pathways in hippocampi from type 1 diabetic BB/Wor rats (hyperglycem

124 Golgi analysis of hippocampi from weanling rats confirmed that development

125 ding field and whole-cell patch recording in hippocampi from wild-type and transgenic mice, we show t

126 foundly upregulated KCNQ2/3 transcription in hippocampi from wild-type, but not AKAP150(-/-), mice af

127 Hippocampi from WNV-NS5-E218A-recovered mice with poor s

128 ynapses or mtHSP70 was seen in myelinated MS hippocampi, further pointing toward a link between the c

129 AT hippocampi had lower levels of phosphorylated cAMP respo

130 Demyelinated hippocampi had minimal neuronal loss but significant dec

131 ing, intact planning in animals with damaged hippocampi has been repeatedly observed.

132 Injury was markedly attenuated in hippocampi having ipsilateral communicating arteries >50

133 In autopsy and most NHS hippocampi, HCN1 mRNA expression was substantial in pyra

134 he diagnostic potential of GSH estimation in hippocampi (HP) and frontal cortices (FC) as a biomarker

135 d in the head and body of the right and left hippocampi in 123 subjects: 62 patients with Alzheimer d

136 crostructural integrity was impaired in both hippocampi in patients.

137 all samples, we found significantly smaller hippocampi in subjects with current PTSD compared with t

138 led activation of both TrkB and PLCgamma1 in hippocampi in the pilocarpine and kindling models in wil

139 uma exposure, we found evidence that smaller hippocampi indeed constitute a risk factor for the devel

140 t to left hippocampal volume ratios, smaller hippocampi initially, and reduced hippocampal growth.

141 tissue lactic acid and FFA were made in the hippocampi, ipsilateral cortex, contralateral cortex, an

142 erlying disease process in the contralateral hippocampi is different from MTS.

143 PLCgamma1 activation was decreased in hippocampi isolated from trkB(PLC/PLC) compared with con

144 matched cannabis users had smaller bilateral hippocampi (left, p=0.002; right, p=0.001) and left amyg

145 increased in myelinated and demyelinated MS hippocampi, mainly in the CA3/2 and CA1 subfields, which

146 rimary neuron-glia co-cultures from P0 mouse hippocampi, male neurons have more complex dendritic arb

147 Several regions, including the hippocampi, medial and lateral parietal cortex, exhibite

148 s (HS; n = 16), non-HS (n = 10), and autopsy hippocampi (n = 9) were studied for NMDAR1 (NR1) and NR2

149 Compared with autopsy hippocampi, non-HS and HS patients showed increased NR2A

150 lmodulin-dependent protein kinase II mRNA in hippocampi obtained during surgical resections for intra

151 n Illumina sequencing reads derived from the hippocampi of 10 colonial tuco-tucos housed in captivity

152 unit neuronal recordings were taken from the hippocampi of 10 male, New Zealand white rabbits during

153 Abeta and plaque loads were observed in the hippocampi of 11-month old Tg2576 mice born to mothers f

154 c imaging measurements were performed in the hippocampi of 14 control subjects and nine patients with

155 Whole human hippocampi of 14 subjects with bipolar disorder and 18 h

156 dentate granule cells acutely isolated from hippocampi of 28- to 35-day-old rats suggests that recep

157 Granule cells were acutely isolated from hippocampi of 7- to 14- and 45- to 52-day-old rats, and

158 Sections from hippocampi of AD brains, brains with Alzheimer neurofibr

159 that UCH-L1 mRNA levels are decreased in the hippocampi of AD brains.

160 ADAM10/AP2 association was increased in the hippocampi of AD patients compared with healthy controls

161 y of these deficits were also present in the hippocampi of adult Df(16)A(+/-) and Zdhhc8-deficient mi

162 In hippocampi of aged (21-28 months) mice, LTP was relayed

163 lular signal-regulated kinase (ERK2) MAPK in hippocampi of aged animals.

164 Findings were compared to hippocampi of Alzheimer disease (AD) and non-neurologica

165 Conversely, microglia from the hippocampi of animals that had exercised were able to ac

166 l, FGF2 gene is delivered bilaterally to the hippocampi of APP+presenilin-1 bigenic mice via an adeno

167 sited amyloid in the vessels of cortices and hippocampi of APP/PS1DeltaE9/apoA-I(KO) mice, measured b

168 table metabolites can be quantified from the hippocampi of cognitively impaired individuals, and that

169 troscopy (MRS) studies of the left and right hippocampi of consenting Gulf War veterans (N=15; 10 wit

170 eurons and interneurons in the neocortex and hippocampi of Dravet adult post-mortem cases.

171 f the cannabinoid type 1 (CB(1)) receptor in hippocampi of epileptic rats following pilocarpine-induc

172 pared with NW piglets at 12 days of age, the hippocampi of EW piglets showed decreased gene expressio

173 In accordance with these conclusions, hippocampi of FABP5-null mice display excess accumulatio

174 Recordings from the hippocampi of freely-moving epileptic rats revealed high

175 ques to record from CA1 pyramidal neurons of hippocampi of GEPR-9s.

176 observed elevated Ephexin5 expression in the hippocampi of hAPP mice.

177 , synaptic pathology was not detected in the hippocampi of HMW oligomer-injected mice.

178 hexin5 expression was highly elevated in the hippocampi of human AD patients, indicating its potentia

179 latency-associated transcripts (LATs) in the hippocampi of immunocompromised mice after intracranial

180 ether HCN isoform expression was modified in hippocampi of individuals with TLE.

181 he differential expression of SNAP-25 in the hippocampi of infected neonates indicates a variable deg

182 rminal beta-amyloid fragment into the dorsal hippocampi of intact mice.

183 et (KD) increases UCP levels and activity in hippocampi of juvenile mice.

184 ed mPT in acutely prepared mitochondria from hippocampi of Kcna1-null animals.

185 Hippocampi of ketamine-treated mice were analysed by met

186 Similarly, GABA concentrations in the hippocampi of mice with a DG knockout of the GRIN1 gene

187 021 prevented PSD95-positive synapse loss in hippocampi of mice with EAE but did not affect developme

188 1H MRS described a metabolite profile in the hippocampi of MRI-negative TLE patients that was differe

189 (MRS), we examined metabolic changes in the hippocampi of MS patients, compared the findings to perf

190 Strikingly, in hippocampi of patients at early stages of late-onset Alz

191 ) cannabinoid receptor protein levels in the hippocampi of patients with Alzheimer's disease remain u

192 e found significant volume reductions in the hippocampi of patients with schizophrenia compared with

193 found in both ipsilateral and contralateral hippocampi of patients.

194 n agreement, beta1AR levels are decreased in hippocampi of PIST-deficient mice.

195 Previously, we showed that the hippocampi of prenatally [embryonic days (E) 11-17] chol

196 how that promoting translational recovery in hippocampi of prion-infected mice is neuroprotective.

197 The posterior hippocampi of taxi drivers were significantly larger rel

198 ired IRS-1 signaling was also present in the hippocampi of Tg mice with a brain condition that models

199 ignificant increase of new mature neurons in hippocampi of TgCRND8 compared with WT mice, suggesting

200 On postnatal days 17 and 27, hippocampi of the ChD animals had the highest AChE and C

201 It is not known whether the hippocampi of the female brain are more vulnerable to al

202 er (GM) atrophy in the temporal lobe and the hippocampi of the NC+ group.

203 of the veterans with syndrome 2 and to both hippocampi of the veterans with syndrome 3.

204 ed in the microsomal fractions prepared from hippocampi of trained rats.

205 presence of dystrophic neurites in both the hippocampi of transgenic mice overexpressing amyloid pre

206 ffect in vivo, lactate was perfused into the hippocampi of unanesthetized rats while recording the fi

207 ndritic spines of CA1 pyramidal cells in the hippocampi of water maze-trained rats vs. controls.

208 Proteomic analysis comparing the hippocampi of Zc3h14+/+ and Zc3h14Deltaex13/Deltaex13 mi

209 Among the proteins increased in the hippocampi of Zc3h14Deltaex13/Deltaex13 mice compared to

210 Connectivity of both hippocampi predicted memory performance in patients.

211 We now report that, in intact hippocampi prepared from neonatal rats and transgenic mi

212 romoter heat shock elements by HSF1 in APP23 hippocampi, primary murine hippocampal neurons, and SH-S

213 In vitro recordings in mice hippocampi produced similar speeds (0.10 +/- 0.03 m/s) a

214 n AQP4 levels in MTLE compared with non-MTLE hippocampi, quantitative ImmunoGold electron microscopy

215 Therefore, the young and aged hippocampi react differently to estrogen replacement, wi

216 tive assessments of mRNA levels in epileptic hippocampi relative to autopsy controls were made by usi

217 ongation of T2 relaxation time identified in hippocampi remote from the seizure focus in all patient

218 of having 50% volume loss bilaterally in his hippocampi, retrieval in Jon was associated with increas

219 Magnetic resonance spectra measured in the hippocampi revealed a significantly lower glutamate conc

220 [3H]L-655,708 binding sites in rat and human hippocampi revealed a strong correlation with the affini

221 ed distant areas, including the neocortices, hippocampi, rostral migratory stream, and olfactory bulb

222 Contralateral hippocampi show different HDM-LD changes, suggesting tha

223 Furthermore, non-HS hippocampi showed increased NR1 and NR2B mRNA levels per

224 cant volume loss (P < 0.0001), contralateral hippocampi showed no significant volume loss.

225 rying with brain parenchymal volume, the MTS hippocampi showed significant volume loss (P < 0.0001),

226 to autopsies both sclerosis and mass lesion hippocampi showed that, in the stratum granulosum, the g

227 l of TLE using 100 epileptic and 100 control hippocampi shows the proconvulsive module is preserved a

228 cutely dissociated from slices prepared from hippocampi surgically removed for the treatment of tempo

229 APOE4 carriers, GM volume loss affected the hippocampi, temporal and parietal lobes, right caudate n

230 cannabis users display smaller amygdalae and hippocampi than controls, and genetic variation accounts

231 sequence, more new neurons remained in their hippocampi than in sex-matched controls.

232 unexposed members-had significantly smaller hippocampi than non-PTSD pairs.

233 The improvers had significantly larger hippocampi than those that declined (P = 0.02) and the s

234 ent of prolongation of T2 relaxation time in hippocampi that are not the primary epileptogenic focus,

235 epilepsy is associated with abnormalities in hippocampi that are not the primary seizure focus.

236 (right and left neocortices, right and left hippocampi, the cerebella, and brainstems) of 21-day-old

237 In their hippocampi, the concentration of GABA was significantly

238 In the contralateral hippocampi, the inferior surface of the hippocampal body

239 solute concentrations of metabolites in both hippocampi, the sites of early Alzheimer's disease, in p

240 ation of a white matter tract connecting the hippocampi, the ventral hippocampal commissure (VHC), wi

241 r piriform cortex and the dorsal and ventral hippocampi underwent MS: electrical stimulation of the l

242 l gray matter, white matter, ventricles, and hippocampi was performed by using software.

243 The mean difference between left and right hippocampi was smallest at fast FLAIR imaging.

244 In mouse hippocampi, we detected relatively low levels of alpha,

245 lobe epilepsy model) and 100 healthy control hippocampi, we identified 256 RNA sites (overlapping wit

246 d with T2-lesion volumes, and right and left hippocampi were affected equally.

247 e imaging (MRI) studies of the amygdalas and hippocampi were conducted in 50 non-epileptic controls (

248 In contrast to AD, MS hippocampi were consistently negative for the terminal c

249 Hippocampi were evaluated as a reference structure.

250 brains were frozen in situ, and cortices and hippocampi were excised at 0 degrees C.

251 Frozen right hippocampi were fixed, sectioned (50 mum), immunostained

252 Hippocampi were obtained from control and chronic DA sea

253 Following retention testing, hippocampi were removed and protein extracted from cytos

254 After the challenge, the hippocampi were removed to assay phosphatase 2A (PP2A) a

255 We found that the hippocampi were significantly active during the retrieva

256 Human hippocampi were stained with a specific polyclonal antib

257 ippocampi with HS, 6 with EFS, and 6 control hippocampi were studied.

258 tal and temporal lobe regions (including the hippocampi) were associated with the decline in PIQ.

259 s callosum, anterior commissure, and fimbria hippocampi, were investigated for structural and functio

260 as required to saturate LTD in primed mutant hippocampi, whereas multiple low-frequency stimuli were

261 articularly in the left hemisphere; (2) that hippocampi will be smaller in multiplex relatives as com

262 will be positively correlated; and (4) that hippocampi will be smaller in patients with schizophreni

263 ression of inhibition when superfusing mouse hippocampi with amyloid-beta.

264 g early posthatching development had smaller hippocampi with fewer neurons and performed worse in a c

265 Fifty-three hippocampi with HS, 6 with EFS, and 6 control hippocampi

266 The mean metabolite content of hippocampi with less than 30% of neurons remaining was t

267 ure of rat hippocampal neurons and the mouse hippocampi with morphine or fentanyl for 3 days, seven m

268 ippocampal sclerosis (HS; n = 17), epileptic hippocampi without HS, or non-HS (NHS; n = 10), and auto