ライフサイエンスコーパス: histamine

1 similar voltammograms, such as adenosine and histamine.

2 ase, which is, at least in part, mediated by histamine.

3 es were C-fibres, and were also sensitive to histamine.

4 eers, and they also release higher levels of histamine.

5 labeling for CD63, CD203c, and intracellular histamine.

6 mber of scratch bouts elicited by SLIGRL and histamine.

7 was triggered with Russell's viper venom and histamine.

8 tronger and more rapid cytotoxic effect than histamine.

9 uch of this response appears to be driven by histamine.

10 omolyn sodium for 1 week to block MC-derived histamine.

11 phenylacetic acid, serotonin, adenosine, and histamine.

12 s responded to fungal antigens by release of histamine.

13 S spectra with characteristic Raman bands of histamine.

14 cating a potential antitumorigenic effect of histamine.

15 greater interaction with eNOS in response to histamine.

16 monstrated appearance of CD63 and release of histamine.

17 gastrointestinal bleeding, and prior use of histamine-2 receptor antagonist therapy (hazard ratio, 1

18 d MI risk associated with PPIs compared with histamine-2 receptor antagonists (H2RAs) in privately in

19 ND & AIMS: Proton pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2RAs) suppress gastri

20 Proton pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2RAs) suppress gastri

21 ant association was found for current use of histamine-2-receptor antagonists (adjusted OR, 1.82; 95%

22 f antacid therapy (proton pump inhibitors or histamine-2-receptor antagonists) for patients with IPF,

23 ules expressed on TH2 lymphocytes, PDE4, the histamine 4 receptor, and Janus kinase) or specifically

24 Half-maximal rates for histamine (4 h) and IL-4 (5 h) secretion were slower tha

25 on of compound 48/80, an MC secretagogue, or histamine, a Weibel-Palade body secretagogue from MCs, p

26 ceptor alpha chain (IL-4Ralpha) signaling in histamine-abelson murine leukemia viral oncogene homolog

27 ty of the developed sensor was manifested by histamine analysis in canned tuna fish samples, where th

28 hage provocation and skin prick testing with histamine and assessed for differences in the quality, i

29 To characterize photic entrainment further, histamine and corazonin were injected.

30 nt new knowledge of neutrophils as source of histamine and ECP in the progression of the periodontiti

31 However, neutrophil-derived histamine and Eosinophil Cationin Protein production and

32 lity to produce several mediators, including histamine and granule proteases, but studies have increa

33 s associated with significantly lower plasma histamine and IgE levels, increased IFN-gamma/IL-4 and I

34 64 mast cells responded to cold by releasing histamine and IL-4, and this medium stimulated UCP1 expr

35 cotreated with IL-3, with minimal effects on histamine and IL-4.

36 via HRH1; this effect could be reproduced by histamine and imidazole acetaldehyde.

37 Histamine and leptin levels were measured by enzyme immu

38 the release of bioactive mediators, such as histamine and leukotrienes, which initiate allergic reac

39 ely, basophils (but not mast cells) released histamine and marked levels of IL-4/IL-13 (10-fold) when

40 Still, histamine and other vasoactive amines remained at low le

41 the release of preformed mediators including histamine and proteases and subsequent de novo formation

42 , and wheezing and had to be treated by anti-histamine and steroid administration, as well as inhalat

43 Histamine and Th17 cytokines induced the osteoclast diff

44 on and osteoclast differentiation induced by histamine and Th17 cytokines.

45 We sought to investigate the role of histamine and TH2 cells in driving epithelial barrier dy

46 amines, via real-time cell analysis, whether histamine and tyramine show synergistic toxicity towards

47 higher amounts, particularly of cadaverine, histamine and tyramine, in low-salt products.

48 A-N), total volatile basis nitrogen (TVB-N), histamine, and hypoxanthine, which were performed at sch

49 urotransmitters such as serotonin, dopamine, histamine, and noradrenaline have important and varied p

50 g two mouse models of ear skin inflammation (histamine- and IgE-mediated passive cutaneous anaphylaxi

51 ABSTRACT: Chloroquine (CQ) and histamine are pruritogens commonly used to study itch in

52 Tyramine and histamine are the biogenic amines (BA) most commonly fou

53 gious itch behavior using mice injected with histamine as the demonstrators.

54 Histamine as well as nasal secretions of AR but not idio

55 The results also show that histamine, at concentrations below the legal limit, incr

56 The influence of histamine blockade post-exercise was notable for 795 gen

57 x, pancreatic insufficiency, meconium ileus, histamine blocker use, and respiratory Pseudomonas aerug

58 small-molecule nucleophiles methylamine and histamine, but when Spy0125 was mechanically unfolded an

59 Culture of cells in 5% O2 (>5 d) decreased histamine- but not shear stress-stimulated endothelial (

60 1R, H2R, H3R, and H4R) respond to the ligand histamine by activating three canonical heterotrimeric G

61 clinical symptoms are due to the release of histamine by cutaneous mast cells, the underlying pathop

62 Human diamine oxidase (hDAO), required for histamine catabolism, has multiple N-glycosylation sites

63 Histamine, chloroquine, and capsaicin intradermally elic

64 Among Fos-positive neurons elicited by id histamine, chloroquine, and capsaicin, respectively, 3.7

65 were Fos positive following id injection of histamine, chloroquine, and capsaicin, respectively.

66 received intradermal (id) microinjection of histamine, chloroquine, capsaicin, or vehicle into the l

67 , 8%, and 22% were Fos-positive following id histamine, chloroquine, or capsaicin.

68 s prior to injection of various pruritogens (histamine, chloroquine, or endothelin-1) and recorded sp

69 ching behavior in response to histaminergic (histamine, compound 48/80, endothelin-1), not non-histam

70 In histamine concentration range 0-200mgkg(-1), significant

71 Both the functional response and histamine content recovered within this time frame.

72 SERS spectra of fish samples with different histamine content.

73 taining 7 ng of Phl p 5 major allergen) or a histamine control.

74 Thus, histamine couples lineage-specific physiological demands

75 We evaluated if inhibition of MC-derived histamine decreases biliary proliferation and fibrosis.

76 Inhibition of MC-derived histamine decreases fibrosis, and regulation of MC media

77 Nevertheless, histamine deficiency leads to behavioral alterations pro

78 ol or baclofen are antipruritic against both histamine-dependent and -independent pruritogens, but th

79 ell, Chen et al. (2017) delineate an elegant histamine-dependent feedback mechanism through which mye

80 elopment of a rapid and sensitive method for histamine determination in fish based on Surface Enhance

81 elopment of rapid and inexpensive method for histamine determination in fish.

82 Histamine determination is relevant for fish safety, qua

83 . reuteri mutant that was unable to generate histamine did not suppress carcinogenesis, indicating a

84 ng (SIM) has been used to determine the anti-histamine diphenhydramine (DPH), anti-anxiety diazepam (

85 Independently of actin remodeling, histamine down-regulates IL12p70 and CXCL10 production i

86 Furthermore, histamine enhanced the signal transducer and activator o

87 e sensor shows excellent selectivity towards histamine even in the presence of many of the common int

88 We show that cAMP mediates inhibition of histamine-evoked Ca(2+) signals by PGE2 Exchange protein

89 We conclude that inhibition of histamine-evoked Ca(2+) signals by PGE2 occurs through "

90 rom PGE2 receptors, through cAMP and PKA, to histamine-evoked Ca(2+) signals.

91 was unaffected by PGE2, but PGE2 attenuated histamine-evoked IP3 accumulation.

92 ominant-negative Rab35 mutant both inhibited histamine-evoked secretion of the WPB cargos von Willebr

93 Munc13-4 promotes histamine-evoked WPB exocytosis and is present on WPBs,

94 AP2 target, the small GTPase Arf6, supported histamine-evoked WPB exocytosis, as shown by knockdown a

95 Pase-activating proteins (RabGAPs) inhibited histamine-evoked, Ca(2+)-dependent WPB exocytosis, presu

96 These data suggest that histamine exerts protective effects by modulating cardia

97 Presented protocol for histamine extraction and purification followed by SERS a

98 to revert into quiescence in the absence of histamine feedback, leading to their depletion, while an

99 The broad histamine footprint on the human exercise transcriptome

100 In vitro studies showed IL-24 to release histamine from human mast cells sensitized with purified

101 e histamine while, in a reciprocal way, this histamine (from ECL cells), stimulates the G-cells to pr

102 Gastrin, from G-cells, and histamine, from enterochromaffin-like (ECL) cells, are t

103 Histamine-generating L. reuteri also decreased the relat

104 is followed by a post-exercise activation of histamine H1 and H2 receptors localized to the previousl

105 effects at the cholecystokinin, dopamine D2, histamine H1 and H2, melanocortin, melatonin, muscarinic

106 eridine) with high ligand efficiency for the histamine H1 receptor (H1R) was used to design derivativ

107 One-week treatment with a histamine H1 receptor antagonist (H1RA) ameliorated the

108 Ca(2+) concentration evoked by activation of histamine H1 receptors.

109 Identification of this histamine H1R/H4R-DC-CD4(+) T-cell axis provides new ins

110 sis and apoptosis in pre-clinical models and histamine H2 receptor antagonist (H2RA) use may improve

111 ew users of PPI (n=173,321) and new users of histamine H2-receptor antagonists (H2 blockers; n=20,270

112 Ciproxifan is a well-investigated histamine H3 receptor (H3R) inverse agonist/antagonist,

113 es and monoamine oxidases A/B as well as the histamine H3 receptor (H3R) were obtained by optimizatio

114 The human histamine H3 receptor (hH3R) is subject to extensive gen

115 Histamine H4 receptor (H4R) has immune-modulatory and ch

116 The histamine H4 receptor (H4R) was brought into focus as a

117 stamine receptors, in particular that of the histamine H4 receptor (H4R), in modulating human basophi

118 a potent and selective agonist of the human histamine H4 receptor (hH4R).

119 Activated mast cells (MCs) release histamine (HA) and MCs infiltrate the liver following bi

120 Histamine (HA) is a biogenic amine that can accumulate t

121 e such circuit is the posterior hypothalamic histamine (HA) system, implicated in supporting wakefuln

122 We used confocal microscopy to map histamine (HA), FMRF-amide, and gamma-aminobutyric acid

123 ypothalamus (Hcrt), tuberomammillary nuclei (histamine; HA), basal forebrain (acetylcholine; ACh), do

124 Histamine has pleiotropic pathophysiological effects, bu

125 eloped for the simultaneous determination of histamine (His) and putrescine (Put).

126 The HDC/histamine/histamine receptor axis, ductular reaction, an

127 c steatohepatitis patients had increased HDC/histamine/histamine receptor signaling.

128 umors from athymic mice treated with saline, histamine, histidine decarboxylase inhibitor, or cromoly

129 Histamine, IL-17, and IL-22 stimulated RANKL expression

130 blood (PB) CD14+ monocytes were treated with histamine, IL-17, IL-21 and IL-22, and a H4R antagonist

131 of CD63 and CD203c as well as the release of histamine, IL-4 and IL-13.

132 were cultured and stimulated with IL-1beta, histamine, IL-4, TNF-alpha, or UV-B irradiation, and cha

133 Histamine, IL-6, IL-17, IL-21 and IL-22 induced the expr

134 t to locusts, colocalization of SIFamide and histamine immunoreactivity occurred not in group 1, but

135 optimized and validated for the analysis of histamine in fish.

136 rified the roles of HDC-expressing cells and histamine in heart failure post-MI using HDC-EGFP transg

137 ast, copper status did not impact storage of histamine in mast cells, nor did alterations in copper l

138 e to produce Eosinophil Cationic protein and histamine in response to Lipopolysaccharides.

139 The concentration of histamine in synovial fluid (SF) and sera in patients wi

140 ting a significant role of the cometabolite, histamine, in suppression of chronic intestinal inflamma

141 nfiltrate following liver injury and release histamine, increasing biliary proliferation.

142 lates mast cell degranulation and release of histamine independently of TRPM7 channel function.

143 ferent, while tyramine caused cell necrosis, histamine induced apoptosis.

144 IL-4- and histamine-induced ABL1 activation in human VE cells and

145 on to evaluate mechanisms underlying CQ- and histamine-induced action potential discharge in itch ner

146 n was used to evaluate chloroquine (CQ)- and histamine-induced activation of afferent nerves in the d

147 uctance on TV membranes that is required for histamine-induced Ca(2+) release from TV stores.

148 more, the calcium oscillation attenuates the histamine-induced cytoskeletal reorganization and cell c

149 We also demonstrate that histamine-induced cytoskeleton organization is at least

150 tence of cowhage-induced itch and diminished histamine-induced flare in nonlesional skin may support

151 whage-induced itch for at least 30 min and a histamine-induced flare of less than 2 cm in diameter we

152 IL-4 exacerbation of histamine-induced hypovolemic shock in mice was dependen

153 hils are recruited during the early phase of histamine-induced inflammation involves the sphingosine

154 amic activity in a NaV1.7-dependent model of histamine-induced pruritus (itch) and additionally in a

155 model where it exhibited robust reversal of histamine-induced scratching bouts in mice.

156 IL-4 amplifies IgE- and histamine-induced VE dysfunction, fluid extravasation, a

157 Histamine induces biliary proliferation and fibrosis and

158 A concentration of histamine inducing a 20% decline in FEV1 (PC20 ) </=16 m

159 In vitro assays further confirmed that histamine inhibited heart fibroblast proliferation.

160 Histamine injections resulted in light-like phase delays

161 -) mice, the beneficial effects of exogenous histamine injections were abrogated in STAT6(-/-) mice.

162 Histamine intolerance is thought to trigger manifold cli

163 the results between patients with suspected histamine intolerance, food allergy and healthy controls

164 rum activities in 33 patients with suspected histamine intolerance, in 21 patients with proven food a

165 the study was to investigate the presence of histamine intolerance, to therefore establish day profil

166 tamine parameters in patients with suspected histamine intolerance.

167 mptoms and strongly suggests the presence of histamine intolerance.

168 Twenty-four percent (8 of 33) suspected histamine-intolerant patients showed elevated histamine

169 compared to the other subgroup of suspected histamine-intolerants.

170 histamine levels in a subgroup of suspected histamine-intolerants.

171 Histamine is a key immunoregulatory mediator and can dam

172 Histamine is a primordial signalling molecule, capable o

173 Although histamine is normally associated with pathological condi

174 A chemical complex of gastrin and histamine is postulated as is also the asymmetric cell d

175 The sensitization of TRPV1 by histamine, its metabolite imidazole acetaldehyde, and su

176 HDC/histamine/leptin signaling may be important in managing

177 Plasma levels of histamine, leukotriene B4, prostaglandin E2, prostagland

178 Histamine level was higher in controls and the 4-aminopy

179 ystematically assessed daily fluctuations of histamine levels and DAO activities in symptomatic patie

180 ance, to therefore establish day profiles of histamine levels and DAO activities, and to compare the

181 The remaining 25 patients presented normal histamine levels and DAO activities, but an increased pr

182 This protection correlated with lower plasma histamine levels and with histological evidence of defec

183 istamine-intolerant patients showed elevated histamine levels during the day.

184 ased DAO activities correlated with elevated histamine levels in a subgroup of suspected histamine-in

185 nt degranulation of mast cells and increased histamine levels in serum.

186 arkedly increased in the injured hearts, and histamine levels were up-regulated in the circulation po

187 mptom scores, core body temperatures, plasma histamine levels, basophil numbers, antigen-specific IgE

188 wer clinical scores, specifically of IgE and histamine levels, compared to offspring from mothers fed

189 ckdown increased histamine neuron number and histamine levels, whereas increased dopaminergic signali

190 temperature, and a lower increase of plasma histamine levels.

191 in nonallergic subjects and allergen-induced histamine liberation from basophils in allergic donors.

192 nuclear and binuclear complexes at parity of histamine ligand is striking.

193 nate, with the distribution dependent on the histamine ligand structure and oxygenation conditions.

194 -containing products from the oxygenation of histamine-ligated copper(I) complexes is demonstrated he

195 Histamine may be an important molecular transducer contr

196 luated as ligands of 34 serotonin, dopamine, histamine, melatonin, acetylcholine, and adrenergic rece

197 Analysis of their results shows that the histamine model is limited by inadequate frequency and d

198 o normal mice observing the well-established histamine model of acute itch in demonstrator mice.

199 we demonstrated that th2 knockdown increased histamine neuron number and histamine levels, whereas in

200 When histamine neurons were made selectively zolpidem-sensiti

201 whose pruritic activity, as well as that of histamine, occurs through the activation of this ion cha

202 t fibroblasts, and the inhibitive effects of histamine on fibroblast proliferation could be blocked b

203 In this study we investigated the effects of histamine on innate immune reaction during the response

204 d in physiologic (5%) O2 and stimulated with histamine or shear stress.

205 erved on basophils after pre-incubation with histamine or the specific H4R agonist ST-1006 (P < 0.01)

206 y gamma-aminobutyric acid (GABA), glutamate, histamine, or changes in pH, and three are putative ACh-

207 sympathetic functions and contain dopamine, histamine, orexin, melanin-concentrating hormone, oxytoc

208 etween subjective complaints and serological histamine parameters in patients with suspected histamin

209 We determined day profiles of histamine plasma levels and DAO serum activities in 33 p

210 e), including receptors for chemokines, PGs, histamine, platelet activating factor, and anaphylatoxin

211 Strikingly, basophil contribution and histamine predominance in mice with IgG1- and IgG2b-indu

212 nt study we investigated if mice lacking the histamine producing enzyme HDC share the morphological a

213 Depleting histamine-producing cells enforces cell cycle entry, ind

214 This histamine-producing probiotic decreased the number and s

215 MATERIALS AND We analyzed ECP and histamine production in response to LPS by ELISA.

216 resulted in luminal hdc gene expression and histamine production in the intestines of Hdc(-/-) mice.

217 d pathway, membrane-spanning 4A gene family, histamine production pathway, and pro-inflammatory cytok

218 oxylase (HDC) is the main enzyme involved in histamine production.

219 Based on the results, histamine, putrescine and cadaverine were selected as in

220 Histidine decarboxylase (HDC) and histamine receptor (HR) expression were detected by qPCR

221 ed by platelet-activating factor receptor or histamine receptor 1 blockade.

222 proinflammatory responses via activation of histamine receptor 2 (H2 R).

223 Herein, we profiled the pharmacology of histamine receptor agonists at the two most abundant hH3

224 Consistently, the histamine receptor antagonist chlorpheniramine potently

225 H1 and H2 histamine receptor antagonists, although developed many

226 rome (IBS) and evaluated if an antagonist of histamine receptor H1 (HRH1) could reduce symptoms of pa

227 tanding of the different aspects involved in histamine receptor pharmacology, which in turn will cont

228 The four histamine receptor subtypes (H1R, H2R, H3R, and H4R) res

229 Pretreatment with histamine receptor-1 antagonist, azelastine prevented th

230 rmeability, gene and protein expression, and histamine receptor-mediated signaling.

231 Crosstalk between histamine receptors and other membrane or nuclear recept

232 Signaling through histamine receptors on dendritic cells (DCs) may be invo

233 Likewise, biased signaling at histamine receptors seems to be a pharmacological featur

234 the pharmacology and molecular mechanisms of histamine receptors that should be contemplated for opti

235 The mRNA expression of the histamine receptors was measured by real-time PCR.

236 ch physically interacts with macrophages via histamine receptors, exhibits substantially diminished b

237 this study, we investigated the role of the histamine receptors, in particular that of the histamine

238 Furthermore, a synthetic analogue of histamine reduces type I interferon production in a mous

239 measurement of basophil CD63 expression and histamine release and casein-specific CD4(+) regulatory

240 These models differentially relied on histamine release and the contribution of mast cells, ba

241 at comparing basophil activation test (BAT), histamine release assay (HR), and passive sensitization

242 elease assay (HR), and passive sensitization histamine release assay (passive HR) in the diagnosis of

243 1 up to 70% and suppressed allergen-mediated histamine release by 10-fold.

244 f mast cell degranulation potently inhibited histamine release by mast cells and inhibited adipocyte

245 ckers were found to inhibit anti-IgE-induced histamine release from basophils in nonallergic subjects

246 Desensitization of IgE-mediated histamine release from human lung mast cells was explore

247 in vitro method to analyze the properties of histamine release from LAD2 cells and characterize the s

248 loped a sensitive and rapid method to detect histamine release from LAD2 cells using liquid chromatog

249 and CNX-774) on IgE-dependent activation and histamine release in blood basophils obtained from aller

250 onfirmed by demonstrating that IgE-dependent histamine release in ex vivo blood basophils is largely

251 drugs are potent inhibitors of IgE-dependent histamine release in human basophils.

252 wed a >/=10% concentration-dependent maximum histamine release in response to the anti-human IgE stim

253 However, IgE-dependent histamine release increased in washed cell preparations

254 multaneous phenotyping and quantification of histamine release might add to our knowledge about the b

255 Constitutive HLMC histamine release was increased in HLMC-HASMC coculture

256 effect of rfhSP-D on basophil activation and histamine release was measured by flow cytometry.

257 On the other hand, concentration-dependent histamine release was not seen in the"NON"responders, su

258 were incubated with participants' serum and histamine release was quantified as HR.

259 Drug effects on allergen-induced histamine release were dose dependent, with IC50 values

260 Allergen-induced basophil responsiveness and histamine release were inhibited in the presence of rfhS

261 Constitutive and FcepsilonRI-dependent HLMC histamine release, HASMC contraction, and beta2-AR phosp

262 ) stimulation revealed strong suppression of histamine release, whereas removal of extracellular Mg(2

263 effect on CD63 and CD203c externalization or histamine release.

264 effects of zolpidem do not depend on reduced histamine release.

265 umvent potential soluble inhibitors, such as histamine released at sites of inflammation, and allow t

266 I, Ando et al. provide a causal link between histamine-releasing factor (HRF) interactions with IgE a

267 The CQ and histamine responses were not influenced by removal of TR

268 MCs, potentiated DVT in wild-type mice, and histamine restored thrombosis in MC-deficient animals.

269 r manifold clinical symptoms after ingesting histamine-rich food due to reduced activity of diamine o

270 decarboxylase short hairpin RNA to decrease histamine secretion and subsequently cocultured with cho

271 Histamine seems to act, via H2 receptor, on inflammatory

272 sponsible for actin remodeling, we show that histamine selectively modifies actin cytoskeleton organi

273 optimised conditions, they could be used for histamine sensing at a very low oxidation potential of +

274 Histamine serum secretion was measured by enzymatic immu

275 The synergistic cytotoxicity of tyramine and histamine should be taken into account when establishing

276 These associations suggest histamine signaling may be important in the pathogenesis

277 Histamine skin prick test responses were diminished in p

278 netic loss-of-function samples, we performed histamine skin prick tests, investigated the contributio

279 LXA4 inhibited histamine-stimulated increases in mucin secretion, [Ca(2

280 in intracellular [Ca(2+)] ([Ca(2+)]i) and on histamine-stimulated responses.

281 (TVs) toward apical membranes in response to histamine stimulation via cyclic AMP elevation.

282 fic monoclonal antibody TF2 (anti-CEA x anti-histamine-succinyl-glycine [HSG]) and the di-HSG-DOTA pe

283 ed cells in PB CD14+ monocytes cultured with histamine, Th17 cytokines and JNJ7777120.

284 idance (IA) memory, because rats depleted of histamine through lateral ventricle injections of alpha-

285 We investigated actin remodeling induced by histamine together with mDCs phenotype, cytokine product

286 and release Eosinophil Cationic Protein and histamine, two important inflammatory mediators previous

287 convenient reagent for the derivatization of histamine, tyramine, tryptamine and 2-phenylethylamine,

288 enabled sensitive and selective analysis of histamine using chronoamperometry without any interferen

289 Co-treatment with tyramine and histamine was associated with a stronger cytotoxic effec

290 SF and serum concentration of histamine was higher in RA, compared with osteoarthritis

291 was assessed by flow cytometry; HR-released histamine was quantified by a glass fiber-based fluorome

292 The response to CQ, but not histamine, was largely absent in mrgpr-cluster Delta(-/-

293 Tyramine and histamine were toxic for HT29 intestinal cell cultures a

294 anatomical proximity to MB-HSCs and produce histamine, which activates the H2 receptor on MB-HSCs to

295 three endogenous GPCR agonists: thrombin and histamine, which disrupt endothelial barrier function, a

296 MCs release histamine, which increases CCA progression and angiogene

297 mulates the ECL cells to produce and secrete histamine while, in a reciprocal way, this histamine (fr

298 Extraction of histamine with 0.4M perchloric acid and purification wit

299 s both immediate and late-phase responses to histamine with reduced extravasation of fluid, SK-1 acti

300 bility of detection and spectral analysis of histamine with SERS.

301 d stimulate cell division of ECL cells while histamine would stimulate that of G-cells.