ライフサイエンスコーパス: histaminergic

1 This histaminergic action appears to be mediated by the H(2)

2 Here we examined the modulatory effects of histaminergic agents on the release of amino acid neurot

3 eviewed the early signaling events following histaminergic and cholinergic activation, the identifica

4 recent findings regarding the involvement of histaminergic and gamma-aminobutyric acidergic mechanism

5 seful anti-pruritic therapeutic approach for histaminergic and non-histaminergic pruritus.

6 eptor, and this enables H3Rs to modulate the histaminergic and other neurotransmitter systems.

7 responses of spinothalamic tract neurons to histaminergic and, for the first time, nonhistaminergic

8 s noradrenergic, dopaminergic, serotonergic, histaminergic, and cholinergic neurons.

9 c, glutaminergic-GABAnergic, serotoninergic, histaminergic, and cholinergic systems.

10 MP-independent agonists such as cholinergic, histaminergic, and purinergic agonists that stimulate CF

11 re disease, inducible urticarias, idiopathic histaminergic angio-oedema without weals as a presentati

12 Histaminergic angioedema generally presents with urticar

13 millary nucleus, the source of the ascending histaminergic arousal system.

14 ion in the caudate-putamen and neocortex of "histaminergic" axonal projections from the TMN evoked to

15 Histaminergic axons broadly innervated every visual regi

16 The breadth of the distribution of histaminergic axons ensures that virtually all levels of

17 Mammalian retinas are innervated by histaminergic axons that originate from perikarya in the

18 Synaptic inhibition of histaminergic cells by GABA(A) receptors, however, was e

19 also known as Arntl or Mop3) clock gene from histaminergic cells removes this variation, producing hi

20 mine, compound 48/80, endothelin-1), not non-histaminergic (chloroquine) pruritogens in Trpv4 keratin

21 Ipsi- and contralateral histaminergic compound eyes are required for photic entr

22 These results indicate a significant histaminergic effect on LGN thalamocortical cells, with

23 that sedation by clozapine results from anti-histaminergic effects, we show that H1 histamine recepto

24 culate nucleus (PGN), which is innervated by histaminergic fibers from the tuberomammillary nucleus o

25 localized with HDC expression in a subset of histaminergic gastric mucosal cells.

26 acid secretion is mediated via activation of histaminergic, gastrinergic, and cholinergic pathways co

27 SIB-1553A showed modest affinity for histaminergic (H3) and serotonergic (5-HT1 and 5-HT2) re

28 dition SIB-1553A also exhibits affinities to histaminergic (H3) and serotonergic (5-HT1 and 5HT2) rec

29 Histaminergic (HA) neurons, found in the posterior hypot

30 ttenuated scratching behavior in response to histaminergic (histamine, compound 48/80, endothelin-1),

31 nd/or REM-off neurons may not be exclusively histaminergic in rats.

32 otassium (GIRK) channel inhibitor, abolishes histaminergic inhibition of MCH neurons.

33 neurons in other brain regions that receive histaminergic innervation and participate in the express

34 optic nucleus (VLPO), which receives a dense histaminergic innervation from the tuberomammillary nucl

35 millary nucleus (TMN) is the major source of histaminergic innervation of the mammalian brain and is

36 However, little is known about the histaminergic innervation of visual areas, or the histam

37 ggest that previously characterized GABA and histaminergic interneurons regulate olfactory input by s

38 s a pruriceptor-TRP in skin keratinocytes in histaminergic itch, a novel basic concept with translati

39 optimizing current therapies, repositioning histaminergic ligands for new therapeutic uses, or even

40 fy the retrieval of emotional memory; hence, histaminergic ligands might reduce dysfunctional aversiv

41 ance of adverse effects, or repositioning of histaminergic ligands.

42 ation of central alpha2-adrenergic or the H2 histaminergic-like receptors.

43 During vestibular compensation, histaminergic modulation of glycine and GABA release may

44 More potent histaminergic modulators may be required to elucidate th

45 We measured histaminergic neuron activity in the dorsomedial, ventro

46 nd female zebrafish brain and quantified the histaminergic neuron numbers.

47 In this study we visualized the entire histaminergic neuron population in adult male and female

48 Histaminergic neurones of the dorsomedial tuberomammilla

49 Previous studies have shown that histaminergic neurones of the tuberomammillary nucleus p

50 These results suggest that afferent histaminergic neurones show increased activity during pr

51 Many regions of the CNS are devoid of histaminergic neurons [11, 12], raising the possibility

52 Noradrenergic, serotonergic, and histaminergic neurons are continuously active during wak

53 Histaminergic neurons are exclusively located in the hyp

54 Histaminergic neurons are silent during sleep, and start

55 Yet most histaminergic neurons contain GABA.

56 At the cellular level, histaminergic neurons deficient in synaptic GABA(A) rece

57 Removing BMAL1 from histaminergic neurons does not, however, affect circadia

58 Thus wake-active histaminergic neurons generate a paracrine GABAergic sig

59 Surprisingly, GABAergic transmission onto histaminergic neurons had no effect in regulating the na

60 The new histaminergic neurons in aging zebrafish brain may arise

61 There were 40-45 histaminergic neurons in both male and female zebrafish

62 This surprising increase in histaminergic neurons in narcolepsy may be a compensator

63 low in patients with narcolepsy, we examined histaminergic neurons in patients with narcolepsy and in

64 also receives modulatory afferents from the histaminergic neurons in the hypothalamus which exhibit

65 OX2Rs eliminates orexin-evoked excitation of histaminergic neurons in the hypothalamus, which gate no

66 In primates the retina receives input from histaminergic neurons in the posterior hypothalamus that

67 rld primates, the retina receives input from histaminergic neurons in the posterior hypothalamus.

68 ibution of one putative local clock in mouse histaminergic neurons in the tuberomamillary nucleus to

69 Histaminergic neurons in the tuberomammilary nucleus (TM

70 Histaminergic neurons in the tuberomammillary nucleus (T

71 The activity of histaminergic neurons in the tuberomammillary nucleus (T

72 Further, we identified cotransmitters of histaminergic neurons in the ventrocaudal hypothalamus,

73 inhibition of the MCH system by wake-active histaminergic neurons may be responsible for silencing M

74 In both experiments, Fos expression in histaminergic neurons of all three TMN subnuclei was hig

75 Histaminergic neurons of the tuberomammillary nucleus (T

76 Histaminergic neurons of the tuberomammillary nucleus (T

77 These "REM-off" neurons were proposed to be histaminergic neurons of the tuberomammillary nucleus (T

78 One key target of the orexin system is the histaminergic neurons of the tuberomammillary nucleus (T

79 esicular GABA transporter (vgat, SLC32A1) in histaminergic neurons produced hyperactive mice with an

80 Dyn inputs to the VLPO, whereas hypothalamic histaminergic neurons provide EM1 inputs to the VLPO.

81 We examined how GABAergic inputs onto histaminergic neurons regulate this behavior.

82 Finally, we show that histaminergic neurons surround th2-expressing neurons in

83 These results demonstrate that histaminergic neurons throughout the TMN are wake-active

84 We identified histaminergic neurons using immunostaining for histidine

85 GABA(B) receptors on histaminergic neurons were dispensable for all behaviors

86 Increases in the number of histaminergic neurons were paralleled by matching increa

87 Similarly, because of the histaminergic neurons' key hub-like place in the arousal

88 ma is associated with a marked loss (41%) of histaminergic neurons.

89 larly interfered with the development of the histaminergic neurons.

90 ems and is particularly highly innervated by histaminergic neurons.

91 loss of consciousness by acting primarily at histaminergic neurons.

92 in the ventrocaudal hypothalamus around the histaminergic neurons.

93 mine receptor agonists reduced the number of histaminergic neurons.

94 and hypothalamic (tuberomammillary nucleus) histaminergic-neurons of gamma2I77 mice were made select

95 anxiety in the interpretation of the role of histaminergic neurotransmission in cognitive function.

96 data from model systems, point to a role for histaminergic neurotransmission in the mechanism and mod

97 These findings reveal the essential role of histaminergic neurotransmission to provide the brain wit

98 kers showed dense innervation of the VLPO by histaminergic, noradrenergic, and serotonergic fibers.

99 sm of action is not attributable to its anti-histaminergic or anti-muscarinic activity, but rather, s

100 of RMP-7 were shown to occur independent of histaminergic or hypotensive mechanisms.

101 In contrast, cholinergic, histaminergic, orexinergic, and serotonergic wake neuron

102 e required to elucidate the possible role of histaminergic pathways in human obesity.

103 hese results support the hypothesis that the histaminergic/peptidergic IV neurons are projection neur

104 how considerable projection specificity, the histaminergic projection exhibited great homogeneity.

105 Here, we present the actions of a histaminergic projection neuron on the rhythmically acti

106 y on TRPV4 for calcium influx in response to histaminergic pruritogens.

107 f mitogen-activated protein kinase, ERK, for histaminergic pruritogens.

108 erapeutic approach for histaminergic and non-histaminergic pruritus.

109 amine receptor agonist, SKF38393, and the H2 histaminergic receptor agonist, ranitidine, also hindere

110 ic receptor antagonist, SCH23390, and the H2 histaminergic receptor antagonist, ranitidine, also hind

111 pears to be mediated by the H(2) subclass of histaminergic receptors and inhibits the single-spike ac

112 ta-noradrenergic, D1/D5-dopaminergic, and H2-histaminergic receptors therein.

113 cyclase with forskolin or activation of H(2)-histaminergic receptors with histamine.

114 ation of central alpha2-adrenergic and/or H2-histaminergic receptors, but not via activation of I1-im

115 use represents a valuable model for studying histaminergic regulation of a variety of behaviors and n

116 myocytes by facilitating beta-adrenergic and histaminergic responses.

117 sensitivity involved a minor contribution of histaminergic/serotonergic receptors, but significant ac

118 to evaluate the effect of AMN+LEP on central histaminergic signaling in lean and obese rats.

119 rain plasticity in both the structure of the histaminergic system and its functions induced by altere

120 The histaminergic system appears to strengthen central trans

121 Hence, our findings indicate that the histaminergic system comprises parallel, coordinated pat

122 utic uses, or even including agonists of the histaminergic system in the treatment of different patho

123 We found that in psen1(-/-) zebrafish, the histaminergic system is altered throughout life.

124 The histaminergic system is involved in basic physiological

125 The histaminergic system is involved in the control of arous

126 first report that the integrity of the brain histaminergic system is necessary for long-term, but not

127 e, we report that the integrity of the brain histaminergic system is necessary for retrieval of inhib

128 Targeting the histaminergic system may modify the retrieval of emotion

129 t increased activity in the tuberomammillary histaminergic system may play a functional role in dampe

130 We investigated the effects of the central histaminergic system on afferent sensory signals in the

131 to demonstrate the modulatory actions of the histaminergic system on neurotransmission in the vestibu

132 ng sensory input may be one way in which the histaminergic system plays a role in arousal.

133 the role of psen1 in plasticity of the brain histaminergic system using a novel psen1 mutant zebrafis

134 Modulatory neurotransmitters, including the histaminergic system, are essential in mediating cogniti

135 Diabetes perturbs the retinal histaminergic system, causing increases in histidine dec

136 Recent studies indicate that the histaminergic system, which is critical for wakefulness,

137 drome (TS) in relation to alterations in the histaminergic system.

138 and that of dopaminergic, noradrenergic, and histaminergic systems in both structures in the consolid

139 These data suggest that the dopaminergic and histaminergic systems in H. americanus appear relatively

140 s were recorded within the boundaries of the histaminergic TM, however, not all waking-related and RE

141 he latter finding makes it unlikely that the histaminergic TMN has a central role in anesthesia.

142 o controls, narcolepsy patients had 94% more histaminergic TMN neurons (233,572 +/- 49,476 vs 120,455

143 Similarly, the number of histaminergic TMN neurons was increased 53% in orexin li

144 he cell bodies and proximal dendrites of the histaminergic TMN.

145 Central nervous system histaminergic tone is thought to play a role in appetite

146 eased sleep need, and therapies that enhance histaminergic tone may improve arousal after head trauma

147 ng of another monosynaptic input to SON, the histaminergic tuberomammillary nucleus (TM) projection,

148 ons to waking/arousal-related neurons in the histaminergic tuberomammillary nucleus (TM), the noradre

149 ng in NPY but not dopaminergic neurons), the histaminergic tuberomammillary nucleus and in cholinergi

150 pothalamic systems, but the integrity of the histaminergic tuberomammillary nucleus, a major arousal-

151 s such as the noradrenergic locus coeruleus, histaminergic tuberomammillary nucleus, serotoninergic r