ライフサイエンスコーパス: histatin

1 s characteristic of PRP-1, PRP-2, PIF-s, and histatins.

2 basic proline-rich proteins, statherin, and histatins.

3 es containing amylase, PRPs, statherins, and histatins.

4 ine-rich proteins, cystatins, statherin, and histatins.

5 These studies indicated that histatin 1 selectively bound to Cysl and Cys2, whereas s

6 ound to Cysl and Cys2, whereas statherin and histatin 1, 3, and 5 selectively bound to Cys8a.

7 lysozyme, proline-rich proteins, statherin, histatin 1, and mucous glycoprotein 1 were observed.

8 zymatic cleavage sites as K(13) and K(17) in histatin 1, R(22), Y(24), and R(25) in histatin 3, and Y

9 acidic proline-rich proteins, statherin, and histatin 1.

10 beta, secretory IgA, and lower lysozyme, and histatins 1 and 5 were found in patients with cirrhosis,

11 Mathematical models predict that histatins 1, 3, and 5 levels in whole saliva stabilize a

12 M, representing 59, 27, and 11% of glandular histatins 1, 3, and 5 levels, respectively.

13 Pure synthetic histatins 1, 3, and 5 were incubated with whole saliva s

14 re on the order of histatin-5 > histatin-3 > histatin-1.

15 ntage, we genetically engineered variants of histatin 3 with one, two, three, or four copies of the f

16 7) in histatin 1, R(22), Y(24), and R(25) in histatin 3, and Y(10), K(11), R(12), K(13), H(15), E(16)

17 fficiency, were on the order of histatin-5 > histatin-3 > histatin-1.

18 partners for the antifungal cationic peptide Histatin 5 (Hst 5) in vivo.

19 Salivary histatin 5 (Hst 5) is a cationic salivary protein with h

20 Human salivary histatin 5 (Hst 5) is a nonimmune salivary protein with

21 Histatin 5 (Hst 5) is a salivary gland-secreted cationic

22 Histatin 5 (Hst 5) is a small cationic human salivary pe

23 Salivary protein histatin 5 (Hst 5) is fungicidal toward Candida albicans

24 ther pathogenic fungi by the catonic protein Histatin 5 (Hst 5) is loss of cytoplasmic small molecule

25 Salivary histatin 5 (Hst 5) kills the fungal pathogen C. albicans

26 Salivary histatin 5 (Hst 5), a potent toxin for the human fungal

27 Histatin 5 (Hst5) is a 24-amino acid (aa) member of the

28 The inhibitory activity of histatin 5 against host and bacterial proteases at physi

29 esidues 9 to 22 showed identical activity to histatin 5 against MMP-9.

30 in these functional characteristics between histatin 5 and dh-5 on the one hand and dhvar1, dhvar4,

31 In contrast, histatin 5 and dh-5 showed fewer or none of these featur

32 dritic cells both demonstrated that 20.0 muM histatin 5 attenuated (p < 0.05) 0.02 muM HagB-induced C

33 ctural modeling studies all demonstrated two histatin 5 binding sites on HagB.

34 In this study, we hypothesized that histatin 5 binds to Porphyromonas gingivalis hemagglutin

35 Histatin 5 bound to immobilized HagB in a surface plasmo

36 more resistant to the antimicrobial peptide histatin 5 but showed essentially normal responses to th

37 hese data indicate that the salivary protein histatin 5 exerts its antifungal function through a mech

38 Fluorimetric measurements showed that histatin 5 induced the formation of reactive oxygen spec

39 Histatin 5 inhibited respiration of isolated C. albicans

40 al proteases, a detailed characterization of histatin 5 inhibition of gingipains from Porphyromonas g

41 e potential mechanistic relationship between histatin 5 interference with the respiratory apparatus a

42 Histatin 5 is a 24-residue peptide from human saliva wit

43 nhibition of the Arg-gingipain revealed that histatin 5 is a competitive inhibitor, affecting only th

44 Thus histatin 5 is capable of attenuating chemokine responses

45 n that the human salivary antifungal peptide histatin 5 is taken up by Candida albicans cells and ass

46 To evaluate the effect of histatin 5 on bacterial proteases, a detailed characteri

47 ing residues 1 to 14 and residues 4 to 15 of histatin 5 showed much lower inhibitory activities (IC50

48 d specifically designed synthetic analogs of histatin 5 to elucidate the role of peptide amphipathici

49 We recently demonstrated that histatin 5 translocates across the yeast membrane and ta

50 Using biotinylated gelatin as a substrate, histatin 5 was found to inhibit the activity of the host

51 ree peptides containing different regions of histatin 5 were synthesized and tested as inhibitors of

52 This study evaluated the potential of histatin 5, a 24-residue histidine-rich salivary antimic

53 re dh-5, comprising the functional domain of histatin 5, and dhvar1 and dhvar4, both designed to maxi

54 Unlike the antifungal peptide histatin 5, it did not require energy-dependent transpor

55 lity of highly protease-susceptible proteins-histatin 5, statherin, and PRP1-was assessed.

56 peptin, antipain, and EDTA could not prevent histatin 5, statherin, or PRP1 degradation in whole sali

57 In contrast to histatin 5, the conventional inhibitors of the respirato

58 nonrespiring yeast cells are insensitive to histatin 5, the potential mechanistic relationship betwe

59 2), K(13), H(15), E(16), K(17), and H(18) in histatin 5.

60 l domain localized in the C-terminal part of histatin 5.

61 proteolytic efficiency, were on the order of histatin-5 > histatin-3 > histatin-1.

62 Human salivary histatin-5 (Hsn-5), a 24-amino acid polypeptide, is a po

63 r candidacidal activity by using recombinant histatin-5 and its variants produced in Escherichia coli

64 The conformational preferences of histatin-5 and variants were determined by circular dich

65 such as Lys-13 and Arg-22 in the sequence of histatin-5 are, indeed, important for candidacidal activ

66 gnificantly less potent than the recombinant histatin-5 as well as m71, indicating that Arg-22 is cru

67 ignificantly less effective than recombinant histatin-5 in killing Candida albicans, suggesting that

68 ns with affinity tags at the N-terminus, and histatin-5, a peptide with multiple histidine residues.

69 wever, are comparable to that of recombinant histatin-5, indicating that Arg-12, Lys-17, His-19, and

70 nce for a comprehensive mechanistic model of histatin-5-provoked yeast cell death in which oxygen rad

71 radykinin, neurokinin A, Met-Lys-bradykinin, histatin 8, and a myosin light chain fragment.

72 cytokines/secretory immunoglobulin A (IgA), histatins and lysozyme in a subsequent group.

73 tance to the antifungal activity of salivary histatins and mucins.

74 The candidacidal activity of histatins appears to be a distinctive multistep mechanis

75 Salivary histatins are a family of small histidine-rich peptides

76 line-rich proteins, statherin, and the major histatins are capable of undergoing crosslink reactions

77 Histatins are human salivary gland peptides with anti-mi

78 Salivary histatins are potent in vitro antifungal proteins and ha

79 Histatins are small molecular weight proteins produced b

80 roline-rich proteins (PRPs), statherins, and histatins but not MG1, sIgA, secretory component, or cys

81 tatherin, and some of the lysines present in histatins, could participate in the crosslink reaction.

82 olyphenols to hydroxyapatite, while enriched histatins did not increase binding.

83 ndem repeats, relatively young proteins like histatins do not contain such repeated domains.

84 oring of the appearance and disappearance of histatin fragments yielded the identification of the fir

85 aromyces cerevisiae that mediates binding of histatin (Hst) 5.

86 Salivary histatins (Hsts) are antifungal peptides with promise as

87 Salivary histatins (Hsts) are potent in vitro antifungal agents a

88 ts to a new potential biological function of histatin in the oral cavity.

89 novel fragments of proline-rich proteins and histatins in abundance.

90 ylase, proline-rich proteins, statherin, and histatins in salivary secretions, and the aim of this st

91 rly perfect correlation was observed between histatin-induced inhibition of respiration and cell kill

92 ,6,6-tetramethylpiperidine-N-oxyl, abolished histatin-induced ROS formation in isolated mitochondria.

93 n components of saliva, including cystatins, histatins, lysozyme, and isoforms and/or fragments of al

94 Components identified in pellicle included histatins, lysozyme, statherin, cytokeratins, and calgra

95 Human salivary histatins possess fungicidal and bactericidal activities

96 e rate and mode of degradation of individual histatin proteins in whole saliva to establish the impac

97 consistent with the presence of lysozyme and histatins, respectively, which may represent the major c

98 Also the previous suggestion that the histatin/statherin gene family, located in this region,

99 The purified recombinant histatins were examined for their candidacidal activity

100 a, Cys8b, Cys8c) of MUC5B with statherin and histatins were investigated.

101 s showed that amylase, PRPs, statherins, and histatins were released.

102 line-rich proteins, statherin, and the major histatins, whereas a glutamine-containing dansylated pep

103 uates the structure-function relationship of histatins with regard to their candidacidal activity by