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1 n when the residues are good ligands such as histidine.
2 m were prepared by hydrothermal treatment of histidine.
3 nal rearrangements that include the reactive histidine.
4 mediate proton relay to the proton-selective histidine.
5 m, caused by a sulfation of a copper binding histidine.
6 ereas TbAAT2-4 transports both ornithine and histidine.
7 eonine (Tpt) or serine (Spt) in place of the histidine.
8 gment 4 (domain 1), the voltage sensor, with histidine.
9 amino acids, especially serine, arginine and histidine.
10 cupancy of the allosteric sites by TIH and L-histidine.
11 er with an iron cofactor coordinated by four histidines.
14 ular health-related interest is the mutation Histidine 147 to Arginine (H147R) in human TRiC subunit
15 The reciprocal substitution of aspartate-to-histidine-193 in Pto abolished AvrPto recognition, confi
16 Val254 or LACC1 with mutations of the nearby histidines (249,250) have reduced PRR-induced outcomes.
17 m involving two water molecules and residues histidine-42, arginine-38, and serine-71 was proposed.
18 nverting these two residues to those in Pto (histidine-49/valine-51) did not restore recognition of A
19 ational-experimental study demonstrates that histidine-547 (H547) of hDAT plays a crucial role in the
20 n subunits with a C-terminally appended hexa-histidine (6His) tag are still assembled into functional
22 tagenomes indicated phoA, phoD and phoX, and histidine acid and cysteine phytase genes were most abun
23 es, as their altered pKa values, relative to histidine, allow for studies of the role of proton trans
24 Hz to the exchangeable proton of a conserved histidine and conclude that the histidine is hydrogen-bo
25 evealed a conserved region unusually rich in histidine and cysteine residues in the TMA-L1 region of
26 e contains a diiron cluster ligated by three histidine and four glutamate residues and activates diox
27 tion of a C-S bond between N-alpha-trimethyl histidine and gamma-glutamyl cysteine, which is the key
30 ed mutagenesis established the importance of histidine and methionine containing motifs for Ag(+) -bi
31 formation of the ion pair associate between histidine and the nano optical samarium tetracycline [Sm
34 as inhibited by the singlet oxygen scavenger histidine and was accompanied by vacuolar collapse and t
35 sRS from Burkholderia thailandensis bound to histidine, and a LysRS from Burkholderia thailandensis b
36 is essential for the biosynthesis of serine, histidine, and methionine; (iv) catabolic end products o
37 d in animals for nutrient signaling, and the histidine- and glutamine-rich domain of TCP20, which is
38 dicationic His4 filter where two of the four histidines are protonated is more proton-selective than
40 for increasing the impact and assessment of histidine as a biomarker for early diagnosis of histidin
43 amphoteric carriers, glutamic acid, aspartyl-histidine (Asp-His), cycloserine (cSer), and arginine, w
44 s an ssDNA-specific nuclease activity in the histidine-aspartate (HD) domain of the Cmr2 subunit of t
45 mid assay showed that mutation either in the histidine-aspartate acid (HD) domain (a quadruple mutati
46 ain-like fold with a characteristic cysteine-histidine-aspartate catalytic triad comprising Cys-73, H
52 e which is very selective and sensitive for [histidine](-) at pH 9.2 in serum and urine samples of hi
53 Cvi-0, one of the two copies of a duplicated histidine biosynthesis gene, HISN6A, is mutated, making
55 the enzyme closely resembles the inhibited L-histidine-bound closed conformation, revealing the uncou
57 modynamic appraisal of copper binding to the histidine-brace in an auxiliary activity family 10 (AA10
58 ansporters, one of which can be modulated by histidine, but both of which affect sensitivity to impor
60 n, decrease incorporation in response to the histidine CAC codon, and improve cell health and growth
61 mplexes demonstrated that heme binding via a histidine can be supported by hydrogen bond interactions
62 tate, as seen in WT M2, but left half of all histidines cationic, unambiguously demonstrating C-termi
63 p variants that increase reassignment of the histidine CAU codon, decrease incorporation in response
64 auxotrophic for the aromatic amino acids and histidine, causes scrub typhus, a potentially deadly inf
70 ) has eight "Xpt" domains; six are canonical histidine-containing phosphotransfer (Hpt) domains and t
71 equence, revealing marked differences in the histidine-containing transmembrane helix behavior betwee
72 itratable amino acid residues in lieu of the histidines could bind protons and how they affect proton
73 posed that involves nucleophilic addition by histidine, cysteine, or lysine residues to the carbonyl-
78 od FCER1A, carboxypeptidase A3 (CPA3), and L-histidine decarboxylase (HDC) gene expression; and serum
79 A premature termination codon in the human histidine decarboxylase (Hdc) gene has been identified i
83 iodontitis patients express higher levels of histidine decarboxylase and ECP than those from healthy
84 Here, we show that cholangiocytes express histidine decarboxylase and its inhibition reduces CCA g
85 athymic mice treated with saline, histamine, histidine decarboxylase inhibitor, or cromolyn sodium.
86 In vitro, cultured MCs were transfected with histidine decarboxylase short hairpin RNA to decrease hi
87 lhistidine (a-FMHis), a suicide inhibitor of histidine decarboxylase, displayed impaired IA memory wh
89 nic mouse line expressing cre recombinase in histidine decarboxylase-expressing neurons (Hdc-Cre) fol
90 cle di-peptides composed of beta-alanine and histidine derivatives such as anserine are extremely imp
91 ata indicates that protonation of the buried histidine destabilizes both PrP variants, but produces a
92 sed to quantitate two biologically important histidine dipeptides, carnosine and anserine, using capa
96 nanocomposite probe comprised of amino acid (histidine) functionalized perylenediimide (PDI-HIS), cop
97 oxylic acid residues but, uniquely, a single histidine functions as the only discernable catalytic am
98 The resulting variant, which has cysteine-histidine-glutamic acid triads on each helix, hydrolyses
103 ime in transmembrane cytochrome, one natural histidine has been replaced by lysine without loss of th
105 s, bacteria, and archaebacteria synthesise L-histidine (His) in a similar, multistep pathway that is
107 11556924), resulting in an arginine (Arg) to histidine (His) substitution in its encoded protein, NIP
108 ominent network-guided GWAS signal was for a histidine (His)-related trait in a region containing two
110 mportantly, BM2 contains a second titratable histidine, His-27, in the tetrameric transmembrane domai
111 d a conserved CXXCH motif of cyt c In cyt c, histidine (His19) of CXXCH acts as an axial ligand to he
112 ences to the presence of a second titratable histidine, His27, which may increase the proton-dissocia
114 nd histidine-lysine (His-Lys) in addition to histidine-histidine (His-His) cross-links were discovere
117 ed as an optical probe for the assessment of histidine in different serum and urine samples of new bo
119 GA1 channels by transition metals requires a histidine in the A' helix following the S6 transmembrane
120 be inhibited by the singlet oxygen scavenger histidine in treatments with AO but not with RB In the c
124 ies further identified a role for the distal histidine, interacting with the hexacoordinated iron ato
125 a conserved histidine and conclude that the histidine is hydrogen-bonded to N2, tuning its reduction
126 ed setup, we demonstrated that the catalytic histidine is not involved in acyl-enzyme formation, but
127 Considering the two tautomeric forms of histidine, it was found that 2-fluorohistidine primarily
130 we aimed to target the TCS signal transducer histidine kinase (HK) by focusing on their highly conser
131 gnal-induced autophosphorylation of a sensor histidine kinase (HK) followed by phosphoryl transfer to
132 rotein was engineered as a functional sensor histidine kinase (TolRSK) and an independent response re
134 osphorelay in which phosphoryl groups from a histidine kinase are successively transferred via relay
135 tners of TlpD, which included the chemotaxis histidine kinase CheAY2, the central metabolic enzyme ac
136 hosphorylation of the receiver domain of the histidine kinase CYTOKININ-INDEPENDENT 1 (CKI1RD) from A
138 that the coiled coil linker and the attached histidine kinase domains undergo a left handed rotation
140 mbined NMR and crystallographic study on the histidine kinase HK853 and its response regulator RR468
143 how a single amino acid substitution in the histidine kinase receptor AgrC of ST22 strains determine
146 and some other S. aureus strains, the sensor histidine kinase SaeS has an L18P (T53C in saeS) substit
149 A interacts with DcuS, the membrane embedded histidine kinase, to transfers DcuS to the responsive st
150 le, while the C-terminal module, including a histidine kinase-related domain (HKRD), does not partici
153 xperimental and calculated distances for the histidine-kinase region when both subunits are in a para
155 ity of downstream signaling proteins such as histidine kinases (HisKa) in a NO-dependent manner.
159 nsduction in sensor histidine kinases.Sensor histidine kinases (SHK) consist of sensor, linker and ki
160 wo-component systems (TCS) comprising sensor histidine kinases and response regulator proteins are am
161 first assess the algorithm's performance on histidine kinases and response regulators from bacterial
164 ically thought to be mediated exclusively by histidine kinases as part of two-component signaling sys
166 tivity of the largest family of bifunctional histidine kinases in response to the change of environme
167 ial phytochromes are dimeric light-regulated histidine kinases that convert red light into signaling
169 a template for signal transduction in sensor histidine kinases.Sensor histidine kinases (SHK) consist
170 ry backgrounds, combinatorially perturbed in histidine, leucine, methionine and uracil biosynthesis.
173 ed histidine mutants enabled localization of histidines likely to be important for triggering this pH
174 y charged, interacts with positively charged histidine located at position 55, thereby stabilizing KI
175 where oxidized histidines react with intact histidine, lysine, and free cysteine to form cross-links
176 nks between an oxidized histidine and intact histidine, lysine, or cysteine residues were discovered
177 with a small group of amino acids (arginine, histidine, lysine, phenylalanine, tyrosine, and tryptoph
178 t time that histidine-cysteine (His-Cys) and histidine-lysine (His-Lys) in addition to histidine-hist
179 ewise, partially purified spinach extensins (histidine/lysine-rich cationic glycoproteins), strongly
180 at MobM follows a previously uncharacterized histidine/metal-dependent DNA processing mechanism, whic
181 he probe contains a naphthalimide core, an l-histidine methyl ester linker, and an acetylated galacto
182 based recognition element, N-methacryloyl-L-histidine methylester (MAH), 2-Hydroxyethyl methacrylate
183 metal ion, we identify a surface-exposed di-histidine motif in MamO that contributes to metal bindin
184 Reverse genetics and rescue of site-directed histidine mutants enabled localization of histidines lik
186 lanine 3.33 in CCR5 TM3 by the corresponding histidine of CCR2 converts J113863 from an antagonist fo
188 the importance of the cysteine and the first histidine of the CX3HX2H motif in the process of copper
189 ates with and dephosphorylates the catalytic histidine on nucleoside diphosphate kinase B (NDPK-B).
190 IV-1, substitution of large residues such as histidine or tryptophan for serine 375 (S375H/W) in the
192 vative, nonionizable substitutions of the TL histidine (or a neighboring TL arginine conserved in bac
194 r lysine residues to the carbonyl-containing histidine oxidation intermediates to form the cross-link
195 10 mug/mL of lysine (p < 0.05) and 10 mug/mL histidine (p < 0.001), 100 mug/mL of glutamic acid (p <
196 nt analysis and associations between HAL and histidine, PAH and phenylalanine, and UPB1 and ureidopro
197 argC, argG, argH and argJ) and two arginine/histidine permease genes (SSA_1568 and SSA_1569) were up
198 and aromatic amino acids (alanine, glycine, histidine, phenylalanine, leucine, isoleucine, valine, a
200 t time phosphoisoform-specific regulation of histidine-phosphorylated proteins in vivo, and we link t
201 ntracellular copper exhibit increased KCa3.1 histidine phosphorylation and channel activity, leading
202 portant step forward in studying the role of histidine phosphorylation in mammalian biology and disea
203 exceedingly well characterized, the role of histidine phosphorylation in mammalian signaling is larg
205 focused auxin signaling triggers ARABIDOPSIS HISTIDINE PHOSPHOTRANSFER PROTEIN6 (AHP6), which then re
207 vates transcription of sda, and Sda inhibits histidine protein kinases required for activation of the
208 res all four histidines with two of the four histidines protonated and if other titratable amino acid
210 a(+) depends on the selectivity filter's (1) histidine protonation state, (2) solvent exposure, (3) o
212 a previously uncharacterized arginine 243 to histidine (R243H) mutation in the G-protein alpha subuni
213 s-links in the HMW fractions, where oxidized histidines react with intact histidine, lysine, and free
214 gen bond shape the dominant position of MOBV histidine relaxases among small promiscuous plasmids and
216 By site-directed mutagenesis we show that a histidine residue (His-347) downstream of S6 reduces inh
217 tion to calcium, phosphorylation of a single histidine residue (His358) in the cytoplasmic region, by
218 ctivity, achieved by introducing a catalytic histidine residue at the terminus of a pH-responsive pep
220 c role was put forward for a fully conserved histidine residue in MraY (His-289 in BsMraY), which has
221 crepancy, we explored the role of the distal histidine residue in muting the reactivity of human neur
223 pecific post-translational modification of a histidine residue of eEF2, is involved in translocation.
224 reveal the binding of two ruthenium atoms to histidine residues 146 and 242, which are both located w
227 is able to bind two b-type hemes through the histidine residues conserved between the MsrQ and NOX pr
229 m long fibrils with the hydrophobic edge and histidine residues extending in an ordered array as the
232 ots were identified, which include conserved histidine residues His292 and His440 in the Fc region an
233 t in canine HSP47, where we have mutated all histidine residues in the collagen binding interface and
235 tivation causes oxidative damage to specific histidine residues in the key proteins in aldose reducta
236 theoretical and experimental study of the 14 histidine residues present in canine HSP47, where we hav
237 tification, and site-directed mutagenesis of histidine residues, we demonstrated that MsrQ is able to
241 r proportion were positive for P. falciparum histidine rich protein 2 (192/246 [78.0%]) vs 811/1154 [
242 diagnostic tests (RDTs) detect P. falciparum histidine rich protein 2 (PfHRP2) and cross react with P
244 ction enhancer, also called LAH4-A4, a short histidine-rich amphipathic peptide derived from the LAH4
246 and interface mapping experiments identified histidine-rich cytoplasmic loops within the ZIP6/ZIP10 h
248 Recently, the liver-derived plasma protein, histidine-rich glycoprotein (HRG), was demonstrated, in
249 5, C6, apolipoproteins A-I, A-IV, C-I and M, histidine-rich glycoprotein, heparin cofactor II and att
250 ted form of Ctr1 lacking the methionine- and histidine-rich metal-binding ectodomain, and it exhibits
251 TabZIPs contain the group-defining cysteine-histidine-rich motifs, which are the predicted binding s
254 ged between 6 months and 6 years using rapid histidine-rich protein 2 (HRP2)-based diagnostic tests (
255 sor was used to detect Plasmodium falciparum histidine-rich protein 2 (PfHRP2), an important malaria
260 diagnostic testing with a multiple-antigen (histidine-rich protein 2 and pan-lactate dehydrogenase p
261 a (i) the detection of Plasmodium falciparum histidine-rich protein 2 antigen and (ii) multiplexed an
262 nge in the presence of Plasmodium falciparum histidine-rich protein 2 at a concentration well below c
263 erformance of Plasmodium falciparum-specific histidine-rich protein 2-based rapid diagnostic tests (R
264 , we investigated the diagnostic accuracy of histidine-rich protein 2-based RDTs using qualitative po
266 gnostic tests based on Plasmodium falciparum histidine-rich protein II (PfHRP-II) and P. falciparum l
267 dy, we assessed the accuracy of a dual-band (histidine-rich protein-2/pan-lactate dehydrogenase [HRP2
268 laria RDT that targets Plasmodium falciparum histidine-rich protein-II (HRPII) and Plasmodium lactate
271 f methyl jasmonate foliar application, i.e., histidine, serine, tryptophan, phenylalanine, tyrosine,
273 ritically important ionization properties of histidine side chains of membrane proteins, when exposed
274 hip desalting, the limit of quantitation for histidine spiked in aCSF is approximately 1 muM, and cal
275 deletion at the C terminus (INTDeltaC15) and histidine substituted at the interaction surface (INT/DS
277 orohistidine primarily forms the common (for histidine) tau-tautomer at neutral pH, while 4-fluorohis
280 -terminal pore at low pH did not convert all histidines to the neutral state, as seen in WT M2, but l
281 nts revealed that a single substitution of a histidine-to-aspartate at position 193 in Pto, which is
282 cysteine, glutamic acid, glutamine, glycine, histidine, total homocysteine, isoleucine, kynurenine, l
283 transcriptional activity is inhibited by the histidine triad nucleotide-binding protein 1 (HINT1) thr
285 petition, YPL067C, uncovered a new family of histidine triad proteins apparently involved in the prev
286 ages employ the 8/4 structure for serine and histidine tRNAs, while minor cysteine and selenocysteine
287 of novel preservation solutions such as new histidine-tryptophan-ketoglutarate (HTK-N) and TiProtec
288 utes of WI, livers were flushed in situ with histidine-tryptophan-ketoglutarate and subsequently pres
289 e preferential COX-2 inhibitor Meloxicam via histidine-tryptophan-ketoglutarate showed the best graft
290 reserved with 8-hour NEVKP or in 4 degrees C histidine-tryptophan-ketoglutarate solution (SCS), follo
293 ack of complete pathways for biosynthesis of histidine, valine, leucine, isoleucine, lysine and proli
294 -gel matrix by various concentrations of the histidine was successfully used as an optical probe for
295 cine, tyrosine, phenylalanine, ornithine and histidine were low, while values for citrulline, methion
296 atty acids, medium chain acylcarnitines, and histidine were: (1) stable in maternal plasma from pregn
297 he model predictions, except for glucose and histidine, which were depleted more slowly than predicte
298 ation range 1.4x10(-5) - 6.5x10(-10)molL(-1) histidine with a correlation coefficient of (0.998) and
299 ed polar interface houses the Zn(2+)-binding histidines with binding geometries unusual in proteins.
300 ton selectivity absolutely requires all four histidines with two of the four histidines protonated an
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